RO109031B1 - Medicinal composition for dermatomycosis treatment at bull youth - Google Patents
Medicinal composition for dermatomycosis treatment at bull youth Download PDFInfo
- Publication number
- RO109031B1 RO109031B1 RO14413890A RO14413890A RO109031B1 RO 109031 B1 RO109031 B1 RO 109031B1 RO 14413890 A RO14413890 A RO 14413890A RO 14413890 A RO14413890 A RO 14413890A RO 109031 B1 RO109031 B1 RO 109031B1
- Authority
- RO
- Romania
- Prior art keywords
- dermatomycosis
- treatment
- youth
- bull
- medicinal composition
- Prior art date
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- 239000000203 mixture Substances 0.000 title claims abstract description 12
- 208000007163 Dermatomycoses Diseases 0.000 title claims abstract description 11
- 201000003929 dermatomycosis Diseases 0.000 title claims abstract description 10
- 244000309464 bull Species 0.000 title claims description 6
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 claims abstract description 8
- 239000003814 drug Substances 0.000 claims abstract description 7
- 229940079593 drug Drugs 0.000 claims abstract description 7
- 239000000725 suspension Substances 0.000 claims abstract description 6
- 235000015277 pork Nutrition 0.000 claims abstract 2
- 239000002674 ointment Substances 0.000 description 11
- 238000002360 preparation method Methods 0.000 description 4
- 239000013543 active substance Substances 0.000 description 3
- 230000000843 anti-fungal effect Effects 0.000 description 3
- 230000003902 lesion Effects 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 2
- 210000003050 axon Anatomy 0.000 description 2
- 244000309466 calf Species 0.000 description 2
- 239000003995 emulsifying agent Substances 0.000 description 2
- 230000001804 emulsifying effect Effects 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 2
- 210000003491 skin Anatomy 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 235000001674 Agaricus brunnescens Nutrition 0.000 description 1
- 241001057184 Axion Species 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 241000283707 Capra Species 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 206010061217 Infestation Diseases 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 239000004100 Oxytetracycline Substances 0.000 description 1
- 206010039509 Scab Diseases 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 125000003785 benzimidazolyl group Chemical class N1=C(NC2=C1C=CC=C2)* 0.000 description 1
- DVBJBNKEBPCGSY-UHFFFAOYSA-M cetylpyridinium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 DVBJBNKEBPCGSY-UHFFFAOYSA-M 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000001143 conditioned effect Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 229960000890 hydrocortisone Drugs 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- IWVCMVBTMGNXQD-PXOLEDIWSA-N oxytetracycline Chemical compound C1=CC=C2[C@](O)(C)[C@H]3[C@H](O)[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-PXOLEDIWSA-N 0.000 description 1
- 229960000625 oxytetracycline Drugs 0.000 description 1
- 235000019366 oxytetracycline Nutrition 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 238000010079 rubber tapping Methods 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- IWVCMVBTMGNXQD-UHFFFAOYSA-N terramycin dehydrate Natural products C1=CC=C2C(O)(C)C3C(O)C4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-UHFFFAOYSA-N 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Invenția se referă la o compoziție medicamentoasă, pentru tratamentul dermatomicozelor, la tineretul taurin, constituitădin 100 ml suspensie 45% de derivat benzimidazolic, în asociere cu 200 ml soluție sulfat de cupru 20.. .25 % și până la 1000 g axungie tehnică, de porc.The invention relates to a composition drug, for the treatment of dermatomycosis, at the bullfighting youth, consisting of 100 ml 45% suspension of benzimidazolic derivative, in combination with 200 ml copper sulphate solution 20 .. .25% and up to 1000 g of pork.
Description
Invenția de față se referă la o compoziție medicamentoasă, destinată tratamentului dermatomicozelor, îa tineretul taurin, în scop preventiv și de tratament. Dermatomicozele la tineretul taurin, din unități de creștere intensivă, au o incidență de 5,..60%.The present invention relates to a medicinal composition, intended for the treatment of dermatomycosis, for the young bull, for preventive and treatment purposes. Dermatomycoses in young bulls, from intensive care units, have an incidence of 5, 60%.
In scopul tratamentului extern, al dermatomicozelor, la tineretul taurin, este cunoscut un unguent pe bază de sulf și sulfat de cupru, care se aplică pe placardele micotice, din două în două zile, cu vindecări după 2-3 săptămâni - dar care prezintă dezavantajul că necesită decrustizarea cu un bisturiu, a placardelor, are o eficacitate scăzută, datorită rezistenței dobândite de miceți, iar terapia îndelungată este neeconomicoasă.For the purpose of external treatment, dermatomycosis, in young bulls, is known an ointment based on sulfur and copper sulphate, which is applied on mycotic placards, from two to two days, with cures after 2-3 weeks - but which has the disadvantage that it requires the scalpel to be decrusted with a scalpel, has a low efficiency, due to the resistance acquired by the mice, and the prolonged therapy is uneconomical.
