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PT92153A - PROCESS FOR THE PREPARATION OF 1,4-DIAZEPINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM - Google Patents

PROCESS FOR THE PREPARATION OF 1,4-DIAZEPINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Info

Publication number
PT92153A
PT92153A PT92153A PT9215389A PT92153A PT 92153 A PT92153 A PT 92153A PT 92153 A PT92153 A PT 92153A PT 9215389 A PT9215389 A PT 9215389A PT 92153 A PT92153 A PT 92153A
Authority
PT
Portugal
Prior art keywords
hydrogen
preparation
pharmaceutical compositions
compositions containing
diazepine derivatives
Prior art date
Application number
PT92153A
Other languages
Portuguese (pt)
Other versions
PT92153B (en
Inventor
Shigeru Souda
Yoshimasa Machida
Kouichi Katayama
Isao Yamatsu
Kazuo Okano
Shuhei Miyazawa
Richard Stephen John Clark
Shinya Abe
Tetsuya Kawahara
Naoyuki Shimomura
Osamu Asano
Hiroyuki Yoshimura
Mitsuaki Miyamoto
Yoshinori Sakuma
Kenzo Muramoto
Hiroshi Obaishi
Koukichi Harada
Hajime Tsunoda
Satoshi Katayama
Kouji Yamada
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Publication of PT92153A publication Critical patent/PT92153A/en
Publication of PT92153B publication Critical patent/PT92153B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

A triazolo-1,4-di-azepine compound of the below given formula and a pharmacologically acceptable salt thereof are disclosed and useful in the pharmaceutical field, especially to allergic diseases.in which R1 and R2 are hydrogen or an alkyl, R3 is hydrogen or a halogen, R4 is hydrogen or an alkyl, X is -OCO-, -NHCO-, -CO- or others and Y is a cycloalkyl, a cycloalkylalkyl, an alkynyl or others.with the proviso that when R₁ is hydrogen then R₂ cannot be methyl.
PT92153A 1988-10-31 1989-10-30 PROCESS FOR THE PREPARATION OF 1,4-DIAZEPINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM PT92153B (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP27546088 1988-10-31
JP29706888 1988-11-24
JP31801688 1988-12-16
JP33162288 1988-12-28

Publications (2)

Publication Number Publication Date
PT92153A true PT92153A (en) 1990-05-31
PT92153B PT92153B (en) 1995-06-30

Family

ID=27479049

Family Applications (1)

Application Number Title Priority Date Filing Date
PT92153A PT92153B (en) 1988-10-31 1989-10-30 PROCESS FOR THE PREPARATION OF 1,4-DIAZEPINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Country Status (15)

