PT90803A - Processo para a preparacao de novos derivados de pirimidina - Google Patents
Processo para a preparacao de novos derivados de pirimidinaInfo
- Publication number
- PT90803A PT90803A PT90803A PT9080389A PT90803A PT 90803 A PT90803 A PT 90803A PT 90803 A PT90803 A PT 90803A PT 9080389 A PT9080389 A PT 9080389A PT 90803 A PT90803 A PT 90803A
- Authority
- PT
- Portugal
- Prior art keywords
- compounds
- chem
- pyrimidine derivatives
- preparing new
- och3
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
- C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE8802173A SE8802173D0 (sv) | 1988-06-10 | 1988-06-10 | Pyrimidine derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT90803A true PT90803A (pt) | 1989-12-29 |
| PT90803B PT90803B (pt) | 1994-10-31 |
Family
ID=20372582
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT90803A PT90803B (pt) | 1988-06-10 | 1989-06-09 | Processo para a preparacao de novos derivados de pirimidina |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US5440040A (pt) |
| EP (2) | EP0357571B1 (pt) |
| JP (1) | JP2851094B2 (pt) |
| KR (1) | KR900701815A (pt) |
| AT (1) | ATE136308T1 (pt) |
| AU (1) | AU637574B2 (pt) |
| CA (1) | CA1339313C (pt) |
| DE (1) | DE68926137T2 (pt) |
| DK (1) | DK291890A (pt) |
| ES (1) | ES2087090T3 (pt) |
| FI (1) | FI94643C (pt) |
| GR (1) | GR3020212T3 (pt) |
| HU (1) | HU211736B (pt) |
| IE (1) | IE62914B1 (pt) |
| MY (1) | MY109743A (pt) |
| NO (1) | NO175981C (pt) |
| PH (1) | PH27219A (pt) |
| PT (1) | PT90803B (pt) |
| SE (1) | SE8802173D0 (pt) |
| WO (1) | WO1989012061A1 (pt) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5159067A (en) * | 1987-01-28 | 1992-10-27 | University Of Georgia Research Foundation Inc. | 5'-Diphosphohexose nucleoside pharmaceutical compositions |
| SE8802173D0 (sv) * | 1988-06-10 | 1988-06-10 | Astra Ab | Pyrimidine derivatives |
| US5688778A (en) * | 1989-05-15 | 1997-11-18 | Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic | Nucleoside analogs |
| CA2297294C (en) * | 1989-05-15 | 2005-11-08 | Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic | Phosphonomethoxymethylpurine/pyrimidine derivatives |
| US5118672A (en) * | 1989-07-10 | 1992-06-02 | University Of Georgia Research Foundation | 5'-diphosphohexose nucleoside pharmaceutical compositions |
| FR2656867A1 (fr) * | 1990-01-09 | 1991-07-12 | Centre Nat Rech Scient | Nouveau derives de la thymidine, leur preparation et les compositions qui les contiennent. |
| CA2039403A1 (en) * | 1990-04-04 | 1991-10-05 | Gerald Saischek | Process for the manufacture of 2-deoxy-d-threo-pentofuranosides, intermediates for their manufacture and their use |
| US5128458A (en) * | 1990-04-20 | 1992-07-07 | Southern Research Institute | 2',3'-dideoxy-4'-thioribonucleosides as antiviral agents |
| ZA914894B (en) * | 1990-07-02 | 1992-04-29 | Squibb & Sons Inc | Purinyl and pyrimidinyl tetrahydrofurans |
| EP0477454A1 (en) * | 1990-09-28 | 1992-04-01 | Merrell Dow Pharmaceuticals Inc. | Novel phosphonate derivatives of certain nucleosides |
| SE9003151D0 (sv) * | 1990-10-02 | 1990-10-02 | Medivir Ab | Nucleoside derivatives |
| US5672697A (en) * | 1991-02-08 | 1997-09-30 | Gilead Sciences, Inc. | Nucleoside 5'-methylene phosphonates |
| DE4110977A1 (de) * | 1991-04-05 | 1992-10-08 | Bayer Ag | Substituierte 2',3'-didesoxy-5-trifluormethyluridine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
