RU2002125858A - Диагностическое устройство с регулированием потока жидкости через капилляр - Google Patents
Диагностическое устройство с регулированием потока жидкости через капиллярInfo
- Publication number
- RU2002125858A RU2002125858A RU2002125858/14A RU2002125858A RU2002125858A RU 2002125858 A RU2002125858 A RU 2002125858A RU 2002125858/14 A RU2002125858/14 A RU 2002125858/14A RU 2002125858 A RU2002125858 A RU 2002125858A RU 2002125858 A RU2002125858 A RU 2002125858A
- Authority
- RU
- Russia
- Prior art keywords
- sample
- measurement zone
- channel
- capillary
- inlet
- Prior art date
Links
- 239000012530 fluid Substances 0.000 title claims 3
- 238000005259 measurement Methods 0.000 claims 10
- PGOHTUIFYSHAQG-LJSDBVFPSA-N (2S)-6-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-1-[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-3-sulfanylpropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxybutanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-oxopentanoyl]amino]-3-phenylpropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-oxobutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-carboxybutanoyl]amino]-5-oxopentanoyl]amino]hexanoic acid Chemical compound CSCC[C@H](N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(O)=O PGOHTUIFYSHAQG-LJSDBVFPSA-N 0.000 claims 3
- 108010000499 Thromboplastin Proteins 0.000 claims 3
- 102000002262 Thromboplastin Human genes 0.000 claims 3
- 239000013060 biological fluid Substances 0.000 claims 3
- 239000012491 analyte Substances 0.000 claims 2
- 239000003146 anticoagulant agent Substances 0.000 claims 2
- 229940127219 anticoagulant drug Drugs 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 230000037361 pathway Effects 0.000 claims 2
- 108010094028 Prothrombin Proteins 0.000 claims 1
- 102100027378 Prothrombin Human genes 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 230000023555 blood coagulation Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 230000013011 mating Effects 0.000 claims 1
- 230000003287 optical effect Effects 0.000 claims 1
- 229940039716 prothrombin Drugs 0.000 claims 1
- 238000002834 transmittance Methods 0.000 claims 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
- G01N33/537—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
- G01N33/538—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody by sorbent column, particles or resin strip, i.e. sorbent materials
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/4905—Determining clotting time of blood
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/2575—Volumetric liquid transfer
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Biochemistry (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- Ecology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Claims (10)
1. Медицинское диагностическое устройство для измерения концентрации анализируемого вещества в биологической жидкости и ее свойств, содержащее входное отверстие для ввода пробы биологической жидкости в устройство, первый капиллярный канал для перемещения пробы от входного отверстия к точке ответвления, капиллярный соединительный канал для перемещения первой части пробы от точки ответвления через зону измерения, в которой измеряется физический параметр пробы, соответствующий концентрации анализируемого вещества в жидкости или ее свойства, к первому стопорному соединению, капиллярный перепускной канал для перемещения второй части пробы в первом направлении от первого участка, проксимального к точке ответвления, к переливному участку, дистальному к точке ответвления, при этом первый участок имеет определенный размер капилляра во втором направлении, перпендикулярном к первому направлению, второе стопорное соединение в перепускном канале, содержащее граничный участок, который разделяет первый и переливной участки, имеет второй заданный размер во втором направлении, больший, чем размер капилляра, и образует угол, который заострен к первой области, посредством чего любая избыточная проба, которая входит во входное отверстие для подачи пробы, будет проходить через второе стопорное соединение в переливной участок.
2. Устройство по п.1, отличающееся тем, что дополнительно содержит всасывающее устройство, сообщающееся по жидкости с первым и вторым стопорными соединениями, для втягивания пробы из входного отверстия для пробы к стопорным соединениям.
3. Устройство по п.2, отличающееся тем, что содержит первый слой и второй слой, по меньшей мере один из которых имеет упругую область на по меньшей мере части своей поверхности, разделенные промежуточным слоем, при этом вырезы в слоях образуют вместе со слоями входное отверстие для пробы, первый канал, соединительный канал, зону измерения и перепускной канал, а всасывающее устройство содержит полость, которая является дистальной от входного отверстия для пробы, содержит по меньшей мере часть упругой области, и имеет объем, который по меньшей мере равен суммарному объему первого канала, зоны измерения, соединительного канала и перепускного канала, первое и второе стопорные соединения содержат совмещающиеся отверстия в первом, втором и промежуточных слоях, между которыми размещены третий и четвертый слои.
4. Устройство по п.3, отличающееся тем, что по меньшей мере первый или второй слой выполнены прозрачными вблизи зоны измерения, при этом физическим параметром, который измеряют, является величина оптического пропускания.
5. Устройство по п.3, отличающееся тем, что физический параметр пробы подвергается изменению в зоне измерения.
6. Устройство по п.5, отличающееся тем, что зона измерения содержит состав, который способствует свертыванию крови, биологической жидкостью является цельная кровь и измеряемым свойством является протромбиновое время.
7. Устройство по п.6, отличающееся тем, что указанный состав содержит тромбопластин.
8. Устройство по п.6, отличающееся тем, что содержит по меньшей мере один дополнительный жидкостной канал от точки ответвления к полости, при этом каждый альтернативный путь содержит соответствующую зону измерения и стопорное соединение.
