RS20120386A1 - COMPOSITION OF MEDICINAL HERBS EXTRACTS FOR APPLICATION IN PERIPHERAL CIRCULATION PROBLEMS - Google Patents

Abstract

The present invention relates to the field of pharmaceutical compositions and preparations (phytopreparations), that is, medical products in the form of capsules, liquid preparations for oral administration, creams and gels based on extracts of wild chestnut seeds Aaesculus hippocastani, herb roegrass Achillea millefolium, herbs live herb Gerani herbs yellow cocktail Melilotus officinalis, white cocktail Melilotus alba herb, Calendula officinalis calendula, Geranium pheum geranium, Linaria vulgaris herb and / or Petasites hybridus herb rhizome and / or rhizome of petasites hybridus, intended to maintain physiological blood flow through venous vessels and venous vessels and capillaries.

Description

COMPOSITION OF EXTRACTS OF MEDICINAL PLANTS FOR APPLICATION IN

PROBLEMS OF PERIPHERAL CIRCULATION

Technical field

The invention in question belongs to the field of pharmaceutical compositions and preparations (phytopreparations), i.e. medical products in the form of capsules, liquid preparations for oral administration, creams and gels based on horse chestnut seed extracts Aesculus hippocastani, yarrow herb Achillea millefolium, live grass herb Geranium robertianum, yellow marigold herb Melilotus officinalis, white marigold herb Melilotus albacveta marigold Calendula officinalis, medicinal herbs Geranium pheum, herbs lanilista Linaria vulgarisi herbs and/or rhizomes of burdock Pelasiles hybridus, intended to maintain physiological blood flow through the venous vessels of the lower extremities and improve the health of venous vessels and capillaries.

According to the International Patent Classification (IPC) it belongs to the following classes: A 61K (9/06, 9/08, 9/66, 9/10, 9/12, 36/20); A 61P 31/00.

Technical problem

The technical problem that is solved by this invention is obtaining an optimal composition of medicinal plants and their extracts, which helps maintain physiological blood flow through the venous vessels of the lower extremities and improves the health of venous vessels and capillaries, and its incorporation into suitable vehicles to obtain phytopreparations in various pharmaceutical forms (capsules, liquid preparations for oral administration, creams, gels), which creates the conditions for a synergistic effect of the active substances of the mentioned plant species and vehicle components.

State of the art

Characteristics and action of selected plant components: seeds of wild chestnut, herbs of yarrow grass, herbs of live grass, herbs of yellow and white kokotac, herbs of salvia. lanilista herbs, herbs and/or rhizomes of burdock and calendula flowers as well as their extracts are described in professional literature, through pharmacopoeial regulations, monographs of the World Health Organization and German Commission E, ESCOP monographs. Through our own development research, the quality of the produced extracts was confirmed (identification of active principles, their quantification) and their stability was monitored. Also, the characterization of the finished products (capsules, liquid preparations for oral use, creams, gels) which contain selected plant raw materials, i.e. their extracts, was carried out.

1. Aesculus hippocastani - horse chestnut

Horse chestnut seeds contain 40-50% starch, sugars, proteins, fatty oil, flavone and coumarin derivatives, tannins, etc. Horse chestnut seed extract contains as the most important active substance the triterpene saponin escin, which has a vasoconstrictive, vasoprotective and anti-inflammatory effect, reduces the permeability of blood vessels and prevents the formation of edema. In addition, it contains flavone glucosides, coumarin derivatives and catechins that enhance the anti-edematous effect of escin, and flavonoids increase the tone of the veins. The components synergistically reduce the path in the venous part of the capillaries and the accumulation of liquid in the tissue, strengthening the resistance of the capillaries. The consequence of such an effect is accelerated blood flow, which has a favorable effect on venous congestion. It has been experimentally shown that the anti-inflammatory activity of chestnut seed extract is stronger than that achieved by the use of escin alone, which proves the joint action of the active substances present. The antioxidant action of flavonoids enables the neutralization of free radicals whose formation in cells has a destructive effect on the integrity of the cell's building elements (proteins, carbohydrates and fats). Horse chestnut extract is used as a vasotonic, antiedematous, hemostatic and antiphlogistic. Herbal preparations are recommended for varicose veins, especially in the legs (tension and pain), hemorrhoids, thrombophlebitis, etc. It is approved for use by Commission E in chronic venous insufficiency (1-13). p. 453

2. Achillea millefolium - yarrow grass

The above-ground part of the plant in flower (herb) is used as an aromatically bitter raw material. Physiologically active ingredients are essential oil, sesquiterpene lactones, polyins, alkamides, flavonoids, betaines, etc. They have an anti-inflammatory, anti-edematous and spasmolytic effect. They have a beneficial effect on wounds caused by varicose veins (1-13). Page 917

3. Geranium robertianum - living grass

The main active principles contained in the herb of living grass are flavonoids and tannins. These agents are natural antioxidants capable of neutralizing free radicals generated during physiological processes or as a consequence of pathological changes. In addition to these substances, the herb of living grass contains bitter compounds, resins, organic acids, etc. which contribute to the overall effect of the raw material. It is more appreciated as an astringent and hemostyptic agent (1-13). p. 441

4. Melilotus officinalis - yellow coot

The aerial part of the plant in flower contains 0.4-0.9% coumarin as the main active substance, followed by hydrocoumarins, flavonoids, triterpene saponins, essential oil. These active substances have an anti-inflammatory, anti-exudative and anti-edematous effect. The use of this drug as an anti-varicose agent is mainly based on long-standing traditional use in chronic venous insufficiency, accompanied by pain and heaviness in the legs, with night cramps, itching and swelling. Also, the crane's herb (as it is still popularly called) is also used for hemorrhoids, inflamed lymph nodes, sprains and sprains. Favorable effects on wound healing have also been proven. It is believed that the carriers of this effect are coumarin heterosides and flavonoids, which reduce the permeability of blood vessels, improve venous circulation and lymphatic drainage. For this reason, cranesbill is used today for disorders of venous and lymphatic circulation, for inflammation, swelling and spasms in the lower extremities, and externally for bruises, sprains and hematomas. Commission E approved the use of coccinea in injuries, hemorrhoids, and vein problems (1-13). p. 829

5. Mellilotus alba - white cicada

The composition and use are similar to yellow crane.

