RO77543A - PROCESS FOR THE PREPARATION OF 8-THIOMETHYL ERGOLINES - Google Patents

PROCESS FOR THE PREPARATION OF 8-THIOMETHYL ERGOLINES

Info

Publication number: RO77543A
Authority: RO; Romania
Prior art keywords: ergolines; thiomethyl; preparation; thiomethyl ergolines
Prior art date: 1974-06-06

Application number

RO7582445A

Other languages

French (fr)

Romanian (ro)

Inventor

Edmund C Kornfeld

Nicholas J Bach

Original Assignee

Eli Lilly And Co,Us

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1974-06-06

Filing date

1975-06-05

Publication date

1982-02-26

1975-06-05 Application filed by Eli Lilly And Co,Us filed Critical Eli Lilly And Co,Us

1982-02-26 Publication of RO77543A publication Critical patent/RO77543A/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

RO7582445A 1974-06-06 1975-06-05 PROCESS FOR THE PREPARATION OF 8-THIOMETHYL ERGOLINES RO77543A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US477136A US3901894A (en)	1974-06-06	1974-06-06	8-thiomethylergolines

Publications (1)

Publication Number	Publication Date
RO77543A true RO77543A (en)	1982-02-26

Family

ID=23894677

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
RO7582445A RO77543A (en)	1974-06-06	1975-06-05	PROCESS FOR THE PREPARATION OF 8-THIOMETHYL ERGOLINES

Country Status (27)

Country	Link
US (1)	US3901894A (en)
JP (1)	JPS582946B2 (en)
AR (1)	AR210736A1 (en)
AT (1)	AT344333B (en)
AU (1)	AU507574B2 (en)
BE (1)	BE829887A (en)
BG (1)	BG24812A3 (en)
CA (1)	CA1071623A (en)
CH (1)	CH617196A5 (en)
CS (1)	CS199591B2 (en)
DD (1)	DD120438A5 (en)
DE (1)	DE2524575A1 (en)
DK (1)	DK144160C (en)
ES (1)	ES438313A1 (en)
FR (1)	FR2273542A1 (en)
GB (1)	GB1505296A (en)
HU (1)	HU173590B (en)
IE (1)	IE41474B1 (en)
IL (1)	IL47424A (en)
NL (1)	NL180911C (en)
PH (1)	PH10992A (en)
PL (1)	PL95738B1 (en)
RO (1)	RO77543A (en)
SE (1)	SE420095B (en)
SU (1)	SU613724A3 (en)
YU (1)	YU145575A (en)
ZA (1)	ZA753638B (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4147789A (en) *	1974-03-14	1979-04-03	Sandoz Ltd.	6-Methyl-8-thiomethyl-ergolene derivatives
US3959288A (en) *	1974-12-13	1976-05-25	Eli Lilly And Company	8-Oxymethylergolines and process therefor
JPS5283894A (en) *	1976-01-01	1977-07-13	Lilly Co Eli	88thiomethyl ergoline
GB1549829A (en) *	1976-05-26	1979-08-08	Farmaceutici Italia	10'-methoxy-1',6'-dimethylergoline-8'-beta-methyl-amino(or thio)-pyrazines
IT1192260B (en) *	1977-07-05	1988-03-31	Simes	ERGOLINE-2-THIOETHERS AND THEIR SULPHOXIDES DERIVATIVES
US4166182A (en) *	1978-02-08	1979-08-28	Eli Lilly And Company	6-n-propyl-8-methoxymethyl or methylmercaptomethylergolines and related compounds
US4180582A (en) *	1978-02-08	1979-12-25	Eli Lilly And Company	6-n-Propyl-8-methoxy-methyl or methylmercaptomethylergolines and related compounds as prolactin inhibitors and to treat Parkinson's syndrome
US4202979A (en) *	1979-01-11	1980-05-13	Eli Lilly And Company	6-Ethyl(or allyl)-8-methoxymethyl or methylmercaptomethylergolines and related compounds
US4246265A (en) *	1979-10-01	1981-01-20	Eli Lilly And Company	6-n-Propyl-8α-methoxymethyl or methylmercaptomethylergolines and related compounds
US4382940A (en) *	1979-12-06	1983-05-10	Farmitalia Carlo Erba S.P.A.	Ercoline derivatives and therapeutic compositions having CNS affecting activity
DE3216870A1 (en) *	1982-05-03	1983-11-03	Schering AG, 1000 Berlin und 4709 Bergkamen	PHARMACEUTICAL PREPARATIONS WITH A CYTOSTATIC EFFECT
FR2526797A1 (en) *	1982-05-12	1983-11-18	Roussel Uclaf	NOVEL 9-OXALYSERGIC ACID DERIVATIVES, THEIR SALTS, PREPARATION METHOD, MEDICAMENT APPLICATION AND COMPOSITIONS COMPRISING THE SAME
CH649998A5 (en) *	1982-08-09	1985-06-28	Sandoz Ag	ERGOL DERIVATIVES, A METHOD FOR THEIR PRODUCTION AND HEALING AGENTS, CONTAINING THESE ERGOL DERIVATIVES AS AN ACTIVE SUBSTANCE.
GB8427536D0 (en) *	1984-10-31	1984-12-05	Lilly Industries Ltd	Ergoline derivatives
US4675322A (en) *	1984-12-10	1987-06-23	Eli Lilly And Company	1-Substituted-6-n-propyl-8β-methylthio-methylergolines
US4801712A (en) *	1985-06-24	1989-01-31	Eli Lilly And Company	2-Alkyl(or phenyl)thio-6-n-alkylergolines are dopamine D-1 antagonists without D-2 agonist activity
FR2589734B1 (en) *	1985-11-13	1988-09-02	Roussel Uclaf	USE OF ERGOLIN DERIVATIVES FOR OBTAINING A GERIATRIC MEDICINE
HU196394B (en) *	1986-06-27	1988-11-28	Richter Gedeon Vegyeszet	Process for preparing 2-halogenated ergoline derivatives
RU2277539C2 (en) *	2001-06-08	2006-06-10	Сосьете Де Консей Де Решерш Э Д`Аппликасьон Сьентифик С.А.С.	Chimeric analogs of somatostatin-dopamine
EP1485382B1 (en) *	2002-03-15	2008-11-19	Antibioticos S.p.A.	Process for the synthesis of pergolide
TWI523863B (en)	2012-11-01	2016-03-01	艾普森藥品公司	Somatostatin-dopamine chimeric analogs
HK1213486A1 (en)	2012-11-01	2016-07-08	Ipsen Pharma S.A.S.	Somatostatin analogs and dimers thereof
DK3197429T3 (en)	2014-09-25	2024-08-26	Boehringer Ingelheim Vetmedica Gmbh	COMBINATION TREATMENT WITH SGLT2 INHIBITORS AND DOPAMINAGONISTS FOR THE PREVENTION OF METABOLIC DISORDERS IN ANIMALS OF THE HORSE FAMILY
WO2019234069A1 (en)	2018-06-08	2019-12-12	Boehringer Ingelheim Vetmedica Gmbh	Liquid pharmaceutical compositions comprising pergolide

