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RU2001117525A - CRYSTALLINE MODIFICATION A 8-CYAN-1-CYCLOPROPYL-7- (1S, 6S-2,8-DIAZABICYCLO [4.3.0] NONAN-8-IL) -6-Fluorine-1, 4-DIHYDRO-4-OXO-3 -QINOLINCARBOXYLIC ACID - Google Patents

CRYSTALLINE MODIFICATION A 8-CYAN-1-CYCLOPROPYL-7- (1S, 6S-2,8-DIAZABICYCLO [4.3.0] NONAN-8-IL) -6-Fluorine-1, 4-DIHYDRO-4-OXO-3 -QINOLINCARBOXYLIC ACID

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Publication number
RU2001117525A
RU2001117525A RU2001117525/04A RU2001117525A RU2001117525A RU 2001117525 A RU2001117525 A RU 2001117525A RU 2001117525/04 A RU2001117525/04 A RU 2001117525/04A RU 2001117525 A RU2001117525 A RU 2001117525A RU 2001117525 A RU2001117525 A RU 2001117525A
Authority
RU
Russia
Prior art keywords
ccdc
modification
nonan
diazabicyclo
cyan
Prior art date
Application number
RU2001117525/04A
Other languages
Russian (ru)
Other versions
RU2247122C2 (en
Inventor
Томас Химмлер
Вернер ХАЛЕНБАХ
Хуберт Раст
Original Assignee
Байер Акциенгезельшафт
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19854356A external-priority patent/DE19854356A1/en
Application filed by Байер Акциенгезельшафт filed Critical Байер Акциенгезельшафт
Publication of RU2001117525A publication Critical patent/RU2001117525A/en
Application granted granted Critical
Publication of RU2247122C2 publication Critical patent/RU2247122C2/en

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Claims (8)

