RU2054848C1 - METHOD FOR OBTAINING AVERMECTINE COMPLEX AND DRUG OF AVERMECTINE COMPLEX FOR PREVENTION AND COMPLEX TREATMENT OF DISEASES CAUSED BY ENDO AND ECOPARASITES OF ANIMALS - Google Patents
METHOD FOR OBTAINING AVERMECTINE COMPLEX AND DRUG OF AVERMECTINE COMPLEX FOR PREVENTION AND COMPLEX TREATMENT OF DISEASES CAUSED BY ENDO AND ECOPARASITES OF ANIMALSInfo
- Publication number
- RU2054848C1 RU2054848C1 RU95102462/13A RU95102462A RU2054848C1 RU 2054848 C1 RU2054848 C1 RU 2054848C1 RU 95102462/13 A RU95102462/13 A RU 95102462/13A RU 95102462 A RU95102462 A RU 95102462A RU 2054848 C1 RU2054848 C1 RU 2054848C1
- Authority
- RU
- Russia
- Prior art keywords
- complex
- avermectins
- series
- nutrient medium
- avermectine
- Prior art date
Links
- 241001465754 Metazoa Species 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 230000002265 prevention Effects 0.000 title 1
- 238000011282 treatment Methods 0.000 title 1
- 239000005660 Abamectin Substances 0.000 abstract 7
- 235000015097 nutrients Nutrition 0.000 abstract 4
- 240000008042 Zea mays Species 0.000 abstract 3
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 abstract 3
- 235000002017 Zea mays subsp mays Nutrition 0.000 abstract 3
- RRZXIRBKKLTSOM-XPNPUAGNSA-N avermectin B1a Chemical compound C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 RRZXIRBKKLTSOM-XPNPUAGNSA-N 0.000 abstract 3
- 235000005822 corn Nutrition 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- 229940088594 vitamin Drugs 0.000 abstract 3
- 239000011782 vitamin Substances 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical class N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 2
- 241001468227 Streptomyces avermitilis Species 0.000 abstract 2
- 239000012141 concentrate Substances 0.000 abstract 2
- 235000008504 concentrate Nutrition 0.000 abstract 2
- 235000013312 flour Nutrition 0.000 abstract 2
- 239000008103 glucose Substances 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- 239000002028 Biomass Substances 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical class [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 229920002261 Corn starch Polymers 0.000 abstract 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 abstract 1
- 238000005273 aeration Methods 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 239000008120 corn starch Substances 0.000 abstract 1
- 239000002054 inoculum Substances 0.000 abstract 1
- 229910052500 inorganic mineral Chemical class 0.000 abstract 1
- 239000008101 lactose Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000013028 medium composition Substances 0.000 abstract 1
- 239000011707 mineral Chemical class 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 239000006188 syrup Substances 0.000 abstract 1
- 235000020357 syrup Nutrition 0.000 abstract 1
- 239000008399 tap water Substances 0.000 abstract 1
- 235000020679 tap water Nutrition 0.000 abstract 1
- 238000004809 thin layer chromatography Methods 0.000 abstract 1
Landscapes
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Fodder In General (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1. Способ получения авермектинового комплекса, включающий культивирование продуцента вида Streptomyces avermitilis в питательной среде, содержащей источники углерода, азота и минеральные соли, в условиях аэрации и перемешивания, отделение мицелиальной биомассы, экстракцию из нее авермектинового комплекса растворителями, смешивающимися с водой, и последующую его очистку, отличающийся тем, что в качестве продуцента используют штамм Streptomyces avermitilis ВНИИСХМ-54, дополнительно перед культивированием методом тонкослойной хроматографии отбирают клоны, продуцирующие авермектиновый комплекс в количестве не ниже 1800 мкг/мл следующего состава, %:Авермектины серии А(А + А ) - 18,0 ± 1,85Авермектины серии А(А + А ) - 26,0 ± 1,62Авермектины серии В(В + В ) - 36,7 ± 1,35Авермектины серии В(В + В ) - 18,88 ± 1,64и проводят выращивание вегетативного посевного материала в два этапа, при этом на первом этапе используют питательную среду следующего состава, мас.%:Лактоза - 1,0 - 2,5Кукурузный экстракт - 0,2 - 0,5Белково-витаминный концентрат - 0,3 - 0,8Вода водопроводная - Остальноена втором этапе используют питательную среду следующего состава, мас.%:Соевая мука - 0,3 - 1,0Глюкоза - 1,0 - 2,0Зеленая патока - 1,0 - 2,0 (по техническому весу)Кукурузный экстракт - 0,2 - 0,6 (по техническому весу)Белково-витаминный концентрат - 0,4 - 1,0Мел - 0,1 - 0,4Калий фосфорно-кислый двузамещенный - 0,01 - 0,1Вода водопроводная - Остальное,культивирование вегетативного посевного материала осуществляют на питательной среде следующего состава, мас.