RO81351A - Procedeu de preparare a unor derivati de benzodiazepina - Google Patents

Procedeu de preparare a unor derivati de benzodiazepina

Info

Publication number: RO81351A
Authority: RO; Romania
Prior art keywords: preparation; benzodiazepine derivatives; benzodiazepine; derivatives
Prior art date: 1979-10-16

Application number

RO80102349A

Other languages

English (en)

French (fr)

Other versions

RO81351B (ro

Inventor

Jiban K Chakrabarti

Terrence M Hotten

Original Assignee

Lilly Industries Ltd,Gb

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-10-16

Filing date

1980-10-13

Publication date

1983-02-15

1980-10-13 Application filed by Lilly Industries Ltd,Gb filed Critical Lilly Industries Ltd,Gb

1983-02-15 Publication of RO81351A publication Critical patent/RO81351A/ro

1983-02-28 Publication of RO81351B publication Critical patent/RO81351B/ro

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Anesthesiology (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

RO102349A 1979-10-16 1980-10-13 Procedeu pentru prepararea unor derivati de benzodiazepinei RO81351B (ro)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB7935846		1979-10-16

Publications (2)

Publication Number	Publication Date
RO81351A true RO81351A (ro)	1983-02-15
RO81351B RO81351B (ro)	1983-02-28

Family

ID=10508540

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
RO108967A RO85822B (ro)	1979-10-16	1980-10-13	Procedeu pentru prepararea unor derivati de benzodiazepina
RO102349A RO81351B (ro)	1979-10-16	1980-10-13	Procedeu pentru prepararea unor derivati de benzodiazepinei

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
RO108967A RO85822B (ro)	1979-10-16	1980-10-13	Procedeu pentru prepararea unor derivati de benzodiazepina

Country Status (33)

Country	Link
US (3)	US4404137A (ro)
EP (1)	EP0027390B1 (ro)
JP (1)	JPS5663987A (ro)
KR (2)	KR850000471B1 (ro)
AR (2)	AR228041A1 (ro)
AT (1)	AT373889B (ro)
AU (1)	AU538500B2 (ro)
BE (1)	BE885729A (ro)
BG (2)	BG34907A3 (ro)
CA (1)	CA1159056A (ro)
CH (1)	CH646700A5 (ro)
CS (1)	CS244409B2 (ro)
DD (1)	DD153692A5 (ro)
DE (1)	DE3068706D1 (ro)
DK (1)	DK437480A (ro)
ES (1)	ES495948A0 (ro)
FI (1)	FI67550C (ro)
FR (1)	FR2467851A1 (ro)
GB (1)	GB8327127D0 (ro)
GR (1)	GR70720B (ro)
HU (1)	HU182213B (ro)
IE (1)	IE50358B1 (ro)
IL (1)	IL61264A (ro)
IT (1)	IT1143047B (ro)
LU (1)	LU82853A1 (ro)
MX (1)	MX6233E (ro)
NZ (1)	NZ195248A (ro)
PH (2)	PH16288A (ro)
PL (2)	PL135044B1 (ro)
PT (1)	PT71913B (ro)
RO (2)	RO85822B (ro)
YU (1)	YU261580A (ro)
ZA (1)	ZA806342B (ro)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4404137A (en) *	1979-10-16	1983-09-13	Lilly Industries Limited	Pyrazolo [3,4-b][1,5]benzodiazepine compounds
US4431589A (en) *	1980-12-11	1984-02-14	Lilly House	Benzodiazepine compounds and their use as pharmaceuticals
US4596799A (en) *	1985-01-29	1986-06-24	Ciba-Geigy Corporation	9H-pyrrolo[2,1-c]-1,2,4-triazolo[4,3-a][1,4]benzodiazepines
TW219896B (ro) *	1988-07-07	1994-02-01	Duphar Int Res
GB8819059D0 (en) *	1988-08-11	1988-09-14	Lilly Industries Ltd	Benzodiazepine compounds & their use as pharmaceuticals
US5631250A (en) *	1995-03-24	1997-05-20	Eli Lilly And Company	Process and solvate of 2-methyl-thieno-benzodiazepine
US5637584A (en) *	1995-03-24	1997-06-10	Eli Lilly And Company	Solvate of olanzapine
US20050250767A1 (en) *	2003-01-23	2005-11-10	Weiner David M	Use of N-desmethylclozapine to treat human neuropsychiatric disease
RU2336879C2 (ru) *	2003-01-23	2008-10-27	Акадиа Фармасьютикалз Инк.	Применение n-десметилклозапина для лечения нейропсихиатрических заболеваний у людей
US20050085463A1 (en) *	2003-01-23	2005-04-21	Weiner David M.	Use of N-desmethylclozapine to treat human neuropsychiatric disease
EP2088147A1 (en) *	2003-12-22	2009-08-12	Arcadia Pharmaceuticals Inc.	Dibenzo-condensed azepine, diazepine, oxazepine and thiazepine derivatives as muscarinic agonists and methods of treatment of neuropsychiatric disorders
EP1756070A2 (en) *	2004-04-01	2007-02-28	Acadia Pharmaceuticals Inc.	Crystalline forms of n-desmethylclozapine
WO2007053618A1 (en) *	2005-10-31	2007-05-10	Acadia Pharmaceuticals Inc.	Prodrugs of muscarinic agonists and methods of treatment of neuropsychiatric disorders
JP5438482B2 (ja) *	2009-12-03	2014-03-12	Ｊｕｋｉ株式会社	ミシン、ミシンの縫製データ編集装置及びミシンの縫製データ編集プログラム

