RO114552B1 - Active complex of hydrolized collagen with natural animal and vegetal substances - Google Patents
Active complex of hydrolized collagen with natural animal and vegetal substances Download PDFInfo
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- RO114552B1 RO114552B1 RO9401808A RO9401808A RO114552B1 RO 114552 B1 RO114552 B1 RO 114552B1 RO 9401808 A RO9401808 A RO 9401808A RO 9401808 A RO9401808 A RO 9401808A RO 114552 B1 RO114552 B1 RO 114552B1
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- collagen
- hydrolysed
- water
- active
- soluble
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- 102000008186 Collagen Human genes 0.000 title claims abstract description 27
- 108010035532 Collagen Proteins 0.000 title claims abstract description 27
- 229920001436 collagen Polymers 0.000 title claims abstract description 27
- 239000000126 substance Substances 0.000 title abstract description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 11
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims abstract description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 10
- 239000012153 distilled water Substances 0.000 claims abstract description 9
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract description 8
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 claims abstract description 8
- 229920002683 Glycosaminoglycan Polymers 0.000 claims abstract description 7
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims abstract description 7
- 239000000203 mixture Substances 0.000 claims abstract description 7
- 102000016942 Elastin Human genes 0.000 claims abstract description 6
- 108010014258 Elastin Proteins 0.000 claims abstract description 6
- 229920002549 elastin Polymers 0.000 claims abstract description 6
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims abstract description 5
- 239000005662 Paraffin oil Substances 0.000 claims abstract description 5
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims abstract description 5
- 229960000541 cetyl alcohol Drugs 0.000 claims abstract description 5
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims abstract description 5
- 229960004889 salicylic acid Drugs 0.000 claims abstract description 5
- 239000000600 sorbitol Substances 0.000 claims abstract description 5
- 229940045860 white wax Drugs 0.000 claims abstract description 5
- 235000021355 Stearic acid Nutrition 0.000 claims abstract description 4
- 229940031955 anhydrous lanolin Drugs 0.000 claims abstract description 4
- 239000004310 lactic acid Substances 0.000 claims abstract description 4
- 235000014655 lactic acid Nutrition 0.000 claims abstract description 4
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims abstract description 4
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims abstract description 4
- 239000008117 stearic acid Substances 0.000 claims abstract description 4
- 239000003755 preservative agent Substances 0.000 claims abstract description 3
- 235000015112 vegetable and seed oil Nutrition 0.000 claims abstract description 3
- 239000008158 vegetable oil Substances 0.000 claims abstract description 3
- 239000003205 fragrance Substances 0.000 claims abstract 2
- 239000005445 natural material Substances 0.000 claims description 6
- 235000011187 glycerol Nutrition 0.000 claims description 5
- 235000013311 vegetables Nutrition 0.000 claims description 3
- 229940099259 vaseline Drugs 0.000 claims description 2
- 239000013543 active substance Substances 0.000 abstract description 3
- 241000218642 Abies Species 0.000 abstract 1
- 241000196324 Embryophyta Species 0.000 abstract 1
- 235000019271 petrolatum Nutrition 0.000 abstract 1
- 239000000839 emulsion Substances 0.000 description 5
- 230000003020 moisturizing effect Effects 0.000 description 5
- 230000001172 regenerating effect Effects 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 4
- 239000002537 cosmetic Substances 0.000 description 4
- 210000002615 epidermis Anatomy 0.000 description 4
- 230000002209 hydrophobic effect Effects 0.000 description 4
- 210000003491 skin Anatomy 0.000 description 4
- BQACOLQNOUYJCE-FYZZASKESA-N Abietic acid Natural products CC(C)C1=CC2=CC[C@]3(C)[C@](C)(CCC[C@@]3(C)C(=O)O)[C@H]2CC1 BQACOLQNOUYJCE-FYZZASKESA-N 0.000 description 3
- RSWGJHLUYNHPMX-UHFFFAOYSA-N Abietic-Saeure Natural products C12CCC(C(C)C)=CC2=CCC2C1(C)CCCC2(C)C(O)=O RSWGJHLUYNHPMX-UHFFFAOYSA-N 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 3
