PT93606A - Processo para a preparacao de novos 4(5)-imidazois que inibem a aromatase - Google Patents
Processo para a preparacao de novos 4(5)-imidazois que inibem a aromataseInfo
- Publication number
- PT93606A PT93606A PT93606A PT9360690A PT93606A PT 93606 A PT93606 A PT 93606A PT 93606 A PT93606 A PT 93606A PT 9360690 A PT9360690 A PT 9360690A PT 93606 A PT93606 A PT 93606A
- Authority
- PT
- Portugal
- Prior art keywords
- bond
- aromatase
- chem
- together form
- imidazoes
- Prior art date
Links
- 102000014654 Aromatase Human genes 0.000 title abstract 3
- 108010078554 Aromatase Proteins 0.000 title abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- 206010006187 Breast cancer Diseases 0.000 abstract 1
- 208000026310 Breast neoplasm Diseases 0.000 abstract 1
- JNCMHMUGTWEVOZ-UHFFFAOYSA-N F[CH]F Chemical compound F[CH]F JNCMHMUGTWEVOZ-UHFFFAOYSA-N 0.000 abstract 1
- 108010081348 HRT1 protein Hairy Proteins 0.000 abstract 1
- 102100021881 Hairy/enhancer-of-split related with YRPW motif protein 1 Human genes 0.000 abstract 1
- 102000004317 Lyases Human genes 0.000 abstract 1
- 108090000856 Lyases Proteins 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229940011871 estrogen Drugs 0.000 abstract 1
- 239000000262 estrogen Substances 0.000 abstract 1
- VUWZPRWSIVNGKG-UHFFFAOYSA-N fluoromethane Chemical compound F[CH2] VUWZPRWSIVNGKG-UHFFFAOYSA-N 0.000 abstract 1
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 1
- 150000002460 imidazoles Chemical class 0.000 abstract 1
- 229940079865 intestinal antiinfectives imidazole derivative Drugs 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Epoxy Resins (AREA)
- Medicines Containing Plant Substances (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Ceramic Products (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8907218A GB2229719B (en) | 1989-03-30 | 1989-03-30 | Novel aromatase inhibiting 4(5)-imidazoles |
| GB8907309A GB2231568B (en) | 1989-03-31 | 1989-03-31 | New aromatase inhibiting 4(5)-imidazoles |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT93606A true PT93606A (pt) | 1990-11-20 |
| PT93606B PT93606B (pt) | 1996-08-30 |
Family
ID=26295152
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT93606A PT93606B (pt) | 1989-03-30 | 1990-03-29 | Processo para a preparacao de novos 4(5)-imidazois que inibem a aromatase |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0390558B1 (pt) |
| JP (1) | JPH032168A (pt) |
| CN (2) | CN1046527A (pt) |
| AT (1) | ATE111084T1 (pt) |
| AU (1) | AU627559B2 (pt) |
| CZ (1) | CZ281611B6 (pt) |
| DE (1) | DE69012184T2 (pt) |
| DK (1) | DK0390558T3 (pt) |
| ES (1) | ES2063260T3 (pt) |
| HU (2) | HU206685B (pt) |
| IE (1) | IE64655B1 (pt) |
| IL (1) | IL93940A (pt) |
| LV (1) | LV11027B (pt) |
| NO (1) | NO172797C (pt) |
| NZ (1) | NZ233127A (pt) |
| PL (1) | PL162513B1 (pt) |
| PT (1) | PT93606B (pt) |
| RU (1) | RU1836354C (pt) |
| UA (1) | UA13471A (pt) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2210875B (en) | 1987-10-09 | 1991-05-29 | Farmos Oy | Aromatase inhibiting 4(5)-imidazoles |
| GB2229719B (en) | 1989-03-30 | 1992-04-29 | Farmos Oy | Novel aromatase inhibiting 4(5)-imidazoles |
| GB2248058B (en) | 1990-09-21 | 1994-09-14 | Orion Yhtymae Oy | Aromatase inhibiting 4(5)-imidazoles |
| GB9125924D0 (en) | 1991-06-18 | 1992-02-05 | Orion Yhtymae Oy | Stereoisomers of an imidazole derivative |
| GB2273704B (en) * | 1992-12-16 | 1997-01-22 | Orion Yhtymae Oy | Triazolyl diaryl selective aromatase inhibiting compounds |
