RU2000100282A - Способ приготовления амлодипин бензолсульфоната - Google Patents
Способ приготовления амлодипин бензолсульфонатаInfo
- Publication number
- RU2000100282A RU2000100282A RU2000100282/04A RU2000100282A RU2000100282A RU 2000100282 A RU2000100282 A RU 2000100282A RU 2000100282/04 A RU2000100282/04 A RU 2000100282/04A RU 2000100282 A RU2000100282 A RU 2000100282A RU 2000100282 A RU2000100282 A RU 2000100282A
- Authority
- RU
- Russia
- Prior art keywords
- benzenesulfonate
- reaction
- carried out
- amlodipine
- preparing amlodipine
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 7
- ZPBWCRDSRKPIDG-UHFFFAOYSA-N amlodipine benzenesulfonate Chemical compound OS(=O)(=O)C1=CC=CC=C1.CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1Cl ZPBWCRDSRKPIDG-UHFFFAOYSA-N 0.000 title claims 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
- 229910052783 alkali metal Inorganic materials 0.000 claims 2
- -1 alkali metal benzenesulfonate Chemical class 0.000 claims 2
- 239000012736 aqueous medium Substances 0.000 claims 2
- 229940077388 benzenesulfonate Drugs 0.000 claims 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical group CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 1
- BDAGIHXWWSANSR-UHFFFAOYSA-M Formate Chemical compound [O-]C=O BDAGIHXWWSANSR-UHFFFAOYSA-M 0.000 claims 1
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 claims 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims 1
- 229910002651 NO3 Inorganic materials 0.000 claims 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 claims 1
- 229960000528 amlodipine Drugs 0.000 claims 1
- FOCAUTSVDIKZOP-UHFFFAOYSA-M chloroacetate Chemical compound [O-]C(=O)CCl FOCAUTSVDIKZOP-UHFFFAOYSA-M 0.000 claims 1
- 229940089960 chloroacetate Drugs 0.000 claims 1
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 claims 1
- 150000007522 mineralic acids Chemical class 0.000 claims 1
- 150000007524 organic acids Chemical class 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 229940077386 sodium benzenesulfonate Drugs 0.000 claims 1
- MZSDGDXXBZSFTG-UHFFFAOYSA-M sodium;benzenesulfonate Chemical group [Na+].[O-]S(=O)(=O)C1=CC=CC=C1 MZSDGDXXBZSFTG-UHFFFAOYSA-M 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Claims (6)
1. Способ приготовления амлодипин бензолсульфоната формулы I, отличающийся тем, что соль амлодипина с неорганической или органической кислотой взаимодействует с бензолсульфонатом щелочного металла в водной среде или в смеси воды - C1-C2 спирта.
2. Способ по п.1, отличающийся тем, что соль амлодипина выбирается из ацетата, формиата, хлорацетата, гидробромида, нитрата, гидрохлорида или метансульфоната, предпочтительно гидрохлорида.
3. Способ по любому из пп.1 и 2, отличающийся тем, что бензолсульфонат щелочного металла является бензолсульфонатом натрия.
4. Способ по любому из пп.1-3, отличающийся тем, что реакция проводится в водно-этанольной смеси, содержащей от 20 до 50% этанола, особенно смеси 1: 1.
5. Способ по любому из пп.1-4, отличающийся тем, что реакция проводится в водной среде.
6. Способ по любому из пп.1-5, отличающийся тем, что реакция проводится при температуре 5-40oС.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL98325757A PL189666B1 (pl) | 1998-04-09 | 1998-04-09 | Sposób otrzymywania benzenosulfonianu amlodypiny |
| PLP.325757 | 1998-04-09 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2000100282A true RU2000100282A (ru) | 2001-09-10 |
| RU2177000C2 RU2177000C2 (ru) | 2001-12-20 |
Family
ID=20071938
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2000100282/04A RU2177000C2 (ru) | 1998-04-09 | 1999-04-08 | Способ приготовления амлодипин бензолсульфоната |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0993447B1 (ru) |
| KR (1) | KR100323244B1 (ru) |
| CN (1) | CN1122023C (ru) |
| AT (1) | ATE302187T1 (ru) |
| AU (1) | AU3061399A (ru) |
| CZ (1) | CZ295311B6 (ru) |