| US6235887B1 (en) | 1991-11-26 | 2001-05-22 | Isis Pharmaceuticals, Inc. | Enhanced triple-helix and double-helix formation directed by oligonucleotides containing modified pyrimidines |
| TW393513B (en) * | 1991-11-26 | 2000-06-11 | Isis Pharmaceuticals Inc | Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines |
| CA2122365C (en) * | 1991-11-26 | 2010-05-11 | Brian Froehler | Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines |
| WO1994001125A1 (en) * | 1992-07-13 | 1994-01-20 | Sherman Kenneth E | Composition and method of treating hepatitis b |
| US6200952B1 (en) * | 1993-06-02 | 2001-03-13 | Sciclone Pharmaceuticals, Inc. | Combination therapy method for treating chronic hepatitis B |
| US5502177A (en) * | 1993-09-17 | 1996-03-26 | Gilead Sciences, Inc. | Pyrimidine derivatives for labeled binding partners |
| US6432924B1 (en) | 1993-12-26 | 2002-08-13 | East Carolina University | Method of treating disorders characterized by overexpression of cytidine deaminase or deoxycytidine deaminase |
| JPH10501809A (ja) * | 1994-06-22 | 1998-02-17 | ネクスター ファーマスーティカルズ，インコーポレイテッド | 分子内求核置換による公知および新規２′−ヌクレオシドの新規製造方法 |
| DE4430401A1 (de) * | 1994-08-26 | 1996-02-29 | Chemprosa Holding Ag | D-Xylofuranose-Derivate, Verfahren zu deren Herstellung, deren Verwendung und neue Zwischenverbindungen für das Verfahren |
| CA2241255A1 (en) * | 1995-12-22 | 1997-07-03 | East Carolina University | Method of treating disorders characterized by overexpression of cytidine deaminase or deoxycytidine deaminase |
| US5747526A (en) * | 1996-01-25 | 1998-05-05 | Hollinshead; Ariel C. | Anti-HIV /Aids Chemo(C)-, immuno(I)-, or ci-therapy using tur (or related compounds) and/or NVA (or EPV) |
| US5869493A (en) | 1996-02-16 | 1999-02-09 | Medivir Ab | Acyclic nucleoside derivatives |
| JP3613424B2 (ja) * | 1996-09-27 | 2005-01-26 | 財団法人国際超電導産業技術研究センター | 酸化物超電導体の製造方法 |
| EP2256133B1 (en) | 1997-01-08 | 2016-12-14 | Sigma-Aldrich Co. LLC | Bioconjugation of macromolecules |
| US7427678B2 (en) * | 1998-01-08 | 2008-09-23 | Sigma-Aldrich Co. | Method for immobilizing oligonucleotides employing the cycloaddition bioconjugation method |
| US6090602A (en) * | 1998-02-18 | 2000-07-18 | Promelas Research Corporation | Levo-monosaccharide in a nucleoside analog for use as an anti-retroviral agent |
| IL138037A0 (en) | 1998-02-25 | 2001-10-31 | Univ Emory | 2'-fluoronucleosides |
| DE60013957T2 (de) | 1999-05-26 | 2006-02-23 | F. Hoffmann-La Roche Ag | Verfahren zur Herstellung von Vinylpyrimidinderivaten |
| KR101005299B1 (ko) | 2000-10-18 | 2011-01-04 | 파마셋 인코포레이티드 | 바이러스 감염 및 비정상적인 세포 증식의 치료를 위한 변형된 뉴클레오시드 |
| JP2005503358A (ja) | 2001-06-22 | 2005-02-03 | フアーマセツト・リミテツド | β−２’−または３’−ハロヌクレオシド |
| US7098326B2 (en) * | 2002-01-23 | 2006-08-29 | Sigma-Aldrich Co. | Methods for the integrated synthesis and purification of oligonucleotides |
| AU2003217863B9 (en) | 2002-02-28 | 2009-10-29 | Biota Scientific Management Pty Ltd | Nucleotide mimics and their prodrugs |
| US7615629B2 (en) * | 2002-12-31 | 2009-11-10 | Sigma-Aldrich Co. | Methods and compositions for the tandem synthesis of two or more oligonucleotides on the same solid support |
| US7262214B2 (en) | 2003-02-26 | 2007-08-28 | Merial Limited | 1-N-arylpyrazole derivatives in prevention of arthropod-borne and mosquito-borne diseases |
| US7531186B2 (en) * | 2003-12-17 | 2009-05-12 | Merial Limited | Topical formulations comprising 1-N-arylpyrazole derivatives and amitraz |
| ES2327252T3 (es) | 2004-08-23 | 2009-10-27 | F. Hoffmann-La Roche Ag | 4'-azido nucleosidos antivirales. |