| US7902247B2 (en) * | 2008-01-09 | 2011-03-08 | Allergan, Inc. | Substituted-aryl-2-phenylethyl-1H-imidazole compounds as subtype selective modulators of alpha 2B and/or alpha 2C adrenergic receptors |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2092569B (en) * | 1981-02-05 | 1984-09-19 | Farmos Oy | Substituted imidazole derivatives and their preparation and use |
| GB2110663B (en) * | 1981-12-04 | 1985-08-07 | Farmos Group Ltd | Imidazole derivatives |
| LU85747A1 (fr) * | 1985-01-28 | 1986-08-04 | Continental Pharma | Derives d'imidazole leur preparation et utilisation ainsi que les compositions pharmaceutiques contenant des derives |
| GB2210875B (en) * | 1987-10-09 | 1991-05-29 | Farmos Oy | Aromatase inhibiting 4(5)-imidazoles |
-
1990
- 1990-03-28 JP JP2080548A patent/JPH032168A/ja active Pending
- 1990-03-28 AU AU52325/90A patent/AU627559B2/en not_active Ceased
- 1990-03-29 DK DK90303362.9T patent/DK0390558T3/da active
- 1990-03-29 DE DE69012184T patent/DE69012184T2/de not_active Expired - Fee Related
- 1990-03-29 HU HU914010A patent/HU206685B/hu not_active IP Right Cessation
- 1990-03-29 IL IL9394090A patent/IL93940A/en not_active IP Right Cessation
- 1990-03-29 AT AT90303362T patent/ATE111084T1/de active
- 1990-03-29 CZ CS901555A patent/CZ281611B6/cs unknown
- 1990-03-29 EP EP90303362A patent/EP0390558B1/en not_active Expired - Lifetime
- 1990-03-29 UA UA4895673A patent/UA13471A/uk unknown
- 1990-03-29 HU HU901894A patent/HU205345B/hu not_active IP Right Cessation
- 1990-03-29 PT PT93606A patent/PT93606B/pt not_active IP Right Cessation
- 1990-03-29 NZ NZ233127A patent/NZ233127A/en unknown
- 1990-03-29 ES ES90303362T patent/ES2063260T3/es not_active Expired - Lifetime
- 1990-03-29 IE IE115290A patent/IE64655B1/en not_active IP Right Cessation
- 1990-03-29 NO NO901451A patent/NO172797C/no unknown
- 1990-03-30 PL PL28455290A patent/PL162513B1/pl unknown
- 1990-03-30 CN CN90102676A patent/CN1046527A/zh active Pending
-
1991
- 1991-06-25 RU SU914895673A patent/RU1836354C/ru active
-
1993
- 1993-07-14 CN CN93108897A patent/CN1086812A/zh active Pending
-
1995
- 1995-09-07 LV LVP-95-273A patent/LV11027B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69012184D1 (de) | 1994-10-13 |
| NO901451L (no) | 1990-10-01 |
| AU627559B2 (en) | 1992-08-27 |
| CZ281611B6 (cs) | 1996-11-13 |
| DE69012184T2 (de) | 1995-01-05 |
| NO172797C (no) | 1993-09-08 |
| HU206685B (en) | 1992-12-28 |
| PT93606B (pt) | 1996-08-30 |
| PL284552A1 (en) | 1991-07-29 |
| PL162513B1 (pl) | 1993-12-31 |
| CN1086812A (zh) | 1994-05-18 |
| IL93940A (en) | 1994-10-07 |
| NO172797B (no) | 1993-06-01 |
| RU1836354C (ru) | 1993-08-23 |
| LV11027B (en) | 1996-08-20 |
| ATE111084T1 (de) | 1994-09-15 |
| IL93940A0 (en) | 1990-12-23 |
| JPH032168A (ja) | 1991-01-08 |
| CZ155590A3 (en) | 1996-08-14 |
| CN1046527A (zh) | 1990-10-31 |
| EP0390558A1 (en) | 1990-10-03 |
| NZ233127A (en) | 1991-03-26 |
| LV11027A (lv) | 1996-02-20 |
| ES2063260T3 (es) | 1995-01-01 |
| UA13471A (uk) | 1997-02-28 |
| IE901152L (en) | 1990-09-30 |
| NO901451D0 (no) | 1990-03-29 |
| AU5232590A (en) | 1990-10-04 |
| HUT53357A (en) | 1990-10-28 |
| EP0390558B1 (en) | 1994-09-07 |
| DK0390558T3 (da) | 1994-10-10 |
| HU901894D0 (en) | 1990-08-28 |
| HU205345B (en) | 1992-04-28 |
| IE64655B1 (en) | 1995-08-23 |
| HU914010D0 (en) | 1992-03-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG3A | Patent granted, date of granting |
Effective date: 19960502 |
|
| MM3A | Annulment or lapse |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 19971130 |