RO81354B - Process for preparing the macrolide antibiotic - tylactone - Google Patents
Process for preparing the macrolide antibiotic - tylactoneInfo
- Publication number
- RO81354B RO81354B RO104734A RO10473481A RO81354B RO 81354 B RO81354 B RO 81354B RO 104734 A RO104734 A RO 104734A RO 10473481 A RO10473481 A RO 10473481A RO 81354 B RO81354 B RO 81354B
- Authority
- RO
- Romania
- Prior art keywords
- dideoxythionolide
- dihydro
- macrolide
- macrolide antibiotic
- tylactone
- Prior art date
Links
- 239000003120 macrolide antibiotic agent Substances 0.000 title abstract 3
- YJSXTLYNFBFHAT-UHFFFAOYSA-N Protylonolide Natural products CCC1CC(C)C(=O)C=CC(C)=CC(C)C(CC)OC(=O)CC(O)C(C)C1O YJSXTLYNFBFHAT-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 240000008042 Zea mays Species 0.000 abstract 2
- 235000002017 Zea mays subsp mays Nutrition 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 229920001353 Dextrin Polymers 0.000 abstract 1
- 239000004375 Dextrin Substances 0.000 abstract 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 abstract 1
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 abstract 1
- 229920002472 Starch Polymers 0.000 abstract 1
- 241000187747 Streptomyces Species 0.000 abstract 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 abstract 1
- 235000016383 Zea mays subsp huehuetenangensis Nutrition 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 229940041514 candida albicans extract Drugs 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 235000005822 corn Nutrition 0.000 abstract 1
- 235000019425 dextrin Nutrition 0.000 abstract 1
- 235000013312 flour Nutrition 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 235000001727 glucose Nutrition 0.000 abstract 1
- 239000001963 growth medium Substances 0.000 abstract 1
- 229940067606 lecithin Drugs 0.000 abstract 1
- 235000010445 lecithin Nutrition 0.000 abstract 1
- 239000000787 lecithin Substances 0.000 abstract 1
- 235000009973 maize Nutrition 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 235000013379 molasses Nutrition 0.000 abstract 1
- 230000000050 nutritive effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 235000019698 starch Nutrition 0.000 abstract 1
- 239000008107 starch Substances 0.000 abstract 1
- 235000015112 vegetable and seed oil Nutrition 0.000 abstract 1
- 239000008158 vegetable oil Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
- 239000012138 yeast extract Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
- C23F—NON-MECHANICAL REMOVAL OF METALLIC MATERIAL FROM SURFACE; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL; MULTI-STEP PROCESSES FOR SURFACE TREATMENT OF METALLIC MATERIAL INVOLVING AT LEAST ONE PROCESS PROVIDED FOR IN CLASS C23 AND AT LEAST ONE PROCESS COVERED BY SUBCLASS C21D OR C22F OR CLASS C25
- C23F11/00—Inhibiting corrosion of metallic material by applying inhibitors to the surface in danger of corrosion or adding them to the corrosive agent
- C23F11/06—Inhibiting corrosion of metallic material by applying inhibitors to the surface in danger of corrosion or adding them to the corrosive agent in markedly alkaline liquids
Landscapes
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Mechanical Engineering (AREA)
- Metallurgy (AREA)
- Organic Chemistry (AREA)
- Preventing Corrosion Or Incrustation Of Metals (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Gas Separation By Absorption (AREA)
Abstract
Procedeu de preparare a antibioticului macrolid tilactona, 20-dihidro 20, 23-dideoxitilonolida cu formula generala I: (vezi formula) caracterizat prin aceea ca microorganismul Streptomices frediae NRRL 12188 se supune cultivarii în conditii aerobe submerse, într-un mediu de cultura continînd surse de carbon alese dintre dextrina, glucoza, amidon si faina de porumb, precum si uleiuri vegetale, de preferinta aminiacizi, ape de la înmuierea porumbului, melasa, lecitina, extract de drojdie de bere,precumsi saruri nutritive, fermentarea avînd loc la temperaturi între 10 si 40 degree C, de preferinta 28 degree C, pîna la obtinerea unei cantitati substantiale de produs, dupa care se procedeaza la recuperarea acestuia, respectiv a macrolidei 20-dihidro-20, 23-dideoxitilonolida (tilactona) prin procedee în sine cunoscute, si daca se doreste poate fi transformata mai departe în derivati acilici.Process for the preparation of the 20-dihydro 20,23-dideoxythionolide macrolide antibiotic of general formula I (see formula) characterized in that the microorganism Streptomyces frediae NRRL 12188 is cultured under submerged aerobic conditions in a culture medium containing sources of carbon selected from dextrin, glucose, starch and corn flour, as well as vegetable oils, preferably amino acids, maize softening water, molasses, lecithin, brewer's yeast extract, and nutritive salts, fermenting at temperatures between 10 and 40 ° C, preferably 28 ° C, until a substantial amount of the product is obtained, after which the 20-dihydro-20,23-dideoxythionolide (tilactone) macrolide is recovered by methods known per se, and if desired, it can be further converted into acyl derivatives.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16397580A | 1980-06-30 | 1980-06-30 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RO81354A RO81354A (en) | 1983-02-15 |
