RS20070190A - Skin-healing preparations - Google Patents

Abstract

Invention herewith described refers to a skin-healing preparation, according to the invention, is a natural auxiliary remedy for healing skin lesions: suffused parts upon shocks with pointless subjects, burns produced by hot liquid, steam, hot metal objects, and burns by chemical compounds: caustic substances (strong acids "nitric acid, sulfuric acid, salt acid etc. strong alkali: e.g. sodium hydroxide, lime and alike; some salts, e.g. silver nitrate, zinc chloride and etc.), that bite into and damage the tissues. The same preparation can be used even for healing open sores (stings, and scars caused by sharp objects or arms) and for healing the so called sore spots i.e. open unheallable inflammations or festering wounds.Preparations are obtained from the treatment of herbal substances: olive oil (oleum olivae), extracts of St. John's wort (Hipericum perforatum), common yarrow (Achilea millefolium ), black pine (Pinus nigra), fir tree (Abies alba), elder (Sambucus nigra), coltsfoot leaves (Farfarae folium), thyme herbs (Serpulli herba), common sage (Salvia officinalis), peppermint (Menta piperita); other natural preparations: yellow wax (Cera flova), sheep's tallow (Sebum ovile) and lanoline oil being introduced in a certain mass ratio into the (corresponding ) mass ratio of ethanol 97% wherefrom are thereupon separated according to the method of straining skin-healing preparations.

Description

PREPARATION TREATMENT OF SKIN INJURIES

TECHNICAL FIELD '

Preparations for the treatment of skin injuries, according to the invention, belong to the field of natural herbal preparations applied for medical or cosmetic purposes in the form of medicinal ointments that are used either for their local effect (on the skin, on mucous membranes, on wounds), or by applying medicinal ointments, drugs are introduced into the body through the skin that manifest their effects, where these medicinal ointments as medical preparations produce certain reactions, and contain substances of undetermined composition from plants and their products.

Int.Cl.<8>: A 61K 9/06 (2009.01); A 61K 36/00 (2009.01); A 61K 131-00 (2009.01)

TECHNICAL PROBLEM

Preparations for the treatment of skin injuries, according to the invention, solve the problem of obtaining an effective all-natural auxiliary medical agent that does not cause any harmful effects and is used for the treatment of skin injuries such as e.g. bruises caused by impact with blunt objects, from burns and the consequences of burns caused by heat of any origin (flame, hot liquids, steam, hot metal objects, and also from burns caused by chemical compounds that are most often caused by the action of pungent, caustic substances that corrode and destroy tissues, such as strong acids - nitric, sulfuric, sodium, etc.; strong alkalis such as, for example, so-called rock soda, lime and si; and certain salts such as e.g. silver nitrate, zinc chloride, etc.), whereby the preparation for healing skin injuries can also be used for the treatment of open wounds such as punctures and cuts caused by sharp objects or weapons, as well as for the treatment of so-called living wounds, ie open inflamed or festering wounds that do not heal.

The technical problem that is solved by the present invention consists in how to achieve the procedure of obtaining the preparation by processing the plant ingredients that make up olive oil (oleum olivae), extracts of St. John's wort (hipericum perforatum), yarrow (achillea millefolium), black pine (pinus nigra), fir (abies), sedge (sambucus nigra), subalpine leaf (farfarae folium), thyme (serpvlli herba), sage or sage (salvia officinalis), mint (mint piperita), other natural preparations - beeswax (cera flova), sheep tallow (sebum ovila) and lanolin oil, which are introduced in a certain mass % into the same mass % of ethanol 97%, from which the preparation for healing skin injuries obtained by the process according to the invention is then separated by squeezing.

STATE OF THE ART

There are well-known procedures for obtaining various skin care products, as well as products for the care of injured skin, especially skin damaged by various types of burns, starting with first-degree burns, which are characterized by skin redness and pain, and when after a few days the skin darkens due to pigmentation and begins to peel (this degree of burns occurs most often after excessive sunbathing), then second-degree burns, in which we have the appearance of blisters filled with a clear liquid, which burst and in their place we have bare fur of the skin and where healing takes place quickly if there is no infection, as well as third-degree burns that involve the entire thickness of the skin, even deeper tissues, and sometimes, if the skin is exposed to the effect of very high temperatures, real charring of the burned tissue occurs, and in which wounds the healing is very slow and when dead tissue must be eliminated.