- 230000002924 anti-infective effect Effects 0.000 description 3
- 239000006071 cream Substances 0.000 description 3
- 239000003974 emollient agent Substances 0.000 description 3
- 239000003995 emulsifying agent Substances 0.000 description 3
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 description 3
- 239000004094 surface-active agent Substances 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- BTXXTMOWISPQSJ-UHFFFAOYSA-N 4,4,4-trifluorobutan-2-one Chemical compound CC(=O)CC(F)(F)F BTXXTMOWISPQSJ-UHFFFAOYSA-N 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 239000008278 cosmetic cream Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000002538 fungal effect Effects 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- 210000002445 nipple Anatomy 0.000 description 2
- 239000002304 perfume Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 229960003415 propylparaben Drugs 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 235000019155 vitamin A Nutrition 0.000 description 2
- 239000011719 vitamin A Substances 0.000 description 2
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 description 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
- 230000003255 anti-acne Effects 0.000 description 1
- 230000000843 anti-fungal effect Effects 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 230000001153 anti-wrinkle effect Effects 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 description 1
- 230000037336 dry skin Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 229960002591 hydroxyproline Drugs 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
- CSNNHWWHGAXBCP-UHFFFAOYSA-L magnesium sulphate Substances [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 1
- 235000019341 magnesium sulphate Nutrition 0.000 description 1
- 229910052752 metalloid Inorganic materials 0.000 description 1
- 150000002738 metalloids Chemical class 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 229940068918 polyethylene glycol 400 Drugs 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000003014 reinforcing effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000007127 saponification reaction Methods 0.000 description 1
- 230000036555 skin type Effects 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 description 1
- 230000001228 trophic effect Effects 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
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- Cosmetics (AREA)
Abstract
Invenția se referă la un complex activ al colagenului hidrolizat cu substanțe naturale de origine animală și vegetală, constituit din: 1 ... 5% colagen hidrolizat hidrosolubil, 0,2 ... 0,5% elastină hidrolizată, 0,2... 0,5% glicozaminoglicani, 0,1...0,5% abietat hidrosolubil, 0,1...1,5% acid salicilic, 1... 4% acid stearic, 1 ...4% acid lactic, 0,5... 1,5 trietanolamină, 1 ... 6% alcool cetilic, 1... 3% ceară albă, 1... 4% cetaceum, 1... 5% lanolină anhidră, 2... 10% ulei de parafină sau ulei vegetal, 2... 6% glicerină, 2...10% vaselină farmaceutică, 1...4% 1,2-propilenglicol, 1...5% sorbitol, la care se adaugă conservanți, apă distilată și, eventual, o compoziție de parfumare, în proporții variabile până la 100%, procentele fiind exprimate în greutate. Revendicări: 1The invention relates to a complex active substance of collagen hydrolysed with substances natural animal and plant origin, consisting of: 1-5% hydrolysed collagen hydrosoluble, 0.2 ... 0.5% hydrolyzed elastin, 0.2 ... 0.5% glycosaminoglycans, 0.1 ... 0.5% water-soluble abies, 0.1 ... 1.5% salicylic acid, 1 ... 4% stearic acid, 1 ... 4% lactic acid, 0.5 ... 1.5 triethanolamine, 1 ... 6% cetyl alcohol, 1 ... 3% white wax, 1 ... 4% cetaceum, 1 ... 5% anhydrous lanolin, 2 ... 10% paraffin oil or vegetable oil, 2 ... 6% glycerol, 2 ... 10% petroleum jelly, 1-4% 1,2-propylene glycol, 1 ... 5% sorbitol to which it is added preservatives, distilled water and possibly o fragrance composition in varying proportions up to 100%, the percentages being expressed in weight. Claims: 1
Description
Invenția se referă la un complex activ al colagenului hidrolizat cu substanțe naturale de origine animală sau vegetală, utilizabile sub forma unor produse farmaceutice, dermatologice și cosmetice.The invention relates to an active complex of hydrolyzed collagen with natural substances of animal or vegetable origin, usable in the form of pharmaceutical, dermatological and cosmetic products.