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3450694A (en) *	1966-02-23	1969-06-17	Abbott Lab	Substituted benzoxazepines and benzothiazepines
US3758479A (en) *	1967-03-22	1973-09-11	Sandoz Ag	Nitro and sulphamoyl substituted dibenzodiazepines
DE1795183B1 (de) *	1968-08-20	1972-07-20	Thomae Gmbh Dr K	5,11-Dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-on-derivate und Arzneimittel
CA918659A (en) *	1969-07-31	1973-01-09	Yoshitomi Pharmaceutical Industries	11-(4-substituted-1-piperazinyl)-dibenzo (b,f) (1,4) thiazepines
US4115568A (en) *	1974-11-26	1978-09-19	Lilly Industries Limited	Thieno[3,2-b]-[1,5]benzodiazepines
US4172831A (en) *	1974-11-26	1979-10-30	Lilly Industries Limited	Thieno-benzodiazepines
US3953430A (en) *	1975-02-24	1976-04-27	American Cyanamid Company	Substituted benzodiazepin-10-ones and method of use
US3951981A (en) *	1975-02-24	1976-04-20	American Cyanamid Company	Substituted benzodiazepines and method of use
DE2707269A1 (de) *	1977-02-19	1978-08-24	Hoechst Ag	Heterocyclische stickstoffverbindungen und verfahren zu ihrer herstellung
DE2707270A1 (de) *	1977-02-19	1978-08-24	Hoechst Ag	Pyrazolo-diazepine und verfahren zu ihrer herstellung
US4097597A (en) *	1977-02-23	1978-06-27	Abbott Laboratories	Dibenzo b,e! 1,4!diazepines
IT7851496A0 (it) *	1977-10-31	1978-10-13	Sandoz Ag	Menti pirazinobenzossazepine loro preparazione e loro impiego quali medica
CH643263A5 (de) *	1979-05-11	1984-05-30	Sandoz Ag	Benzodiazepine, ihre herstellung und verwendung.
EP0064775A1 (de) *	1979-08-03	1982-11-17	Byk Gulden Lomberg Chemische Fabrik GmbH	Substituierte Tetraazatricyclen, Verfahren zu ihrer Herstellung und ihre Verwendung
US4404137A (en) *	1979-10-16	1983-09-13	Lilly Industries Limited	Pyrazolo [3,4-b][1,5]benzodiazepine compounds