1. 8-Циан-1-циклопропил-7-(1S,6S-2,8-диазабицикло[4.3.0]нонан-8-ил)-6-фтор-1,4-дигидро-4-оксо-3-хинолинкарбоновая кислота (CCDC) кристаллической модификации А, отличающаяся тем, что она имеет рентгено-дифрактограмму со следующими рефлексами (2 тэта) с повышенной и средней интенсивностью.1. 8-Cyan-1-cyclopropyl-7- (1S, 6S-2,8-diazabicyclo [4.3.0] nonan-8-yl) -6-fluoro-1,4-dihydro-4-oxo-3- quinoline carboxylic acid (CCDC) of crystalline modification A, characterized in that it has an X-ray diffraction pattern with the following reflexes (2 theta) with high and medium intensity. 2θ(2 тэта)2θ (2 theta) 6,706.70 8,928.92 12,4412.44 13,6613.66 15,9615.96 17,6017.60 21,4221,42 21,7821.78 28,9728.97 2. 8-Циан-1-циклопропил-7-(1S,6S-2,8-диазабицикло[4.3.0]нонан-8-ил)-6-фтор-1,4-дигидро-4-оксо-3-хинолинкарбоновая кислота (CCDC) кристаллической модификации А, отличающаяся тем, что она имеет рентгено-дифрактограмму со следующими рефлексами (2 тэта) с повышенной и средней интенсивностью.2. 8-Cyan-1-cyclopropyl-7- (1S, 6S-2,8-diazabicyclo [4.3.0] nonan-8-yl) -6-fluoro-1,4-dihydro-4-oxo-3- quinoline carboxylic acid (CCDC) of crystalline modification A, characterized in that it has an X-ray diffraction pattern with the following reflexes (2 theta) with high and medium intensity. 2θ(2 тэта)2θ (2 theta) 6,706.70 8,928.92 12,4412.44 13,6613.66 15,9615.96 17,6017.60 21,4221,42 21,7821.78 28,9728.97 и имеет определенную с помощью ДТА среднею температуру плавления 249-252°С.and has an average melting point of 249-252 ° C. determined by DTA. 3. 8-Циан-1-циклопропил-7-(1S,6S-2,8-диазабицикло[4.3.0]нонан-8-ил)-6-фтор-1,4-дигидро-4-оксо-3-хинолинкарбоновая кислота (CCDC) кристаллической модификации А, полученная путем растворения в воде или смеси вода - спирт CCDC неизвестной модификации или аморфной CCDC и последующей добавки спирта в тепле в виде выпавшего осадка.3. 8-Cyan-1-cyclopropyl-7- (1S, 6S-2,8-diazabicyclo [4.3.0] nonan-8-yl) -6-fluoro-1,4-dihydro-4-oxo-3- quinoline carboxylic acid (CCDC) of crystalline modification A, obtained by dissolving in water or a water-alcohol mixture of CCDC of unknown modification or amorphous CCDC and subsequent addition of alcohol in heat as a precipitate. 4. Способ получения CCDC модификации А по п.1, отличающийся тем, что CCDC неизвестной модификации или аморфную CCDC растворяют в воде или смеси вода-спирт и в тепле добавляют спирт, после чего выпадает осадок.4. The method of producing CCDC modification A according to claim 1, characterized in that CCDC of unknown modification or amorphous CCDC is dissolved in water or a water-alcohol mixture and alcohol is added in heat, after which a precipitate precipitates. 5. Способ получения CCDC модификации А по п.4, отличающийся тем, что спирт является этанолом или изопропанолом.5. The method of producing CCDC modification A according to claim 4, characterized in that the alcohol is ethanol or isopropanol. 6. Лекарственное средство, отличающееся тем, что оно содержит наряду с обычными вспомогательными веществами и наполнителями CCDC модификации А по одному из пп.1-3.6. A medicine, characterized in that it contains, along with the usual excipients and excipients, CCDC modifications A according to one of claims 1 to 3. 7. Применение CCDC модификации А по одному из пп.1-3 для изготовления лекарственных средств.7. The use of CCDC modification A according to one of claims 1 to 3 for the manufacture of medicines. 8. Применение CCDC модификации А по одному из пп.1-3 в антибактерицидных средствах.8. The use of CCDC modification A according to one of claims 1 to 3 in antibacterial agents.
RU2001117525/04A 1998-11-25 1999-11-15 8-cyano-1-cyclopropyl-7-(1s,6s)-2,8-diazabicyclo- [4.3.0]-nonane-8-yl)-6- fl uoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid with crystalline modification a and drug eliciting effect against pathogenic microorganisms RU2247122C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19854356.5 1998-11-25
DE19854356A DE19854356A1 (en) 1998-11-25 1998-11-25 Crystal modification A of 8-cyan-1-cyclopropyl-7- (1S, 6S-2,8-diazabicyclo- / 4.3.0 / nonan-8-yl) -6-fluoro-1,4-dihydro-4-oxo 3-quinoline carboxylic acid

Publications (2)

Publication Number Publication Date
RU2001117525A true RU2001117525A (en) 2003-09-27
RU2247122C2 RU2247122C2 (en) 2005-02-27

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
RU2001117525/04A RU2247122C2 (en) 1998-11-25 1999-11-15 8-cyano-1-cyclopropyl-7-(1s,6s)-2,8-diazabicyclo- [4.3.0]-nonane-8-yl)-6- fl uoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid with crystalline modification a and drug eliciting effect against pathogenic microorganisms

Country Status (27)

