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RU1824392C - 2-oxy-3,5- dichloro -3ъ-carboxyazobenzene exhibiting antimicrobial activity - Google Patents

2-oxy-3,5- dichloro -3ъ-carboxyazobenzene exhibiting antimicrobial activity

Info

Publication number
RU1824392C
RU1824392C SU914937591A SU4937591A RU1824392C RU 1824392 C RU1824392 C RU 1824392C SU 914937591 A SU914937591 A SU 914937591A SU 4937591 A SU4937591 A SU 4937591A RU 1824392 C RU1824392 C RU 1824392C
Authority
RU
Russia
Prior art keywords
dichloro
carboxyazobenzene
antimicrobial activity
oxy
exhibiting antimicrobial
Prior art date
Application number
SU914937591A
Other languages
Russian (ru)
Inventor
Абдухамит Гафурович Махсумов
Фарход Алиевич Норматов
Махмуд Саримсакович Эргашев
Тулкин Искандарович Искандаров
Инеса Борисовна Бойко
Ольга Владимировна Патрушоева
Фируз Юсупович Гариб
Original Assignee
1-й Ташкентский государственный медицинский институт
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 1-й Ташкентский государственный медицинский институт filed Critical 1-й Ташкентский государственный медицинский институт
Priority to SU914937591A priority Critical patent/RU1824392C/en
Application granted granted Critical
Publication of RU1824392C publication Critical patent/RU1824392C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B29/00—Monoazo dyes prepared by diazotising and coupling
    • C09B29/02—Monoazo dyes prepared by diazotising and coupling from diazotised o-amino-hydroxy compounds
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B29/00—Monoazo dyes prepared by diazotising and coupling
    • C09B29/06—Monoazo dyes prepared by diazotising and coupling from coupling components containing amino as the only directing group
    • C09B29/08—Amino benzenes
    • C09B29/0801—Amino benzenes containing acid groups, e.g. COOH, SO3H, PO3H2, OSO3H, OPO3H2; SO2NHSO2R or salts thereof, R being hydrocarbonyls
    • C09B29/0802—Amino benzenes containing acid groups, e.g. COOH, SO3H, PO3H2, OSO3H, OPO3H2; SO2NHSO2R or salts thereof, R being hydrocarbonyls containing COOH

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Использование: в медицине как соединение , про вл ющее антимикробную активность . Сущность изобретени : продукт - 2-окси-3,5-дихлор-3 -карбоксиазобензол, БФ С1зНаС12Т20з, выход 84%, Т.пл. 198- 200°С, LDso 1375 мг/кг. Реагент 1: м-ами- нобензойна  кислота. Реагент 2: 2,4-дихлорфенил. Услови  реакции: в присутствии 2,5%-ной сол ной кислоты и азотнокислого натри  при 0-5°С. 2 табл.Use: in medicine, as a compound exhibiting antimicrobial activity. SUMMARY OF THE INVENTION: the product is 2-hydroxy-3,5-dichloro-3-carboxyazobenzene, BF C1zNaC12T20z, 84% yield, mp. 198-200 ° C, LDso 1375 mg / kg. Reagent 1: m-aminobenzoic acid. Reagent 2: 2,4-dichlorophenyl. Reaction conditions: in the presence of 2.5% hydrochloric acid and sodium nitrate at 0-5 ° C. 2 tab.

Description

ды:dy:

а) Метод навесок.a) Method of hitching.

Дл  вы влени  антимикробного действи  препарат (0,1 г/мл) помещают в лунки м со-пептонного и сахарного агара, предварительно засе нного по типу газона соответствующей микробной взвеси.In order to detect the antimicrobial effect, the preparation (0.1 g / ml) was placed in wells of co-peptone and sugar agar, previously seeded by the lawn type of the corresponding microbial suspension.

Чашки инкубируют в термостате при 37°С 18 часов. Наличие антимикробных свойств определ ют по диаметру зоны бактерицидного действи  препарата (мм).The plates are incubated in an incubator at 37 ° C for 18 hours. The presence of antimicrobial properties is determined by the diameter of the zone of bactericidal action of the drug (mm).

Установлена минимально подавл юща  концентраци  препарата.The minimum inhibitory concentration of the drug has been established.

4040

Claims (1)

Формула изобретени The claims 2-Окси-3,5-дихлор-3 -карбоксиаэобен- зол формулы2-hydroxy-3,5-dichloro-3-carboxyaeobenzene of the formula 4545 Ј)Ј) СООН ОНUNO OH 50fifty про вл ющий антимикробную активность.showing antimicrobial activity. Таблица 1Table 1 Таблица 2table 2
SU914937591A 1991-04-04 1991-04-04 2-oxy-3,5- dichloro -3ъ-carboxyazobenzene exhibiting antimicrobial activity RU1824392C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
SU914937591A RU1824392C (en) 1991-04-04 1991-04-04 2-oxy-3,5- dichloro -3ъ-carboxyazobenzene exhibiting antimicrobial activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SU914937591A RU1824392C (en) 1991-04-04 1991-04-04 2-oxy-3,5- dichloro -3ъ-carboxyazobenzene exhibiting antimicrobial activity

Publications (1)

Publication Number Publication Date
RU1824392C true RU1824392C (en) 1993-06-30

Family

ID=21575229

Family Applications (1)

Application Number Title Priority Date Filing Date
SU914937591A RU1824392C (en) 1991-04-04 1991-04-04 2-oxy-3,5- dichloro -3ъ-carboxyazobenzene exhibiting antimicrobial activity

Country Status (1)

Country Link
RU (1) RU1824392C (en)

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Машковский М.Д. Лекарственные средства. М.: Медицина. 1986, ч. 2, с. 207, 221. *

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