RO115938B1 - Dermatological ointment - Google Patents
Dermatological ointment Download PDFInfo
- Publication number
- RO115938B1 RO115938B1 RO9701892A RO9701892A RO115938B1 RO 115938 B1 RO115938 B1 RO 115938B1 RO 9701892 A RO9701892 A RO 9701892A RO 9701892 A RO9701892 A RO 9701892A RO 115938 B1 RO115938 B1 RO 115938B1
- Authority
- RO
- Romania
- Prior art keywords
- vitamin
- ointment
- dermatological
- palmitate
- acetate
- Prior art date
Links
- 239000002674 ointment Substances 0.000 title claims abstract description 11
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 10
- VYGQUTWHTHXGQB-FFHKNEKCSA-N Retinol Palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C VYGQUTWHTHXGQB-FFHKNEKCSA-N 0.000 claims abstract description 10
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 claims abstract description 5
- VYGQUTWHTHXGQB-UHFFFAOYSA-N Retinol hexadecanoate Natural products CCCCCCCCCCCCCCCC(=O)OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C VYGQUTWHTHXGQB-UHFFFAOYSA-N 0.000 claims abstract description 5
- 229930003571 Vitamin B5 Natural products 0.000 claims abstract description 5
- FAPWYRCQGJNNSJ-UBKPKTQASA-L calcium D-pantothenic acid Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UBKPKTQASA-L 0.000 claims abstract description 5
- 229960002079 calcium pantothenate Drugs 0.000 claims abstract description 5
- 235000011187 glycerol Nutrition 0.000 claims abstract description 5
- 229940108325 retinyl palmitate Drugs 0.000 claims abstract description 5
- 235000019172 retinyl palmitate Nutrition 0.000 claims abstract description 5
- 239000011769 retinyl palmitate Substances 0.000 claims abstract description 5
- 235000009492 vitamin B5 Nutrition 0.000 claims abstract description 5
- 239000011675 vitamin B5 Substances 0.000 claims abstract description 5
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims description 5
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 claims description 5
- 229940042585 tocopherol acetate Drugs 0.000 claims description 5
- IRHTZOCLLONTOC-UHFFFAOYSA-N hexacosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCCO IRHTZOCLLONTOC-UHFFFAOYSA-N 0.000 claims description 4
- 239000004698 Polyethylene Substances 0.000 claims description 3
- 235000019271 petrolatum Nutrition 0.000 claims description 3
- -1 polyethylene Polymers 0.000 claims description 3
- 229920000573 polyethylene Polymers 0.000 claims description 3
- 239000003883 ointment base Substances 0.000 claims 1
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 abstract description 5
- 229960000541 cetyl alcohol Drugs 0.000 abstract description 3
- 239000002202 Polyethylene glycol Substances 0.000 abstract description 2
- NWGKJDSIEKMTRX-AAZCQSIUSA-N Sorbitan monooleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O NWGKJDSIEKMTRX-AAZCQSIUSA-N 0.000 abstract description 2
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 abstract description 2
- 229920001223 polyethylene glycol Polymers 0.000 abstract description 2
- 229950004959 sorbitan oleate Drugs 0.000 abstract description 2
- 229940099259 vaseline Drugs 0.000 abstract description 2
- 229940053682 vitamine e acetate Drugs 0.000 abstract 1
- RGZSQWQPBWRIAQ-CABCVRRESA-N (-)-alpha-Bisabolol Chemical compound CC(C)=CCC[C@](C)(O)[C@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-CABCVRRESA-N 0.000 description 3
- 239000001500 (2R)-6-methyl-2-[(1R)-4-methyl-1-cyclohex-3-enyl]hept-5-en-2-ol Substances 0.000 description 3
- RGZSQWQPBWRIAQ-LSDHHAIUSA-N alpha-Bisabolol Natural products CC(C)=CCC[C@@](C)(O)[C@@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-LSDHHAIUSA-N 0.000 description 3
- 210000003491 skin Anatomy 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- 201000004624 Dermatitis Diseases 0.000 description 2
- 201000009053 Neurodermatitis Diseases 0.000 description 2
- 201000004681 Psoriasis Diseases 0.000 description 2
- 208000010668 atopic eczema Diseases 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- QWOJMRHUQHTCJG-UHFFFAOYSA-N CC([CH2-])=O Chemical compound CC([CH2-])=O QWOJMRHUQHTCJG-UHFFFAOYSA-N 0.000 description 1