6. Calendulae officinalis - calendula

Whole or partially decomposed flower heads are used. The active ingredients are triterpene saponins, triterpene alcohols, flavonoids, hydrocoumarins, carotenoids, essential oil, water-soluble polysaccharides, polyins. The anti-inflammatory action of this drug has been confirmed experimentally. Faradiol monoester proved to be the most relevant anti-inflammatory principle primarily due to its significant presence in the plant material, while the non-esterified form is considered the most active ingredient with equivalent action as indomethacin. Because of this, but also because of its antiviral effect and its effect on wound healing, calendula is used as a dermatological agent (1-13). p. 559

7. Petasides hybridus- burdock

The rhizome and herb contain a group of sesquiterpene compounds, the so-called petasins, which are considered to have muscle relaxant and analgesic effects (petasin, neopetasin, isopetasin or furanopetasin and 9-hydroxyfuranoeremophilon) and essential oil. Flavonoids, mucilages and tannins are found in the burdock herb. The herb also contains pyrazolidine alkaloids (senecionine, integerimine, senkirquine, mostly in traces), and the rhizome contains senecionine and integerimine. The plant, especially its rhizome, is traditionally used for kidney stones and as an aid in case of renal colic. The spasmolytic effect has been proven experimentally on animals. There are also data on its use in cough, headache, migraine, asthma and stress. It is also used in people's situations of stress, for calming and facilitating sleep. The use of rhizomes is approved by Commission E for kidney and bladder stones. It is popularly used in the treatment of acute, spastic pain in urinary infections, and especially in pain caused by the presence of stones in the urinary tract. It is used for migraines and headaches caused/followed by increased pressure. p. 646

8. Geranium feum- medicinal plant

Composition and use similar to live grass.

9. Linaria vulgaris - lanilis

The herb lanilista as its main components contains flavonoids (linarin, pectolinarin, linariin) and then monoterpene iridoids (antirinoside), tannic acid, phytosterols, aurones as well as the alkaloid peganine. Due to the mentioned ingredients, it exhibits anti-inflammatory action. The diaphoretic and diuretic effect of this plant has been documented. p. 923

Capsules

Capsules are solid preparations intended for oral use. They consist of a hard shell containing one dose of medicinal substance. In contact with digestive fluids, the wall of the capsule dissolves and releases the contents, i.e. medicinal principles. Hard gelatin capsules consist of two hollow cylindrical parts that are rounded and closed on one side and open on the other. Active substances in hard capsules are in the form of powder or granules.

Through the rational use of optimal excipients, it is possible to formulate capsules that have an appropriate dissolution rate and satisfactory stability. Several important aspects of capsule production are critical to any desired performance of the finished product. They include ensuring the appropriate particle size of the mass for filling the capsules and their size distribution, homogeneous distribution of active substances, maintaining the appropriate moisture content of the mass and achieving its optimal flowability. The formulation factors that are primarily responsible for the control of these parameters are the presence of fillers, especially lubricants in optimal concentration and the grinding of powder components to a satisfactory level of particle size. Lubricants reduce the tendency of encapsulating mass particles to stick together and form aggregates, which ensures optimal mass flow during the encapsulation process.

Liquid preparations for oral use

Liquid preparations for oral use can be solutions containing one or more active substances in a suitable vehicle. Solutions are made by mixing liquid components (ingredients) or by dissolving measured active substances and other substances (excipients) in the prescribed amount of solvent (or mixture of solvents), with mixing. They can also be prepared from concentrated liquid preparations, by dilution. They are available in multi-dose or single-dose packages. They are dosed per ml or per drop. Each multi-dose package must contain a teaspoon or dropper for accurately measuring the prescribed amount of the preparation.

Semi-solid preparations for external use

Semi-solid preparations for external use are intended for use on the skin or a specific mucous membrane, for the purpose of local action or percutaneous penetration of the medicinal substance or for protective action. They must have a homogeneous appearance. They consist of simple or complex bases in which one or more active substances are dissolved or dispersed (suspended). Substrates can influence the action of the preparation and the release of active principles. The formulation of modern phytopreparations with plant extracts in an optimal concentration that enables effective action with comfortable application, implies defining the technological procedure of making such a preparation that enables the treatment of certain conditions with a simple application of the preparation that can be applied to larger areas of the skin as well as to places where it is not easy to apply a poultice, which is easily spread, does not oil the skin, which quickly absorbs it after application and enables the action of active substances.

Types of semi-solid preparations for external use are: ointments, creams, gels and pastes.

Creams are multiphase preparations consisting of a fatty (lipophilic) and aqueous phase. They are polyphase, dispersed systems where one phase is homogeneously dispersed in another.

Gels consist of liquids gelled with suitable gelling agents. Gel builders, gelling agent, liquid phase-vehicle and, if necessary, other ingredients (solubilizers, emollients, penetration accelerators, preservatives, antioxidants...) are used to make the gel. Numerous substances of natural, semi-synthetic and synthetic origin are used as gel builders. The most commonly used are cellulose derivatives (methyl cellulose, hydroxyethyl cellulose, carboxymethyl cellulose), cabroxyvinyl polymer, but also starch, gelatin, alginates, polyvinylpyrrolidone, poloxamers, etc. The liquid phase of the gel is usually water or a mixture of water and ethanol or water and isopropranol. The composition of the liquid phase often includes humectants (glycerol, sorbitol, propylene glycol) that prevent the gel from drying out and are film plasticizers. Gels and creams are a suitable medium for the development of microorganisms, due to their high water content, so they should be preserved. The medicinal substance/s, in accordance with its physico-chemical properties, can be dissolved in part or the entire amount of the liquid phase, or suspended in a prepared gel or cream base.

Water-soluble medicinal substances can be dissolved in part or all of the liquid phase. Increasing the solubility of lipophilic medicinal substances can be achieved by using solubilizers. When dealing with extremely hydrophobic substances, the use of wetting agents is recommended.

State of the art (patent documentation available)

In order to determine the state of the art, the available patent literature was reviewed. Several patent applications seek protection for one or a combination of two or three plant species listed in our patent.

Thus, the patent application EP1707213 (Al), 2006-10-04: "Herbal composition for the treatment of cutaneous Ervthema" (applicant Kern Elizabeth), seeks protection of the process of making calendula extract, i.e. alcoholic tincture of this plant.

Protection of extracts of yarrow and calendula is claimed in patent application WO/2006/032091, 30.03.2006: (applicant R.P. Scherer Holdings Pty.Ltd). Water, ethanol, methanol, acetone are listed as extractants.

Herbal compositions such as mixtures of tinctures of calendula, horse chestnut and yarrow are patent protected through the patent application of the applicant Lavnder hill Projects Pty Ltd.

In the patent CA2437259 (Al), 2002-09-12, the protection of a herbal composition containing 6 herbal components (chestnut, calendula, lanifolia, white and yellow cocotac and comfrey) is requested. Our composition differs from the above in the absence of comfrey (which is not recommended for internal use) and the presence of other plant components responsible for the effectiveness of the action (live grass, sedum, burdock).