1980
- 1980-10-02 US US06/193,200 patent/US4404137A/en not_active Expired - Lifetime
- 1980-10-11 GR GR63138A patent/GR70720B/el unknown
- 1980-10-13 CS CS806938A patent/CS244409B2/cs unknown
- 1980-10-13 RO RO108967A patent/RO85822B/ro unknown
- 1980-10-13 YU YU02615/80A patent/YU261580A/xx unknown
- 1980-10-13 PH PH24717A patent/PH16288A/en unknown
- 1980-10-13 NZ NZ195248A patent/NZ195248A/xx unknown
- 1980-10-13 IL IL61264A patent/IL61264A/xx unknown
- 1980-10-13 MX MX809093U patent/MX6233E/es unknown
- 1980-10-13 RO RO102349A patent/RO81351B/ro unknown
- 1980-10-13 FR FR8021823A patent/FR2467851A1/fr active Granted
- 1980-10-14 AT AT0510180A patent/AT373889B/de not_active IP Right Cessation
- 1980-10-14 PT PT71913A patent/PT71913B/pt unknown
- 1980-10-14 CA CA000362328A patent/CA1159056A/en not_active Expired
- 1980-10-14 CH CH763980A patent/CH646700A5/fr not_active IP Right Cessation
- 1980-10-14 AU AU63252/80A patent/AU538500B2/en not_active Ceased
- 1980-10-14 IT IT49899/80A patent/IT1143047B/it active
- 1980-10-15 ES ES495948A patent/ES495948A0/es active Granted
- 1980-10-15 IE IE2135/80A patent/IE50358B1/en unknown
- 1980-10-15 PL PL1980231270A patent/PL135044B1/pl unknown
- 1980-10-15 BG BG049366A patent/BG34907A3/xx unknown
- 1980-10-15 KR KR1019800003960A patent/KR850000471B1/ko not_active Expired
- 1980-10-15 LU LU82853A patent/LU82853A1/fr unknown
- 1980-10-15 FI FI803253A patent/FI67550C/fi not_active IP Right Cessation
- 1980-10-15 DK DK437480A patent/DK437480A/da not_active Application Discontinuation
- 1980-10-15 BE BE6/47291A patent/BE885729A/fr not_active IP Right Cessation
- 1980-10-15 JP JP14423180A patent/JPS5663987A/ja active Pending
- 1980-10-15 DE DE8080303649T patent/DE3068706D1/de not_active Expired
- 1980-10-15 HU HU802502A patent/HU182213B/hu not_active IP Right Cessation
- 1980-10-15 EP EP80303649A patent/EP0027390B1/en not_active Expired
- 1980-10-15 DD DD80224618A patent/DD153692A5/de unknown
- 1980-10-15 BG BG057344A patent/BG35042A3/xx unknown
- 1980-10-15 PL PL1980227306A patent/PL126824B1/pl unknown
- 1980-10-15 ZA ZA00806342A patent/ZA806342B/xx unknown
- 1980-10-16 AR AR282893A patent/AR228041A1/es active
1982
- 1982-07-21 AR AR290034A patent/AR228101A1/es active
- 1982-07-28 PH PH27643A patent/PH17759A/en unknown
- 1982-09-29 US US06/426,580 patent/US4486591A/en not_active Expired - Fee Related
1983
- 1983-10-11 GB GB838327127A patent/GB8327127D0/en active Pending
1984
- 1984-07-24 KR KR1019840004388A patent/KR850000472B1/ko not_active Expired
- 1984-08-06 US US06/638,181 patent/US4542131A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
ATA510180A (de)	1983-07-15
AT373889B (de)	1984-02-27
ZA806342B (en)	1982-05-26
PL227306A1 (ro)	1981-09-18
PH16288A (en)	1983-09-05
CH646700A5 (fr)	1984-12-14
BG34907A3 (en)	1983-12-15
FI67550B (fi)	1984-12-31
AU6325280A (en)	1981-04-30
RO81351B (ro)	1983-02-28
US4404137A (en)	1983-09-13
PT71913A (en)	1980-11-01
IL61264A0 (en)	1980-12-31
PT71913B (en)	1981-08-31
US4486591A (en)	1984-12-04
PL126824B1 (en)	1983-09-30
RO85822A (ro)	1984-11-25
KR850000471B1 (ko)	1985-04-08
JPS5663987A (en)	1981-05-30
IE50358B1 (en)	1986-04-02
US4542131A (en)	1985-09-17
FI67550C (fi)	1985-04-10
FR2467851A1 (fr)	1981-04-30
CA1159056A (en)	1983-12-20
HU182213B (en)	1983-12-28
FI803253L (fi)	1981-04-17
MX6233E (es)	1985-01-14
KR850001463A (ko)	1985-03-18
KR850000472B1 (ko)	1985-04-08
IE802135L (en)	1981-04-16
ES8106905A1 (es)	1981-09-16
GR70720B (ro)	1983-01-18
DE3068706D1 (en)	1984-08-30
AU538500B2 (en)	1984-08-16
RO85822B (ro)	1984-11-30
PL231270A1 (ro)	1981-12-23
BE885729A (fr)	1981-04-15
EP0027390A1 (en)	1981-04-22
IT1143047B (it)	1986-10-22
KR830004300A (ko)	1983-07-09
ES495948A0 (es)	1981-09-16
PH17759A (en)	1984-12-05
LU82853A1 (fr)	1982-05-10
EP0027390B1 (en)	1984-07-25
AR228101A1 (es)	1983-01-14
AR228041A1 (es)	1983-01-14
FR2467851B1 (ro)	1985-04-05
GB8327127D0 (en)	1983-11-09
DK437480A (da)	1981-04-17
YU261580A (en)	1983-12-31
BG35042A3 (en)	1983-01-16
IT8049899A0 (it)	1980-10-14
CS244409B2 (en)	1986-07-17
NZ195248A (en)	1983-11-18
DD153692A5 (de)	1982-01-27
PL135044B1 (en)	1985-09-30
IL61264A (en)	1985-08-30