%:Глюкоза - 5,0 - 7,0Крахмал кукурузный - 1,0 - 2,0Соевая мука - 0,6 - 1,2Кукурузный экстракт - 0,2 - 0,6 (по техническому весу)Белково-витаминный концентра�1. A method for producing an avermectin complex, comprising cultivating a producer of the species Streptomyces avermitilis in a nutrient medium containing carbon, nitrogen and mineral salts under aeration and mixing conditions, separating the mycelial biomass, extracting the avermectin complex from it with solvents miscible with water, and its subsequent purification, characterized in that the producer uses the strain of Streptomyces avermitilis VNIISKHM-54, additionally, before cultivation by thin layer chromatography, clones are selected, producing avermectin complex in an amount of not less than 1800 μg / ml of the following composition,%: Avermectins of series A (A + A) - 18.0 ± 1.85 Avermectins of series A (A + A) - 26.0 ± 1.62 Avermectins of series B ( B + B) - 36.7 ± 1.35 Avermectins of series B (B + B) - 18.88 ± 1.64 and carry out the cultivation of vegetative seed in two stages, while the first stage uses nutrient medium of the following composition, wt.% : Lactose - 1.0 - 2.5 Corn extract - 0.2 - 0.5 Protein-vitamin concentrate - 0.3 - 0.8 Tap water - The rest of the second stage, use the following nutrient medium composition, wt.%: Soy flour - 0.3 - 1.0 Glucose - 1.0 - 2.0 Green syrup - 1.0 - 2.0 (by technical weight) Corn extract - 0.2 - 0.6 (by technical weight) Protein-vitamin concentrate - 0.4 - 1.0 Mel - 0.1 - 0.4 Potassium phosphoric acid disubstituted - 0.01 - 0.1 Water tap - The rest, the cultivation of vegetative inoculum is carried out on a nutrient medium of the following composition, wt.%: Glucose - 5.0 - 7.0 Corn starch - 1.0 - 2.0 Soy flour - 0.6 - 1.2 Corn extract - 0.2 - 0.6 (by technical weight) Protein-vitamin concentration�
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU95102462/13A RU2054848C1 (en) | 1995-02-28 | 1995-02-28 | METHOD FOR OBTAINING AVERMECTINE COMPLEX AND DRUG OF AVERMECTINE COMPLEX FOR PREVENTION AND COMPLEX TREATMENT OF DISEASES CAUSED BY ENDO AND ECOPARASITES OF ANIMALS |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU95102462/13A RU2054848C1 (en) | 1995-02-28 | 1995-02-28 | METHOD FOR OBTAINING AVERMECTINE COMPLEX AND DRUG OF AVERMECTINE COMPLEX FOR PREVENTION AND COMPLEX TREATMENT OF DISEASES CAUSED BY ENDO AND ECOPARASITES OF ANIMALS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2054848C1 true RU2054848C1 (en) | 1996-02-20 |
| RU95102462A RU95102462A (en) | 1997-03-27 |
Family
ID=48432936
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU95102462/13A RU2054848C1 (en) | 1995-02-28 | 1995-02-28 | METHOD FOR OBTAINING AVERMECTINE COMPLEX AND DRUG OF AVERMECTINE COMPLEX FOR PREVENTION AND COMPLEX TREATMENT OF DISEASES CAUSED BY ENDO AND ECOPARASITES OF ANIMALS |
Country Status (1)
| Country | Link |
|---|---|
| RU (1) | RU2054848C1 (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2124895C1 (en) * | 1998-05-28 | 1999-01-20 | Головкина Любовь Павловна | "avermectin" antiparasitic ointment |
| RU2155052C1 (en) * | 2000-01-18 | 2000-08-27 | ЗАО "Агроветсервис" | Complex antiparasitic preparation without immunosuppression effect |
| RU2156064C1 (en) * | 2000-03-15 | 2000-09-20 | ЗАО "Агроветсервис" | Avermectin-containing insecticide preparation with enhanced contact effect |
| WO2001058464A1 (en) * | 2000-02-14 | 2001-08-16 | Sergei Vyacheslavovich Semenov | Water dispersed ivermectin dosage form used for curing ecto- and endoparasitic diseases |
| RU2182174C2 (en) * | 2000-01-31 | 2002-05-10 | Мосин Владимир Александрович | Method of isolation of avermectin complexes |
| RU2201243C2 (en) * | 2000-01-28 | 2003-03-27 | Мосин Владимир Александрович | Antiparasitic veterinary injection preparation |
| RU2201244C2 (en) * | 2000-01-31 | 2003-03-27 | Мосин Владимир Александрович | Preparation for protection of animals and plants |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998056939A1 (en) * | 1997-06-09 | 1998-12-17 | Vladimir Alexandrovich Mosin | Streptomyces avermitilis strain, method for separating avermectin complexes and preparations for protecting plants and animals |
-
1995
- 1995-02-28 RU RU95102462/13A patent/RU2054848C1/en active
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2124895C1 (en) * | 1998-05-28 | 1999-01-20 | Головкина Любовь Павловна | "avermectin" antiparasitic ointment |
| RU2155052C1 (en) * | 2000-01-18 | 2000-08-27 | ЗАО "Агроветсервис" | Complex antiparasitic preparation without immunosuppression effect |
| RU2201243C2 (en) * | 2000-01-28 | 2003-03-27 | Мосин Владимир Александрович | Antiparasitic veterinary injection preparation |
| RU2182174C2 (en) * | 2000-01-31 | 2002-05-10 | Мосин Владимир Александрович | Method of isolation of avermectin complexes |
| RU2201244C2 (en) * | 2000-01-31 | 2003-03-27 | Мосин Владимир Александрович | Preparation for protection of animals and plants |
| WO2001058464A1 (en) * | 2000-02-14 | 2001-08-16 | Sergei Vyacheslavovich Semenov | Water dispersed ivermectin dosage form used for curing ecto- and endoparasitic diseases |
| RU2156064C1 (en) * | 2000-03-15 | 2000-09-20 | ЗАО "Агроветсервис" | Avermectin-containing insecticide preparation with enhanced contact effect |
Also Published As
| Publication number | Publication date |
|---|---|
| RU95102462A (en) | 1997-03-27 |
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