Within the patent application RO121671 (BI): "Hygiene gel composition and process for preparing the same" (applicants Lord Echel Radu and collaborators); the composition and preparation of the gel with tinctures of St. John's wort and calendula and horse chestnut extract are protected.

The designation LV11434 (B) refers to the patent application: "Extracts of plants for preparation of medicines, velerinarv preparative and cosmelics" (applicant Kirsfelds Karlis) which seeks protection of the process of making an ethanolic extract of Melilotus albus, Melilotus albus annus, Melilotus altissima or Melilotus albus altissima fruit, flower, seed, seed-coat, fruit cortex, for use to improve circulation and prevent damage to blood vessels.

In their patent application: "Dressing containing a naturopathic medicinal product for treating wound", applicants Secar Vasile and Ungureanu Gheorghe seek patent protection for an extract that is a mixture of extracts of four plants: burdock, yarrow, calendula and comfrey.

In the patent application VVO/2006/032091, 30/03/2006: "Herbal composition" (Applicant Lavender Hill projects Ltd, protection of the herbal composition is sought. The content of this composition includes calendula, wild chestnut and yarrow.

The specific characteristics of our invention in solving the technical problem in question in relation to similar preparations for which patent protection is sought and those in circulation are the following: the original combination of herbal components, the percentage representation of extracts/tinctures/selected herbal drugs in the final products, their successful and safe application in the intended/recommended indications, which is scientifically and confirmed.

Description of the solution to the technical problem with implementation examples

The essence of the invention is the composition of plant raw materials, the technology of making extracts, the formulation and the technology of making phytopreparations based on plant raw materials intended for maintaining physiological blood flow through the venous vessels of the lower extremities and improving the health of venous vessels and capillaries. This includes the application of this pharmaceutical composition in phytopreparations of different pharmaceutical forms (capsules, liquid preparations for oral administration, creams, gels) that ensure the effective action of all components and the best effect. The applicability of this composition is based on the scientifically confirmed biological properties of the active components. Although the medicinal properties of the active principles of the plant components are individually known to a large extent from traditional application and recently scientifically confirmed, the proposed herbal composition is new and original, and the formulation of the phytopreparation is such that the active principles can achieve maximum effect.

For the preparation of phytopreparations from selected medicinal plants: Aesculus hippocastani, Achilea

millefolium, Geranium robertianum, Geranium pheum, Melilotus officinalis, Melilotus albus,

Linaria vulgaris, Petazites hybridusi Calendula officinalis, extracts were prepared by a method that was optimized through a series of experiments.

The invention will be further illustrated by the following non-limiting examples.

Example 1.

Production of herbal extracts

For the purposes of making phytopreparations that represent the invention, extracts of the mentioned plant medicinal raw materials obtained by using fruit distillate as an extractant were used. Drugs obtained from plant material collected in the wider area of Mount Cer are used as starting plant material. For the production of marigold flower extract, the starting plant material is grown on our own plantations. The dried plant material for extraction is first crushed to a degree that allows maximum extraction of active compounds (degree of comminution from 0.30 to 2). The extraction of plant ingredients lasts from 2 to 12 hours at room temperature, after which the finished extract is separated from the plant mass by squeezing and filtering. The drug:extract ratio ranges from 1:2 to 1:5. The extracts were aged for 1-5 days at room temperature to precipitate ballast substances, after which they were filtered. Extraction products are extracts with a characteristic color, specific taste and smell that depend on the plant raw material used.

All extracts were defined through the determination of relative density, refractive index, ethanol content, dry residue and pH value. As carriers of vasotonic, vasoconstrictor, spasmolytic and anti-inflammatory effects, extracts of horse chestnut seeds, kokotca herb, burdock root and burdock rhizome are characterized by the determination of the content of escin (horse chestnut seed, horse chestnut seed extract), coumarin (kokotka herb, kokotka herb extract), petazine (burdock rhizome and burdock rhizome extract) and antioxidant activity (bordock herb, extract yarrow herb).

Example 2.

Capsule manufacturing process

Making encapsulation mass

The prepared liquid extracts are evaporated on a vacuum evaporator until the content of dry matter is min. 75%. The dried, ground extracts are sieved (sieve diameter 0.3 mm) and mixed with each other in a precisely defined ratio: horse chestnut seed extract (Aesculus hypocastani) in the range 0.5-35.0%, yarrow herb extract (Achillea millefolium) in the range 1.0-25.0%, geranium robertianum extract in the range 0.0-15.0 %, Melilotus officinalis herb extract in the range of 0.0-12.5%, Melilotus alba extract in the range of 0.0-15.0%, Geranium feum extract in the range of 0.0-12.5%, Lanilista herb extract (Linarium vulgaris) in the range of 0.0-10.0%), rhizome and/or burdock herb extract ( Petasides hybridus) in the range 0.0-10.0%, calendula flower extract (Calendula officinalis) in the range of 1.5-15%). Then fillers are added to the measured mixture of extracts: starch, microcrystalline cellulose pH 101, lactose, colloidal SiO2 and the mass is mixed for 5-15 minutes. At the end, magnesium stearate is added and mixing continues for another 1-10 minutes.

Encapsulation

The previously prepared mass is encapsulated on the machine into capsules of size 0, whereby capsules with the following characteristics are formed:

Theoretical mass of capsules: 450.00 mg

Permissible deviation:

- weight variation of individual capsules: ±5% (two capsules ±10%)

- average mass: ±3%

- degradability: decomposition time 15 min. (for all capsules)

Capsules are filled in adequate packaging and signed.

Example 3.

Procedure for making a solution (liquid preparation for oral administration)

A solution based on selected extracts, intended for maintaining physiological blood flow through the venous vessels of the lower extremities and improving the health of venous vessels and capillaries, is made by mixing them and, if necessary, adding co-solvents and solubilizers.

Horse chestnut seed extract (Aesculus hypocastani) in the range of 0.5-35.0%, yarrow herb extract (Achillea millefolium) in the range of 1.0-25.0%, Geranium robertianum herb extract in the range of 0.0-15.0%, Melilotus officinalis herb extract in the range of 0.0-12.5%, herb extract Melilotus alba in the range of 0.5-15.0%, Geranium feum extract in the range of 0.0-12.5%, Linarium vulgaris extract in the range of 0.0-10.0%), rhizome and/or burdock root extract

(Petasides hybridus) in the range of 0.5-10.0%, calendula flower extract (Calendula officinalis) in the range of 1.5-15% and, if necessary, co-solvents and solubilizers: ethanol in the range of 0.0-15.0%, water in the range of 0.0-15.0%, propylene glycol in the range of 0.0-15.0% and polysorbate 20 in the range 0.0-15.0%) are mixed in a vessel with a propeller mixer, at a speed of 500-700 rpm, to form a homogeneous solution (15-45 minutes). The solution is left for 24 hours to settle any insoluble particles that may have formed, and then it is filtered and filled into glass or plastic bottles with or without a sprayer.

