PT87191A - Process for the preparation of nucleosides - Google Patents

Process for the preparation of nucleosides

Info

Publication number: PT87191A
Authority: PT; Portugal
Prior art keywords: nucleosides; preparation
Prior art date: 1987-04-09

Application number

PT87191A

Other languages

English (en)

Other versions

PT87191B (pt

Inventor

George Walter Koszalka

Thomas Anthony Krenitsky

Janet Litster Ridecut

Charlene Louise Burns

Original Assignee

Wellcome Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-04-09

Filing date

1988-04-08

Publication date

1988-05-01

1987-04-09 Priority claimed from GB878708512A external-priority patent/GB8708512D0/en

1987-05-29 Priority claimed from GB878712691A external-priority patent/GB8712691D0/en

1987-09-30 Priority claimed from GB878723013A external-priority patent/GB8723013D0/en

1988-04-08 Application filed by Wellcome Found filed Critical Wellcome Found

1988-05-01 Publication of PT87191A publication Critical patent/PT87191A/pt

1993-02-26 Publication of PT87191B publication Critical patent/PT87191B/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Immunology (AREA)
Veterinary Medicine (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

PT87191A 1987-04-09 1988-04-08 Processo para a preparacao de nucleosidos PT87191B (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB878708512A GB8708512D0 (en)	1987-04-09	1987-04-09	Therapeutic nucleosides
GB878712691A GB8712691D0 (en)	1987-05-29	1987-05-29	Therapeutic nucleosides
GB878723013A GB8723013D0 (en)	1987-09-30	1987-09-30	Therapeutic nucleosides

Publications (2)

Publication Number	Publication Date
PT87191A true PT87191A (pt)	1988-05-01
PT87191B PT87191B (pt)	1993-02-26

Family

ID=27263377

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT87191A PT87191B (pt)	1987-04-09	1988-04-08	Processo para a preparacao de nucleosidos

Country Status (20)

Country	Link
US (1)	US5068320A (pt)
EP (1)	EP0286425B1 (pt)
JP (1)	JP2763888B2 (pt)
KR (1)	KR880012630A (pt)
AP (1)	AP78A (pt)
AT (1)	ATE116984T1 (pt)
AU (1)	AU608590B2 (pt)
CA (1)	CA1326237C (pt)
CS (1)	CS274461B2 (pt)
DE (1)	DE3852710T2 (pt)
DK (1)	DK191688A (pt)
FI (1)	FI87214C (pt)
HU (1)	HU201954B (pt)
IL (1)	IL86007A0 (pt)
MC (1)	MC1915A1 (pt)
NO (1)	NO171641C (pt)
NZ (1)	NZ224189A (pt)
PL (1)	PL154956B1 (pt)
PT (1)	PT87191B (pt)
RU (1)	RU1779256C (pt)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL86007A0 (en) *	1987-04-09	1988-09-30	Wellcome Found	6-substituted purine nucleosides,their preparation and pharmaceutical compositions containing them
US5185437A (en) *	1987-04-09	1993-02-09	Burroughs Wellcome Co.	Therapeutic nucleosides
US5077280A (en) *	1988-04-12	1991-12-31	Brown University Research Foundation	Treatment of viral infections
IE882585L (en) *	1988-08-25	1990-02-25	Prendergast Patrick T	Viral treatment system
EP0366385B1 (en) *	1988-10-24	1993-06-09	The Wellcome Foundation Limited	Guanine derivatives having antiviral activity and their pharmaceutically acceptable salts
AU4817490A (en) *	1988-11-29	1990-06-26	Institut Fur Molekularbiologie Und Analytik (Ima) G.M.B.H.	2',3'-dideoxyribofuranosides and process for producing them
JP2619710B2 (ja) *	1989-02-27	1997-06-11	日本製紙株式会社	２′，３′−ジデオキシプリンヌクレオシド類の製造方法
US5585364A (en) *	1989-04-13	1996-12-17	British Technology Group Limited	Antiviral compounds
US5013829A (en) *	1989-04-26	1991-05-07	University Of Iowa Research Foundation	Stable congener of 2',3'-dideoxyadenosine
DE4020529A1 (de) *	1989-09-12	1991-03-21	Roxana Vasiloiu	Multifunktionelle(s) enzym(e) mit nucleosid-didesoxyribosyltransferase(n) und/oder nucleoside-desoxyribosyltransferasen(n) und/oder kinease- und/oder reduktase- und/oder desaminase- und/oder polymerase-aktivitaet
JPH0637391B2 (ja) *	1989-09-29	1994-05-18	日本製紙株式会社	抗エイズウイルス剤
PT95516A (pt) *	1989-10-06	1991-08-14	Wellcome Found	Processo para a preparacao de derivados de 2',3'-didesoxi nucleosidos 6-substituidos
CA2075490A1 (en) *	1990-02-09	1991-08-10	Hiroaki Mitsuya	6-halo-and 2-amino-6-halo-purine 2',3'-dideoxy nucleosides and their use as antiviral agents
US5654286A (en) *	1993-05-12	1997-08-05	Hostetler; Karl Y.	Nucleotides for topical treatment of psoriasis, and methods for using same
OA11741A (en) *	1998-12-23	2005-05-13	Iaf Biochem Int	Antiviral nucleoside analogues.
CN101220071B (zh) *	2008-01-17	2011-04-06	南京长澳医药科技有限公司	稳定的6-甲氧基-2’,3’-双脱氧鸟嘌呤核苷及其制备方法和包含它的药物组合物
CN102234280B (zh) *	2010-04-26	2014-01-08	北京大学	D,l-鸟嘌呤核苷类似物及其制备方法和应用
CA2810928A1 (en)	2010-09-22	2012-03-29	Alios Biopharma, Inc.	Substituted nucleotide analogs
AU2012262021B2 (en) *	2011-06-01	2016-07-28	Janus Biotherapeutics, Inc.	Novel immune system modulators
CA2860234A1 (en)	2011-12-22	2013-06-27	Alios Biopharma, Inc.	Substituted phosphorothioate nucleotide analogs
HK1206362A1 (zh)	2012-03-21	2016-01-08	Alios Biopharma, Inc.	硫代氨基磷酸酯核苷酸前藥的固體形式
US9012427B2 (en)	2012-03-22	2015-04-21	Alios Biopharma, Inc.	Pharmaceutical combinations comprising a thionucleotide analog
JP2016513621A (ja) *	2013-03-05	2016-05-16	エフ．ホフマン−ラロシュアーゲーＦ．Ｈｏｆｆｍａｎｎ−ＬａＲｏｃｈｅＡｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ	ブルトンチロシンキナーゼの阻害剤

