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RU2001117522A - METHOD FOR PRODUCING MEDICINES FROM VEGETABLE EXTRACTS IN SOLID FORM - Google Patents

METHOD FOR PRODUCING MEDICINES FROM VEGETABLE EXTRACTS IN SOLID FORM

Info

Publication number
RU2001117522A
RU2001117522A RU2001117522/15A RU2001117522A RU2001117522A RU 2001117522 A RU2001117522 A RU 2001117522A RU 2001117522/15 A RU2001117522/15 A RU 2001117522/15A RU 2001117522 A RU2001117522 A RU 2001117522A RU 2001117522 A RU2001117522 A RU 2001117522A
Authority
RU
Russia
Prior art keywords
dry extract
auxiliary substances
compacted
particles
solid form
Prior art date
Application number
RU2001117522/15A
Other languages
Russian (ru)
Other versions
RU2199312C1 (en
Inventor
Вилли Купер
Панагиотис МАИДОНИС
Original Assignee
Штайгервальд Арцнаймиттельверк Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Штайгервальд Арцнаймиттельверк Гмбх filed Critical Штайгервальд Арцнаймиттельверк Гмбх
Priority claimed from DE19957472A external-priority patent/DE19957472A1/en
Application granted granted Critical
Publication of RU2199312C1 publication Critical patent/RU2199312C1/en
Publication of RU2001117522A publication Critical patent/RU2001117522A/en

Links

Claims (7)

1. Способ получения лекарственного средства в твердой форме из растительных экстрактов, в частности, таблеток с экстрактом зверобоя, согласно которому жидкий растительный экстракт обрабатывают путем добавления определенных вспомогательных веществ с получением сухого экстракта, отличающийся тем, что частицы сухого экстракта уплотняют при подмешивании улучшающих грануляцию связующих и уплотненный гранулят - после регулирования однородной величины частиц в процессе просеивания - перемешивают с диоксидом титана, тальком и высокодисперсным диоксидом кремния для нанесения маскировочного покрытия на отдельные компактные частицы и прессуют компактные частицы в таблетки.1. A method of obtaining a medicinal product in solid form from plant extracts, in particular tablets with St. John's wort, according to which the liquid plant extract is treated by adding certain auxiliary substances to obtain a dry extract, characterized in that the particles of the dry extract are compacted by mixing granulation-improving binders and compacted granulate - after adjusting the uniform particle size during the sieving process - mix with titanium dioxide, talc and finely divided nym silica for applying masking particles to separate and compact compact particles compressed into tablets. 2. Способ по п.1, отличающийся тем, что в качестве связующего при уплотнении сухого экстракта подмешивают моногидрат лактозы.2. The method according to claim 1, characterized in that lactose monohydrate is mixed as a binder in the compaction of the dry extract. 3. Способ по п.1, отличающийся тем, что маскировочное покрытие на последующих стадиях перемешивания обрабатывают дополнительными вспомогательными веществами.3. The method according to claim 1, characterized in that the camouflage coating in the subsequent stages of mixing is treated with additional excipients. 4. Способ по п.3, отличающийся тем, что в качестве дополнительных вспомогательных веществ вначале применения используют моногидрат лактозы и/или карбоксиметилцеллюлозу натрия и затем стеарат магния и/или стеариновую кислоту.4. The method according to claim 3, characterized in that, as additional auxiliary substances, lactose monohydrate and / or sodium carboxymethyl cellulose and then magnesium stearate and / or stearic acid are used at the beginning of use. 5. Способ по пп.1-4, отличающийся тем, что содержание вспомогательных веществ по отношению к растительному сухому экстракту не превышает 35 мас.%.5. The method according to claims 1 to 4, characterized in that the content of auxiliary substances in relation to the plant dry extract does not exceed 35 wt.%. 6. Способ по одному из пп.1-5, отличающийся тем, что содержание вспомогательных веществ не превышает при получении сухого экстракта 10 мас.%, при уплотнении 5 мас.% и при нанесении маскировочного покрытия 20 мас.%.6. The method according to one of claims 1 to 5, characterized in that the content of auxiliary substances does not exceed 10 wt.% When dry extract is obtained, 5 wt.% When compacted and 20 wt.% When applying a camouflage coating. 7. Способ по п.1, отличающийся тем, что маскирование уплотненного вещества проводят сначала диоксидом титана, затем тальком и затем высокодисперсным диоксидом кремния.7. The method according to claim 1, characterized in that the masking of the densified substance is carried out first with titanium dioxide, then talc and then finely divided silica.
RU2001117522/14A 1998-11-24 1999-11-24 Method of preparing medicinal agents in solid form from vegetable extracts RU2199312C1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19855287 1998-11-24
DE19957472A DE19957472A1 (en) 1998-11-24 1999-11-24 Process for the production of pharmaceuticals in solid dosage form from plant extracts
DE19957472.3 1999-11-24
DE19855287.4 1999-11-24