Example 4.

The process of making gel with plant extracts

Horse chestnut seed extract (Aesculus hypocastani) in the range of 0.5-15.0%, yarrow herb extract (Achillea millefolium) in the range of 1.0-15.0%, Geranium robertianum herb extract in the range of 0.1-5.0%, Melilotus officinalis extract in the range of 0.5-12.5%, white herb extract Melilotus alba in the range of 0.5-5.0%, Geranium feum extract in the range of 0.0-12.5%, Linarium vulgaris extract in the range of 0.0-5.0%>, rhizome and/or burdock herb extract (Petasides hybridus) in the range of 0.5-5.0% and calendula flower extract (Calendula officinalis) in the range of 1.5-15% are mixed with with phosphatidyl-choline in the amount of 0.0-5.0% in a vessel with a propeller mixer at a speed of 500-700 rpm (5-15 minutes). Then ethanol in the range of 0.0-15.0%, water in the range of 0.0-15.0%, propylene glycol in the range of 0.0-15.0%, glycerol in the range of 0.0-5.0% and polysorbate 20 in the range of 0.0-15% are added to the mass as needed. An antioxidant (tocopherol-acetate in the amount of 1.0-5.0%) and a preservative (sodium benzoate 0.1-0.2%) are dissolved in the mass, and then a gelling agent (carbomer) is spread over the surface of the solution in an amount of 0.5-1.2%. After swelling of the polymer (15 minutes) and mixing (same speed, 15 minutes), a gelling agent (10% sodium hydroxide solution) is added. The formed gel is homogenized (700 rpm) and left to stand at room temperature for 24 hours for complete structuring of the system. It is filled in plastic, laminate or aluminum tubes.

Example 5.

The process of obtaining creams with plant extracts

In a duplicate vessel with a mixer and a homogenizer, measured amounts of the fatty phase components are added: Laurvl Glucoside (and) Polyglyceryl-2 Dipolyhydroxystearac (and) Glycerin 0.0-5.0%, Cetyl alcohol 0.1-2.5%, Stearyl alcohol 0.1-2.5%), Silicon oil DC 200 0.0-5%o, Shea butter 0.1-5.0%, Triglucerides caprylic and caproic acids 0.0-7%) and heated to the melting temperature and then the temperature of the mass is adjusted to 70°C.

The required amount of purified water is put into a stainless steel vessel (25-75%), propylene glycol in the amount of 0.1-12%, Na2EDTA 0.01-0.1%, Carbomer (0.1-0.5%), check the pH (it is necessary that the solution has a pH in the range 4.5-6.5), leave it at room temperature for 15 minutes and then heat it to 72°C. If the pH value is below the prescribed limit, adjust it by adding a 10% NaOH solution. If the pH value is above the prescribed limit, it is corrected by adding 1% EDTA solution, which should be added gradually in portions. After adding the base or acid, mix and homogenize the mass for 15 minutes and measure the pH.

The water phase in portions is added to the vessel with the prepared fatty phase while the mixer is running and the homogenizer is occasionally turned on. Under the mentioned conditions, the system is mixed for 30 minutes and then cooling begins with unchanged mixing and homogenization conditions. At a mass temperature of 45°C, extracts are added: horse chestnut seeds (Aesculus hypocastani) in the range of 0.5-25.0%, yarrow herbs (Achillea millefolium) in the range of 1.0-15.0%, wild grass herbs (Geranium robertianum) in the range of 0.1-5.0%, yellow cockle grass (Melilotus officinalis) in the range 0.5-12.5%, Melilotus alba herb in the range of 0.5-5.0%, Geranium feum extract in the range of 0.1-12.5%, Linarium vulgaris herb extract in the range of 0.1-5.0%, rhizome and/or burdock herb extract (Petasides hybridus) in the range of 0.1-15.0%, flowers calendula (Calendula officinalis) in the range of 1.5-15% and other components sensitive to elevated temperature (tocopherol-acetate 1.0-5.0%, ascorbic acid 0.1-1.5%), avocado oil 0.1-5.0%, soybean oil 0.1-5.0%, olive oil 0.1-5.0%). Cool the mass with unchanged mixing and homogenization conditions to room temperature.

Example 6.

The procedure for obtaining creams with a combination of (twenty-nine) plant extracts

In a duplicate vessel with a mixer and a homogenizer, measured amounts of the fatty phase components are added: Glyceryl Stearate (and) Ceteareth-20 (and) Ceteareth-12 (and) Cetearyl Alcohol (and) Cetyl Palmitate 0.0-5.0%, Cetyl alcohol 0.1-2.5%, Stearyl alcohol 0.1-2.5%, Silicon oil DC 200 0.0-5%, Shea butter0.1-5.0%>, Triglycerides of caprylic and caproic acid 0.0-7%>) and heat to the melting temperature and then adjust the temperature of the mass to 70°C.

The required amount of purified water is put into a stainless steel vessel (25-75%), propylene glycol in the amount of 0.1-12%, Na2EDTA 0.01-0.1% is added, the pH is checked (it is necessary that the solution has a pH in the range of 4.5-6.5) and heated to 72°C. If the pH value is below the prescribed limit, adjust it by adding a 10% NaOH solution. If the pH value is above the prescribed limit, it is corrected by adding \% EDTA solution, which should be added gradually in portions. After adding the base or acid, mix and homogenize the mass for 15 minutes and measure the pH.

The water phase in portions is added to the vessel with the prepared fatty phase while the mixer is running and the homogenizer is occasionally turned on. Under the mentioned conditions, the system is mixed for 30 minutes and then cooling begins with unchanged mixing and homogenization conditions. At a mass temperature of 45°C, extracts are added: horse chestnut seeds (Aesculus hypocastani) in the range of 0.5-25.0%, yarrow herbs (Achillea millefolium) in the range of 1.0-15.0%, wild grass herbs (Geranium robertianum) in the range of 0.1-5.0%, yellow cockle grass (Melilotus officinalis) in the range 0.5-12.5%), Melilotus alba herb in the range of 0.5-5.0%, Geranium feum extract in the range of 0.1-12.5%, Linarium vulgaris herb extract in the range of 0.1-5.0%, rhizome and/or burdock herb extract (Petasides hybridus) in the range of 0.1-15.0%, flowers marigold (Calendula officinalis) in the range of 1.5-15% and other components sensitive to elevated temperature (tocopherol-acetate 1.0-5.0%, ascorbic acid 0.1-1.5%), avocado oil 0.1-5.0%, soybean oil 0.1-5.0%), olive oil 0.1-5.0%). Cool the mass with unchanged mixing and homogenization conditions to room temperature.