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1573777A (en) *	1977-11-03	1980-08-28	Wellcome Found	9-d-arabinonucleosides and an enzymatic process for their preparation
US4724232A (en) *	1985-03-16	1988-02-09	Burroughs Wellcome Co.	Treatment of human viral infections
MC1742A1 (fr) *	1985-03-16	1987-02-26	Wellcome Found	Procede pour preparer un derive de 3'-azido-3'desoxythymigline et procede pour preparer une formulation pharmaceutique le contenant
HU196607B (en) *	1985-05-15	1988-12-28	Wellcome Found	Process for producing dideoxy-nucleosides and pharmaceutics comprising such compounds
AU570855B2 (en) *	1985-08-26	1988-03-24	United States of America, as represented by the Secretary, U.S. Department of Commerce, The	Inhibition of in vitro infectivity and cytopathic effect of htlv-111/lav by 2' 3' -dideoxycytidine
ATE190064T1 (de) *	1985-09-17	2000-03-15	Wellcome Found	Kombination therapeutische nukleoside mit weiteren therapeutisch wirksamen komponenten.
IT1203558B (it) *	1986-05-20	1989-02-15	Firestone Int Dev Spa	Metodo per la realizzazione di un pneumatico radiale di prima fase per veicoli
EP0342203B1 (en) *	1987-03-24	1994-07-06	Nycomed Imaging As	2',3' dideoxyribofuranoxide derivatives
IL86007A0 (en) *	1987-04-09	1988-09-30	Wellcome Found	6-substituted purine nucleosides,their preparation and pharmaceutical compositions containing them
NZ225447A (en) *	1987-07-20	1991-12-23	Merck & Co Inc	Piperazinyl derivatives of purine and purine isosteres and pharmaceutical compositions