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE712054A (en) *	1967-03-16	1968-07-15
DE1935556A1 (en) *	1969-07-12	1971-01-21	Hoechst Ag	Process for the production of lysergol
JPS5012398A (en) *	1973-06-08	1975-02-07

1974
- 1974-06-06 US US477136A patent/US3901894A/en not_active Expired - Lifetime
1975
- 1975-05-16 JP JP50059191A patent/JPS582946B2/en not_active Expired
- 1975-06-03 HU HU75EI623A patent/HU173590B/en unknown
- 1975-06-03 CA CA228,332A patent/CA1071623A/en not_active Expired
- 1975-06-03 CS CS753882A patent/CS199591B2/en unknown
- 1975-06-03 IE IE1221/75A patent/IE41474B1/en unknown
- 1975-06-03 SE SE7506327A patent/SE420095B/en not_active IP Right Cessation
- 1975-06-03 DE DE19752524575 patent/DE2524575A1/en not_active Ceased
- 1975-06-03 NL NLAANVRAGE7506584,A patent/NL180911C/en not_active IP Right Cessation
- 1975-06-03 GB GB23869/75A patent/GB1505296A/en not_active Expired
- 1975-06-03 PH PH17225A patent/PH10992A/en unknown
- 1975-06-04 AU AU81827/75A patent/AU507574B2/en not_active Expired
- 1975-06-04 BG BG030188A patent/BG24812A3/en unknown
- 1975-06-04 DK DK249975A patent/DK144160C/en not_active IP Right Cessation
- 1975-06-04 PL PL1975180897A patent/PL95738B1/en unknown
- 1975-06-04 IL IL47424A patent/IL47424A/en unknown
- 1975-06-05 RO RO7582445A patent/RO77543A/en unknown
- 1975-06-05 ZA ZA3638A patent/ZA753638B/en unknown
- 1975-06-05 YU YU01455/75A patent/YU145575A/en unknown
- 1975-06-05 SU SU752140862A patent/SU613724A3/en active
- 1975-06-05 AT AT427975A patent/AT344333B/en not_active IP Right Cessation
- 1975-06-05 BE BE1006709A patent/BE829887A/en not_active IP Right Cessation
- 1975-06-05 FR FR7517652A patent/FR2273542A1/en active Granted
- 1975-06-06 AR AR259118A patent/AR210736A1/en active
- 1975-06-06 ES ES438313A patent/ES438313A1/en not_active Expired
- 1975-06-06 CH CH731075A patent/CH617196A5/de not_active IP Right Cessation
1976
- 1976-06-05 DD DD186472A patent/DD120438A5/xx unknown