Country Link
EP (3) EP0677524B1 (en)
JP (1) JP2756004B2 (en)
KR (1) KR910009332B1 (en)
CN (1) CN1036520C (en)
AT (3) ATE183187T1 (en)
AU (1) AU621413B2 (en)
CA (1) CA2000985C (en)
DE (3) DE68929049T2 (en)
DK (1) DK540689A (en)
FI (1) FI95708C (en)
HU (1) HU217127B (en)
NO (1) NO175259C (en)
NZ (1) NZ231188A (en)
PH (1) PH27461A (en)
PT (1) PT92153B (en)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH30676A (en) * 1986-07-22 1997-09-16 Boehringer Ingelhein Kg Hetrazepine compounds which have useful pharmaceutical utility
GB8907257D0 (en) * 1989-03-31 1989-05-17 Rech Et D Applic Scient Scras New derivatives of hetrazepine as anti-paf and anti-ischemic agents
GB8907256D0 (en) * 1989-03-31 1989-05-17 Rech Et D Applic Scient Scras New derivatives of hetrazepine as anti-asthmatic anti-allergic and gastro-intestinal protectors
AT394563B (en) * 1990-05-09 1992-05-11 Scras METHOD FOR PRODUCING THIENO-TRIAZOLODIAZEPINE DERIVATIVES
DE4027470A1 (en) * 1990-08-30 1992-03-05 Boehringer Ingelheim Kg NEW HETRAZEPINOIDE AMIDE
DE4107521A1 (en) * 1991-03-08 1992-09-10 Boehringer Ingelheim Kg NEW ACYLAMINOSUBSTITUTED HETRAZEPINE
DE69230891T2 (en) * 1991-12-11 2000-10-05 Yoshitomi Pharmaceutical Industries, Ltd. Medicines used to treat autoimmune diseases
TW219935B (en) * 1991-12-25 1994-02-01 Mitsubishi Chemicals Co Ltd
US5639782A (en) * 1992-03-04 1997-06-17 Center For Innovative Technology Neolignan derivatives as platelet activating factor receptor antagonists and 5-lipoxygenase inhibitors
US5530141A (en) * 1992-03-04 1996-06-25 Center For Innovative Technology 2,4-diaryl-1,3-dithiolanes; 2,4-diaryl-1,3-dioxolanes; 2,4-diaryl-1,3-oxathiolanes; and 2,5-diaryl-1,3-oxathiolanes for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase
US5648486A (en) * 1992-07-13 1997-07-15 Cytomed, Inc. Compounds and methods for the treatment of inflammatory and immune disorders
US5463083A (en) * 1992-07-13 1995-10-31 Cytomed, Inc. Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
JPH08502243A (en) 1992-07-13 1996-03-12 サイトメッド，インコーポレイテッド 2,5-Diaryltetrahydro-thiophenes, -furans and analogues for the treatment of inflammatory and immune disorders
US5434151A (en) * 1992-08-24 1995-07-18 Cytomed, Inc. Compounds and methods for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase
US5358938A (en) * 1992-07-13 1994-10-25 Cytomed, Inc. Compounds and methods for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase
ES2061406B1 (en) * 1993-05-07 1995-06-01 Uriach & Cia Sa J NEW DERIVATIVES OF 2- (QUINOLINE) WITH PHARMACOLOGICAL ACTIVITY.
JP2523259B2 (en) * 1993-06-30 1996-08-07 エスオーエンジニアリング株式会社 Glass temperature control method in the forehearth
US5750565A (en) * 1995-05-25 1998-05-12 Cytomed, Inc. Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
US5703093A (en) * 1995-05-31 1997-12-30 Cytomed, Inc. Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
US5792776A (en) * 1994-06-27 1998-08-11 Cytomed, Inc., Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
WO1998058930A1 (en) * 1997-06-25 1998-12-30 Nikken Chemicals Co., Ltd. Triazolo-1,4-diazepine compounds and medicinal composition containing the same
FR2779652B1 (en) * 1998-06-15 2001-06-08 Sod Conseils Rech Applic USE OF DIAZEPINES FOR THE PREPARATION OF MEDICINES FOR THE TREATMENT OF CONDITIONS OR DISEASES IN WHICH ONE OF THE SOMATOSTATIN RECEPTORS IS INVOLVED
SG109000A1 (en) 2003-07-16 2005-02-28 Asml Netherlands Bv Lithographic apparatus and device manufacturing method
US7977336B2 (en) 2006-12-28 2011-07-12 Banyu Pharmaceutical Co. Ltd Aminopyrimidine derivatives as PLK1 inhibitors
AR084070A1 (en) 2010-12-02 2013-04-17 Constellation Pharmaceuticals Inc BROMODOMINIUM INHIBITORS AND USES OF THE SAME
US9249161B2 (en) 2010-12-02 2016-02-02 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
EP2705039B1 (en) 2011-05-04 2017-07-26 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
WO2012174487A2 (en) 2011-06-17 2012-12-20 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
US9624244B2 (en) 2012-06-06 2017-04-18 Constellation Pharmaceuticals, Inc. Benzo [B] isoxazoloazepine bromodomain inhibitors and uses thereof
TWI602820B (en) 2012-06-06 2017-10-21 星宿藥物公司 Bromodomain inhibitors and uses thereof
US10092574B2 (en) 2012-09-26 2018-10-09 Valorisation-Recherche, Limited Partnership Inhibitors of polynucleotide repeat-associated RNA foci and uses thereof
LT3157928T (en) 2014-06-20 2019-05-27 Constellation Pharmaceuticals, Inc. Crystalline forms of 2-((4s)-6-(4-chlorophenyl)-1-methyl-4h-benzo[c]isoxazolo[4,5-e]azepin-4-yl)acetamide