- 239000005662 Paraffin oil Substances 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- PGBHMTALBVVCIT-VCIWKGPPSA-N framycetin Chemical compound N[C@@H]1[C@@H](O)[C@H](O)[C@H](CN)O[C@@H]1O[C@H]1[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](N)C[C@@H](N)[C@@H]2O)O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CN)O2)N)O[C@@H]1CO PGBHMTALBVVCIT-VCIWKGPPSA-N 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 125000005456 glyceride group Chemical group 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- IPCSVZSSVZVIGE-UHFFFAOYSA-M hexadecanoate Chemical compound CCCCCCCCCCCCCCCC([O-])=O IPCSVZSSVZVIGE-UHFFFAOYSA-M 0.000 description 1
- 238000010907 mechanical stirring Methods 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000004089 microcirculation Effects 0.000 description 1
- 229940053050 neomycin sulfate Drugs 0.000 description 1
- 238000005502 peroxidation Methods 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000037309 reepithelialization Effects 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000021470 vitamin B5 (pantothenic acid) Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 239000003871 white petrolatum Substances 0.000 description 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
Invenția se referă la un unguent dermatologic, pentru tratamentul dermatologic al neurodermitelor, psoriazisului și a altor eczeme atipice.The invention relates to a dermatological ointment, for the dermatological treatment of neurodermitis, psoriasis and other atypical eczema.
Se cunoaște un unguent cu acțiune terapeutică, constituit din triamicinolon acetonid, sulfat de neomicină și o bază care conține gliceridă de semisinteză, ulei de parafină și vaselină.A therapeutic action ointment known as triamycinolone acetonide, neomycin sulfate and a base containing semisynthesis glyceride, paraffin oil and petroleum jelly is known.
Invenția de față lărgește gama unguentelor dermatologice, prin folosirea concomitentă a combinației realizate în unguentul de tip A/U, ce conține α bisabolol, care acționează asupra pielii înroșite și inflamate, vitamina B5, care favorizează creșterea celulelor pielii și o protejează față de influența mediului, vitamina A palmitat, ce reglează procesele de reepitelizare a celulelor, și vitamina E acetat, care acționează ca antioxidant împotriva peroxidării acizilor grași, împiedicând creșterea radicalilor liberi, care duc în final la îmbătrânirea organismului. De asemenea, vitamina E influențează pozitiv flexibilitatea pielii și îi îmbunătățește microcirculația.The present invention broadens the range of dermatological ointments, by concomitant use of the combination made in the A / U type ointment, containing α bisabolol, which acts on red and inflamed skin, vitamin B5, which promotes skin cell growth and protects it from the environment. , Vitamin A palmitate, which regulates cell reepithelialization processes, and Vitamin E acetate, which acts as an antioxidant against fatty acid peroxidation, preventing the growth of free radicals, which eventually lead to aging of the body. Vitamin E also positively influences the skin's flexibility and improves its microcirculation.
Unguentul conform invenției este constituit din 0,71 % 1,5 - dimetil -1-(4 metilciclohexan-3-n-1-il)hex-4-n-ol, 2,15 % vitamina A palmitat, 1,79 % vitamina B5 și 3,58 % vitamina E acetat, înglobate într-o bază de unguent grasă conținând 17,92% vaselină, 10,75 % glicerină, 12,18 % alcool cerilic și 5 % polietilenglicolsorbitanoleat, procentele fiind exprimate în greutate.The ointment according to the invention consists of 0.71% 1,5-dimethyl -1- (4 methylcyclohexane-3-n-1-yl) hex-4-n-ol, 2.15% vitamin A palmitate, 1.79% Vitamin B5 and 3.58% Vitamin E acetate, embedded in a base of ointment containing 17.92% Vaseline, 10.75% glycerin, 12.18% Ceryl alcohol and 5% Polyethylene glycolsorbitanoleate, the percentages being expressed by weight.
Invenția prezintă următoarele avantaje:The invention has the following advantages:
- întregește tratamentul dermatologic optim al neurodermitelor, psoriazisului și a altor eczeme atipice;- supports the optimal dermatological treatment of neurodermatitis, psoriasis and other atypical eczema;
- nu produce ocluziunea porilor pielii;- does not produce skin pore occlusion;
- îndeplinește condițiile dermatologice;- meets the dermatological conditions;
- îndeplinește condițiile cosmetice.- meets the cosmetic conditions.
Se dă în continuare un exemplu de realizare a invenției.An example of the invention is given below.
