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RU2002104574A - 2-арилимино-2,3-дигидротиазолы и их использование в качестве лигандов рецепторов соматостатина - Google Patents

2-арилимино-2,3-дигидротиазолы и их использование в качестве лигандов рецепторов соматостатина

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Publication number
RU2002104574A
RU2002104574A RU2002104574/04A RU2002104574A RU2002104574A RU 2002104574 A RU2002104574 A RU 2002104574A RU 2002104574/04 A RU2002104574/04 A RU 2002104574/04A RU 2002104574 A RU2002104574 A RU 2002104574A RU 2002104574 A RU2002104574 A RU 2002104574A
Authority
RU
Russia
Prior art keywords
arylimino
thiazoles
dihydro
ligands
somatostatin receptors
Prior art date
Application number
RU2002104574/04A
Other languages
English (en)
Other versions
RU2266287C2 (ru
Inventor
Кристоф МУАНЕ (FR)
Кристоф Муане
Кароль САКЮР (FR)
Кароль САКЮР
Кристоф ТЮРЬО (FR)
Кристоф ТЮРЬО
Original Assignee
Сосьете де Консей де Решерш э Д'Аппликасьон Сьентифик (С.К.Р.А.С.) (FR)
Сосьете Де Консей Де Решерш Э Д'Аппликасьон Сьентифик (С.К.Р.А.С.)
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Application filed by Сосьете де Консей де Решерш э Д'Аппликасьон Сьентифик (С.К.Р.А.С.) (FR), Сосьете Де Консей Де Решерш Э Д'Аппликасьон Сьентифик (С.К.Р.А.С.) filed Critical Сосьете де Консей де Решерш э Д'Аппликасьон Сьентифик (С.К.Р.А.С.) (FR)
Publication of RU2002104574A publication Critical patent/RU2002104574A/ru
Application granted granted Critical
Publication of RU2266287C2 publication Critical patent/RU2266287C2/ru

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    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
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Claims (1)

  1. Текст формулы в факсимильном виде (см. графическую часть).
RU2002104574/04A 1999-07-22 2000-07-21 2-арилимино-2,3-дигидротиазолы, способы их получения и фармацевтическая композиция, их содержащая RU2266287C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR99/09496 1999-07-22
FR9909496A FR2796643B1 (fr) 1999-07-22 1999-07-22 Derives de 2-arylimino-2, 3-dihydrothiazoles, leurs procedes de preparation et leur utilisation therapeutique

Publications (2)

Publication Number Publication Date
RU2002104574A true RU2002104574A (ru) 2004-01-20
RU2266287C2 RU2266287C2 (ru) 2005-12-20

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RU2002104574/04A RU2266287C2 (ru) 1999-07-22 2000-07-21 2-арилимино-2,3-дигидротиазолы, способы их получения и фармацевтическая композиция, их содержащая