Burnt areas usually become infected. The loss of proteins through the wound, insufficient nutrition and the destruction of red blood cells, which occurs due to hemolysis, lead the patient to a severe state of exhaustion and emaciation.

Healing ie. treatment of the burned area begins only when the dead tissue is eliminated and the infection recedes. In superficial burns, healing is fast. In deep ones, the resulting scar shrinks, creating cosmetic defects and often hindering the movements of the limb joints.

Keloids are solid growths in the skin made of fibrous tissue (tight connective tissue) and most often appear in scars after surgery, after wounds or deep burns, and sometimes also after insignificant and small injuries, coating with iodine tincture, scars, etc., and they can develop in the skin without any reason.

There are various procedures for obtaining funds as well as methods for treating skin injuries. Among these means there are various means for cleaning and disinfecting the wound environment, as well as various physiological solutions, soaps and other means for washing injuries on the skin, especially injuries where the skin itself is damaged, peeled, cut, punctured or burned, and various means for covering and coating injuries are also known, which accelerate the action of various medicinal ingredients of these means on the skin, and whose action leads to accelerated healing of wounds and healing of the skin.

Bactericidal ointments are known for treating wounds, which typically contain an antibiotic or antibacterial agent on a neutral carrier, e.g. fats based on paraffin or based on oil emulsions dissolved in water.

Published PCT application WO84/00111 A1 describes a heat-sterilizable aqueous gelatinous wound treatment composition containing a pharmaceutically acceptable glycol, preferably propylene glycol, and cellulose derivatives. According to the description, the mixture exhibits an exceptional bactericidal effect and has a high degree of action against a number of viruses or fungi. It is considered to be suitable as the only means for cleaning superficial burns, lacerations, wounds, abrasions and similar injuries. Also, this mixture is said to include an antiseptic or some antibiotic.

In the Yugoslav application available to the public P 799/78 Al, the procedure for obtaining an anti-burn agent is described, which is obtained by mixing beeswax, vegetable oil (olive oil), white incense and pieces of scallion bark in a vessel until the mass boils, and then the scallion pieces are removed from the mass, while the mass is heated and stirred for some time, and then cooled. An undetermined amount of natural brandy is poured into the cooled mass, with constant stirring, until the mass thickens, and then the excess brandy is squeezed out so that the brandy binds to the mass in a much smaller mass % compared to the total weight of the mass. After that, the mass is cooled to ambient temperature (room temperature) when it is ready for use.

Known means obtained by known procedures for obtaining them did not show the best results because scars still remained at the places of skin injuries, the skin often changed color in those places, contractures and deformations, carciomatous degeneration of scars, keloids, and other changes appeared. The known procedures proved to be expensive and complex, and thus the technological procedure of obtaining the preparation was time-consuming, expensive equipment had to be used, and all this affected the price of the preparation itself, so that it was expensive and inaccessible to a wide range of users - patients.