Also Published As

Publication number	Publication date
FR2273542A1 (en)	1976-01-02
PH10992A (en)	1977-10-20
SU613724A3 (en)	1978-06-30
IL47424A0 (en)	1975-08-31
NL7506584A (en)	1975-12-09
JPS582946B2 (en)	1983-01-19
SE7506327L (en)	1975-12-08
BG24812A3 (en)	1978-05-12
DK249975A (en)	1975-12-07
NL180911C (en)	1987-05-18
ES438313A1 (en)	1977-05-16
CH617196A5 (en)	1980-05-14
NL180911B (en)	1986-12-16
AT344333B (en)	1978-07-10
SE420095B (en)	1981-09-14
ZA753638B (en)	1977-01-26
DK144160B (en)	1981-12-28
CA1071623A (en)	1980-02-12
DE2524575A1 (en)	1975-12-18
AU507574B2 (en)	1980-02-21
IE41474B1 (en)	1980-01-16
AR210736A1 (en)	1977-09-15
GB1505296A (en)	1978-03-30
YU145575A (en)	1982-02-28
FR2273542B1 (en)	1978-10-06
DD120438A5 (en)	1976-06-12
CS199591B2 (en)	1980-07-31
IE41474L (en)	1975-12-06
IL47424A (en)	1979-11-30
PL95738B1 (en)	1977-11-30
AU8182775A (en)	1976-12-09
ATA427975A (en)	1977-11-15
US3901894A (en)	1975-08-26
BE829887A (en)	1975-12-05
DK144160C (en)	1982-06-07
JPS50160300A (en)	1975-12-25
HU173590B (en)	1979-06-28

Publication	Publication Date	Title
RO69763A (en)	1982-02-26	PROCESS FOR PREPARATION OF 3-ARYLOXY-3-PHENYLPROPYLAMINE COMPOUNDS
RO77543A (en)	1982-02-26	PROCESS FOR THE PREPARATION OF 8-THIOMETHYL ERGOLINES
BE833823A (en)	1976-03-25	POLYURETHANNES PREPARATION PROCESS
BE831843A (en)	1976-01-29	POLYURIDE PREPARATION PROCESS
FR2283114A1 (en)	1976-03-26	PROCESS FOR THE PREPARATION OF BUTANEDIOLS
RO70581A (en)	1982-05-10	PROCESS FOR THE PREPARATION OF AMIDOXYMES
FR2319609A1 (en)	1977-02-25	PROCESS FOR THE PREPARATION OF RESORCINS
BE828672A (en)	1975-11-03	PROCESS FOR THE PREPARATION OF BUTYNE-DIOL
BE817113A (en)	1975-01-02	CYCLO-ALKENES PREPARATION PROCESS
BE832428A (en)	1976-02-16	PROCESS FOR THE PREPARATION OF 2-METHYL-TETRA-HYDROPYRIMIDINES 1- SUBSTITUTES
BE829779A (en)	1975-12-02	PROCESS FOR THE PREPARATION OF PYRAZOLO-BENZAZEPINES
RO72708A (en)	1982-09-09	PROCESS FOR THE PREPARATION OF PERCHLORATMETHYLMERCAPTANE
BE813169A (en)	1974-10-02	PROCESS FOR PREPARING 3-FLUOROCEPHALOSPORINS
FR2277060A1 (en)	1976-01-30	MONOALCENYLBENZENES PREPARATION PROCESS
FR2314167A1 (en)	1977-01-07	PROCESS FOR THE PREPARATION OF PARA-ALKYLPHENOLS
BE824612A (en)	1975-07-22	PROCESS FOR PREPARING 3-AMINOPHENOLS
FR2295942A1 (en)	1976-07-23	PINACOLINE PREPARATION PROCESS
BE841768A (en)	1976-11-16	PROCESS FOR THE PREPARATION OF 2-ARYL-2H-BENZOTRIAZOLES
FR2279778A1 (en)	1976-02-20	POLYURIDE PREPARATION PROCESS
RO66137A (en)	1980-02-15	PROCESS FOR THE PREPARATION OF CARNITIVE CLORHIDRATE
FR2289536A1 (en)	1976-05-28	PROCESS FOR PREPARING C
FR2281937A1 (en)	1976-03-12	PROCESS FOR THE PREPARATION OF STERYL-B-D-GLUCOSIDE PALMITATES
RO72510A (en)	1982-09-09	PROCESS FOR THE PREPARATION OF PHENYLPYRAZINES
FR2353516A2 (en)	1977-12-30	FLUORONITROBENZENES PREPARATION PROCESS
BE828032A (en)	1975-10-17	PROCESS FOR THE PREPARATION OF 2-ALCOXY-4-PROPENE- (1) -YL-PHENOLS