RU2000124097A

RU2000124097A - CONNECTION ON THE BASIS OF CYCLIC AMIDES

Info

Publication number: RU2000124097A
Application number: RU2000124097/04A
Authority: RU
Inventors: Хироюки Исивата; Сейити Сато; Мотоцугу КАБЕЯ; Соити Ода; Юкио ХАТТОРИ; Макото СУДА; Манабу Сибасаки; Хироси НАКАО; Такао НАГОЯ
Original assignee: Кова Ко., Лтд.
Priority date: 1998-02-19
Filing date: 1999-02-16
Publication date: 2002-08-27

Claims

1. The compound represented by the following General formula (1)

in which A represents the residue of an alicyclic compound that can be substituted, an aromatic compound that can be substituted, or a heterocyclic compound that can be substituted;
X is a single bond; a lower alkylene group which may be substituted; the bivalent residue of an alicyclic compound that may be substituted, an aromatic compound that may be substituted, or a heterocyclic compound that may be substituted; an imino group which may be substituted; or a sulfur atom or an oxygen atom;
Y represents a single bond or a lower alkyl alkyl, imino or lower alkyl amino group;
Z is a group -CH = CH-, -C = C-, - (CH = CH) ₂ -,
-C = C-CH = CH- or -CH = CH-C = C-, or the bivalent residue of benzene, pyridine, pyrimidine or pyrazine, which can be substituted;
B is a nitrogen atom or = CH-; and
m and n-essence are the same or different and independently of each other take integer values from 1 to 4, provided that when -YXY- is a lower alkylene group that is not substituted, and Z is -CH = CH-, And is neither a phenyl group which is unsubstituted, nor 3,4-methylenedioxyphenyl, a salt of this compound or a solvate of this compound.

2. A compound, a salt of this compound or a solvate thereof according to claim 1, wherein A is an indenyl, phenyl, naphthyl, dihydronaphthyl, indodyl, isoindolyl, pyridyl, quinolyl or isoquinolyl group, which may be substituted with 1–3 substituents selected from hydroxyl groups, halogen atoms, lower alkyl groups which may be substituted with 1 to 3 halogen atoms, lower alkoxy groups or amino group, monoalkylamino groups, dialkylamino groups and lower alkylthio groups.

3. The compound, salt of this compound or its solvate according to claim 1, in which X represents a lower alkylene group which may be substituted by one or more substituents selected from halogen atoms, a hydroxyl group, lower alkyl groups which may be substituted by an amino group , monoalkylamino or dialkylamino, lower alkoxy, carboxyl, lower alkoxycarbonyl, amino, alkylamino, dialkylamino, nitro, cyano and aralkyl groups pami; or imino group, which may be substituted by a lower alkyl group.

4. The compound, salt of this compound or its solvate according to claim 1, wherein X is a bivalent residue of a cycloalkane having from 5 to 8 carbon atoms, which may be substituted by one or more substituents selected from halogen atoms, hydroxyl group, groups lower alkyl which may be substituted by an amino group, a monoalkylamino group or a dialkylamino group, a lower alkoxy group, a carboxyl group, a lower alkoxy-carbonyl group, an amino group, an alkylamino group, a dialkylamino group, a nitro group ppoy, cyano group and aralkyl groups.

5. The compound, salt of this compound or its solvate according to claim 1, wherein X is a phenylene group which may be substituted by one or more substituents selected from halogen atoms, hydroxyl group, lower alkyl groups that may be substituted by an amino group, monoalkylamino or dialkylamino, lower alkoxy groups, carboxyl group, lower alkoxy-carbonyl groups, amino group, alkylamino groups, dialkylamino groups, nitro group, cyano group and aralkyl groups.

6. The compound, salt of this compound or its solvate according to claim 1, wherein X is a divalent residue of pyridine, pyrrolidine, piperidine, piperazine or homopiperazine, which may be substituted by one or more substituents selected from halogen atoms, hydroxyl group, lower alkyl groups which may be substituted by an amino group, a monoalkylamino group or a dialkylamino group, a lower alkoxy group, a carboxyl group, a lower alkoxy-carbonyl group, an amino group, alkylamino groups, dialkyl inogruppami, nitro group, cyano group, and aralkyl groups.

7. Drug containing as active principle a compound, its salt or its solvate according to any one of claims. 1-6.

8. The drug according to claim 7, which is an agent for inhibiting the production of IgE antibodies.

9. The drug according to claim 7 or 8, which is an agent for the prevention and treatment of an immunological allergic disease.

10. Drug in PP. 7-9, which is an agent for the prevention and treatment of asthma, atopic dermatitis, allergic rhinitis, inflammatory diseases of the large intestine, contact dermatitis or allergic ophthalmopathy.

11. A pharmaceutical composition comprising a compound, its salt or a solvate thereof according to any one of claims. 1-6 and a pharmaceutically acceptable carrier.

12. The compound, its salt or its solvate according to any one of paragraphs. 1-6 as a drug.

13. The compound, its salt or its solvate according to claim 12, wherein said drug is an agent for the prevention and treatment of an immunological allergic disease.

14. The compound, its salt or its solvate according to claim 12, wherein said drug is an agent for the prevention and treatment of asthma, atopic dermatitis, allergic rhinitis, inflammatory bowel disease, contact dermatitis, or allergic ophthalmopathy.

15. A method of treating an immunological allergic disease, which includes the administration of a compound, its salt or its solvate according to any one of claims. 1-6.