Claims (32)

1) Pharmaceutical composition based on medicinal herbs, indicated by the fact that it consists of pulverized drugs and plant extracts, horse chestnut seeds Aesculus hippocastani, yarrow herb (Achillea millefolium), live grass herb (Geranium robertianum), yellow marigold herb (Melilotus officinalis), white marigold herb (Melilotus alba), calendula flower (Calendula officinalis), marigold herb (Geranium pheum), lanilista herb (Linaria vulgaris) and herbs and/or burdock rhizomes (Petasites hybridus) for the production of various pharmaceutical forms (capsules, liquid preparations for oral administration, creams, gels). 2) Pharmaceutical preparation according to patent claim 1, indicated by the fact that it contains pulverized drugs and/or plant extracts of horse chestnut seeds (Aesculus hippocastani) in the range of 0.5-25.0%, yarrow herb (Achillea millefolium) in the range of 1.0-15%, live grass herb (Geranium robertianum) in the range of 0.1-5.0%, Melilotus officinalis) in the range of 0.5-12.5%, Melilotus alba in the range of 0.5-5.0%, Calendula officinalis in the range of 1.5-15%o, Geraniumpheum in the range of 0.1-12.5%, Linaria vulgaris in the range of 0.1-5.0% and herbs and/or burdock rhizome (Petasites hybridus). range 0.1-15.0%) and common pharmaceutical additives to obtain the appropriate pharmaceutical form 3) Pharmaceutical preparation according to patent claim 1, indicated by the fact that it contains pulverized drugs and/or plant extracts of horse chestnut seeds (Aesculus hippocastani) in the range of 0.5-25.0%, yarrow herb (Achillea millefolium) in the range of 1.0-15%), geranium robertianum herb in the range of 0.1-5.0%, Melilotus officinalis) in the range of 0.5-12.5%, Melilotus alba in the range of 0.5-5.0%, Geraniumpheum in the range of 0.1-12.5%, Lanilista herb (Linaria vulgaris) in the range of 0.1-5.0%> and herbs and/or burdock rhizomes (Petasites hybridus) in the range 0.1-15.0%) and common pharmaceutical additives yes the appropriate pharmaceutical form would be obtained 4) Pharmaceutical preparation according to patent claim 1, indicated by the fact that it contains pulverized drugs and/or plant extracts of horse chestnut seeds (Aesculushippocastani) in the range of 0.5-25.0%, yarrow herbs (Achillea millefolium) in the range of 1.0-15%, live grass herbs (Geranium robertianum) in the range of 0.1-5.0%, yarrow herbs ( Melilotus officinalis) in the range of 0.5-12.5%, Melilotus alba in the range of 0.5-5.0%, calendula flower (Calendula officinalis) in the range of 1.5-15%), Geranium pheum in the range of 0.1-12.5%, and herbs and/or burdock rhizomes (Petasites hybridus) in the range of 0.1-15.0%) and common pharmaceutical supplements in order to received the appropriate pharmaceutical form 5) Pharmaceutical preparation according to patent claim 1, indicated by the fact that it contains pulverized drugs and/or plant extracts of horse chestnut seeds (Aesculus hippocastani) in the range of 0.5-25.0%, yarrow grass (Achillea millefolium) in the range of 1.0-15%, live grass herbs (Geranium robertianum) in the range of 0.1-5.0%, Melilotus officinalis) in the range of 0.5-12.5%>, Melilotus alba) in the range of 0.5-5.0%, calendula flower (Calendula officinalis) in the range of 1.5-15%, lanilista herb (Linaria vulgaris) in the range of 0.1-5.0% and burdock herb and/or rhizome (Petasites hybridus) in the range of 0.1-15.0% and common pharmaceutical supplements to obtain appropriate pharmaceutical form 6) Pharmaceutical preparation according to patent claim 1, indicated by the fact that it contains pulverized drugs and/or plant extracts of horse chestnut seeds (Aesculus hippocastani) in the range of 0.5-25.0%, yarrow herb (Achillea millefolium) in the range of 1.0-15%), geranium robertianum herb in the range of 0.1-5.0%, Melilotus officinalis) in the range of 0.5-12.5%), white cockle grass (Melilotus alba) in the range of 0.5-5.0%), calendula flower (Calendula officinalis) in the range of 1.5-15%, Geranium pheum in the range of 0.1-12.5%, lanilista herb (Linaria vulgaris) in the range of 0.1-5.0% and common pharmaceutical additives to obtain appropriate pharmaceutical form 7) Pharmaceutical preparation according to patent claim 1, indicated by the fact that it contains pulverized drugs and/or plant extracts of horse chestnut seeds (Aesculus hippocastani) in the range of 0.5-25.0%, yarrow herbs (Achillea millefolium) in the range of 1.0-15%, live grass herbs (Geranium robertianum) in the range of 0.1-5.0%, Melilotus officinalis) in the range of 0.5-12.5%, marigold herb (Melilotus alba) in the range of 0.5-5.0%), calendula flower (Calendula officinalis) in the range of 1.5-15% and common pharmaceutical additives to obtain the appropriate pharmaceutical form 8) The method for obtaining capsules according to claim 2, characterized by the fact that starch, microcrystalline cellulose pH 101, lactose, colloidal SiC>2 and magnesium stearate are mixed with plant pulps/extracts of horse chestnut seeds (Aesculus hippocastani) in the range of 0.5-25.0%, yarrow herbs (Achillea millefolium) in the range of 1.0-15%, herbs of mercury grass (Geranium robertianum) in the range of 0.1-5.0%, yellow sedum herb (Melilotus officinalis) in the range of 0.5-12.5%, white sedum herb (Melilotus alba) in the range of 0.5-5.0%, calendula flower (Calendula officinalis) in the range of 1.5-15%, medicinal herb (Geraniumpheum) in the range 0.1-12.5%, Linaria vulgaris herb in the range of 0.1-5.0% and herbs and/or burdock rhizomes (Petasites hybridus) in the range of 0.1-15.0% and the mass prepared in this way is encapsulated and translated into the final pharmaceutical form. 9) The method for obtaining capsules according to claim 3, characterized by the fact that starch, microcrystalline cellulose pH 101, lactose, colloidal SiC>2 and magnesium stearate are mixed with herbal powders/extracts of horse chestnut seeds (Aescidus hippocastani) in the range of 0.5-25.0%, yarrow herbs (Achillea millefolium) in the range of 1.0-15%, herbs of mercury grass (Geranium