Se cunoaște o compoziție antiseptică și cicatrizantă, alcătuită din 5...10% colagen hidrolizat, 1...3% iod metaloid, 2...6% iodură de potasiu, 1...5% citrat de sodiu, 0,1...0,5% acid salicilic, cu eventual 5% glicerină și 2% polietilenglicol 400, și până la 100% apă distilată, procentele fiind exprimate în greutate.An antiseptic and healing composition is known, consisting of 5 ... 10% hydrolyzed collagen, 1 ... 3% metalloid iodine, 2 ... 6% potassium iodide, 1 ... 5% sodium citrate, 0, 1 ... 0.5% salicylic acid, with possibly 5% glycerin and 2% polyethylene glycol 400, and up to 100% distilled water, the percentages being expressed by weight.
De asemenea, se cunoaște o compoziție de ingredient cosmetic și farmaceutic, constituită din 85...90% colagen solubil, 5...15% un amestec de polimeri sintetici, alcătuit din 40...60% polialcool vinilic, 20...40% poliacrilamidă și 20...40% carboximetilceluloză, procentele fiind exprimate în greutate.Also known is a composition of cosmetic and pharmaceutical ingredient, consisting of 85 ... 90% soluble collagen, 5 ... 15% a mixture of synthetic polymers, consisting of 40 ... 60% vinyl polyalcohol, 20. .40% polyacrylamide and 20 ... 40% carboxymethylcellulose, the percentages being expressed by weight.
Hidrolizatele de colagen sunt substanțele naturale cu cea mai mare abilitate în formarea complexelor active, prin structura lor formată din acizi aminați cu caracter amfoter. Caracterul amforter, imprimat de aminoacizii structurali care conferă proprietăți tensioactive de emulgator ce poate acționa ca atare,'atât în mediu hidrofil cât și hidrofob, conferă șanse mari de formare de complexe active.Collagen hydrolyzates are the natural substances with the highest ability in the formation of active complexes, by their structure consisting of amphotoric amino acids. The reinforcing character, imprinted by structural amino acids that confer surfactant properties of emulsifier that can act as such, both in hydrophilic and hydrophobic environment, gives high chances of formation of active complexes.
Complexele active, formate prin legături intermoleculare - legături de hidrogen, Van der Waals sau electrostatice, acționează sinergie în realizarea activității bilogice specifice, fără ca vreuna din componente să-și piardă individualitatea. Aceasta este, dimpotrivă, accentuată sau completă, după caz.The active complexes, formed by intermolecular bonds - hydrogen, van der Waals or electrostatic links, act synergistically in the realization of the specific bilogical activity, without any of the components losing their individuality. This is, on the contrary, accentuated or complete, as the case may be.
Hidrolizatele de colagen își datorează activitatea benefică (emolientă, nutritivă, hidratantă) asupra pielii prin structura lor constituită din aminoacizi hidrofili, în care predomină glicina, prolina și hidroxiprolina (specifice colagenului), elemente de bază ale reglării echilibrului hidrolipidic, precum și aportului de colagen solubil (fibrile) cu efect regenerator al epidermei.Collagen hydrolyzates owe their beneficial activity (emollient, nourishing, moisturizing) to the skin through their structure consisting of hydrophilic amino acids, in which glycine, proline and hydroxyproline (collagen specific) predominate, basic elements of the regulation of hydrolipidic balance, as well as collagen intake. soluble (fibrils) with regenerative effect of the epidermis.
Complexele active ale hidrolizatelor de colagen își modifică proprietățile biologice dependent de cele ale substanței naturale cu care se formează, de caracterul hidrofil sau hidrofob al acesteia, fapt care determină tipul de emulsie și emulgatorul necesar pentru obținerea unor creme stabile.The active complexes of collagen hydrolyzates modify their biological properties depending on those of the natural substance with which they are formed, by their hydrophilic or hydrophobic character, which determines the type of emulsion and emulsifier necessary to obtain stable creams.