| DE (1) | DE69926704D1 (ru) |
| ES (1) | ES2245823T3 (ru) |
| HU (1) | HUP0003300A3 (ru) |
| PL (1) | PL189666B1 (ru) |
| PT (1) | PT993447E (ru) |
| RU (1) | RU2177000C2 (ru) |
| SK (1) | SK282736B6 (ru) |
| UA (1) | UA57091C2 (ru) |
| WO (1) | WO1999052873A1 (ru) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2403241C1 (ru) * | 2006-07-21 | 2010-11-10 | Ханми Фарм. Ко., Лтд. | (s)-(-)-амлодипина камзилат или его гидрат и фармацевтическая композиция, включающая их |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR0116553A (pt) | 2000-12-29 | 2004-02-03 | Pfizer Ltd | Composto, composição farmacêutica para tratamento de angina ou hipertensão, processo, processo para tratamento ou prevenção de angina ou hipertensão, composição de ingredientes farmaceuticamente ativos, composição farmacêutica para tratamento ou prevenção de angina ou hipertensão e processo para tratar ou prevenir angina ou hipertensão |
| WO2002053538A1 (en) | 2000-12-29 | 2002-07-11 | Pfizer Limited | Amlodipine fumarate |
| AP2003002820A0 (en) * | 2000-12-29 | 2003-06-30 | Pfizer Ltd | "Process for making amlodipine maleate" |
| GB2371862B (en) | 2000-12-29 | 2004-07-14 | Bioorg Bv | Reference standards for determining the purity or stability of amlodipine maleate and processes therefor |
| US7335380B2 (en) | 2000-12-29 | 2008-02-26 | Synthon Ip Inc. | Amlodipine free base |
| AT5874U1 (de) | 2000-12-29 | 2003-01-27 | Bioorg Bv | Pharmazeutische zubereitungen enthaltend amlodipinmaleat |
| BR0116552A (pt) | 2000-12-29 | 2004-02-03 | Pfizer Ltd | Hemi-maleato de amlodipina, processo, método para o tratamento ou prevenção de angina ou hipertensão, composição farmacêutica, para uso no tratamento e/ou de angina ou da hipertensão |
| MXPA03005882A (es) | 2000-12-29 | 2005-04-19 | Pfizer Ltd | Derivado amida de amlodipina. |
| KR20030066782A (ko) * | 2000-12-29 | 2003-08-09 | 화이자 리미티드 | 암로디핀 말레에이트를 제조하는 방법 |
| US6653481B2 (en) | 2000-12-29 | 2003-11-25 | Synthon Bv | Process for making amlodipine |
| BR0116554A (pt) | 2000-12-29 | 2004-02-03 | Pfizer Ltd | Composto, composição farmacêutica para o tratamento da angina ou hipertensão, processo, processo para o tratamento ou prevenção da angina ou hipertensão, composição do ingrediente farmaceuticamente ativo e composição farmacêutica para o tratamento ou prevenção da angina ou hipertensão |
| DK1221438T3 (da) * | 2001-01-09 | 2007-06-18 | Siegfried Generics Int Ag | Salte af Amlodipinmesylat |
| US7153970B2 (en) | 2001-07-06 | 2006-12-26 | Lek Pharmaceuticals D.D. | High purity amlodipine benzenesulfonate and a process for its preparation |
| US6680334B2 (en) | 2001-08-28 | 2004-01-20 | Pfizer Inc | Crystalline material |
| AR037565A1 (es) * | 2001-11-21 | 2004-11-17 | Synthon Bv | Formas de sales de amlodipina y procedimientos para prepararlas. |
| KR100462304B1 (ko) | 2002-07-30 | 2004-12-17 | 씨제이 주식회사 | 암로디핀의 유기산염 |
| KR100496436B1 (ko) | 2002-07-30 | 2005-06-20 | 씨제이 주식회사 | 암로디핀의 유기산염 |
| KR100538641B1 (ko) | 2002-07-30 | 2005-12-22 | 씨제이 주식회사 | 암로디핀의 유기산염 |
| KR100467669B1 (ko) | 2002-08-21 | 2005-01-24 | 씨제이 주식회사 | 암로디핀의 유기산염 |
| US6784297B2 (en) | 2002-09-04 | 2004-08-31 | Kopran Limited | Process for the preparation of anti-ischemic and anti-hypertensive drug amlodipine besylate |
| AU2003253460A1 (en) * | 2002-09-19 | 2004-04-08 | Cj Corporation | Crystalline organic acid salt of amlodipine |
| WO2005089353A2 (en) * | 2004-03-16 | 2005-09-29 | Sepracor Inc. | (s)-amlodipine malate |
| CN100391946C (zh) * | 2006-05-26 | 2008-06-04 | 苏州东瑞制药有限公司 | 一种苯磺酸氨氯地平的制备方法 |
| PL236001B1 (pl) | 2012-12-21 | 2020-11-30 | Adamed Spolka Z Ograniczona Odpowiedzialnoscia | Złożona kompozycja farmaceutyczna zawierająca kandesartan cyleksetylu oraz amlodypinę, sposób jej wytwarzania oraz jednostkowa postać dawkowania zawierająca tę kompozycję |