9. Устройство по п.8, отличающееся тем, что первый альтернативный путь является путем к зоне измерения, которая нейтрализует действие антикоагулянта, а второй альтернативный путь является путем к зоне измерения, которая частично нейтрализует действие антикоагулянта.
10. Устройство по п.9, отличающееся тем, что зона измерения в первом альтернативном пути содержит тромбопластин, элюат бовина и рекомбинант фактор УПа, а зона измерения во втором альтернативном пути содержит тромбопластин и элюат бовина.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/541,376 US6908593B1 (en) | 2000-03-31 | 2000-03-31 | Capillary flow control in a fluidic diagnostic device |
| US09/541,376 | 2000-03-31 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2002125858A true RU2002125858A (ru) | 2004-03-10 |
| RU2238147C2 RU2238147C2 (ru) | 2004-10-20 |
Family
ID=24159321
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2002125858A RU2238147C2 (ru) | 2000-03-31 | 2001-03-22 | Диагностическое устройство с регулированием потока жидкости через капилляр |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6908593B1 (ru) |
| EP (1) | EP1280602B1 (ru) |
| JP (1) | JP2003529763A (ru) |
| KR (1) | KR20020087448A (ru) |
| CN (1) | CN1238112C (ru) |
| AR (1) | AR028529A1 (ru) |
| AT (1) | ATE295227T1 (ru) |
| AU (2) | AU6292301A (ru) |
| CA (1) | CA2404521A1 (ru) |
| CZ (1) | CZ20023250A3 (ru) |
| DE (1) | DE60110781T2 (ru) |
| ES (1) | ES2241828T3 (ru) |
| IL (1) | IL151965A0 (ru) |
| MX (1) | MXPA02009700A (ru) |
| MY (1) | MY134187A (ru) |
| PL (1) | PL357113A1 (ru) |
| PT (1) | PT1280602E (ru) |
| RU (1) | RU2238147C2 (ru) |
| TW (1) | TW519567B (ru) |
| WO (1) | WO2001075433A2 (ru) |
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- 2000-03-31 US US09/541,376 patent/US6908593B1/en not_active Expired - Lifetime
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2001
- 2001-03-22 RU RU2002125858A patent/RU2238147C2/ru not_active IP Right Cessation
- 2001-03-22 JP JP2001572861A patent/JP2003529763A/ja active Pending
- 2001-03-22 CZ CZ20023250A patent/CZ20023250A3/cs unknown
- 2001-03-22 AT AT01937160T patent/ATE295227T1/de active
- 2001-03-22 ES ES01937160T patent/ES2241828T3/es not_active Expired - Lifetime
- 2001-03-22 CN CNB018076386A patent/CN1238112C/zh not_active Expired - Fee Related
- 2001-03-22 IL IL15196501A patent/IL151965A0/xx unknown
- 2001-03-22 KR KR1020027012999A patent/KR20020087448A/ko not_active Withdrawn
- 2001-03-22 CA CA002404521A patent/CA2404521A1/en not_active Abandoned
- 2001-03-22 AU AU6292301A patent/AU6292301A/xx active Pending
- 2001-03-22 PT PT01937160T patent/PT1280602E/pt unknown
- 2001-03-22 PL PL01357113A patent/PL357113A1/xx not_active Application Discontinuation
- 2001-03-22 EP EP01937160A patent/EP1280602B1/en not_active Expired - Lifetime
- 2001-03-22 DE DE60110781T patent/DE60110781T2/de not_active Expired - Lifetime
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- 2001-03-22 AU AU2001262923A patent/AU2001262923B2/en not_active Ceased
- 2001-03-22 WO PCT/US2001/009237 patent/WO2001075433A2/en not_active Ceased
- 2001-03-29 MY MYPI20011507A patent/MY134187A/en unknown
- 2001-03-30 AR ARP010101547A patent/AR028529A1/es unknown
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| KR20020087448A (ko) | 2002-11-22 |
| AU6292301A (en) | 2001-10-15 |
| WO2001075433A2 (en) | 2001-10-11 |
| PT1280602E (pt) | 2005-07-29 |
| MXPA02009700A (es) | 2004-09-06 |
| CZ20023250A3 (cs) | 2003-06-18 |
| US6908593B1 (en) | 2005-06-21 |
| DE60110781T2 (de) | 2006-02-23 |
| MY134187A (en) | 2007-11-30 |
| AU2001262923B2 (en) | 2005-02-03 |
| TW519567B (en) | 2003-02-01 |
| PL357113A1 (en) | 2004-07-12 |
| CN1422180A (zh) | 2003-06-04 |
| EP1280602B1 (en) | 2005-05-11 |
| CA2404521A1 (en) | 2001-10-11 |
| WO2001075433A3 (en) | 2002-03-14 |
| ATE295227T1 (de) | 2005-05-15 |
| AR028529A1 (es) | 2003-05-14 |
| RU2238147C2 (ru) | 2004-10-20 |
| EP1280602A2 (en) | 2003-02-05 |
| IL151965A0 (en) | 2003-04-10 |
| JP2003529763A (ja) | 2003-10-07 |
| CN1238112C (zh) | 2006-01-25 |
| HK1050650A1 (en) | 2003-07-04 |
| DE60110781D1 (de) | 2005-06-16 |
| ES2241828T3 (es) | 2005-11-01 |
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