Complexul activ al colagenului hidrolizat cu substanțe naturale de origine animală sau vegetală, conform invenției, este constituit din: 1...5% colagen hidrolizat hidrosolubil, 0,2...0,5% elastină hidrolizată, 0,2...0,5% glicozaminoglicani, 0,1...5% abietat hidrosolubil, 0,5...1,5% acid salicilic, 1...4% acid stearic, 1...4% acid lactic, 0,5...1,5%trietanolamină, 1 ...6% alcool cetilic, 1 ...3% ceară albă, 1 ...4% cetaceum,The active complex of hydrolysed collagen with natural substances of animal or vegetable origin, according to the invention, consists of: 1 ... 5% water-soluble hydrolysed collagen, 0.2 ... 0.5% hydrolysed elastin, 0.2 ... 0.5% glycosaminoglycans, 0.1 ... 5% water soluble, 0.5 ... 1.5% salicylic acid, 1 ... 4% stearic acid, 1 ... 4% lactic acid, 0, 5 ... 1.5% triethanolamine, 1 ... 6% cetyl alcohol, 1 ... 3% white wax, 1 ... 4% cetaceum,
1.. .5% lanolină anhidră, 2...10% ulei de parafină sau ulei vegetal, 2...6% glicerină,1 .. .5% anhydrous lanolin, 2 ... 10% paraffin oil or vegetable oil, 2 ... 6% glycerin,
2.. .10% vaselină farmaceutică, 1 ...4% 1,2-propilenglicol, 1 ...5% sorbitol, la care se adaugă conservanți, apă distilată și eventual o compoziție de parfumare, în proporții variabile până la 100%, procentele fiind exprimate în greutate.2 .. .10% pharmaceutical vaseline, 1 ... 4% 1,2-propylene glycol, 1 ... 5% sorbitol, to which are added preservatives, distilled water and possibly a perfume composition, in varying proportions up to 100. %, the percentages being expressed by weight.
Complexele active, prezentate în această invenție, au următoarele avantaje:The active complexes presented in this invention have the following advantages:
- hidrolizatele hidrosolubile de colagen sunt materii prime cu cea mai mare abilitate de formare a unor complexe active utilizabile în preparate dermatologice și dermato-cosmetice, având deci acțiune benefică asupra pielii normale și a celei îmbătrânite sau lezate;- water-soluble collagen hydrolyzates are raw materials with the highest ability to form active complexes usable in dermatological and dermato-cosmetic preparations, thus having a beneficial action on normal and aged or damaged skin;
- complexele active obținute prezintă substantivitate (biocompatibilitate perfectă) față de epidermă, fiind formate din unele elemente structurale comune;- the active complexes obtained have substantivity (perfect biocompatibility) with respect to the epidermis, being formed from some common structural elements;
- preparatele active obținute sunt stabile în timp din punct de vedere fizico-chimic și microbiologic;- the active preparations obtained are stable over time from a physico-chemical and microbiological point of view;
- complexele active obținute se pot reproduce ușor în producția industrială, având la bază tehnologii simple și materii prime accesibile.- the active complexes obtained can be easily reproduced in industrial production, based on simple technologies and accessible raw materials.
Se dau două exemple de realizare a invenției.Two examples of embodiments of the invention are given.
Exemplul 1.Example 1
- colagen hidrolizat solubil 2 g- soluble hydrolyzed collagen 2 g
- abietat de sodiu 1 g- sodium abietate 1 g
- elastină hidrolizată 0,2 g- hydrolysed elastin 0.2 g
- glicozaminoglicani (GAG) 0,3 g- glycosaminoglycans (GAG) 0.3 g
- alcool cetilic 5 g- cetyl alcohol 5 g
- acid salicilic 1,5 g- 1.5 g salicylic acid
- cetaceum 3 g- cetaceum 3 g
- ceară albă 1 g- 1 g white wax
- ulei de parafină 8 g- paraffin oil 8 g
- glicerină 4 g- glycerin 4 g
- 1,2-propilenglicol 2g- 1,2-propylene glycol 2g
- sorbitol 1 g- sorbitol 1 g
- trietanolamină 0,5 g- triethanolamine 0.5 g
- nipagin 0,2 g- 0.2 g nipple
- nipasol 0,1 g- nipasol 0.1 g
- apă distilată până la 100 g- distilled water up to 100 g
Substanțele grase se topesc într-o capsulă emailată la 7O...8O°C pe baie de apă și se solubilizează conservanții în această fază. Apa distilată se încălzește la aceeași temperatură. In 30 g apă distilată, se dizolvă substanțele active și celelalte componente hidrosolubile. Faza grasă se emulsionează cu restul de apă distilată, la un pH de 6,5...7,0 obținându-se prin adăugare de trietanolamină. Când emulsia atingeThe fatty substances are melted in an enamelled capsule at 7O ... 8O ° C in a water bath and the solubility is conserved in this phase. The distilled water is heated to the same temperature. In 30 g of distilled water, dissolve the active substances and the other water-soluble components. The fatty phase is emulsified with the remainder of distilled water, at a pH of 6.5 ... 7.0, obtained by the addition of triethanolamine. When the emulsion touches
35...40°C, se adaugă soluția apoasă cu substanțele active și celelalte componente hidrosolubile dizolvate amestecând continuu, apoi se parfumează sau nu (după caz).35 ... 40 ° C, add the aqueous solution with the active substances and the other water-soluble components dissolved by stirring continuously, then perfume or not (as the case may be).