We eliminated the above-mentioned defects and described them in our previous Yugoslav patent YU 46307 C3, where we described the procedure for obtaining a preparation for the treatment of burns and for the protection of the skin by extraction from plants and biological products by pouring olive oil (oleum olivae) of a certain weight into a container to which 5 to 10 wt.% of the mass of olive oil finely ground St. John's wort (hypericum perforatum) is added, when the container is hermetically closed and left to stand at least 240 hours at ambient temperature (18° to 20°C). After that, add at least 35 to 40% by weight of black pine (pinus nigra) or fir (abies) resin extract, at least 25 to 35% by weight of white beeswax (cera ilova), at least 45 to 50% by weight of sheep tallow (ovile sebum); at least 0.8 to 1 wt.% of white frankincense and at least 1 to 1.5 wt.% of extract from the inner bark called (sambucs nigra). The mass thus obtained is poured into an airtight container with the same mass % ethanol 97% when the container is closed and heated for about one (1) hour up to a temperature of 90° to 100°C, and then heated for 10 to 20 minutes to soften it. After that, electrophoresis is performed using a direct current of 40A and a voltage of 12V, for a period of 2 hours. The mass cooled to a temperature of 50°C and under a pressure of 8 bar is squeezed, and distilled water is added to the squeezed mass in the amount that will dilute the ethanol 97% to 10%, when the excess is squeezed out and the resulting preparation is poured into containers for use and cooled to ambient temperature (from 18° to 20°C). This preparation has proven to be an extremely effective and inexpensive auxiliary medicinal agent for the treatment of burns and for the protection of the skin.

In our second Yugoslav patent YU 46308 C3, we described the process of obtaining an extremely useful and effective means for removing keloids and removing burn scars by extracting it from plants and biological products by pouring olive oil (oleum olivae) of a certain mass into a container to which 25 to 30 wt.% of the mass of olive oil is added finely ground yarrow (achileum millefolium), when the container is hermetically closed and left to stand at least 240 hours at ambient temperature (18° to 20°C). After that, from another container with 1 to 2 wt.% of quicklime (calcium oxide) and 2 to 4 wt.% of water, in which they are mixed and settled for at least 30 minutes at ambient temperature, when the calcium hydroxide obtained in this way is filtered and added with mixing to a container with a mixture of olive oil and yarrow, and then 1 to 2 wt.%) of extract of the inner bark of elm (ulmus compestris), 0.8 to 1 wt.% is added to that mass. of an extract from the inner bark called (sambucus nigra) After that, the mass is subjected to electrophoresis under the action of a direct current of 40A and a voltage of 12V, for a period of 1 hour at ambient temperature. The mass is then settled for 15 minutes when the water is separated by squeezing through sterile gauze, and 3 wt.% of hen's egg yolks are added to the remaining settled mass when the whole mass is homogenized to a temperature of 0°C.

In our later Yugoslav patent documents, we described the procedures for obtaining preparations by extraction from plants and biological products, namely in YU 48251 C2 preparations for removing stretch marks, in YU 48392 C2 preparations for caring for human skin and in YU 48434 C2 preparations for sun protection.

The preparation for the treatment of skin injuries obtained by the process according to this invention is one of the more suitable aids that we perfected through subsequent research and development work on our previous inventions and which is effectively used for the healing of skin injuries, especially open wounds of various origins, bruises caused by impact with blunt objects, burns and the consequences of burns caused by heat of any origin (flame, hot liquids, steam, hot metal objects, and also from burns caused by chemical compounds which are most often caused by the action of strong, caustic substances, such as nitric, sulfuric, etc., and certain salts, such as silver nitrate, etc., in which the preparation can also be used to heal wounds caused by sharp objects or firearms treatment of the so-called living wounds, ie open inflamed or festering wounds that do not heal for a long time.

DESCRIPTION OF THE INVENTION

Since vegetable fats or resinous substances that are treated as extracts from plant ingredients in combination with products of biological composition have proven to be effective and successful preparations for the treatment of the skin, especially due to their better and more efficient action on microbes that fix in one place, isolate them, prevent them from multiplying and moving to other places, and also act as an antiseptic agent with their cinnamic acid and, finally, cause leukocytosis - i.e. they cause the action of white blood cells, which act as antibodies and save the body. The preparation for the treatment of skin injuries and the procedure for obtaining it will be described in the following text by describing the treatment of selected medicinal plants, their extracts and biological products from which the active substances, the ingredients of plant extracts, are conveniently extracted with ethanol 97%.

The mentioned shortcomings of the classical methods of treating skin injuries and the preparations used for the treatment of those methods are eliminated by the use of preparations for the treatment of skin injuries according to the invention, both open wounds on the skin and deep wounds on the surface of the body that can be of different origins: from burns, superficial and deeper, from inflammation and suppuration, from impact with a blunt, sharp, rough object or weapon, from a grain, a cut with a knife, a nail puncture, etc. which will be detailed in the further text of the description.