robertianum) in the range of 0.1-5.0%, yellow sedum herb (Melilotus officinalis) in the range of 0.5-12.5%, white sedum herb (Melilotus alba) in the range of 0.5-5.0%, heather (Geraniumpheum) in the range of 0.1-12.5%), lanilista herb (Linaria vulgaris) in the range 0.1-5.0 % of herbs and/or rhizomes burdock (Petasites hybridus) in the range of 0.1-15.0% and the mass prepared in this way is encapsulated and translated into the final pharmaceutical form. 10) The method for obtaining capsules according to claim 4, characterized by the fact that starch, microcrystalline cellulose pH 101, lactose, colloidal SiO2 and magnesium stearate are mixed with herbal powders/extracts of horse chestnut seeds (Aesculus hippocastani) in the range of 0.5-25.0%, yarrow herbs (Achillea millefolium) in the range of 1.0-15%, herbs of mercury grass (Geranium robertianum) in the range of 0.1-5.0%, yellow marigold herb (Melilotus officinalis) in the range of 0.5-12.5%, white marigold herb (Melilotus alba) in the range of 0.5-5.0%), calendula flower (Calendula officinalis) in the range of 1.5-15%, sedum herb (Geraniumpheum) in the range of 0.1-12.5% and herbs and/or burdock rhizomes ( Petasites hybridus) in the range of 0.1-15.0% and the mass prepared in this way is encapsulated and translated into the final pharmaceutical form. 11) The method for obtaining capsules according to claim 5, characterized by the fact that starch, microcrystalline cellulose pH 101, lactose, colloidal SiC>2 and magnesium stearate are mixed with herbal powders/extracts of horse chestnut seeds (Aesculus hippocastani) in the range of 0.5-25.0%, yarrow herbs (Achillea millefolium) in the range of 1.0-15%, herbs of mercury grass (Geranium robertianum) in the range of 0.1-5.0%, yellow marigold herb (Melilotus officinalis) in the range of 0.5-12.5%, white marigold herb (Melilotus alba) in the range of 0.5-5.0%), calendula flower (Calendula officinalis) in the range of 1.5-15%, lanilista herb (Linaria vulgaris) in the range of 0.1-5.0% and herbs and/or rhizomes of burdock ( Petasites hybridus) in the range of 0.1-15.0% and the mass prepared in this way is encapsulated and translated into the final pharmaceutical form. 12) The method for obtaining capsules according to claim 6, characterized by the fact that starch, microcrystalline cellulose pH 101, lactose, colloidal SiC>2 and magnesium stearate are mixed with herbal powders/extracts of horse chestnut seeds (Aesculus hippocastani) in the range of 0.5-25.0%, yarrow herbs (Achillea millefolium) in the range of 1.0-15%, herbs of mercury grass (Geranium robertianum) in the range of 0.1-5.0%, yellow marigold herb (Melilotus officinalis) in the range of 0.5-12.5%, white marigold herb (Melilotus alba) in the range of 0.5-5.0%, calendula flower (Calendula officinalis) in the range of 1.5-15%, medicinal herb (Geranium pheum) in the range of 0.1-12.5% and herbs lanilista (Linaria vulgaris) in the range of 0.1-5.0% and the mass prepared in this way is encapsulated and translated into the final pharmaceutical form. 13) The method for obtaining capsules according to claim 7, characterized by the fact that starch, microcrystalline cellulose pH 101, lactose, colloidal SiC>2 and magnesium stearate are mixed with herbal powders/extracts of horse chestnut seeds (Aesculus hippocastani) in the range of 0.5-25.0%, yarrow herbs (Achillea millefolium) in the range of 1.0-15%, herbs of mercury grass (Geranium robertianum) in the range of 0.1-5.0%, yellow marigold herb (Melilotus officinalis) in the range of 0.5-12.5%, white marigold herb (Melilotus alba) in the range of 0.5-5.0%, calendula flower (Calendula officinalis) in the range of 1.5-15% and the mass prepared in this way is encapsulated and translated into the final pharmaceutical form. 14) Liquid preparation for oral administration according to claim 2, indicated by the fact that it contains herbal extracts of horse chestnut seeds (Aesculus hypocastani) in the range of 0.5-35.0%, extract of the herb of yarrow (Achillea millefolium) in the range of 1.0-25.0%, extract of the herb of living grass (Geranium robertianum) in the range of 0.0-15.0%, extract of the herb of yellow Melilotus officinalis in the range of 0.5-12.5%, Melilotus alba extract in the range of 0.5-15.0%, Geranium feum extract in the range of 0.5-12.5%), Linarium vulgaris extract in the range of 0.5-10.0%, rhizome and/or burdock root extract (Petasides hybridus) in range 0.5-10.0%), extract calendula flowers (Calendula officinalis) in the range of 1.5-15% and ethanol 0.0-15.0%, water 0.0-15.0%, propylene glycol 0.0-15.0% and polysorbate 20 0.0-15.0%. 15) Liquid preparation for oral administration according to claim 3, indicated by the fact that it contains herbal extracts of horse chestnut seeds (Aesculus hypocastani) in the range of 0.5-35.0%, extract of the herb of yarrow (Achillea millefolium) in the range of 1.0-25.0%>, extract of the herb of living grass (Geranium robertianum) in the range of 0.5-15.0%, extract of the herb of yellow Melilotus officinalis in the range of 0.5-12.5%, Melilotus alba extract in the range of 0.5-15.0%, Geranium feum extract in the range of 0.5-12.5%, Linarium vulgaris extract in the range of 0.5-10.0%), rhizome and/or burdock herb extract (Petasides hybridus) in range 0.5-10.0%) i ethanol 0.0-15.0%, water 0.0-15.0%, propylene glycol 0.0-15.0% and polysorbate 20 0.0-15.0%. 16) Liquid preparation for oral administration according to claim 4, indicated by the fact that it contains plant extracts of horse chestnut seeds (Aesculus hypocastani) in the range of 0.5-35.0%, extract of the herb of yarrow (Achillea millefolium) in the range of 1.0-25.0%, extract of the herb of living grass (Geranium robertianum) in the range of 0.5-15.0%, extract of the herb of yellow (Melilotus officinalis) in the range of 0.5-12.5%, Melilotus alba extract in the range of 0.5-15.0%, Geranium feum extract in the range of 0.5-12.5%, rhizome and/or burdock herb extract (Petasides hybridus) in the range of 0.5-10.0%, calendula flower extract (Calendula officinalis) in the range 1.5-15%) and ethanol 0.0-15.0%, water 0.0-15.0%), propylene glycol 0.0-15.0% and polysorbate 20 0.0-15.0%. 