RU1810345C - Method of synthesis of 2,3-dioxo-1,10@ - diphenyl - 2,3 - dihydro - 1h - pyrrolo - [2,3-b] [1,5] benzothiazepine - 4 - carboxylic acid isopropyl ester - Google Patents
Method of synthesis of 2,3-dioxo-1,10@ - diphenyl - 2,3 - dihydro - 1h - pyrrolo - [2,3-b] [1,5] benzothiazepine - 4 - carboxylic acid isopropyl esterInfo
- Publication number
- RU1810345C RU1810345C SU904872940A SU4872940A RU1810345C RU 1810345 C RU1810345 C RU 1810345C SU 904872940 A SU904872940 A SU 904872940A SU 4872940 A SU4872940 A SU 4872940A RU 1810345 C RU1810345 C RU 1810345C
- Authority
- RU
- Russia
- Prior art keywords
- diphenyl
- dihydro
- dioxo
- benzothiazepine
- carboxylic acid
- Prior art date
Links
- 238000003786 synthesis reaction Methods 0.000 title abstract description 3
- 238000000034 method Methods 0.000 title description 2
- 230000015572 biosynthetic process Effects 0.000 title 1
- -1 1, 5 benzothiazepine-4- carboxylic acid Chemical compound 0.000 abstract description 3
- VRVRGVPWCUEOGV-UHFFFAOYSA-N 2-aminothiophenol Chemical compound NC1=CC=CC=C1S VRVRGVPWCUEOGV-UHFFFAOYSA-N 0.000 abstract description 2
- 239000003814 drug Substances 0.000 abstract description 2
- 239000003153 chemical reaction reagent Substances 0.000 abstract 2
- ZAFNJMIOTHYJRJ-UHFFFAOYSA-N Diisopropyl ether Chemical compound CC(C)OC(C)C ZAFNJMIOTHYJRJ-UHFFFAOYSA-N 0.000 abstract 1
- 230000000845 anti-microbial effect Effects 0.000 abstract 1
- 239000004599 antimicrobial Substances 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000013078 crystal Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000002421 anti-septic effect Effects 0.000 description 1
- 239000000010 aprotic solvent Substances 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 150000001735 carboxylic acids Chemical class 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
Landscapes
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Использование: в качестве полупродукта в органическом синтезе и в качестве антимикробного вещества в медицине. Сущность изобретени : продукт: изопропи- ловый эфир 2,3-диоксо-1,10а-дифенил-2,3- д и г и д ро-1 Н-п и р рол , 3-Ь 1 ,5 бензотиазепин-4-карбоноврй кислоты ф-лы Н COOC3H7i / ,0 С6н5| с6н5, ; - . ; БФ C27H22N204S, выход 60-61%, т.пл, 242- 243°С. Реагент 1: 4-изрпропоксалил-1,5-ди- фенил-2,3-дигидро-2,3-пирролдион. Реагент. 2:о-аминотиофенол. Услови реакции: в инертном органическом растворителе при комнатной температуре. елUsage: as an intermediate in organic synthesis and as an antimicrobial substance in medicine. The inventive product: isopropyl ether 2,3-dioxo-1,10a-diphenyl-2,3-d and g and d ro-1 H-p and r roll, 3-b 1, 5 benzothiazepine-4- carboxylic acid f-crystals Н COOC3H7i /, 0 С6н5 | s6n5,; -. ; BP C27H22N204S, yield 60-61%, mp 242-243 ° C. Reagent 1: 4-isrpropoxalyl-1,5-diphenyl-2,3-dihydro-2,3-pyrroldione. Reagent. 2: o-aminothiophenol. Reaction conditions: in an inert organic solvent at room temperature. ate
Description
Изобретение относитс к органической химии, а именно к новому способу получени нового изопропилового эфира 2,3-диок- со-1,10а-дифенил-2,3-дигидро-1Н-пирроло 2,,5 бензотиазепин-4-карбоновой кислоты формулы 1 н СООС3Н71The invention relates to organic chemistry, and in particular to a new method for producing a new isopropyl ester of 2,3-dioxo-1,10a-diphenyl-2,3-dihydro-1H-pyrrolo 2, 5 benzothiazepine-4-carboxylic acid of the formula 1 n СООС3Н71
4-t° . 4-t °.
/ N С6Н5|/ N C6H5 |
С6Н5C6H5
который может быть использован в органическом синтезе и в медицине в качестве антисептического средства,which can be used in organic synthesis and in medicine as an antiseptic,
Целью изобретени вл етс разработка технологичного, простого, обеспечивающего высокий выход целевых продуктов нового способа получени изопропиловогоThe aim of the invention is to develop a technologically advanced, simple, high yield target products of a new method for the production of isopropyl
эфира З.З-диоксо- Юа-дифенил- З-дигид- ро-1Н-пирроло 2,3-Ь11,5 бензотиазеп 1Н -4 карбоновой кислоты, обладающего биологической активностью.ester of Z. D-dioxo-Yua-diphenyl-3-dihydro-1H-pyrrolo 2,3-b11,5 benzothiazep 1H-4 carboxylic acids having biological activity.
Указанна цель достигаетс тем, что 4- изопропоксолил-1,5-дифенил-2,3-дигидро- 2,3пирролдион подвергают взаимодействию с о-аминотиофенолОм в инертном ап- ротонном растворителе,This goal is achieved by the fact that 4-isopropoxolyl-1,5-diphenyl-2,3-dihydro-2,3-pyrroldione is reacted with o-aminothiophenol in an inert aprotic solvent,
0000
о ыabout s
4 СП4 joint venture
1С3Н7ОСОСб О1С3Н7ОСОСб О
.ХХ .XX
нгЧ.ngch.
с6н5, кто HS c6n5 who is HS
С6Н5C6H5
н COOC3H7-i Ч ° n COOC3H7-i H °
СбН3|SbN3 |
с6н5s6n5
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU904872940A RU1810345C (en) | 1990-10-11 | 1990-10-11 | Method of synthesis of 2,3-dioxo-1,10@ - diphenyl - 2,3 - dihydro - 1h - pyrrolo - [2,3-b] [1,5] benzothiazepine - 4 - carboxylic acid isopropyl ester |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU904872940A RU1810345C (en) | 1990-10-11 | 1990-10-11 | Method of synthesis of 2,3-dioxo-1,10@ - diphenyl - 2,3 - dihydro - 1h - pyrrolo - [2,3-b] [1,5] benzothiazepine - 4 - carboxylic acid isopropyl ester |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU1810345C true RU1810345C (en) | 1993-04-23 |
Family
ID=21539823
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU904872940A RU1810345C (en) | 1990-10-11 | 1990-10-11 | Method of synthesis of 2,3-dioxo-1,10@ - diphenyl - 2,3 - dihydro - 1h - pyrrolo - [2,3-b] [1,5] benzothiazepine - 4 - carboxylic acid isopropyl ester |
Country Status (1)
| Country | Link |
|---|---|
| RU (1) | RU1810345C (en) |
-
1990
- 1990-10-11 RU SU904872940A patent/RU1810345C/en active
Non-Patent Citations (1)
| Title |
|---|
| Авторское свидетельство СССР № 677355, кл. С 07 D 513/04, 1977. * |
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