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RU2000111744A - Очищенная и выделенная днк, химерный полинуклеотид, вектор экспрессии и клетка-хозяин - Google Patents

Очищенная и выделенная днк, химерный полинуклеотид, вектор экспрессии и клетка-хозяин Download PDF

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Publication number
RU2000111744A
RU2000111744A RU2000111744/13A RU2000111744A RU2000111744A RU 2000111744 A RU2000111744 A RU 2000111744A RU 2000111744/13 A RU2000111744/13 A RU 2000111744/13A RU 2000111744 A RU2000111744 A RU 2000111744A RU 2000111744 A RU2000111744 A RU 2000111744A
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RU
Russia
Prior art keywords
promoter
purified
expression vector
chimeric polynucleotide
dna
Prior art date
Application number
RU2000111744/13A
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English (en)
Inventor
Патрик Дю КИЛГЭННОН (US)
Патрик Дю КИЛГЭННОН
Ую Майкл ГЭЛЛАТИН (US)
Ую Майкл ГЭЛЛАТИН
Original Assignee
Айкос Корпорейшн (Us)
Айкос Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Айкос Корпорейшн (Us), Айкос Корпорейшн filed Critical Айкос Корпорейшн (Us)
Publication of RU2000111744A publication Critical patent/RU2000111744A/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70525—ICAM molecules, e.g. CD50, CD54, CD102
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2821—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against ICAM molecules, e.g. CD50, CD54, CD102
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Plant Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Semiconductor Memories (AREA)
  • Treatment And Processing Of Natural Fur Or Leather (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Control Of Vending Devices And Auxiliary Devices For Vending Devices (AREA)

Claims (10)

1. Очищенная и выделенная ДНК, содержащая промотор для ICAM-4 млекопитающего.
2. ДНК по п. 1, отличающаяся тем, что указанный промотор представляет собой промотор для человеческого ICAM-4.
3. ДНК по п. 2, отличающаяся тем, что указанный промотор включен в последовательность SEQ ID N0: 33.
4. ДНК по п. 3, отличающаяся тем, что указанный промотор включен в последовательность из нуклеотидов от приблизительно нуклеотида 1204 до приблизительно нуклеотида 1666 в SEQ ID N0: 33.
5. ДНК по любому из пп. 1-4, отличающаяся тем, что указанный промотор способен специфически стимулировать транскрипцию полинуклеотида, связанного в действии с указанным промотором в нейронной клетке.
6. ДНК по п. 5, отличающаяся тем, что указанная нейронная клетка представляет собой клетку гиппокампа.
7. Химерный полинуклеотид, содержащий промотор для гена человеческого ICAM-4.
8. Химерный полинуклеотид по п. 7, отличающийся тем, что указанный промотор включен в последовательность из нуклеотидов от приблизительно нуклеотида 1204 до приблизительно нуклеотида 1666 в SEQ ID N0: 33.
9. Вектор экспрессии, содержащий ДНК по п. 1 или 7.
10. Клетка-хозяин, трансформированная вектором по п. 9.
RU2000111744/13A 1995-06-07 2000-05-12 Очищенная и выделенная днк, химерный полинуклеотид, вектор экспрессии и клетка-хозяин RU2000111744A (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/481,130 US5702917A (en) 1992-01-27 1995-06-07 Polynucleotides encoding human ICAM-4
US08/481,130 1995-06-07

Publications (1)

Publication Number Publication Date
RU2000111744A true RU2000111744A (ru) 2002-09-10

Family

ID=23910735

Family Applications (2)

Application Number Title Priority Date Filing Date
RU97104028/13A RU2155345C2 (ru) 1995-06-07 1996-06-06 Способ скрининга невропатологии
RU2000111744/13A RU2000111744A (ru) 1995-06-07 2000-05-12 Очищенная и выделенная днк, химерный полинуклеотид, вектор экспрессии и клетка-хозяин

Family Applications Before (1)

Application Number Title Priority Date Filing Date
RU97104028/13A RU2155345C2 (ru) 1995-06-07 1996-06-06 Способ скрининга невропатологии

Country Status (21)

Country Link
US (1) US5702917A (ru)
EP (2) EP0789763B1 (ru)
JP (2) JP3349514B2 (ru)
CN (2) CN1152960C (ru)
AT (1) ATE224448T1 (ru)
AU (1) AU721316B2 (ru)
BR (1) BR9606440A (ru)
CA (2) CA2288401A1 (ru)
CZ (1) CZ291974B6 (ru)
DE (1) DE69623746T2 (ru)
DK (1) DK0789763T3 (ru)
ES (1) ES2183961T3 (ru)
FI (1) FI970503L (ru)
HU (1) HUP9901123A3 (ru)
IL (2) IL120095A0 (ru)
MX (1) MX9700941A (ru)
NO (1) NO317150B1 (ru)
PL (2) PL188612B1 (ru)
RU (2) RU2155345C2 (ru)
SK (1) SK284161B6 (ru)
WO (1) WO1996040916A1 (ru)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2343195C2 (ru) * 2003-03-24 2009-01-10 Дзе Скриппс Рисерч Инститьют Днк-вакцины против опухолевого роста и способы их применения

