RU2002110115A - PETROPYRANE DERIVATIVE - Google Patents

Claims (8)

1. The benzopyran derivative of the formula (I)

where R ¹ and R ² each independently represent a hydrogen atom, a C _1-6 alkyl group, wherein said alkyl group may be optionally substituted with a halogen atom, a C _1-6 alkoxy group or a hydroxyl group; or a phenyl group, wherein said phenyl group may be optionally substituted with a halogen atom, a hydroxyl group, a nitro group, a cyano group, a C _1-6 alkyl group or a C _1-6 alkoxy group, R ³ represents a hydroxyl group or a C _1-6 alkylcarbonyloxy group, R ⁴ represents a hydrogen atom, or R ³ and R ⁴ together form a bond, m represents an integer from 0 to 4, n represents an integer from 0 to 4, Y is absent or represents CR ¹¹ R ¹² , where R ¹¹ and R ¹² each independently represents a hydrogen atom or a C _1-6 alkyl group, R ⁵ represents an aryl group or a heteroaryl group, wherein said aryl group and said heteroaryl group may be optionally substituted with q (R ¹⁰ ), where R ¹⁰ represents a halogen atom, a hydroxyl group, a C _1-6 alkyl group, wherein said alkyl the group may be optionally substituted with a halogen atom or a C _1-6 alkoxy group; or R ¹⁰ represents a nitro group, a cyano group, a formyl group, formamide group, amino, C _1-6 -alkylamino, di-C _1-6 -alkylamino, C _1-6 -alkilkarbonilaminogruppu, C _1-6 -alkilsulfonilaminogruppu, aminocarbonyl group, C _1-6 -alkmlaminokarbonilnuyu group, a di-C _1-6 -alkilaminokarbonilnuyu group, a C _1-6 alkylcarbonyl group, a C _1-6 alkoxycarbonyl group, aminosulfonyl group, C _1-6 -alkilsulfonilnuyu group, a carboxyl group or an arylcarbonyl group , q is an integer from 1 to 3, and each R ¹⁰ m can be the same or different if q is 2 or 3, R ⁶ represents a hydrogen atom or a C _1-6 alkyl group, R ⁷ represents a hydrogen atom or a C _1-6 alkyl group, X is absent or represents C = O or SO ₂ , R ⁸ represents a hydrogen atom, a C _1-6 alkyl group, wherein said alkyl group may be optionally substituted with a halogen atom, a hydroxyl group or a C _1-6 alkoxy group, or a C _3-6 cycloalkyl group, and R ⁹ represents a hydrogen atom, a halogen atom, a nitro group or a cyano group; or a pharmaceutically acceptable salt thereof. 2. The benzopyran derivative or a pharmaceutically acceptable salt thereof according to claim 1, wherein R ¹ and R ² are both methyl groups, R ³ is a hydroxyl group, and R ⁴ is a hydrogen atom. 3. The benzopyran derivative or its pharmaceutically acceptable salt according to claim 2, where R ⁹ represents a hydrogen atom or a nitro group. 4. The benzopyran derivative or a pharmaceutically acceptable salt thereof according to claim 3, wherein X is C = O, and R ⁶ and R ⁷ are both hydrogen atoms. 5. The benzopyran derivative or a pharmaceutically acceptable salt thereof according to claim 4, wherein R ⁵ is a benzene ring, Y is absent, m is 0, an is 1 or 2. 6. The benzopyran derivative or a pharmaceutically acceptable salt thereof according to claim 5, wherein R ⁸ is an alkyl group, R ⁹ is a nitro group, and n is 2. 7. A drug, characterized in that it includes a benzopyran derivative or its pharmaceutically acceptable salt according to claim 1 as an active ingredient. 8. A medicament for treating arrhythmia, characterized in that it includes a benzopyran derivative or a pharmaceutically acceptable salt thereof according to claim 1 as an active ingredient.