| CN103044314A (zh) * | 2013-01-06 | 2013-04-17 | 先声药业有限公司 | 马来酸氨氯地平的制备方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8608335D0 (en) * | 1986-04-04 | 1986-05-08 | Pfizer Ltd | Pharmaceutically acceptable salts |
| SI9200344B (sl) * | 1992-11-26 | 1998-06-30 | Lek, | Postopek za pripravo amlodipin benzensulfonata |
-
1998
- 1998-04-09 PL PL98325757A patent/PL189666B1/pl unknown
-
1999
- 1999-04-08 EP EP99912189A patent/EP0993447B1/en not_active Expired - Lifetime
- 1999-04-08 AU AU30613/99A patent/AU3061399A/en not_active Abandoned
- 1999-04-08 KR KR1019997011291A patent/KR100323244B1/ko not_active Expired - Fee Related
- 1999-04-08 WO PCT/PL1999/000011 patent/WO1999052873A1/en not_active Ceased
- 1999-04-08 PT PT99912189T patent/PT993447E/pt unknown
- 1999-04-08 CN CN99800509A patent/CN1122023C/zh not_active Expired - Fee Related
- 1999-04-08 RU RU2000100282/04A patent/RU2177000C2/ru not_active IP Right Cessation
- 1999-04-08 HU HU0003300A patent/HUP0003300A3/hu unknown
- 1999-04-08 AT AT99912189T patent/ATE302187T1/de not_active IP Right Cessation
- 1999-04-08 SK SK1698-99A patent/SK282736B6/sk not_active IP Right Cessation
- 1999-04-08 ES ES99912189T patent/ES2245823T3/es not_active Expired - Lifetime
- 1999-04-08 CZ CZ19994669A patent/CZ295311B6/cs not_active IP Right Cessation
- 1999-04-08 DE DE69926704T patent/DE69926704D1/de not_active Expired - Lifetime
- 1999-08-04 UA UA2000010042A patent/UA57091C2/ru unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2403241C1 (ru) * | 2006-07-21 | 2010-11-10 | Ханми Фарм. Ко., Лтд. | (s)-(-)-амлодипина камзилат или его гидрат и фармацевтическая композиция, включающая их |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2000100282A (ru) | Способ приготовления амлодипин бензолсульфоната | |
| Melchiorre et al. | Molecular properties of the adrenergic. alpha. receptor. 2. Optimum covalent inhibition by two different prototypes of polyamine disulfides | |
| DK1029861T3 (da) | Benzisothiazol-piperazinylderivat og dets anvendelse som neuroleptikum | |
| AR012845A1 (es) | Compuesto ligador de amiloides, metodo para sintetizarlo, composicion farmaceutica que lo contiene y su uso en la fabricacion de composicionesfarmaceuticas | |
| NO162977B (no) | Filt for fremstilling av en vaatpressefilt for en papirmaskin, samt fremgangsmaate ved fremstilling derav. | |
| KR840002819A (ko) | 벤조티아제핀 유도체의 제조방법 | |
| KR900007803A (ko) | 3,5-디메틸-4-메톡시피리딘 유도체의 제조방법 및 이를 제조하기 위한 중간체 | |
| RU2004127981A (ru) | Способ получения натриевой соли правастатина в кристаллической форме и натриевая соль правастатина, полученная этим способом | |
| GB909357A (en) | Naphthalene derivatives | |
| KR927002214A (ko) | 단사정계 결정구조를 갖고 감열, 감광 및 감습성(moisture-sensitive)이 있는 활성성분을 함유하는 정제 또는 당의정의 제조방법 | |
| ES8506031A1 (es) | Un procedimiento para la preparacion de derivados de ergolina | |
| GB1395243A (en) | Process for preparing piperidine derivatives | |
| DE69909848D1 (de) | Verfahren zur herstellung substituierter allylamin derivative und deren salze | |
| KR850007259A (ko) | 벤조디옥시노피롤 유도체의 제조방법 | |
| US3136770A (en) | Indolyl substituted piperidines | |
| GB1461876A (en) | Alpha-1-aralkylaminoalkyl-aralkoxybenzyl alcohols process for their manufacture and pharamaceutical preparations con taining them | |
| KR900014344A (ko) | 아미노벤젠술폰산 유도체 | |
| KR870006144A (ko) | 양이온성 하이드라존 염료의 제조방법 | |
| JPS57188569A (en) | Preparation of piperidino-propanol derivative | |
| Russell et al. | A New Condensed Pyrimidine System: Some p-Oxazino [2, 3-d] pyrimidines | |
| SU741792A3 (ru) | Способ получени производных -/втор-амино/-о-нитробутирофенона или его солей | |
| GB1018119A (en) | Improvements in or relating to 3,4-benzoaporphine and derivatives thereof | |
| JPS5522699A (en) | Novel 3-amino-1-benzylpyrrolidine derivative | |
| JPS562951A (en) | Preparation of 2-cyanophenol derivative | |
| JPS57142966A (en) | (1-alkyl-2-pyrrolyl)glyoxylic acid amide derivative |