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RU2000122618A - SURFACE-ACTIVE COPOLYMERS BASED ON METHILIDENMALONATE - Google Patents

SURFACE-ACTIVE COPOLYMERS BASED ON METHILIDENMALONATE

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Publication number
RU2000122618A
RU2000122618A RU2000122618/04A RU2000122618A RU2000122618A RU 2000122618 A RU2000122618 A RU 2000122618A RU 2000122618/04 A RU2000122618/04 A RU 2000122618/04A RU 2000122618 A RU2000122618 A RU 2000122618A RU 2000122618 A RU2000122618 A RU 2000122618A
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RU
Russia
Prior art keywords
paragraphs
fragment
copolymers according
poly
copolymers
Prior art date
Application number
RU2000122618/04A
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Russian (ru)
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RU2216551C2 (en
Inventor
Николь БРЮ-МАНЬЕ
Виржини ЛАРРА
Жерар РЬЕСС
Паскаль БРЕТОН
Патрик КУВРЕР
Клод РОК-КАРМ
Original Assignee
Вирсоль
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Priority claimed from FR9801001A external-priority patent/FR2774096B1/en
Application filed by Вирсоль filed Critical Вирсоль
Publication of RU2000122618A publication Critical patent/RU2000122618A/en
Application granted granted Critical
Publication of RU2216551C2 publication Critical patent/RU2216551C2/en

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Claims (1)

1. Биосовместимые сополимеры, включающие по меньшей мере один фрагмент, имеющий гидрофильный характер, и по меньшей мере один фрагмент, имеющий гидрофобный характер, отличающиеся тем, что фрагмент гидрофобного характера образован либо гомополимером, состоящим из повторяющихся звеньев общей формулы (I):
Figure 00000001

в которой R1 представляет собой алкильную группу, имеющую от 1 до 6 атомов углерода, или группу (СН2)m-СООR3, в которой m является целым числом от 1 до 5, а R3 представляет собой алкильную группу, имеющую от 1 до 6 атомов углерода;
R2 представляет собой алкильную группу, имеющую от 1 до 6 атомов углерода; а
n является целым числом от 1 до 5;
либо статистическим сополимером, состоящим из разных повторяющихся звеньев указанной выше формулы (I):
либо статистическим сополимером, большей частью состоящим из звеньев указанной выше формулы (I).1. Biocompatible copolymers comprising at least one fragment having a hydrophilic character and at least one fragment having a hydrophobic character, characterized in that the fragment of a hydrophobic character is formed by either a homopolymer consisting of repeating units of the general formula (I):
Figure 00000001

in which R 1 represents an alkyl group having from 1 to 6 carbon atoms, or a group (CH 2 ) m —COOR 3 , in which m is an integer from 1 to 5, and R 3 represents an alkyl group having from 1 up to 6 carbon atoms;
R 2 represents an alkyl group having from 1 to 6 carbon atoms; but
n is an integer from 1 to 5;
or a statistical copolymer consisting of different repeating units of the above formula (I):
or a statistical copolymer, mostly consisting of units of the above formula (I). 2. Сополимеры по п. 1, отличающиеся тем, что фрагмент гидрофобного характера состоит из повторяющихся звеньев указанной выше общей формулы (I), в которой R1 представляет собой алкильную группу, имеющую от 1 до 6 атомов углерода, R2 представляет собой алкильную группу, имеющую от 1 до 6 атомов углерода, а n является целым числом, равным единице.2. Copolymers according to claim 1, characterized in that the fragment of a hydrophobic character consists of repeating units of the aforementioned general formula (I) in which R 1 is an alkyl group having from 1 to 6 carbon atoms, R 2 is an alkyl group , having from 1 to 6 carbon atoms, and n is an integer equal to one. 3. Сополимеры по п. 1, отличающиеся тем, что фрагмент гидрофобного характера состоит из повторяющихся звеньев формулы:
Figure 00000002

4. Сополимеры по какому-либо из пп. 1-3, отличающиеся тем, что фрагмент гидрофильного характера выбирается из поли(оксиэтилена), поли(винилового спирта), поли(винилпирролидона, поли(N-2-гидроксипропилметакриламида), поли(гидроксиэтилметакрилата), гидрофильной поли(аминокислоты), такой как полилизин, полисахарид.3. Copolymers under item 1, characterized in that the fragment of a hydrophobic character consists of repeating units of the formula:
Figure 00000002