Produsul obținut este semisolid, cu pH neutru, stabil fizico-chimic și microbiolo70 gic.The product obtained is semi-solid, with neutral pH, physico-chemical stable and microbiolo70 gic.
Exemplul 2.Example 2.
- colagen hidrolizat hidrosolubil 3 g- water-soluble hydrolyzed collagen 3 g
- abietat de trietanol 5 g- Abet of triethanol 5 g
- elastină hidrolizată 0,2 g- hydrolysed elastin 0.2 g
- alcool cetilic 4 g- cetyl alcohol 4 g
- acid stearic 4 g- 4 g stearic acid
- lanolină anhidră 5 g- anhydrous lanolin 5 g
- ceară albă 1 g- 1 g white wax
- ulei de parafină 6 g- Paraffin oil 6 g
- glicerină 3 g- glycerin 3 g
- 1,2-propilenglicol 2 g- 1,2-propylene glycol 2 g
- acid lactic 1 g- lactic acid 1 g
- sorbitol 1 g- sorbitol 1 g
- sulfat de magneziu 0,5 g- magnesium sulfate 0.5 g
- nipagin 0,2 g- 0.2 g nipple
-nipasol 0,1 g-nipasol 0.1 g
- apă distilată până la 100 g- distilled water up to 100 g
Se lucrează ca în exemplul 1.It works as in Example 1.
Produsul obținut are efecte hidratante, emoliente, nutritive, regeneratoare, tonifiante, având asigurată sterilitatea microbiană și fungică.The product obtained has moisturizing, emollient, nourishing, regenerating, invigorating effects, ensuring microbial and fungal sterility.
Stabilitatea emulsiei este asigurată de emulsia U/A obținută prin saponificare. Această stabilitate este explicabilă datorită formării complexelor active între componentele tensioactîve și baza grasă.The stability of the emulsion is ensured by the U / A emulsion obtained by saponification. This stability is explained by the formation of active complexes between the surfactant components and the fat base.
Complexele active, preparate conform invenției, arată variația nuanțată a propietăților complexelor active, obținute sub formă de creme cosmetice și dermatologice, funcție de componenta activă.The active complexes, prepared according to the invention, show the nuanced variation of the properties of the active complexes, obtained in the form of cosmetic and dermatological creams, depending on the active component.
Complex activ cu hidrolizat de colagen - sub formă de cremă cosmetică, emulsie U/A, se formează prin legăturile intramoleculare cu baza grasă de origine naturală sau chiar cu componente inerte cum este parafina, în prezența unui emulgator.Active complex with collagen hydrolyzate - in the form of cosmetic cream, U / A emulsion, is formed by intramolecular connections with the natural base fat or even with inert components such as paraffin, in the presence of an emulsifier.
Prin variația compoziției bazei grase, se obțin creme cosmetice cu propietăți hidratante, nutritive, regeneratoare, emoliente, pentru toate felurile de ten: normal, uscat, gras.By varying the composition of the fat base, cosmetic creams with moisturizing, nourishing, regenerating, emollient properties are obtained for all skin types: normal, dry, oily.
Complex activ colagen hidrolizat - glicozaminoglicani (GAG) asociat unei baze grase adecvate conduce la obținerea unui produs cu calități superioare, antirid, păstrând și proprietățile complexului activ care conține numai hidrolizat de colagen și baza grasă corespunzătoare fiecărui tip de ten.Hydrolyzed active collagen complex - Glycosaminoglycans (GAGs) combined with a suitable fat base leads to obtaining a product with superior qualities, anti-wrinkle, while preserving the properties of the active complex containing only collagen hydrolyzate and the fat base corresponding to each type of skin.