| RO81354B true RO81354B (en) | 1983-02-28 |
Family
ID=22592441
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO104734A RO81354B (en) | 1980-06-30 | 1981-06-30 | Process for preparing the macrolide antibiotic - tylactone |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP0043525B1 (en) |
| JP (1) | JPS604272B2 (en) |
| AR (1) | AR228276A1 (en) |
| AT (1) | ATE10293T1 (en) |
| AU (1) | AU542053B2 (en) |
| BR (1) | BR8104104A (en) |
| CA (1) | CA1158852A (en) |
| CS (1) | CS242870B2 (en) |
| DE (1) | DE3167178D1 (en) |
| ES (1) | ES8300875A1 (en) |
| GR (1) | GR75712B (en) |
| HU (1) | HU185932B (en) |
| IN (1) | IN154625B (en) |
| MX (1) | MX161784A (en) |
| NO (1) | NO163537C (en) |
| NZ (1) | NZ197575A (en) |
| PH (1) | PH16622A (en) |
| PL (2) | PL130311B1 (en) |
| RO (1) | RO81354B (en) |
| ZA (1) | ZA814278B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60180877U (en) * | 1984-05-14 | 1985-11-30 | 新潟ビ−．エス．アンド．ビ−．セイフテイ．システムズ株式会社 | Retaining structure of welded rupture disc |
| JPS6254696U (en) * | 1985-09-24 | 1987-04-04 | ||
| JPH02119192U (en) * | 1989-03-13 | 1990-09-26 | ||
| JPH02122691U (en) * | 1989-03-15 | 1990-10-08 | ||
| AR010696A1 (en) * | 1996-12-12 | 2000-06-28 | Sasol Tech Pty Ltd | A METHOD FOR THE ELIMINATION OF CARBON DIOXIDE FROM A PROCESS GAS |
| FR2994861B1 (en) | 2012-08-30 | 2014-08-22 | IFP Energies Nouvelles | PROCESS FOR ABSORPTION OF ACIDIC COMPOUNDS CONTAINED IN A GASEOUS EFFLUENT BY MEANS OF AQUEOUS AMINO ACID SOLUTION |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3808140A (en) * | 1970-07-13 | 1974-04-30 | B Mago | Antimony-vanadium corrosion inhibitors for alkanolamine gas treating system |
| US3896044A (en) * | 1971-11-22 | 1975-07-22 | Union Carbide Corp | Nitro-substituted aromatic acid corrosion inhibitors for alkanolamine gas treating system |
| US3959170A (en) * | 1971-11-22 | 1976-05-25 | Union Carbide Corporation | Corrosion inhibitors for alkanolamine gas treating system |
| US3951844A (en) * | 1974-04-29 | 1976-04-20 | Union Carbide Corporation | Corrosion inhibition of aqueous potassium carbonate gas treating systems |
-
1981
- 1981-06-24 ZA ZA814278A patent/ZA814278B/en unknown
- 1981-06-24 IN IN682/CAL/81A patent/IN154625B/en unknown
- 1981-06-24 NO NO812157A patent/NO163537C/en unknown
- 1981-06-26 EP EP81104985A patent/EP0043525B1/en not_active Expired
- 1981-06-26 AT AT81104985T patent/ATE10293T1/en active
- 1981-06-26 CA CA000380674A patent/CA1158852A/en not_active Expired
- 1981-06-26 DE DE8181104985T patent/DE3167178D1/en not_active Expired
- 1981-06-27 JP JP56100386A patent/JPS604272B2/en not_active Expired
- 1981-06-29 GR GR65370A patent/GR75712B/el unknown
- 1981-06-29 PL PL1981239063A patent/PL130311B1/en unknown
- 1981-06-29 PH PH25830A patent/PH16622A/en unknown
- 1981-06-29 MX MX188064A patent/MX161784A/en unknown
- 1981-06-29 BR BR8104104A patent/BR8104104A/en unknown
- 1981-06-29 CS CS814945A patent/CS242870B2/en unknown
- 1981-06-29 HU HU811888A patent/HU185932B/en unknown
- 1981-06-29 AR AR285900A patent/AR228276A1/en active
- 1981-06-29 ES ES503481A patent/ES8300875A1/en not_active Expired
- 1981-06-30 NZ NZ197575A patent/NZ197575A/en unknown
- 1981-06-30 AU AU72401/81A patent/AU542053B2/en not_active Ceased
- 1981-06-30 RO RO104734A patent/RO81354B/en unknown
- 1981-09-26 PL PL1981231927A patent/PL127863B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PH16622A (en) | 1983-11-28 |
| AU542053B2 (en) | 1985-02-07 |
| CA1158852A (en) | 1983-12-20 |
| NO163537C (en) | 1990-06-13 |
| RO81354A (en) | 1983-02-15 |
| JPS604272B2 (en) | 1985-02-02 |
| DE3167178D1 (en) | 1984-12-20 |
| PL231927A1 (en) | 1982-03-15 |
| ES503481A0 (en) | 1982-11-16 |
| ATE10293T1 (en) | 1984-11-15 |
| NZ197575A (en) | 1984-10-19 |
| PL127863B1 (en) | 1983-12-31 |
| JPS5739178A (en) | 1982-03-04 |
| IN154625B (en) | 1984-11-24 |
| PL130311B1 (en) | 1984-07-31 |
| HU185932B (en) | 1985-04-28 |
| AR228276A1 (en) | 1983-02-15 |
| BR8104104A (en) | 1982-03-16 |
| GR75712B (en) | 1984-08-02 |
| MX161784A (en) | 1990-12-27 |
| EP0043525B1 (en) | 1984-11-14 |
| CS494581A2 (en) | 1984-06-18 |
| NO163537B (en) | 1990-03-05 |
| ES8300875A1 (en) | 1982-11-16 |
| ZA814278B (en) | 1982-07-28 |
| AU7240181A (en) | 1982-01-07 |
| EP0043525A1 (en) | 1982-01-13 |
| NO812157L (en) | 1982-01-04 |
| CS242870B2 (en) | 1986-05-15 |
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