Country Link
US (1) US6436955B1 (en)
EP (1) EP1133496B1 (en)
JP (1) JP2002530406A (en)
KR (1) KR100740947B1 (en)
CN (1) CN1135230C (en)
AR (1) AR031216A1 (en)
AT (1) ATE264858T1 (en)
AU (1) AU763883B2 (en)
BR (1) BRPI9915669B8 (en)
CA (1) CA2351712C (en)
CZ (1) CZ300016B6 (en)
DE (2) DE19854356A1 (en)
DK (1) DK1133496T3 (en)
ES (1) ES2217843T3 (en)
HK (1) HK1042703B (en)
HU (1) HUP0104465A3 (en)
IL (2) IL142696A0 (en)
NO (1) NO318066B1 (en)
NZ (1) NZ511861A (en)
PL (1) PL196085B1 (en)
PT (1) PT1133496E (en)
RU (1) RU2247122C2 (en)
SK (1) SK285540B6 (en)
TR (1) TR200101438T2 (en)
TW (1) TW576835B (en)
UA (1) UA67874C2 (en)
WO (1) WO2000031075A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19854355A1 (en) 1998-11-25 2000-05-31 Bayer Ag Crystal modification B of 8-cyan-1-cyclopropyl-7- (1S, 6S-2,8-diazabicyclo- / 4.3.O / nonan-8-yl) -6-fluoro-1,4-dihydro-4-oxo 3-quinoline carboxylic acid
DE19908448A1 (en) 1999-02-26 2000-08-31 Bayer Ag Crystal modification D of 8-cyan-1-cyclopropyl-7- (1S, 6S-2,8-diazabicylo [4.3.0) nonan-8-yl) -6-fluoro-1,4-dihydro-4-oxo-3 -chino incarboxylic acid
DE19908449A1 (en) 1999-02-26 2000-08-31 Bayer Ag Crystal modification C of 8-cyan-1-cyclopropyl-7- (1S, 6S-2,8-diazabicylo- [4.3.0] nonan-8-yl) -6-fluoro-1,4-dihydro-4-oxo 3-chino / incarboxylic acid
DE102004015981A1 (en) * 2004-04-01 2005-10-20 Bayer Healthcare Ag New kirstalline form of 8-cyano-1-cyclopropyl-7- (1S, 6S-2,8-diazabicyclo [4.3.0] nonan-8-yl) -6-fluoro-1,4-dihydro-4-oxo 3-quinolinecarboxylic
CR20190370A (en) 2017-02-13 2019-10-21 Bayer Animal Health Gmbh Liquid composition containing pradofloxacin

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2676521B2 (en) * 1988-03-22 1997-11-17 北陸製薬株式会社 Method for producing quinolone carboxylic acid compound type I crystals
DE3906365A1 (en) * 1988-07-15 1990-01-18 Bayer Ag 7- (1-PYRROLIDINYL) -3-CHINOLONE AND NAPHTHYRIDONE CARBOXYLIC ACID DERIVATIVES, METHOD AND SUBSTITUTED (OXA) DIAZABICYCLOOCTANES AND NONANESE AS INTERMEDIATE PRODUCTS, AND ANTIBACTERIAL AGENTS AND FOOD ADDITIVES CONTAINING THEM
DE3910663A1 (en) * 1989-04-03 1990-10-04 Bayer Ag 5-ALKYLCHINOLON CARBONIC ACIDS
CZ138297A3 (en) 1994-11-18 1997-10-15 Pharmacia & Upjohn Novel physically stable form of solid fluoroquinolone
DE19546249A1 (en) * 1995-12-12 1997-06-19 Bayer Ag New crystal modification of 1-cyclopropyl-7 - ([S, S] -2,8-diazabicyclo [4,3,0] non-8-yl) -6-fluoro-1,4-dihydro-8-methoxy-4 -oxo-3-quinoline carboxylic acid hydrochloride (CDCH), process for its preparation and pharmaceutical preparations containing it
EP0882049B1 (en) * 1996-02-23 2002-11-20 Bayer Ag Possibly substituted 8-cyano-1-cyclopropyl-7-(2,8-diazabicyclo- 4.3.0]-nonan-8-yl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolin carboxylic acids and their derivatives
DE19633805A1 (en) 1996-02-23 1997-08-28 Bayer Ag Optionally substituted 8-cyano-l-cyclopropyl-7- (2,8-diazabicyclo- [4.3.0] -nonan-8-yl) -6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids and their derivatives
DE19854355A1 (en) 1998-11-25 2000-05-31 Bayer Ag Crystal modification B of 8-cyan-1-cyclopropyl-7- (1S, 6S-2,8-diazabicyclo- / 4.3.O / nonan-8-yl) -6-fluoro-1,4-dihydro-4-oxo 3-quinoline carboxylic acid
DE19908448A1 (en) 1999-02-26 2000-08-31 Bayer Ag Crystal modification D of 8-cyan-1-cyclopropyl-7- (1S, 6S-2,8-diazabicylo [4.3.0) nonan-8-yl) -6-fluoro-1,4-dihydro-4-oxo-3 -chino incarboxylic acid
DE19908449A1 (en) 1999-02-26 2000-08-31 Bayer Ag Crystal modification C of 8-cyan-1-cyclopropyl-7- (1S, 6S-2,8-diazabicylo- [4.3.0] nonan-8-yl) -6-fluoro-1,4-dihydro-4-oxo 3-chino / incarboxylic acid

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