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3435973A1 (en) * 1984-10-01 1986-04-10 Boehringer Ingelheim KG, 6507 Ingelheim PHARMACEUTICAL COMPOSITIONS CONTAINING DIAZEPINE WITH PAF-ANTAGONISTIC EFFECT
DE3502392A1 (en) * 1985-01-25 1986-07-31 Boehringer Ingelheim KG, 6507 Ingelheim NEW THIENO-TRIAZOLO-1,4-DIAZEPINO-2-CARBONIC ACID AMIDES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS
ES2037013T3 (en) 1986-01-21 1993-06-16 Boehringer Ingelheim Kg PROCEDURE FOR PREPARING TIENO-1,4-DIAZEPINES.
DE3724031A1 (en) 1986-07-22 1988-01-28 Boehringer Ingelheim Kg NEW HETRAZEPINES AND METHOD FOR THEIR PRODUCTION
PH30676A (en) 1986-07-22 1997-09-16 Boehringer Ingelhein Kg Hetrazepine compounds which have useful pharmaceutical utility
ES2039408T3 (en) * 1986-11-17 1993-10-01 Yoshitomi Pharmaceutical Industries, Ltd. A PROCEDURE FOR PREPARING A TIENOTRIAZOLODIAZEPINE COMPOUND.
EP0368175A1 (en) * 1988-11-06 1990-05-16 Boehringer Ingelheim Kg 3S,7S-3-(Morpholinocarbonyl)-5-(2-chlorphenyl)-7,10-dimethyl-3,4-dihydro-2H,7H-cyclopenta[4,5]thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine.
GB8911030D0 (en) * 1989-05-13 1989-06-28 Scras Hetrazepine derivatives
EP0407955A1 (en) * 1989-07-12 1991-01-16 Boehringer Ingelheim Kg New hetrazepines acting as PAF antagonists, process for their production and their use as drugs
AT394563B (en) * 1990-05-09 1992-05-11 Scras METHOD FOR PRODUCING THIENO-TRIAZOLODIAZEPINE DERIVATIVES

Also Published As

Publication number Publication date
EP0606103B1 (en) 2003-03-12
DE68929372T2 (en) 2002-10-02
EP0677524A1 (en) 1995-10-18
FI95708B (en) 1995-11-30
EP0677524B1 (en) 2002-02-13
HU895609D0 (en) 1990-01-28
DE68929049D1 (en) 1999-09-16
DK540689D0 (en) 1989-10-30
NO175259B (en) 1994-06-13
FI95708C (en) 1996-03-11
DE68929049T2 (en) 2000-01-27
NO175259C (en) 1994-09-21
CA2000985C (en) 2000-01-18
AU621413B2 (en) 1992-03-12
CN1121076A (en) 1996-04-24
EP0606103A1 (en) 1994-07-13
JPH02256682A (en) 1990-10-17
DE68929372D1 (en) 2002-03-21
KR900006342A (en) 1990-05-08
CN1036520C (en) 1997-11-26
KR910009332B1 (en) 1991-11-11
DE68929455D1 (en) 2003-04-17
NO894287L (en) 1990-05-02
DE68929455T2 (en) 2004-01-08
CA2000985A1 (en) 1990-04-30
EP0367110A1 (en) 1990-05-09
PH27461A (en) 1993-07-09
NO894287D0 (en) 1989-10-27
DK540689A (en) 1990-05-01
ATE213247T1 (en) 2002-02-15
HUT53106A (en) 1990-09-28
ATE183187T1 (en) 1999-08-15
HU217127B (en) 1999-11-29
AU4376189A (en) 1990-05-03
NZ231188A (en) 1991-06-25
JP2756004B2 (en) 1998-05-25
FI894867A0 (en) 1989-10-13
EP0367110B1 (en) 1999-08-11
PT92153B (en) 1995-06-30
ATE234306T1 (en) 2003-03-15

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Legal Events

Date Code Title Description
MM3A Annulment or lapse

Effective date: 20050620