The substances contained in the preparation obtained by such a procedure have an antibacterial effect and the same preparation can be used both in medicine and in veterinary medicine for the treatment of skin injuries, because its ingredients have an inhibitory effect. The procedure for obtaining a preparation for the treatment of skin injuries will be described through examples.

EXAMPLE 1.

A certain mass % of unrefined and unfiltered olive oil (oleum olivae) obtained from olive fruits (olea europea) is poured into a glass bottle and 5 to 10 mass %, in relation to the mass of olive oil, of finely ground flowers of St. John's wort (hvpericum perforatum) are placed in the same container. In a hermetically sealed container, the mixture of these substances is left to stand for at least 10 days at ambient temperature (18° to 20°C).

After a standing time of at least 10 days, at least 35 to 40 wt.% pure resin from black pine (pinus nigra) or fir (abies) is added to this mixture; then at least 25 to 30% by mass of white beeswax (cera flora) and at least 45 to 50% sheep tallow (ovile sebum) are added. Then, at least 0.8 to 1 wt.% of white incense and at least 1 to 1.5 wt.% of the extract of the inner bark called (sambucus nigra), at least 0.5 to 0.8 wt.% of subalpine leaf (farfarae folium) and at least 0.5 to 0.8 wt.% of thyme (serpvlli herba) are added to this mixture and everything is placed together in a container with ethanol 97%, which is hermetically sealed and heated for a period of 1 hour until boiling, where it is heated at the boiling point for at least 10 to 20 minutes. After that, the whole mixture is subjected to electrophoresis with direct current of 40A and voltage of 12V. The mass is then cooled in a time of up to 2 hours to a temperature of 50°C and then in such a hot state it is filtered through sterile gauze and distilled water of ambient temperature (18° to 20°C) is added from the mass until the concentrated ethanol 97%) is diluted to 10%, the excess is squeezed out and the remaining mass is poured into packaging containers and homogenized under normal conditions to normal ambient temperature (18° to 20%).

After cooling, the preparation has the appearance of normal creams and is stored under normal conditions and in all other conditions except low temperatures. The shelf life and effectiveness are unlimited.

EXAMPLE 2.

A certain mass % of unrefined and unfiltered olive oil (oleum olivae) obtained from olive fruits (olea europea) is poured into a glass bottle and in the same container 10 to 15 mass % of finely ground St. John's wort flowers (hvpericum perforatum) and at least 20 to 30 mass % of finely ground yarrow (achillea millefolium) are placed in the same container. In a hermetically sealed container, the mixture of these substances is left to stand for at least 10 days at ambient temperature (18° to 20°C).

After a standing time of at least 10 days, a mixture of at least 1 to 2 wt.%, relative to the mass of olive oil, calcium oxide (lime) and at least 2 to 4 wt.% of water stored in another container, is added to this mixture, and the resulting calcium peroxide is filtered after settling for at least 30 minutes at normal ambient temperature and poured into a separate container together with a solution of olive oil and yarrow. At least 1 to 2 wt.% in relation to the mass of olive oil, an extract obtained from the inner bark of elm (ulmus compestris) and 0.5 to 0.8 wt.% is added to this special vessel. % extract from the inner bark of sambucus nigra, such as 0.5 to 0.8 wt.% of sage or sage (salvia officinalis); then at least 25 to 30 wt.%) of white beeswax (cera flora) and at least 45 to 50 % sheep tallow (ovile sebum) are added, and at least 0.8 to 1.2 wt.% of mint (menta piperita). Then the whole mixture is subjected to electrophoresis with direct current of 40A and voltage of 12V. The mass is then settled for up to 15 minutes, then the water is filtered through sterile gauze and 3 wt.%) of chicken egg yolks are added to the settled mass, and then the entire mass thus obtained is poured into packaging containers and homogenized under normal conditions to normal ambient temperature (18° to 20%)

The resulting preparation for the treatment of wounds, according to example 1, has a pH value of 5-7 in a ten percent ethanol solution and looks like a normal cream for use on the surface of the skin., while the preparation according to example 2 has a particularly effective effect on severely damaged skin surfaces with the appearance of keloids (hard growths in the skin formed from compacted connective tissue (fibrous tissue)) when it effectively complements the loss of proteins that are lost through the wound and when it helps replenish red blood cells and avoiding hemolysis.

