RU2000129499A - TREATMENT OF DEPRESSION AND PHARMACEUTICAL DRUGS FOR THIS PURPOSE - Google Patents

Claims (8)

1. A pharmaceutical dosage form of an antidepressant containing such an amount of ISF or ISF and an amount of folic acid or another folate precursor that the administration of 1-8 units of the dosage form should provide a dose of ISI or ISH equivalent to a usually prescribed daily dose and 400-5000 micrograms of folate.  2. The use of DIH or IHF administered simultaneously with folate at a dose of 400-5000 micrograms per day for the treatment of depression.  3. The use of folic acid or another folate precursor in conjunction with IPD or IPI for the treatment of depression in patients with cardiovascular disease, or patients at risk of cardiovascular disease, for example, due to elevated cholesterol or triglycerides or with high blood pressure.  4. The use of folic acid or another folate precursor in conjunction with fluoxetine, fluvoxamine, paroxetine, sertraline, citalopram, venlafaxine, nefazodone, trazodone, reboxetine or any other STI or OI to reduce adverse side effects in the treatment of depression.  5. A method of treating depression, which includes administering to the patient an antidepressant selected from the class of FMD or DI, and characterized by the addition of additional folic acid or another folate precursor in an amount equivalent to from 400 to 5000 micrograms / day of folate.  6. The method of claim 5, wherein the amount of folic acid or folate precursor is equivalent to a dose of 400 to 2000 micrograms / day of folate.  7. The method according to p. 5 or 6, in which the source of folate is folic acid or MTHF.  8. The method according to any one of paragraphs. 5-7, in which the ISS or ISN are selected from fluoxetine, fluvoxamine, paroxetine, sertraline, citalopram, venlafaxine, nefazodone, trazodone and reboxetine.