17) Liquid preparation for oral administration according to claim 5, indicated by the fact that it contains plant extracts of horse chestnut seeds (Aesculus hypocastani) in the range of 0.5-35.0%, yarrow herb extract (Achillea millefolium) in the range of 1.0-25.0%, Geranium robertianum extract in the range of 0.5-15.0%, Melilotus officinalis in the range of 0.5-12.5%, Melilotus alba extract in the range of 0.5-15.0%, Linarium vulgaris extract in the range of 0.5-10.0%, rhizome and/or burdock herb extract (Petasides hybridus) in the range of 0.5-10.0%, calendula flower extract (Calendula officinalis) in in the range of 1.5-15% and ethanol 0.0-15.0%, water 0.0-15.0%, propylene glycol 0.0-15.0% and polysorbate 20 0.0-15.0%. 18) Liquid preparation for oral administration according to claim 6, indicated by the fact that it contains plant extracts of horse chestnut seeds (Aesculus hypocastani) in the range of 0.5-35.0%>, extract of the herb of yarrow (Achillea millefolium) in the range of 1.0-25.0%, extract of the herb of living grass (Geranium robertianum) in the range of 0.5-15.0%, extract of the herb of yellow Melilotus officinalis in the range of 0.5-12.5%, Melilotus alba extract in the range of 0.5-15.0%, Geranium feum extract in the range of 0.5-12.5%, Linarium vulgaris extract in the range of 0.5-10.0%, Calendula officinalis extract in the range of 1.5-15%) and ethanol 0.0-15.0%, water 0.0-15.0%), propylene glycol 0.0-15.0% and polysorbate 20 0.0-15.0%. 19) Liquid preparation for oral administration according to claim 7, indicated by the fact that it contains herbal extracts of horse chestnut seeds (Aesculus hypocastani) in the range of 0.5-35.0%, extract of the herb of yarrow (Achillea millefolium) in the range of 1.0-25.0%, extract of the herb of living grass (Geranium robertianum) in the range of 0.0-15.0%, extract of the herb of yellow (Melilotus officinalis) in the range of 0.0-12.5%, extract of the herb of white cockle (Melilotus alba) in the range of 0.5-15.0%, calendula flower extract (Calendula officinalis) in the range of 1.5-15% and ethanol 0.0-15.0%), water 0.0-15.0%, propylene glycol 0.0-15.0%) and polysorbate 20 0.0-15.0%). 20) The preparation in the form of a gel according to claim 2, characterized by the fact that it contains plant extracts of horse chestnut seeds (Aesculus hypocastani) in the range of 0.5-35.0%, yarrow herb extract (Achillea millefolium) in the range of 1.0-25.0%, Geranium robertianum herb extract in the range of 0.5-15.0%, yellow sedge herb extract ( Melilotus officinalis) in the range of 0.5-12.5%, extract of the herb Melilotus alba in the range of 0.5-15.0%, extract of the herb Geranium feum in the range of 0.0-12.5%, extract of the herb Lanilista (Linarium vulgaris) in the range of 0.5-10.0%, extract of the rhizome and/or herb of burdock (Petasides hybridus) in the range 0.5-10.0%, flower extract calendula (Calendula officinalis) in the range of 1.5-15%, ethanol 0.0-5.0%, water 0.0-75.0%), propylene glycol 0.0-15.0% and polysorbate 20 0.0-5.0%, carbomer 0.5-1.2% and other additives to form a gel with a satisfactory structure. 21) The preparation in the form of a gel according to claim 3, characterized by the fact that it contains plant extracts of horse chestnut seeds (Aesculus hypocastani) in the range of 0.5-35.0%, yarrow herb extract (Achillea millefolium) in the range of 1.0-25.0%, Geranium robertianum herb extract in the range of 0.5-15.0%, yarrow herb extract ( Melilotus officinalis) in the range of 0.5-12.5%, extract of the herb Melilotus alba in the range of 0.5-15.0%, extract of the herb Geranium feum in the range of 0.5-12.5%, extract of the herb lanilista (Linarium vulgaris) in the range of 0.5-10.0%), extract of the rhizome and/or sedge (Petasides hybridus) in the range 0.5-10.0%, ethanol 0.0-5.0%, water 0.0-75.0%), propylene glycol 0.0-15.0% and polysorbate 20 0.0-5.0%), carbomer 0.5-1.2%) and other additives to form a gel of satisfactory structure. 22) Preparation in the form of a gel according to claim 4, indicated by the fact that it contains plant extracts of horse chestnut seeds (Aesculus hypocastani) in the range of 0.5-35.0%>, yarrow herb extract (Achillea millefolium) in the range of 1.0-25.0%, Geranium robertianum herb extract in the range of 0.5-15.0%, yarrow herb extract ( Melilotus officinalis) in the range of 0.5-12.5%, extract of the herb Melilotus alba (Melilotus alba) in the range of 0.5-15.0%, extract of the herb Geranium feum (Geranium feum) in the range of 0.5-12.5%, extract of the rhizome and/or burdock herb (Petasides hybridus) in the range of 0.5-10.0%), extract of the calendula flower (Calendula officinalis) in the range 1.5-15%, ethanol 0.0-5.0%o, water 0.0-75.0%o, propylene glycol 0.0-15.0% and polysorbate 20 0.0-5.0%, carbomer 0.5-1.2% and other additives to form a gel of satisfactory structure. 23) The preparation in the form of a gel according to claim 5, characterized by the fact that it contains plant extracts of horse chestnut seeds (Aesculus hypocastani) in the range of 0.5-35.0%, yarrow herb extract (Achillea millefolium) in the range of 1.0-25.0%, Geranium robertianum herb extract in the range of 0.5-15.0%, yellow sedge herb extract ( Melilotus officinalis) in the range 0.5-12.5%, extract of the herb Melilotus alba (Melilotus alba) in the range 0.5-15.0%, extract of the herb Linarium vulgaris (Linarium vulgaris) in the range 0.5-10.0%, extract of the rhizome and/or burdock herb (Petasides hybridus) in the range 0.5-10.0%, extract of the calendula flower (Calendula officinalis) in the range 1.5-15%), ethanol 0.0-5.0%, water 0.0-75.0%, propylene glycol 0.0-15.0% and polysorbate 20 0.0-5.0%), carbomer 0.5-1.2% and other additives to form a gel of satisfactory structure. 