Complex activ colagen hidrolizat - elastina + baza grasă cu proprietăți hidratante superioare pentru regenerarea pielii uscate, cu tendințe de descuamare, reface echilibrul hidrolipidic al epidermei și redă elasticitatea și tonicitatea normală.Hydrolyzed active collagen complex - elastin + fat base with superior moisturizing properties for dry skin regeneration, with flaking tendencies, restores the hydrolipidic balance of the epidermis and restores normal elasticity and tonicity.
Complex activ colagen hidrolizat - vitamine A+E, crema medicinală trofică, epitelizante, cicatrizantă, demonstrează creșterea acțiunii regeneratoare a colagenului asupra pielii prin acțiunea sinergică a vitaminei A, stimulată și protejată prin acțiunea antioxidantă a vitaminei E.Hydrolyzed active collagen complex - vitamins A + E, trophic medicinal cream, epithelizing, healing, demonstrates the increase of the regenerative action of collagen on the skin by the synergistic action of vitamin A, stimulated and protected by the antioxidant action of vitamin E.
Complex activ antiinfecțios colagen hidrolizat - acid abietic sare solubilă cu trietanlamină constituie un produs dermatologic antiinfecțios prin acidul abietic cu proprietăți antimicrobie, antifungice tensioactîve, peliculogene.Hydrolyzed collagen anti-infective active complex - abietic acid soluble salt with triethanolamine is a dermatological anti-infectious product with abietic acid with antimicrobial, surfactant, pelicogenic antifungal properties.
Eficace în toate infecțiile dermatologice bacteriene și fungice este antiseboreic și antiacneic.Effective in all bacterial and fungal dermatological infections is anti-seborrheic and anti-acne.
Simultan, se manifestă și acțiunea specifică colagenului, regeneratoare, hidratantă, care acționează sinergie la refacerea țesutului lezat.At the same time, collagen-specific, regenerating, moisturizing action is also manifested, which acts synergistically in the repair of the damaged tissue.
□in aceste exemple, se observă eficiența crescută a complexelor active obținute cu substanțe naturale. Aceste acțiuni specifice sunt diferite în funcție de substanțele naturale componente.□ In these examples, we observe the increased efficiency of the active complexes obtained with natural substances. These specific actions are different depending on the natural constituent substances.
Rolul deosebit al hidrolizatelor de colagen în formarea complexelor constă în asigurarea biocompatibilității acestora, făcând posibilă pătrunderea lor prin bariera hidrolipidică. De remarcat în mod deosebit acest aspect la complexul antiinfecțios în care componenta activă acidul abietic produs natural de origine vegetală este hidrofobă.The particular role of collagen hydrolyzates in the formation of complexes is to ensure their biocompatibility, making it possible to penetrate them through the hydrolipid barrier. Particularly noteworthy is this aspect in the anti-infectious complex in which the active component naturally occurring abietic acid of plant origin is hydrophobic.
Complexul hidrofil - hidrofob, format în acest caz, contribuie la refacerea barierei hidrolipidice a epidermei.The hydrophilic - hydrophobic complex, formed in this case, contributes to the restoration of the hydrolipidic barrier of the epidermis.
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO9401808A RO114552B1 (en) | 1994-11-08 | 1994-11-08 | Active complex of hydrolized collagen with natural animal and vegetal substances |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO9401808A RO114552B1 (en) | 1994-11-08 | 1994-11-08 | Active complex of hydrolized collagen with natural animal and vegetal substances |
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| Publication Number | Publication Date |
|---|---|
| RO114552B1 true RO114552B1 (en) | 1999-06-30 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO9401808A RO114552B1 (en) | 1994-11-08 | 1994-11-08 | Active complex of hydrolized collagen with natural animal and vegetal substances |
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| Country | Link |
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| RO (1) | RO114552B1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006010606A1 (en) * | 2004-07-28 | 2006-02-02 | Cargill, Incorporated | Physiologically-active composition based on collagen |
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1994
- 1994-11-08 RO RO9401808A patent/RO114552B1/en unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006010606A1 (en) * | 2004-07-28 | 2006-02-02 | Cargill, Incorporated | Physiologically-active composition based on collagen |
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