Publication	Publication Date	Title
RO84151A (ro)	1984-05-23	Procedeu de preparare a unor derivati de penicilanoilo0imetilpenicilanat 1,1-dio0id
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RO70897A (ro)	1982-02-26	Procedeu pentru prepararea unor derivati de fenoxibenziloxicarbonil substituiti
RO82962A (ro)	1984-01-14	Procedeu pentru prepararea unor derivati de cefalosporina
RO77731A (ro)	1981-11-24	Procedeu pentru prepararea unor derivati de fenetanolamina
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RO81351A (ro)	1983-02-15	Procedeu de preparare a unor derivati de benzodiazepina
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RO77228A (ro)	1981-08-17	Procedeu de preparare a unor derivati ai mercaptoacilprolinei
RO84100A (ro)	1984-05-12	Procedeu pentru prepararea unor derivati de benzodiazopina
RO78765A (ro)	1984-10-30	Procedeu pentru prepararea unor derivati de n-trifluoracetil n-fosfonometilglicina
RO80087A (ro)	1983-02-01	Procedeu de preparare a unor tiazoliliden-oxo-propionitrili
RO81930A (ro)	1983-06-01	Procedeu pentru prepararea unor derivati de pirimidona
RO76166A (ro)	1981-11-04	Procedeu pentru prepararea unor derivati ai ergolinei
RO82013A (ro)	1983-06-01	7rocedeu pentru prepararea unor derivati de carbostiril
RO79687A7 (ro)	1982-08-17	Procedeu de preparare a unor derivati de 4''-dezoxi-4''-aminoeritromicina a