The authors did not intend to limit the invention to the examples given, because changing certain stages of the procedure, or omitting ingredients that only in the overall composition give the described effects, does not go beyond the scope of the inventor's idea that the invention achieves a relatively simple and inexpensive procedure that creates an effective preparation with natural ingredients that effectively and successfully causes healing and heals the skin injury described in the description of the invention.

Claims (2)

1. A preparation for the treatment of skin injuries based on a certain amount in % by weight of unrefined and unfiltered olive oil (oleum olivae) obtained from olive fruits (olea europea), mixed with 5 to 10% by weight in relation to the mass of olive oil of finely ground flowers of the St. John's wort (hvpericum perforatum), when this mixture is left to stand for at least 10 days at ambient temperature (18° to 20°C), where this mixture is then add, in relation to the mass of olive oil, at least 35 to 40 wt.% pure resin from black pine (pinus nigra) or fir (abies); then to the total mixture he adds at least 25 to 30 wt.% of white beeswax (cera flora) and at least 45 to 50% of sheep tallow (sebum ovile) and to this mixture is added at least 0.8 to 1 wt.% of white incense and at least 1 to 1.5 wt.% of the extract of the inner bark called (sambucus nigra), it is also indicated that 0.5 to 0.8 wt.% of subalpine is added leaf (farfarae folium) and 0.5 to 0.8 wt.%> thyme (serpvlli herba) and put everything together in a container with ethanol 97% which is hermetically closed and heated for about 1 hour until boiling, where it is cooked at the boiling point for at least 10 to 20 minutes, when the whole mixture is subjected to electrophoresis with direct current of 40A and voltage of 12V. after which it is cooled for about 2 hours to a temperature of 50°C, and then in such a hot state it is filtered through sterile gauze, and distilled water at ambient temperature (18° to 20°C) is added to the drained liquid part of the mass until the concentrated ethanol 97% is diluted to 10%>, its excess is squeezed out and the remaining mass is homogenized in containers under normal conditions to normal ambient temperature (18° to 20%). 2. A preparation for the treatment of skin injuries based on a certain mass % of unrefined and unfiltered olive oil (oleum olivae) obtained from olive fruits (olea europea), mixed with 10 to 15 mass % in relation to the mass of olive oil of finely ground flowers of St. in a hermetically sealed container, let it stand for at least 10 days at ambient temperature (18° to 20°C), when a mixture of at least 1 to 2 wt.% is added to this mixture, in relation to the mass of olive oil, calcium oxide (lime) and at least 2 to 4 wt.%> of water stored in another container, and the thus obtained calcium peroxide is filtered after settling for at least 30 minutes at ambient temperature (18° to 20°C) and poured into another container together with with a solution of olive oil and yarrow grass, indicated by adding at least 1 to 2 wt.% in relation to the mass of olive oil, an extract obtained from the inner bark of elm (ulmus compestris) and 0.5 to 0.8 wt. % extract from the inner bark of sambucus nigra, such as 0.5 to 0.8 wt.% of sage or sage (salvia officinalis); and which is then added at least 25 to 30 wt.%) of white beeswax (cera flora) and at least 45 to 50% sheep tallow (ovile sebum), and at least 0.8 to 1.2 wt.% mild mint (menta piperita) when the whole mixture is then subjected to electrophoresis with a direct current of 40A and voltage of 12V and then the mass settles for up to 15 minutes when water is filtered through sterile gauze, and 3 wt.% of egg yolks from hen's eggs are subsequently added to the deposited mass, and then the entire mass thus obtained is homogenized in containers under normal conditions to normal ambient temperature (18° to 20%