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RU2001116104A - Vancorezmycin, a method for its preparation and its use as a medicine - Google Patents

Vancorezmycin, a method for its preparation and its use as a medicine

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Publication number
RU2001116104A
RU2001116104A RU2001116104/13A RU2001116104A RU2001116104A RU 2001116104 A RU2001116104 A RU 2001116104A RU 2001116104/13 A RU2001116104/13 A RU 2001116104/13A RU 2001116104 A RU2001116104 A RU 2001116104A RU 2001116104 A RU2001116104 A RU 2001116104A
Authority
RU
Russia
Prior art keywords
pharmaceutically acceptable
derivative
vancorezmycin
acceptable salt
dsm
Prior art date
Application number
RU2001116104/13A
Other languages
Russian (ru)
Other versions
RU2228337C2 (en
Inventor
Нигори Венката Стайа РАМАКРИШНА
Рави Гайанан БХАТ
Йаммадичийил Санкаранарайанан СРИКУМАР
Ерра Котесвара Стайа ВИЙАЯКУМАР
Шантилал Дайарам НАКЕР
Уттара Винайак ЭУК
Райендра Пракаш ТАНПУР
Кордула ХОПМАНН
Михаэл КУРЦ
Йоахим ВИНК
Герхард ЗАЙБЕРТ
БЕЛЛЕ Доминик ЛЕ
Жозсеф АСЗОДИ
Original Assignee
Авентис Фарма Дойчланд Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Авентис Фарма Дойчланд Гмбх filed Critical Авентис Фарма Дойчланд Гмбх
Publication of RU2001116104A publication Critical patent/RU2001116104A/en
Application granted granted Critical
Publication of RU2228337C2 publication Critical patent/RU2228337C2/en

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Claims (8)

1. Ванкорезмицин, соединение формулы1. Vancorresmicin, a compound of the formula
Figure 00000001
Figure 00000001
 и его фармацевтически приемлемые соли и производные, во всех стереоизомерных и таутомерных формах.and its pharmaceutically acceptable salts and derivatives, in all stereoisomeric and tautomeric forms. 2. Ванкорезмицин, соединение молекулярной формулы C71H126N2O21, получаемое культивированием микроорганизма Amycolatopsis вида HIL-006734 (DSM 12216) или одного из его мутантов в аэробных условиях в питательной среде, содержащей источники углерода и азота, с последующим выделением и очисткой обычными методами, и его фармацевтически приемлемые соли и производные во всех стереоизомерных и таутомерных формах.2. Vancorezmycin, a compound of molecular formula C 71 H 126 N 2 O 21 , obtained by culturing an Amycolatopsis microorganism of the form HIL-006734 (DSM 12216) or one of its mutants under aerobic conditions in a nutrient medium containing carbon and nitrogen sources, followed by isolation and purification by conventional methods, and its pharmaceutically acceptable salts and derivatives in all stereoisomeric and tautomeric forms. 3. Способ получения ванкорезмицина или его соли или производного по п.1 или 2, включающий культивирование микроорганизма Amycolatopsis вида HIL-006734 (DSM 12216) или одного из его мутантов в аэробных условиях в питательной среде, содержащей источники углерода и азота, с последующим выделением и очисткой обычными методами.3. The method of producing vancorezmycin or its salt or derivative according to claim 1 or 2, comprising cultivating an Amycolatopsis microorganism of the form HIL-006734 (DSM 12216) or one of its mutants under aerobic conditions in a nutrient medium containing carbon and nitrogen sources, followed by isolation and cleaning by conventional methods. 4. Способ по п.3, также включающий взаимодействие ванкорезмицина с подходящим агентом для получения фармацевтически приемлемой соли или производного.4. The method according to claim 3, also comprising reacting vancoresmycin with a suitable agent to obtain a pharmaceutically acceptable salt or derivative. 5. Amycolatopsis вида HIL-006734 (DSM 12216) или один из его мутантов.5. Amycolatopsis species HIL-006734 (DSM 12216) or one of its mutants. 6. Ванкорезмицин или его фармацевтически приемлемая соль или производное по п.1 или 2 для использования в качестве лекарственного средства.6. Vancorezmycin or a pharmaceutically acceptable salt or derivative thereof according to claim 1 or 2 for use as a medicine. 7. Фармацевтическая композиция, содержащая эффективное количество ванкорезмицина или его фармацевтически приемлемой соли или производного по п.1 или 2 и фармацевтически приемлемый носитель.7. A pharmaceutical composition comprising an effective amount of vancoresmicin or a pharmaceutically acceptable salt or derivative thereof according to claim 1 or 2, and a pharmaceutically acceptable carrier. 8. Ванкорезмицин или его фармацевтически приемлемая соль или производное по п.1 или 2 для использования в качестве антибиотика.8. Vancorresmicin or a pharmaceutically acceptable salt or derivative thereof according to claim 1 or 2 for use as an antibiotic.
RU2001116104/13A 1998-11-09 1999-11-04 Vancoresmycin (variants), its application, strain amycolatopsis of species hil-006734 for its preparing RU2228337C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98121299 1998-11-09
EP98121299.6 1998-11-09