Mai sunt, de asemenea, cunoscute unguentul și soluția pe bază de bromură cu cetilpiridină, care s-au scos din uz, datorită unor reacții adverse, ca și un unguent de uz veterinar, constituit din 2...4% oxitetraciclină, 2% hidrocortizon și 5% lidocanină înglobate într-o bază grasă.Also known are the cetylpyridine bromide ointment and solution, which have been discontinued due to adverse reactions, as well as a veterinary ointment, consisting of 2 ... 4% oxytetracycline, 2% hydrocortisone and 5% lidocanin embedded in a fat base.
Se punea problema creării unui preparat medicamentos, cu eficacitate crescută, în tratamentul extern, al dermatomicozelor, cu cheltuieli mai mici, aplicat fără efectuarea decrustizării și care să nu producă efecte secundare, nedorite.The problem was the creation of a drug preparation, with high efficacy, in the external treatment, of the dermatomycosis, with lower costs, applied without performing the decrusting and which does not produce undesirable side effects.
Compoziția medicamentoasă, conform invenției, înlătură dezavantajele preparatelor cunoscute, prin aceea că, în scopul realizării unei acțiuni antimicotiee superioare, este constituită din 100 ml suspensie de derivat benzimidazolic 2,5%, 200 ml soluție sulfat de cupru tehnic 20...25% și până la 1000 g, axungie tehnică.The drug composition, according to the invention, removes the disadvantages of the known preparations, in that, for the purpose of performing a superior antifungal action, it consists of 100 ml suspension of 2.5% benzimidazole derivative, 200 ml of technical copper sulphate solution 20 ... 25% and up to 1000 g, technical axion.
Compoziția medicamentoasă, pentru tratamentul dermatomicozelor, la tineretul taurin, conform invenției, prezintă următoarele avantaje:The drug composition for the treatment of dermatomycosis in young bulls according to the invention has the following advantages:
- conține derivat benzimidazolic, de natură carboguanofenilamidică, cu acțiune puternică antimicotică, substanță neutilizată, până în prezent, în terapia dermatomicozelor la animale: acțiunea acestuia este potențată de cuprul anorganic;- contains a benzimidazolic derivative, of a carboguanophenylamide nature, with strong antifungal action, a substance not used so far in the dermatomycosis therapy in animals: its action is potentiated by inorganic copper;
- ca bază de unguent, folosește axungia tehnică, bine tolerată de piele, care este un produs ieftin, cu o compoziție complexă, în substanțe grase și compuși cu proprietăți emulgatoare; datorită acestora din urmă, sulfatul de cupru este dispersat uniform, în unguent, prin emulsionarea soluției, la fel și suspensia de derivat benzimidazolic;- as a base of ointment, it uses the technical axon, well tolerated by the skin, which is a cheap product, with a complex composition, in fatty substances and compounds with emulsifying properties; due to the latter, copper sulphate is uniformly dispersed in the ointment by emulsifying the solution, as well as the suspension of benzimidazolic derivative;
- substanțele active sunt fin dispersate în unguent și cristalele lor nu produc iritații mecanice: unguentul are aspect omogen, se comportă bine la variații de temperatură: la baza de unguent nu se adaugă emulgatori, axungia conținând emulgatori naturali, de origine animală;- the active substances are finely dispersed in the ointment and their crystals do not produce mechanical irritation: the ointment has a homogeneous appearance, it behaves well at temperature variations: no emulsifiers are added to the base of the ointment, axung containing natural emulsifiers of animal origin;
- se aplică ușor, aderând bine de placardele tricofitice, se topește în momentul aplicării prin fricționare spontană și determinată refacerea epidermei;- it is easily applied, adhering well to the trichophytic cupboards, it melts when applied by spontaneous friction and determined to restore the epidermis;
- dozele nu s-au dovedit toxice, la loturile experimentale, mai mult, prin lingere, are acțiune antimicotică și antihelmitică.- the doses did not prove toxic, in the experimental groups, moreover, by means of licks, it has antifungal and antihelmic action.
In cele ce urmează, se dă un exemplu de realizare a compoziției, conform invenției.In the following, an embodiment of the composition according to the invention is given.