| WO2006076102A2 (en) * | 2004-12-10 | 2006-07-20 | The Regents Of The University Of California | Fluorescent nucleoside analogs that mimic naturally occurring nucleosides |
| US8895531B2 (en) | 2006-03-23 | 2014-11-25 | Rfs Pharma Llc | 2′-fluoronucleoside phosphonates as antiviral agents |
| WO2007122634A2 (en) * | 2006-04-24 | 2007-11-01 | Jubilant Biosys Limited | Pyrimidinediones as tyrosine kinase inhibitors |
| NZ573758A (en) * | 2006-07-05 | 2012-01-12 | Aventis Agriculture | 1-Phenyl-3-cyano-pyrazole derivatives and pesticidal formulations containing them |
| EP2084175B1 (en) | 2006-10-10 | 2010-12-29 | Medivir AB | Hcv nucleoside inhibitor |
| US7947447B2 (en) | 2007-01-16 | 2011-05-24 | Somalogic, Inc. | Method for generating aptamers with improved off-rates |
| US8404830B2 (en) * | 2007-07-17 | 2013-03-26 | Somalogic, Inc. | Method for generating aptamers with improved off-rates |
| GB0815968D0 (en) * | 2008-09-03 | 2008-10-08 | Angeletti P Ist Richerche Bio | Antiviral agents |
| KR101660068B1 (ko) | 2008-11-19 | 2016-09-26 | 메리얼 인코포레이티드 | 기생충 감염 치료를 위한 1-아릴피라졸 단독 또는 포름아미딘과의 조합을 포함하는 조성물 |
| KR101246911B1 (ko) * | 2009-11-02 | 2013-03-25 | 한국화학연구원 | 신규한 2,4-피리미딘 유도체 및 이의 용도 |
| WO2011075592A1 (en) | 2009-12-17 | 2011-06-23 | Merial Limited | Compositions comprising macrocyclic lactone compounds and spirodioxepinoindoles |
| UA108641C2 (uk) | 2010-04-02 | 2015-05-25 | Паразитицидна композиція, яка містить чотири активних агенти, та спосіб її застосування | |
| EP2558586B1 (en) | 2010-04-12 | 2016-10-12 | Somalogic, Inc. | APTAMERS TO ß-NGF AND THEIR USE IN TREATING ß-NGF MEDIATED DISEASES AND DISORDERS |
| CA2855954C (en) | 2011-11-17 | 2020-09-01 | Merial Limited | Compositions comprising an aryl pyrazole and a substituted imidazole, methods and uses thereof. |
| JO3626B1 (ar) | 2012-02-23 | 2020-08-27 | Merial Inc | تركيبات موضعية تحتوي على فيبرونيل و بيرميثرين و طرق استخدامها |
| TWI579274B (zh) | 2012-04-20 | 2017-04-21 | 龍馬躍公司 | 製備１－芳基－５－烷基吡唑化合物的改良方法 |
| BR112016010165A2 (pt) | 2013-11-21 | 2017-12-05 | Somalogic Inc | composições de nucleotídeos modificados de citidina-5-carboxamida e métodos relacionados às mesmas |
| ES2887302T3 (es) | 2014-10-31 | 2021-12-22 | Boehringer Ingelheim Animal Health Usa Inc | Composiciones parasiticidas que comprenden fipronil |
| CN104892706A (zh) * | 2015-04-27 | 2015-09-09 | 河南师范大学 | 具有抗寄生虫活性的异噁唑-核苷杂化体及其制备方法和应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2721466A1 (de) * | 1977-05-12 | 1978-11-16 | Robugen Gmbh | Verfahren zur herstellung von 2'-desoxyribofuranosylnucleosiden |
| JPS54112880A (en) * | 1978-02-21 | 1979-09-04 | Matsura Teruo | Novel uracil derivative and its manufacture |
| US4211773A (en) * | 1978-10-02 | 1980-07-08 | Sloan Kettering Institute For Cancer Research | 5-Substituted 1-(2'-Deoxy-2'-substituted-β-D-arabinofuranosyl)pyrimidine nucleosides |
| AU575918B2 (en) * | 1984-03-06 | 1988-08-11 | Sloan-Kettering Institute For Cancer Research | Hepatitis treatment with pyrimidine nucleoside compounds |
| US4666892A (en) * | 1984-03-06 | 1987-05-19 | Sloan-Kettering Memorial Cancer Center | Method and composition for hepatitis treatment with pyrimidine nucleoside compounds |
| SE8605503D0 (sv) * | 1986-12-19 | 1986-12-19 | Astra Laekemedel Ab | Novel medicinal use |
| SE8802173D0 (sv) * | 1988-06-10 | 1988-06-10 | Astra Ab | Pyrimidine derivatives |
-
1988
- 1988-06-10 SE SE8802173A patent/SE8802173D0/xx unknown
-