1988
- 1988-04-07 IL IL86007A patent/IL86007A0/xx unknown
- 1988-04-08 AT AT88303158T patent/ATE116984T1/de not_active IP Right Cessation
- 1988-04-08 FI FI881651A patent/FI87214C/fi not_active IP Right Cessation
- 1988-04-08 RU SU884355537A patent/RU1779256C/ru active
- 1988-04-08 PT PT87191A patent/PT87191B/pt active IP Right Grant
- 1988-04-08 AP APAP/P/1988/000086A patent/AP78A/en active
- 1988-04-08 EP EP88303158A patent/EP0286425B1/en not_active Expired - Lifetime
- 1988-04-08 JP JP63087034A patent/JP2763888B2/ja not_active Expired - Lifetime
- 1988-04-08 NO NO881537A patent/NO171641C/no unknown
- 1988-04-08 CS CS242188A patent/CS274461B2/cs unknown
- 1988-04-08 KR KR1019880003964A patent/KR880012630A/ko not_active Ceased
- 1988-04-08 NZ NZ224189A patent/NZ224189A/xx unknown
- 1988-04-08 DK DK191688A patent/DK191688A/da not_active Application Discontinuation
- 1988-04-08 AU AU14444/88A patent/AU608590B2/en not_active Ceased
- 1988-04-08 PL PL1988271722A patent/PL154956B1/pl unknown
- 1988-04-08 HU HU881784A patent/HU201954B/hu not_active IP Right Cessation
- 1988-04-08 DE DE3852710T patent/DE3852710T2/de not_active Expired - Fee Related
- 1988-04-08 MC MC881970A patent/MC1915A1/fr unknown
- 1988-04-08 CA CA000563634A patent/CA1326237C/en not_active Expired - Fee Related
1989
- 1989-10-06 US US07/417,989 patent/US5068320A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
FI881651A0 (fi)	1988-04-08
EP0286425A3 (en)	1990-12-05
FI87214B (fi)	1992-08-31
EP0286425B1 (en)	1995-01-11
CS242188A2 (en)	1990-09-12
IL86007A0 (en)	1988-09-30
HUT48269A (en)	1989-05-29
JPS63267796A (ja)	1988-11-04
DK191688D0 (da)	1988-04-08
DE3852710T2 (de)	1995-05-24
CA1326237C (en)	1994-01-18
DK191688A (da)	1988-10-10
NO171641C (no)	1993-04-14
AU1444488A (en)	1988-10-13
ATE116984T1 (de)	1995-01-15
NO881537D0 (no)	1988-04-08
HU201954B (en)	1991-01-28
MC1915A1 (fr)	1989-04-06
RU1779256C (ru)	1992-11-30
PL154956B1 (en)	1991-10-31
FI87214C (fi)	1992-12-10
AP78A (en)	1990-03-12
AP8800086A0 (en)	1988-02-01
FI881651L (fi)	1988-10-10
NZ224189A (en)	1991-09-25
AU608590B2 (en)	1991-04-11
NO171641B (no)	1993-01-04
NO881537L (no)	1988-10-10
JP2763888B2 (ja)	1998-06-11
CS274461B2 (en)	1991-04-11
US5068320A (en)	1991-11-26
EP0286425A2 (en)	1988-10-12
KR880012630A (ko)	1988-11-28
PT87191B (pt)	1993-02-26
PL271722A1 (en)	1989-01-23
DE3852710D1 (de)	1995-02-23

Publication	Publication Date	Title
PT86875A (pt)	1988-04-01	Process for the preparation of phenylcarbamate
FI875660L (fi)	1987-12-22	Menetelmä terapeuttisesti käyttökelpoisten 5-fenyyli-2-pyrimidinonijohdannaisten valmistamiseksi
FI875024A7 (fi)	1988-05-15	Menetelmä terapeuttisesti käyttökelpoisten 1-alkyyli-6-halogeenitetrahydronaftaleenijohdannaisten valmistamiseksi
FI900087A0 (fi)	1990-01-08	Menetelmä atsitromysiinidihydraatin valmistamiseksi
PT87191A (pt)	1988-05-01	Process for the preparation of nucleosides
PT86800A (pt)	1988-03-01	Process for the preparation of erythromycin derivatives
FI893100L (fi)	1989-06-26	Analogiamenetelmä asyylideoksiribonukleosidijohdannaisten valmistamiseksi
PT86660A (pt)	1988-02-01	Process for preparing adenosine 5:-carboxamide derivatives
FI895417A0 (fi)	1989-11-14	Menetelmä uusien terapeuttisesti käyttökelpoisten 2'-halometylideeninukleosidien valmistamiseksi
FI881303A0 (fi)	1988-03-18	Menetelmä ibuprofeenin valmistamiseksi
PT87153A (pt)	1988-05-01	Process for the preparation of acid ribofuranuronic derivatives
FI906408L (fi)	1991-06-29	Menetelmä terapeuttisesti käyttökelpoisten 2-aminopyrimidiini-4-karboksamidijohdannaisten valmistamiseksi
FI91961C (fi)	1994-09-12	Menetelmä (S)- -etyyli-2-okso-1-pyrrolidiiniasetamidin valmistamiseksi
FI880467A0 (fi)	1988-02-02	Menetelmä terapeuttisesti käyttökelpoisten substituoitujen 3,4-dihydro-2H-bentsopyraanien valmistamiseksi
PT87854A (pt)	1988-07-01	Process for the preparation of thio-urea derivatives
FI890186A7 (fi)	1989-07-16	Menetelmä 1-hydroksialkyyli-5-nitroimidatsolien valmistamiseksi
FI882165A7 (fi)	1988-11-16	Menetelmä 4-amino-androsteenidioni-johdannaisten valmistamiseksi.
FI890185A7 (fi)	1989-07-16	Menetelmä 1-alkyyli-5-nitroimidatsolien valmistamiseksi
FR2599369B1 (fr)	1989-03-31	Procede de preparation de disilylmethanes
FR2626883B1 (fr)	1991-02-22	Procede de preparation de n-phosphonomethyl-imino-diacetique
ES2022952B3 (es)	1991-12-16	Proceso para la preparacion de naftacenos
PT87643A (pt)	1988-07-01	Process for the preparation of pyran compounds
PT87359A (pt)	1989-05-31	Process for the preparation of pyrrolidine derivatives
PT87705A (pt)	1988-07-01	Process for the preparation of 6-deoxy guanine derivative
FI890188A7 (fi)	1989-07-16	Menetelmä 1-hydroksialkyyli-2-metyyli-5-nitroimidatsolien valmistamiseksi

Legal Events

Date	Code	Title	Description
1993-02-26	FG3A	Patent granted, date of granting	Effective date: 19920806