într-un vas emailat se introduc 50 g vaselină albă, 34 g alcool cetilic, 30 g glicerină, 14 g polietilenglicolsorbitanoleat și se încălzesc pe baia de apă la 65 ... 7O°C, sub agitare mecanică continuă, până la topirea completă a substanțelor. Se adaugă în continuare 10 g vitamina E acetat (10.000 Ul), 2 g α bisabolol (1,5,dimetil1[4 metilciclohexan-3- η-1-il] hex-4-/?-ol), 6 g vitamina A palmitat (6000000 Ul) și se continuă agitarea fără a depăși 70°C. Apoi se adaugă, sub agitare, în fir subțire, 128 ml apă distilată încălzită la 65 ... 70°C, în care s-au dizolvat 5000 mg vitamina B5 (acid pantotenic). După ce apa a fost complet înglobată, se continuă agitarea până când temperatura masei ajunge la temperatura ambiantă, masa obținută introducându-se în final în tuburi vernisate de 40 g.50 g of white petroleum jelly, 34 g of cetyl alcohol, 30 g of glycerine, 14 g of polyethylene glycol or sorbitanoleate are introduced into an enamelled vessel and heated on the water bath at 65 ... 7 ° C, under continuous mechanical stirring, until complete melting of substances. Further 10 g of vitamin E acetate (10,000 µl), 2 g of α bisabolol (1.5, dimethyl 1 [4 methylcyclohexane-3- η-1-yl] hex-4 -? - ol), 6 g of vitamin A are added palmitate (6000000 Ul) and stirring is continued without exceeding 70 ° C. Then, 128 ml of distilled water heated to 65 ... 70 ° C, in which 5000 mg of vitamin B5 (pantothenic acid), was dissolved in shaken wire. After the water has been completely embedded, stirring is continued until the temperature of the mass reaches the ambient temperature, the mass obtained finally being introduced into 40 g varnished tubes.
Produsul astfel obținut este un unguent dermatologic, ce conține o combinație de substanțe active formată din α bisabolol, vitamina A palmitat, vitamina B5 și vitamina E acetat, înglobate într-o bază grasă formată din vaselină, alcool cetilic, glicerină și polietilenglicolsorbitanoleat.The product thus obtained is a dermatological ointment, which contains a combination of active substances consisting of α bisabolol, vitamin A palmitate, vitamin B5 and vitamin E acetate, embedded in a fatty base consisting of petroleum jelly, cetyl alcohol, glycerine and polyethylene glycolsorbitanolate.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO9701892A RO115938B1 (en) | 1997-10-14 | 1997-10-14 | Dermatological ointment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO9701892A RO115938B1 (en) | 1997-10-14 | 1997-10-14 | Dermatological ointment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RO115938B1 true RO115938B1 (en) | 2000-08-30 |
Family
ID=20105531
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO9701892A RO115938B1 (en) | 1997-10-14 | 1997-10-14 | Dermatological ointment |
Country Status (1)
| Country | Link |
|---|---|
| RO (1) | RO115938B1 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006129161A3 (en) * | 2005-06-01 | 2007-02-08 | Connetics Australia Pty Ltd | Vitamin formulation |
| WO2013155584A1 (en) | 2012-04-20 | 2013-10-24 | Biolab Sanus Farmacêutica Ltda. | Topical pharmaceutical composition, method for producing the topical pharmaceutical composition, use of the topical pharmaceutical composition and method for the topical treatment of psoriasis, atopic dermatitis or chronic eczema |
-
1997
- 1997-10-14 RO RO9701892A patent/RO115938B1/en unknown
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006129161A3 (en) * | 2005-06-01 | 2007-02-08 | Connetics Australia Pty Ltd | Vitamin formulation |
| AU2006253913B2 (en) * | 2005-06-01 | 2010-09-16 | Mayne Pharma Llc | Vitamin formulation |
| US8298515B2 (en) | 2005-06-01 | 2012-10-30 | Stiefel Research Australia Pty Ltd. | Vitamin formulation |
| US8629128B2 (en) | 2005-06-01 | 2014-01-14 | Stiefel West Coast, Llc | Vitamin formulation |
| WO2013155584A1 (en) | 2012-04-20 | 2013-10-24 | Biolab Sanus Farmacêutica Ltda. | Topical pharmaceutical composition, method for producing the topical pharmaceutical composition, use of the topical pharmaceutical composition and method for the topical treatment of psoriasis, atopic dermatitis or chronic eczema |
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