1989
- 1989-06-06 CA CA000601897A patent/CA1339313C/en not_active Expired - Fee Related
- 1989-06-07 AU AU37504/89A patent/AU637574B2/en not_active Ceased
- 1989-06-07 WO PCT/SE1989/000322 patent/WO1989012061A1/en not_active Ceased
- 1989-06-07 KR KR1019900700287A patent/KR900701815A/ko not_active Withdrawn
- 1989-06-07 DE DE68926137T patent/DE68926137T2/de not_active Expired - Fee Related
- 1989-06-07 US US07/613,900 patent/US5440040A/en not_active Expired - Fee Related
- 1989-06-07 ES ES89850184T patent/ES2087090T3/es not_active Expired - Lifetime
- 1989-06-07 AT AT89850184T patent/ATE136308T1/de not_active IP Right Cessation
- 1989-06-07 JP JP1506227A patent/JP2851094B2/ja not_active Expired - Lifetime
- 1989-06-07 HU HU894340A patent/HU211736B/hu not_active IP Right Cessation
- 1989-06-07 EP EP89850184A patent/EP0357571B1/en not_active Expired - Lifetime
- 1989-06-07 EP EP95113626A patent/EP0691333A2/en not_active Withdrawn
- 1989-06-09 PH PH38770A patent/PH27219A/en unknown
- 1989-06-09 PT PT90803A patent/PT90803B/pt not_active IP Right Cessation
- 1989-06-09 MY MYPI89000776A patent/MY109743A/en unknown
- 1989-06-12 IE IE181689A patent/IE62914B1/en not_active IP Right Cessation
-
1990
- 1990-12-07 NO NO905300A patent/NO175981C/no not_active IP Right Cessation
- 1990-12-07 FI FI906053A patent/FI94643C/fi not_active IP Right Cessation
- 1990-12-07 DK DK291890A patent/DK291890A/da not_active Application Discontinuation
-
1995
- 1995-02-28 US US08/395,877 patent/US5576429A/en not_active Expired - Lifetime
-
1996
- 1996-06-12 GR GR960401591T patent/GR3020212T3/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PT90803A (pt) | Processo para a preparacao de novos derivados de pirimidina | |
| PT97888A (pt) | Processo para a preparacao de compostos heterociclicos derivados de indol e de composicoes farmaceuticas que os contem | |
| PT89769B (pt) | Processo para a preparacao de derivados do acido 3-alcenil-1-azabiciclo-{3,2,0}hept-2-eno-2-carboxilico | |
| DK436081A (da) | Substituerede acyl-derivater af 1,2,3,4-tetrahydroisoquinolin-3-carboxylsyrer og farmaceutisk acceptable salte deraf fremgangsmaade til deres fremstilling og deres anvendelse | |
| PT90478A (pt) | Processo para a preparacao de derivados da purina e de composicoes farmaceuticas que os contem | |
| PT83843B (pt) | Processo para a preparacao de promedicamentos de rapamicina | |
| ES2196004T3 (es) | Procedimiento para preparar 1,3-oxatiolanos sustituidos con propiedades antivirales. | |
| PT92540A (pt) | Processo para a preparacao de derivados de anfotericina b | |
| HUT53522A (en) | Process for producing pharmaceutical compositions comprising purine derivatives | |
| PT89098A (pt) | Processo para a preparacao de derivados de guanina | |
| DE69519895D1 (de) | Pyrimidinderivate und pharmazeutische Zusammensetzungen | |
| PT98186A (pt) | Processo para a preparacao de purinil- e de pirimidinil-tetra-hidrofuranos e de composicoes farmaceuticas que os contem | |
| ES537850A0 (es) | Un procedimiento para producir los antibioticos x-14889 a, b, c y d | |
| ATE29133T1 (de) | Troponon-derivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzung. | |
| ES453869A1 (es) | Procedimiento para la produccion de una preparacion terapeu-tica antitrombotica. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG3A | Patent granted, date of granting |
Effective date: 19940420 |
|
| MM3A | Annulment or lapse |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 20001031 |