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5702917A (en) * 1992-01-27 1997-12-30 Icos Corporation Polynucleotides encoding human ICAM-4
GB9715164D0 (en) * 1997-07-19 1997-09-24 Medical Res Council Improvements in or relating to expression of nucleic acid sequences in cerebellar cells
BR9806294A (pt) * 1997-10-02 2001-09-25 Icos Corp Processo de seleção para neuropatologia em um indivìduo
WO1999020762A1 (en) * 1997-10-22 1999-04-29 Icos Corporation Icam-6 materials and methods
EP1146837A4 (en) * 1998-11-30 2002-10-31 Ivf Sciences Colorado Inc SEQUENTIAL CULTURE SYSTEM AND MEDIA FOR USE IN IN VITRO FERTILIZATION
RU2238025C1 (ru) * 2003-06-18 2004-10-20 Государственное учреждение Межотраслевой научно-технический комплекс "Микрохирургия глаза" им. акад. С.Н. Федорова Способ ранней диагностики нейропатии зрительного нерва при отечном экзофтальме

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0289949B1 (en) * 1987-05-04 1995-10-04 Dana Farber Cancer Institute Intercellular adhesion molecules, and their binding ligands
PT88641B (pt) * 1987-10-02 1993-04-30 Genentech Inc Metodo para a preparacao de uma variante de adesao
US5272263A (en) * 1989-04-28 1993-12-21 Biogen, Inc. DNA sequences encoding vascular cell adhesion molecules (VCAMS)
US5264554A (en) * 1990-01-19 1993-11-23 The Blood Center Of Southeastern Wisconsin, Inc. Platelet cell adhesion molecule and variants thereof
GB9009548D0 (en) * 1990-04-27 1990-06-20 Celltech Ltd Chimeric antibody and method
EP0468257B1 (en) * 1990-07-20 1999-09-01 Bayer Corporation Multimeric form of human rhinovirus receptor protein
ATE166230T1 (de) * 1990-08-31 1998-06-15 Boehringer Ingelheim Pharma Verwendung von anti-icam antikörpern zur herstellung eines präparats für die behandlung von endotoxinschock
SK279937B6 (sk) * 1991-06-11 1999-06-11 Center For Blood Research Rekombinantná molekula dna schopná kódovať icam-3
US5702917A (en) * 1992-01-27 1997-12-30 Icos Corporation Polynucleotides encoding human ICAM-4
WO1993014776A1 (en) * 1992-01-27 1993-08-05 Icos Corporation Icam-related protein

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2343195C2 (ru) * 2003-03-24 2009-01-10 Дзе Скриппс Рисерч Инститьют Днк-вакцины против опухолевого роста и способы их применения

Also Published As

Publication number Publication date
EP1308514A2 (en) 2003-05-07
HUP9901123A2 (hu) 1999-07-28
JPH10505508A (ja) 1998-06-02
EP0789763A1 (en) 1997-08-20
RU2155345C2 (ru) 2000-08-27
SK16597A3 (en) 1998-02-04
ES2183961T3 (es) 2003-04-01
CZ29297A3 (en) 1997-10-15
MX9700941A (es) 1998-01-31
ATE224448T1 (de) 2002-10-15
IL120095A0 (en) 1997-04-15
CZ291974B6 (cs) 2003-06-18
NO317150B1 (no) 2004-08-30
CN1164870A (zh) 1997-11-12
PL188878B1 (pl) 2005-05-31
BR9606440A (pt) 1997-09-30
PL318545A1 (en) 1997-06-23
FI970503A7 (fi) 1997-04-04
CA2196431C (en) 2000-08-15
EP0789763B1 (en) 2002-09-18
FI970503L (fi) 1997-04-04
CN1152960C (zh) 2004-06-09
DE69623746D1 (de) 2002-10-24
WO1996040916A1 (en) 1996-12-19
EP1308514A3 (en) 2004-01-02
DK0789763T3 (da) 2003-01-27
JP3349514B2 (ja) 2002-11-25
NO970546D0 (no) 1997-02-06
DE69623746T2 (de) 2003-05-08
IL146447A0 (en) 2002-07-25
FI970503A0 (fi) 1997-02-06
NO970546L (no) 1997-04-07
AU721316B2 (en) 2000-06-29
JP2003047493A (ja) 2003-02-18
HUP9901123A3 (en) 2001-10-29
CN1597950A (zh) 2005-03-23
CA2196431A1 (en) 1996-12-19
CA2288401A1 (en) 1996-12-19
PL188612B1 (pl) 2005-03-31
SK284161B6 (sk) 2004-10-05
AU6256096A (en) 1996-12-30
US5702917A (en) 1997-12-30

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Effective date: 20051108