Compoziția medicamentoasă, destinată tratamentului dermatomicozelor, la tineretul taurin, este alcătuită dintr-un amestec format din derivat benzimidazolic, în suspensie 2,5%, cu sulfat de cupru, soluție 20%, care se încorporează în axungia tehnică, fuzionată. Preparatul se omogenizează până la răcire, într-o baie cu apă rece.The drug composition, intended for the treatment of dermatomycosis, in young bullfighters, is composed of a mixture of benzimidazolic derivative, 2.5% in suspension, with copper sulphate, 20% solution, which is incorporated into the technical axon, fused. The mixture is stirred until cooled in a cold water bath.
Stabilirea cantităților de substanțe active, din preparat, s-a realizat prin tatonări, examene, urmărindu-se eficacitatea terapeutică. La vițeii cu dermatomicoze, din unități de producție sau din biobază, s-a apreciat, prin metode semilogice, vindecarea leziunilor tricofitice, în corelație cu numărul de aplicații, iar prin examene culturale și microscopice, tipul de ciuperci și floarea bacteriană de asociație, implicate în patogenia bolii.The determination of the quantities of active substances, from the preparation, was done by tapping, exams, following the therapeutic effectiveness. In the calves with dermatomycosis, from production units or from the biobased, it was appreciated, by semilogical methods, the healing of trichophytic lesions, in correlation with the number of applications, and by cultural and microscopic examinations, the type of mushrooms and the bacterial flower of association, involved in the pathogenesis. disease.
Pentru a obține 1000 g compoziție medicamentoasă, se asociază 100 ml suspensie de derivat benzimidozolic, de concentrație 2,5%, cu o soluție 20...25% de sulfat de cupru tehnic, obținută din 40 g sulfat de cupru dizolvat în 160 ml apă și se condiționează, sub formă de unguent, prin încorporarea substanțelor active și până la 1000 g axungie tehnică topită, omogenizându-se, până la răcire, într-o baie de apă rece.In order to obtain 1000 g of drug composition, 100 ml suspension of benzimidosole derivative, 2.5% concentration, with a 20 ... 25% solution of technical copper sulphate, obtained from 40 g of copper sulphate dissolved in 160 ml, is combined. water and it is conditioned, in the form of an ointment, by incorporating the active substances and up to 1000 g molten technical axonium, mixing, until cooling, in a cold water bath.
Preparatul se aplică extern, manual, operatorul având mănușă de cauciuc sau plastic sau o spatulă de lemn, învelită în tifon. Se fricționează suprafața de piele eu leziuni derinatoinicotice, depășindu-se cu circa 1 cm conturul acesteia. Crustele cad, fără a mai face decrustizarea cu bisturiul, în decurs de 24...48 5The preparation is applied externally, manually, the operator having a rubber or plastic glove or a wooden spatula, wrapped in gauze. The skin surface and derinatoinotic lesions are rubbed, exceeding by about 1 cm its contour. The crusts fall without decrusting with the scalpel, within 24 ... 48 5
h. Aplicarea locală se repetă la interval de 3-4 zile, de 2-5 ori, dependent de gravitatea leziunilor. La o administrare, se folosesch. Local application is repeated every 3-4 days, 2-5 times, depending on the severity of the lesions. In an administration, they are used
50.. .100 g unguent.50 .. .100 g ointment.
Vindecarea completă se produce după 10Complete healing occurs after 10
15.. .20 zile.15 .. .20 days.
Eficacitatea terapeutică este deThe therapeutic efficacy is
90.. .95%, în sezoanele reci și de 95... 100%, în cele calde. Se recomandă asocierea tratamentului cu vitaminoterapie (iarna) și 15 efectuarea dezinfecției.90 .. .95%, in the cold seasons and 95 ... 100%, in the hot ones. It is recommended to combine the treatment with vitamin therapy (in winter) and to perform the disinfection.
In scop profilactic, Ia trecerea vițeilor de la vacile mame, în boxele contaminate, se aplică în zonele tricofitogene (cap, gât, salbă), reducându-se infestația cu 50%. Unguentul se păstrează la rece.For prophylactic purpose, the passage of the calves from the mother cows, in the contaminated boxes, is applied in the trichophytogenic areas (head, neck, goat), reducing the infestation by 50%. The ointment is kept cold.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO14413890A RO109031B1 (en) | 1990-02-12 | 1990-02-12 | Medicinal composition for dermatomycosis treatment at bull youth |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO14413890A RO109031B1 (en) | 1990-02-12 | 1990-02-12 | Medicinal composition for dermatomycosis treatment at bull youth |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RO109031B1 true RO109031B1 (en) | 1994-11-30 |
Family
ID=20126779
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO14413890A RO109031B1 (en) | 1990-02-12 | 1990-02-12 | Medicinal composition for dermatomycosis treatment at bull youth |
Country Status (1)
| Country | Link |
|---|---|
| RO (1) | RO109031B1 (en) |
-
1990
- 1990-02-12 RO RO14413890A patent/RO109031B1/en unknown
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