24) The preparation in the form of a gel according to claim 6, indicated by the fact that it contains plant extracts of horse chestnut seeds (Aesculus hypocastani) in the range of 0.5-35.0%, yarrow herb extract (Achillea millefolium) in the range of 1.0-25.0%, Geranium robertianum herb extract in the range of 0.5-15.0%, yarrow herb extract ( Melilotus officinalis) in the range of 0.5-12.5%, Melilotus alba extract in the range of 0.5-15.0%, Geranium feum extract in the range of 0.5-12.5%, Lanilista herb extract (Linarium vulgaris) in the range of 0.5-10.0%), Calendula flower extract (Calendula officinalis) in the range of 1.5-15%, ethanol 0.0-5.0%), water 0.0-75.0%, propylene glycol 0.0-15.0% and polysorbate 20 0.0-5.0%, carbomer 0.5-1.2% and other additives to form a gel of satisfactory structure. 25) The preparation in the form of a gel according to claim 7, indicated by the fact that it contains plant extracts of horse chestnut seeds (Aesculus hypocastani) in the range of 0.5-35.0%, yarrow herb extract (Achillea millefolium) in the range of 1.0-25.0%, Geranium robertianum herb extract in the range of 0.5-15.0%, yellow sedge herb extract ( Melilotus officinalis) in the range of 0.5-12.5%, extract of the herb of white cockle (Melilotus alba) in the range of 0.5-15.0%, extract of the calendula flower (Calendula officinalis) in the range of 1.5-15%>, ethanol 0.0-5.0%, water 0.0-75.0%, propylene glycol 0.0-15.0% and polysorbate 20 0.0-5.0%, carbomer 0.5-1.2% and other additives to form a gel with a satisfactory structure. 26) Preparation in the form of a cream according to claim 2, indicated by the fact that it contains plant extracts of horse chestnut seeds (Aesculus hypocastani) in the range of 0.5-35.0%, yarrow herb extract (Achillea millefolium) in the range of 1.0-25.0%, Geranium robertianum herb extract in the range of 0.1-15.0%, yellow sedge herb extract ( Melilotus officinalis) in the range of 0.1-12.5%, extract of the herb Melilotus alba in the range of 0.5-15.0%, extract of the herb Geranium feum in the range of 0.1-12.5%, extract of the herb lanilista (Linarium vulgaris) in the range of 0.1-10.0%>, extract of rhizomes and/or the herb of lop (Petasides hybridus) in the range 0.5-10.0%, extract calendula flowers (Calendula officinalis) in the range of 1.5-15% and other additives to form a cream with a satisfactory structure. 27) The preparation in the form of a cream according to claim 3, indicated by the fact that it contains plant extracts of horse chestnut seeds (Aesculus hypocastani) in the range of 0.5-35.0%, yarrow herb extract (Achillea millefolium) in the range of 1.0-25.0%, Geranium robertianum herb extract in the range of 0.1-15.0%, yellow sedge herb extract ( Melilotus officinalis) in the range of 0.1-12.5%, extract of the herb Melilotus alba in the range of 0.5-15.0%, extract of the herb Geranium feum in the range of 0.1-12.5%, extract of the herb lanilista (Linarium vulgaris) in the range of 0.1-10.0%), extract of the rhizome and/or herb (Petasides hybridus) in the range 0.5-10.0% and other additions yes a cream with a satisfactory structure would be formed. 28) The preparation in the form of a cream according to claim 4, characterized by the fact that it contains plant extracts of horse chestnut seeds (Aesculus hypocastani) in the range of 0.5-35.0%, yarrow herb extract (Achillea millefolium) in the range of 1.0-25.0%, Geranium robertianum herb extract in the range of 0.1-15.0%, yarrow herb extract ( Melilotus officinalis) in the range of 0.1-12.5%, Melilotus alba extract in the range of 0.5-15.0%, Geranium feum extract in the range of 0.1-12.5%, rhizome and/or burdock herb extract (Petasides hybridus) in the range of 0.5-10.0%, calendula flower extract (Calendula officinalis) in the range 1.5-15% and other additions in order to formed a cream of satisfactory structure. 29) The preparation in the form of a cream according to claim 5, indicated by the fact that it contains plant extracts of horse chestnut seeds (Aesculus hypocastani) in the range of 0.5-35.0%, yarrow herb extract (Achillea millefolium) in the range of 1.0-25.0%, Geranium robertianum herb extract in the range of 0.1-15.0%, yarrow herb extract ( Melilotus officinalis) in the range of 0.1-12.5%, Melilotus alba extract in the range of 0.5-15.0%, Linarium vulgaris herb extract in the range of 0.1-10.0%, rhizome and/or burdock herb extract (Petasides hybridus) in the range of 0.5-10.0%, calendula flower extract (Calendula officinalis) in the range 1.5-15% and other allowances in order to a cream of satisfactory structure was formed. 30) Preparation in the form of a cream according to claim 6, characterized by the fact that it contains plant extracts of horse chestnut seeds (Aesculus hypocastani) in the range of 0.5-35.0%>, yarrow herb extract (Achillea millefolium) in the range of 1.0-25.0%, Geranium robertianum herb extract in the range of 0.1-15.0%, yellow sedge herb extract (Melilotus officinalis) in the range of 0.1-12.5%, the extract of the herb of the white cockle (Melilotus alba) in the range of 0.5-15.0%, the extract of the herb of the geranium (Geranium feum) in the range of 0.1-12.5%, the extract of the herb of lanilista (Linarium vulgaris) in the range of 0.1-10.0%), the extract of the calendula flower (Calendula officinalis) in the range of 1.5-15% and other additions to form the cream satisfactorily structures. 31) The preparation in the form of a cream according to claim 7, characterized by the fact that it contains plant extracts of horse chestnut seeds (Aesculus hypocastani) in the range of 0.5-35.0%, yarrow herb extract (Achillea millefolium) in the range of 1.0-25.0%, Geranium robertianum herb extract in the range of 0.1-15.0%, yellow sedge herb extract ( Melilotus officinalis) in the range of 0.1-12.5%, extract of the herb of white cockle (Melilotus alba) in the range of 0.5-15.0%, calendula flower extract (Calendula officinalis) in the range of 1.5-15% and other additives to form a cream with a satisfactory structure. 32) Preparations according to claims 2-31 intended to maintain physiological blood flow through the venous vessels of the lower extremities and improve the health of venous vessels and capillaries.