RO72831B - Process for preparing phenylpiperazines - Google Patents
Process for preparing phenylpiperazinesInfo
- Publication number
- RO72831B RO72831B RO90106A RO9010677A RO72831B RO 72831 B RO72831 B RO 72831B RO 90106 A RO90106 A RO 90106A RO 9010677 A RO9010677 A RO 9010677A RO 72831 B RO72831 B RO 72831B
- Authority
- RO
- Romania
- Prior art keywords
- phenylpiperazines
- radical
- preparing
- alkylsulfonamide
- nitro
- Prior art date
Links
- YZTJYBJCZXZGCT-UHFFFAOYSA-N phenylpiperazine Chemical class C1CNCCN1C1=CC=CC=C1 YZTJYBJCZXZGCT-UHFFFAOYSA-N 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 125000004422 alkyl sulphonamide group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 125000004442 acylamino group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/24—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/40—Radicals substituted by oxygen atoms
- C07D307/42—Singly bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Furan Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Procedeu pentru prepararea unor fenilpiperazine cu formula I din pag.1 a descrierii, în care substituentul R1 este un radical benzil, alchil cu 2...6 atomi de carbon, fenil eventual substituit cu unul sau doi radicali alesi dintre halogen, C1-4 alchil, C1-4 haloalchenil, amino, C2-4 acilamino, hidroxi, C1-4 alcoxi, nitro si C1-4 alchilsulfonamida, R2 este un radical fenil eventual substituit cu unul sau doi radicali alesi dintre halogen, C1-4 alchil, C1-4 halogenalchil, amino, C2-4 acilamino, hidroxi, C1-4 alcoxi, nitro si C1-4 alchilsulfonamida, R3 este un atom de hidrogen sau un radical alchil cu 1...4 atomi de carbon, Q este un radical de tiazol, m este 1 pîna la 3, iar n este 0 sau 1.A process for the preparation of phenylpiperazines of formula I of the disclosure in which the substituent R1 is a benzyl, alkyl of 2-6 carbon atoms, phenyl optionally substituted by one or two radicals selected from halogen, C1-4 C1-4 alkoxy, nitro and C1-4 alkylsulfonamide; R2 is a phenyl radical optionally substituted by one or two radicals selected from halogen, Amino, C 2-4 acylamino, hydroxy, C 1-4 alkoxy, nitro and C 1-4 alkylsulfonamide, R 3 is a hydrogen atom or an alkyl radical of 1-4 carbon atoms, Q is a radical of thiazole, m is 1 to 3, and n is 0 or 1.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB16526/76A GB1575904A (en) | 1976-04-23 | 1976-04-23 | Phenyl piperazines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RO72831B true RO72831B (en) | 1983-07-30 |
| RO72831A RO72831A (en) | 1983-08-03 |
Family
ID=10078930
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO7790106A RO72831A (en) | 1976-04-23 | 1977-04-20 | PROCEDURE FOR THE PREPARATION OF PHENYLPIPERAZINE |
Country Status (34)
| Country | Link |
|---|---|
| JP (1) | JPS52151183A (en) |
| AR (2) | AR222003A1 (en) |
| AT (1) | AT355579B (en) |
| AU (1) | AU514822B2 (en) |
| BE (1) | BE853899A (en) |
| BG (2) | BG28055A3 (en) |
| CA (1) | CA1087617A (en) |
| CH (2) | CH625802A5 (en) |
| CS (1) | CS196360B2 (en) |
| DD (1) | DD129790A5 (en) |
| DE (1) | DE2717415A1 (en) |
| DK (1) | DK176177A (en) |
| ES (2) | ES457988A1 (en) |
| FI (1) | FI63937C (en) |
| FR (1) | FR2348925A1 (en) |
| GB (1) | GB1575904A (en) |
| GR (1) | GR64084B (en) |
| HU (1) | HU176820B (en) |
| IE (1) | IE44730B1 (en) |
| IL (1) | IL51787A (en) |
| LU (1) | LU77170A1 (en) |
| MX (1) | MX4596E (en) |
| NL (1) | NL7704456A (en) |
| NO (1) | NO146710C (en) |
| NZ (1) | NZ183715A (en) |
| OA (1) | OA05643A (en) |
| PH (1) | PH14124A (en) |
| PL (1) | PL117466B1 (en) |
| PT (1) | PT66452B (en) |
| RO (1) | RO72831A (en) |
| SE (1) | SE7704536L (en) |
| SU (2) | SU664564A3 (en) |