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Country Link
US (1) US6727269B1 (ru)
EP (1) EP1202980A1 (ru)
JP (2) JP4063537B2 (ru)
KR (1) KR100692352B1 (ru)
CN (1) CN100443479C (ru)
AR (1) AR035321A1 (ru)
AU (1) AU782187B2 (ru)
BR (1) BR0012647A (ru)
CA (1) CA2382940C (ru)
CZ (1) CZ302073B6 (ru)
FR (1) FR2796643B1 (ru)
HU (1) HUP0202425A3 (ru)
IL (3) IL147582A0 (ru)
MX (1) MXPA02000723A (ru)
NO (1) NO322394B1 (ru)
NZ (1) NZ516599A (ru)
PL (1) PL353831A1 (ru)
RU (1) RU2266287C2 (ru)
WO (1) WO2001007424A1 (ru)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2819508B1 (fr) 2001-01-12 2005-01-21 Sod Conseils Rech Applic Derives de 2-arylimino-2, 3-dihydorthiazoles, leurs procedes de preparation et leur utilisation therapeutiques
CA2413000C (en) 2000-06-30 2010-01-19 Sumitomo Pharmaceuticals Company, Limited Five-membered ring compounds
DE10133665A1 (de) * 2001-07-11 2003-01-30 Boehringer Ingelheim Pharma Carbonsäurederivate, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Herstellung
WO2003057214A1 (en) 2001-12-28 2003-07-17 Somatocor Pharmaceuticals, Inc. Imidazolidin-2,4-dione derivatives as non-peptide somatostatin receptor ligands
US7067538B2 (en) 2002-08-09 2006-06-27 Warner-Lambert Company, Llc MCP-1 receptor antagonists and methods of use thereof
WO2005030740A1 (ja) * 2003-09-30 2005-04-07 Takeda Pharmaceutical Company Limited チアゾリン誘導体およびその用途
JP4896387B2 (ja) * 2003-09-30 2012-03-14 武田薬品工業株式会社 チアゾリン誘導体およびその用途
WO2005082844A1 (en) * 2004-02-27 2005-09-09 Oy Juvantia Pharma Ltd Treatment of diseases by using a somatostatin receptor agonist
WO2005082845A1 (en) * 2004-02-27 2005-09-09 Oy Juvantia Pharma Ltd Novel therapies with somatostatin receptor agonists
HRP20110694T1 (hr) 2004-03-15 2011-12-31 Janssen Pharmaceutica Nv Novi spojevi kao modulatori opioidnog receptora
AU2012202459B2 (en) * 2004-03-15 2014-06-12 Janssen Pharmaceutica, N.V. Novel compounds as opioid receptor modulators
WO2006032273A1 (en) * 2004-09-22 2006-03-30 H. Lundbeck A/S 2-acylaminothiazole derivatives
US7674912B2 (en) * 2005-04-25 2010-03-09 H. Lundbeck A/S Pro-drugs of N-thiazol-2-yl-benzamide derivatives
CN101454302A (zh) 2006-05-31 2009-06-10 艾博特公司 用作大麻素受体配位体的噻唑化合物及其用途
US8841334B2 (en) 2006-05-31 2014-09-23 Abbvie Inc. Compounds as cannabinoid receptor ligands and uses thereof
ES2645995T3 (es) * 2006-05-31 2017-12-11 Abbvie Inc. Compuestos como ligandos del receptor cannabinoide y sus usos
US7868038B2 (en) 2006-08-31 2011-01-11 Abbott Laboratories Compounds as cannabinoid receptor ligands
US7985768B2 (en) 2006-08-31 2011-07-26 Abbott Laboratories Compounds as cannabinoid receptor ligands
US7875640B2 (en) 2007-03-28 2011-01-25 Abbott Laboratories Compounds as cannabinoid receptor ligands
US7872033B2 (en) 2007-04-17 2011-01-18 Abbott Laboratories Compounds as cannabinoid receptor ligands
CN101711253A (zh) 2007-05-18 2010-05-19 雅培制药有限公司 用作大麻素受体配体的新化合物
KR100863239B1 (ko) 2007-05-23 2008-10-15 한국과학기술연구원 신규한 2-이미노-1,3-티아졸린계 화합물 및 이를 함유하는ｔ-형 칼슘 채널 저해제
US9193713B2 (en) 2007-10-12 2015-11-24 Abbvie Inc. Compounds as cannabinoid receptor ligands
CA2716857A1 (en) 2008-03-11 2009-09-17 Teodozyi Kolasa Novel compounds as cannabinoid receptor ligands
US8846730B2 (en) 2008-09-08 2014-09-30 Abbvie Inc. Compounds as cannabinoid receptor ligands
EP2428507B1 (en) 2008-09-16 2015-10-21 AbbVie Bahamas Ltd. Cannabinoid receptor ligands
PA8854001A1 (es) 2008-12-16 2010-07-27 Abbott Lab Compuestos novedosos como ligandos de receptores de canabinoides
WO2012020726A1 (ja) * 2010-08-09 2012-02-16 株式会社ファルマデザイン カゼインキナーゼ１δ及びカゼインキナーゼ１ε阻害剤
WO2021005082A1 (de) * 2019-07-10 2021-01-14 Bayer Aktiengesellschaft Verfahren zur herstellung von 2-(phenylimino)-1,3-thiazolidin-4-onen
WO2021005081A1 (de) * 2019-07-10 2021-01-14 Bayer Aktiengesellschaft Verfahren zur herstellung von 2-(phenylimino)-1,3-thiazolidin-4-onen

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3345257A (en) * 1962-01-19 1967-10-03 Ciba Ltd Method for combatting microorganisms
US3264316A (en) * 1963-09-18 1966-08-02 Res Lab Dr C Janssen N V Certain 2-acylimino-3-substitutedthiazoline-4 compounds
DE2926771A1 (de) * 1979-07-03 1981-01-15 Hoechst Ag Thiazolidinderivate und verfahren zu ihrer herstellung
DE3049460A1 (de) * 1980-12-30 1982-07-29 Hoechst Ag, 6000 Frankfurt "thiazolinderivate, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen
JPH07324079A (ja) * 1994-04-04 1995-12-12 Sumitomo Chem Co Ltd イミノチアゾリン誘導体およびその用途
CN1113242A (zh) * 1994-04-04 1995-12-13 住友化学工业株式会社 亚氨基噻唑啉衍生物及含有它们作为活性成分的除草剂
GB9705428D0 (en) * 1997-03-15 1997-04-30 Knoll Ag Therapeutic agents

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WO2001007424A1 (fr) 2001-02-01
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BR0012647A (pt) 2002-04-09
US6727269B1 (en) 2004-04-27
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