Publications (2)

Publication Number Publication Date
RU2199312C1 RU2199312C1 (en) 2003-02-27
RU2001117522A true RU2001117522A (en) 2004-04-20

Family

ID=26050475

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2001117522/14A RU2199312C1 (en) 1998-11-24 1999-11-24 Method of preparing medicinal agents in solid form from vegetable extracts

Country Status (17)

Country Link
US (1) US6680072B1 (en)
EP (1) EP1135147B1 (en)
JP (1) JP3782936B2 (en)
CN (1) CN1333690A (en)
AR (1) AR020343A1 (en)
AT (1) ATE247479T1 (en)
AU (1) AU761750B2 (en)
BR (1) BR9916869A (en)
CA (1) CA2352542C (en)
CZ (1) CZ20011766A3 (en)
DE (1) DE59906705D1 (en)
EE (1) EE200100277A (en)
HU (1) HUP0104975A3 (en)
NO (1) NO20012518D0 (en)
PL (1) PL351410A1 (en)
RU (1) RU2199312C1 (en)
WO (1) WO2000030605A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6340478B1 (en) * 1999-06-07 2002-01-22 Bio Dar Ltd. Microencapsulated and controlled-release herbal formulations
IL131508A (en) 1999-08-19 2006-12-10 David Cohen Microencapsulated and controlled-release formulations of isoflavone from enriched fractions of soy and other plants
DE10127897B4 (en) * 2001-06-08 2006-04-20 Bionorica Ag Coated tablet with dry plant extracts
DE10144108A1 (en) * 2001-09-03 2003-04-30 Steigerwald Arzneimittelwerk Process for the production of tablets from plant extracts
US20060115556A1 (en) * 2004-12-01 2006-06-01 Foulger Sidney W Nutritional supplement drink containing xanthone extracts
US20060115555A1 (en) * 2004-12-01 2006-06-01 Foulger Sidney W Nutritional supplements containing xanthone extracts
US7491202B2 (en) * 2005-03-31 2009-02-17 Covidien Ag Electrosurgical forceps with slow closure sealing plates and method of sealing tissue
CN101091725A (en) * 2006-06-23 2007-12-26 天津天士力制药股份有限公司 Chinese traditional medicine grains and preparation method

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS587608B2 (en) * 1979-08-22 1983-02-10 株式会社ツムラ Manufacturing method for Chinese herbal medicine hard capsules
JPS5936621A (en) * 1982-08-25 1984-02-28 Tsumura Juntendo Inc Improving agent for cancerous symptom
IL72381A (en) * 1983-07-20 1988-03-31 Sanofi Sa Pharmaceutical composition based on valproic acid
JPS60136513A (en) * 1983-12-26 1985-07-20 Eisai Co Ltd Remedy and preventive for diabetes
RU2053764C1 (en) * 1991-07-19 1996-02-10 Эгиш Дьедьсердьяр Soft gelatin capsule and method for its production
ES2088523T3 (en) * 1991-09-05 1996-08-16 Tsumura & Co PROCEDURE FOR THE PREPARATION OF HARD GELATIN CAPSULES CONTAINING CHINESE HERBS EXTRACTS.
US5579764A (en) * 1993-01-08 1996-12-03 Goldreyer; Bruce N. Method and apparatus for spatially specific electrophysiological sensing in a catheter with an enlarged ablating electrode
US5965162A (en) * 1993-09-10 1999-10-12 Fuisz Technologies Ltd. Process for forming chewable quickly dispersing multi-vitamin preparation and product therefrom
CH687810A5 (en) * 1995-05-24 1997-02-28 Mepha Ag Pellet Formulation with omeprazole.
JP4494539B2 (en) * 1997-02-28 2010-06-30 ディーエスエム アイピー アセッツ ビー．ブイ． Free-flowing dry particles

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