Publications (2)

Publication Number Publication Date
RU2001116104A true RU2001116104A (en) 2003-09-10
RU2228337C2 RU2228337C2 (en) 2004-05-10

Family

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RU2001116104/13A RU2228337C2 (en) 1998-11-09 1999-11-04 Vancoresmycin (variants), its application, strain amycolatopsis of species hil-006734 for its preparing

Country Status (26)

Country Link
US (2) US6387943B1 (en)
EP (1) EP1129208B1 (en)
JP (1) JP2002529477A (en)
KR (1) KR100623405B1 (en)
CN (1) CN1325656C (en)
AR (1) AR024226A1 (en)
AT (1) ATE225854T1 (en)
AU (1) AU761782B2 (en)
BR (1) BR9915161A (en)
CA (1) CA2351222A1 (en)
CZ (1) CZ20011593A3 (en)
DE (1) DE69903465T2 (en)
DK (1) DK1129208T3 (en)
ES (1) ES2181506T3 (en)
HK (1) HK1041026B (en)
HU (1) HU224610B1 (en)
ID (1) ID28381A (en)
IL (1) IL142848A0 (en)
PL (1) PL195995B1 (en)
PT (1) PT1129208E (en)
RU (1) RU2228337C2 (en)
SI (1) SI1129208T1 (en)
TR (1) TR200101279T2 (en)
UA (1) UA70974C2 (en)
WO (1) WO2000028064A1 (en)
ZA (1) ZA200103191B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10060810A1 (en) 2000-12-07 2002-06-20 Aventis Pharma Gmbh Coniosetin and derivatives thereof, processes for making and using the same
TW200637834A (en) * 2004-12-22 2006-11-01 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Method of purifying macrolides
US8552208B2 (en) * 2007-09-11 2013-10-08 University of Tennesseee Research Foundation Analogs of tetramic acid
JP6465299B2 (en) * 2015-05-29 2019-02-06 株式会社山田養蜂場本社 Honey fraction
CN109608523B (en) * 2018-11-23 2023-01-10 江苏九阳生物制药有限公司 Production process of high-purity teicoplanin
WO2021188543A2 (en) * 2020-03-17 2021-09-23 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Antibacterial and antifungal polyketides from environmental amycolatopsis spp

Family Cites Families (6)

* Cited by examiner, † Cited by third party
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JPH05163289A (en) * 1991-08-27 1993-06-29 Microbial Chem Res Found New immunosuppressive substance, m1710-51f6 substance and its production
JP3192723B2 (en) * 1992-01-29 2001-07-30 明治製菓株式会社 Novel macrolide antibiotics SF2748B, SF2748C1, SF2748D and SF2748E and their production
JP3107455B2 (en) * 1992-05-08 2000-11-06 財団法人微生物化学研究会 New antibiotic MI481-42F4-A and method for producing the same
JPH09157266A (en) * 1995-12-04 1997-06-17 Microbial Chem Res Found Novel antibiotics, epoxyquinomycins A and B, and method for producing the same
JPH1011477A (en) * 1996-06-26 1998-01-16 Dainippon Printing Co Ltd Device for creating input files for simulation of integrated circuits
EP0818539A1 (en) * 1996-07-11 1998-01-14 Hoechst Aktiengesellschaft Methylsulfomycin I, a process for its production and its use

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