| YU (1) | YU104477A (en) |
| ZA (1) | ZA771849B (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1601310A (en) * | 1978-05-23 | 1981-10-28 | Lilly Industries Ltd | Aryl hydantoins |
| DE3142608A1 (en) * | 1981-10-28 | 1983-05-05 | Basf Ag, 6700 Ludwigshafen | POLYAZO DYES |
| JPH07157477A (en) * | 1993-12-02 | 1995-06-20 | Asahi Kagaku Kogyo Kk | Method for producing thiazole derivative |
| EP0749966A4 (en) * | 1994-03-11 | 1997-07-02 | Yamanouchi Pharma Co Ltd | 5-ht 3 receptor agonist, novel thiazole derivative, and intermediate therefor |
| CA2144669A1 (en) * | 1994-03-29 | 1995-09-30 | Kozo Akasaka | Biphenyl derivatives |
| GB9517381D0 (en) * | 1995-08-24 | 1995-10-25 | Pharmacia Spa | Aryl and heteroaryl piperazine derivatives |
| DZ3292A1 (en) * | 2001-09-13 | 2005-05-14 | Solvay Pharm Gmbh | Novel 1-[1-(hetero)aryl-1-perhydroxyalkylmethyl]-piperazine compounds, process for their preparation and medicaments containing these compounds |
| US8927546B2 (en) | 2006-02-28 | 2015-01-06 | Dart Neuroscience (Cayman) Ltd. | Therapeutic piperazines |
| EP1989188B1 (en) * | 2006-02-28 | 2015-07-22 | Dart Neuroscience (Cayman) Ltd | Therapeutic piperazines as pde4 inhibitors |
-
1976
- 1976-04-23 GB GB16526/76A patent/GB1575904A/en not_active Expired
-
1977
- 1977-03-28 ZA ZA00771849A patent/ZA771849B/en unknown
- 1977-03-28 NZ NZ183715A patent/NZ183715A/en unknown
- 1977-03-30 IL IL51787A patent/IL51787A/en unknown
- 1977-03-30 CA CA275,160A patent/CA1087617A/en not_active Expired
- 1977-03-30 IE IE671/77A patent/IE44730B1/en unknown
- 1977-04-13 MX MX775629U patent/MX4596E/en unknown
- 1977-04-13 CH CH455777A patent/CH625802A5/en not_active IP Right Cessation
- 1977-04-13 CH CH525781A patent/CH633009A5/en not_active IP Right Cessation
- 1977-04-14 PH PH19656A patent/PH14124A/en unknown
- 1977-04-18 AU AU24386/77A patent/AU514822B2/en not_active Expired
- 1977-04-18 PT PT66452A patent/PT66452B/en unknown
- 1977-04-19 FR FR7711669A patent/FR2348925A1/en active Granted
- 1977-04-19 GR GR53236A patent/GR64084B/en unknown
- 1977-04-20 ES ES457988A patent/ES457988A1/en not_active Expired
- 1977-04-20 BG BG037191A patent/BG28055A3/en unknown
- 1977-04-20 DE DE19772717415 patent/DE2717415A1/en not_active Withdrawn
- 1977-04-20 RO RO7790106A patent/RO72831A/en unknown
- 1977-04-20 BG BG036062A patent/BG27746A3/en unknown
- 1977-04-20 SE SE7704536A patent/SE7704536L/en not_active Application Discontinuation
- 1977-04-20 OA OA56149A patent/OA05643A/en unknown
- 1977-04-21 CS CS772668A patent/CS196360B2/en unknown
- 1977-04-21 LU LU77170A patent/LU77170A1/xx unknown
- 1977-04-21 YU YU01044/77A patent/YU104477A/en unknown
- 1977-04-21 DK DK176177A patent/DK176177A/en not_active Application Discontinuation
- 1977-04-22 HU HU77LI311A patent/HU176820B/en unknown
- 1977-04-22 NO NO771398A patent/NO146710C/en unknown
- 1977-04-22 NL NL7704456A patent/NL7704456A/en not_active Application Discontinuation
- 1977-04-22 AT AT285177A patent/AT355579B/en not_active IP Right Cessation
- 1977-04-22 DD DD7700198558A patent/DD129790A5/en unknown
- 1977-04-22 BE BE6045977A patent/BE853899A/en not_active IP Right Cessation
- 1977-04-22 FI FI771287A patent/FI63937C/en not_active IP Right Cessation
- 1977-04-22 SU SU772474105A patent/SU664564A3/en active
- 1977-04-22 PL PL1977197550A patent/PL117466B1/en unknown
- 1977-04-22 AR AR267310A patent/AR222003A1/en active
- 1977-04-23 JP JP4727677A patent/JPS52151183A/en active Pending
- 1977-12-28 SU SU772558499A patent/SU727146A3/en active
-
1978
- 1978-03-16 ES ES467948A patent/ES467948A1/en not_active Expired
- 1978-03-22 AR AR271519A patent/AR222635A1/en active
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