4. Copolymers according to any of paragraphs. 1-3, characterized in that the fragment of hydrophilic character is selected from poly (oxyethylene), poly (vinyl alcohol), poly (vinyl pyrrolidone, poly (N-2-hydroxypropyl methacrylamide), poly (hydroxy ethyl methacrylate), hydrophilic poly (amino acid), such polylysine, polysaccharide. 5. Сополимеры по какому-либо из пп. 1-4, отличающиеся тем, что они имеют блочную структуру, предпочтительно двухблочную или трехблочную, или привитую структуру. 5. Copolymers according to any of paragraphs. 1-4, characterized in that they have a block structure, preferably a two-block or three-block, or a graft structure. 6. Сополимеры по какому-либо из пп. 1-5, отличающиеся тем, что массовое содержание фрагмента гидрофобного характера в них составляет 5 - 95%, предпочтительно 10 - 90%. 6. Copolymers according to any of paragraphs. 1-5, characterized in that the mass content of a fragment of a hydrophobic character in them is 5 - 95%, preferably 10 - 90%. 7. Сополимеры по какому-либо из пп. 1-6, отличающиеся тем, что общая молекулярная масса фрагментов гидрофобного характера составляет 1,000 - 80,000 г/моль и предпочтительно, 1,000 - 50,000 г/моль. 7. Copolymers according to any of paragraphs. 1-6, characterized in that the total molecular weight of fragments of a hydrophobic nature is 1,000 to 80,000 g / mol, and preferably 1,000 to 50,000 g / mol. 8. Сополимеры по какому-либо из пп. 1-7 для получения мицеллярных систем, эмульсий, для получения или стабилизации наночастиц или для инкапсулирования активных веществ. 8. Copolymers according to any of paragraphs. 1-7 for obtaining micellar systems, emulsions, for obtaining or stabilizing nanoparticles or for encapsulating active substances. 9. Сополимеры по любому из пп. 1-7 в качестве агентов для поверхностной обработки материалов или биоматериалов, в частности, для придания гидрофильного характера обрабатываемым поверхностям путем закрепления названных сополимеров на обрабатываемых поверхностях. 9. Copolymers according to any one of paragraphs. 1-7 as agents for the surface treatment of materials or biomaterials, in particular, to impart a hydrophilic character to the treated surfaces by fixing the mentioned copolymers on the treated surfaces. 10. Сополимеры по любому из пп. 1-7 в качестве агентов для поверхностной обработки материалов или биоматериалов, способных входить в контакт с тканями животных, с клетками или биомолекулами, в частности, для снижения межфазного сцепления с названными тканями животных, с клетками или биомолекулами. 10. Copolymers according to any one of paragraphs. 1-7 as agents for the surface treatment of materials or biomaterials that can come into contact with animal tissues, with cells or biomolecules, in particular, to reduce the interfacial adhesion with these animal tissues, cells or biomolecules.
RU2000122618/04A 1998-01-29 1999-01-29 Methylidenemalonate-base surface-active copolymers RU2216551C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9801001A FR2774096B1 (en) 1998-01-29 1998-01-29 NOVEL SURFACTANT COPOLYMERS BASED ON METHYLIDENE MALONATE
FR98/01001 1998-01-29

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RU2000122618A true RU2000122618A (en) 2002-08-10
RU2216551C2 RU2216551C2 (en) 2003-11-20

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EP (1) EP1051436B1 (en)
JP (1) JP2002501953A (en)
KR (1) KR20010040476A (en)
CN (1) CN1114633C (en)
AR (1) AR018536A1 (en)
AT (1) ATE253602T1 (en)
AU (1) AU744995B2 (en)
BR (1) BR9908537A (en)
CA (1) CA2318828A1 (en)
CZ (1) CZ294928B6 (en)
DE (1) DE69912578T2 (en)
ES (1) ES2211028T3 (en)
FR (1) FR2774096B1 (en)
HU (1) HUP0100238A3 (en)
IL (1) IL137441A0 (en)
NO (1) NO20003873L (en)
NZ (1) NZ505946A (en)
PL (1) PL341934A1 (en)
RU (1) RU2216551C2 (en)
SK (1) SK11042000A3 (en)
WO (1) WO1999038898A1 (en)
ZA (1) ZA99721B (en)

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