PT836648E - Virus mva recombinante e sua utilizacao - Google Patents
Virus mva recombinante e sua utilizacaoInfo
- Publication number
- PT836648E PT836648E PT96925654T PT96925654T PT836648E PT 836648 E PT836648 E PT 836648E PT 96925654 T PT96925654 T PT 96925654T PT 96925654 T PT96925654 T PT 96925654T PT 836648 E PT836648 E PT 836648E
- Authority
- PT
- Portugal
- Prior art keywords
- recombinant mva
- utilization
- viruses
- mva viruses
- recombinant
- Prior art date
Links
- 241000700605 Viruses Species 0.000 abstract 1
- 230000037430 deletion Effects 0.000 abstract 1
- 238000012217 deletion Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000001415 gene therapy Methods 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
- 239000013603 viral vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0091—Purification or manufacturing processes for gene therapy compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0055—Oxidoreductases (1.) acting on diphenols and related substances as donors (1.10)
- C12N9/0057—Oxidoreductases (1.) acting on diphenols and related substances as donors (1.10) with oxygen as acceptor (1.10.3)
- C12N9/0059—Catechol oxidase (1.10.3.1), i.e. tyrosinase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1241—Nucleotidyltransferases (2.7.7)
- C12N9/1247—DNA-directed RNA polymerase (2.7.7.6)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24141—Use of virus, viral particle or viral elements as a vector
- C12N2710/24143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16311—Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
- C12N2740/16322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Manufacturing & Machinery (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pulmonology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK78295 | 1995-07-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT836648E true PT836648E (pt) | 2003-09-30 |
Family
ID=8097499
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT96925654T PT836648E (pt) | 1995-07-04 | 1996-07-03 | Virus mva recombinante e sua utilizacao |
Country Status (26)
| Country | Link |
|---|---|
| US (6) | US6440422B1 (pt) |
| EP (3) | EP1312678B1 (pt) |
| JP (3) | JP4312260B2 (pt) |
| KR (1) | KR19990028617A (pt) |
| CN (3) | CN1782071A (pt) |
| AT (3) | ATE239796T1 (pt) |
| AU (1) | AU721735B2 (pt) |
| BR (1) | BR9609303B8 (pt) |
| CA (3) | CA2608864C (pt) |
| CZ (1) | CZ292460B6 (pt) |
| DE (3) | DE69628011T2 (pt) |
| DK (3) | DK0836648T3 (pt) |
| EE (3) | EE04753B1 (pt) |
| ES (3) | ES2199294T3 (pt) |
| HU (2) | HU229261B1 (pt) |
| IL (5) | IL122120A (pt) |
| MX (1) | MX9800025A (pt) |
| NO (1) | NO322476B1 (pt) |
| NZ (1) | NZ313597A (pt) |
| PL (1) | PL186857B1 (pt) |
| PT (1) | PT836648E (pt) |
| RU (1) | RU2198217C2 (pt) |
| SI (3) | SI1312679T1 (pt) |
| TW (2) | TW575664B (pt) |
| UA (3) | UA68327C2 (pt) |
| WO (1) | WO1997002355A1 (pt) |
Families Citing this family (124)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA68327C2 (en) * | 1995-07-04 | 2004-08-16 | Gsf Forschungszentrum Fur Unwe | A recombinant mva virus, an isolated eukaryotic cell, infected with recombinant mva virus, a method for production in vitro of polypeptides with use of said cell, a method for production in vitro of virus parts (variants), vaccine containing the recombinant mva virus, a method for immunization of animals |
| US7118754B1 (en) * | 1996-07-30 | 2006-10-10 | Transgene S.A. | Pharmaceutical composition for treating papillomavirus tumors and infection |
| WO1998013500A2 (en) * | 1996-09-24 | 1998-04-02 | Bavarian Nordic Research Institute A/S | Recombinant mva virus expressing dengue virus antigens, and the use thereof in vaccines |
| MY119381A (en) * | 1996-12-24 | 2005-05-31 | Gsf Forschungszentrum Umwelt | Recombinant mva virus, and the use thereof |
| US6969609B1 (en) * | 1998-12-09 | 2005-11-29 | The United States Of America As Represented By The Department Of Health And Human Serivces | Recombinant vector expressing multiple costimulatory molecules and uses thereof |
| FR2784997A1 (fr) * | 1998-10-22 | 2000-04-28 | Transgene Sa | Materiel biologique pour la preparation de compositions pharmaceutiques destinees au traitement de mammiferes |
| US20040265324A1 (en) * | 1999-03-23 | 2004-12-30 | Cardosa Mary Jane | Recombinant MVA virus expressing dengue virus antigens, and the use thereof in vaccines |
| AU5397100A (en) * | 1999-05-28 | 2000-12-18 | Gsf - Forschungszentrum Fur Umwelt Und Gesundheit Gmbh | Vector for integration of heterologous sequences into poxviral genomes |
| US20150231227A1 (en) * | 2000-03-02 | 2015-08-20 | Emory University | Compositions and methods for generating an immune response |
| DE60113512T2 (de) | 2000-03-14 | 2006-06-22 | Bavarian Nordic A/S | Veränderter stamm des modifizierten vaccinia-virus ankara (mva) |
| RU2217162C2 (ru) * | 2000-04-10 | 2003-11-27 | Государственный научный центр вирусологии и биотехнологии "Вектор" | Вакцина против вирусных инфекций |
| DE10042598A1 (de) * | 2000-08-30 | 2002-03-28 | Gsf Forschungszentrum Umwelt | Rekombinantes MVA mit der Fähigkeit zur Expression des HER-2/Neu-GENS |
| AU2002211654A1 (en) * | 2000-10-10 | 2002-04-22 | Genstar Therapeutics | Minimal adenoviral vector and recombinant vaccines based thereon |
| US7445924B2 (en) | 2000-11-23 | 2008-11-04 | Bavarian Nordic A/S | Modified Vaccinia Ankara virus variant and cultivation method |
| BRPI0115533B8 (pt) | 2000-11-23 | 2021-05-25 | Bavarian Nordic As | variação do vírus vaccinia ankara modificado |
| US7628980B2 (en) | 2000-11-23 | 2009-12-08 | Bavarian Nordic A/S | Modified vaccinia virus ankara for the vaccination of neonates |
| US7740863B2 (en) | 2001-04-06 | 2010-06-22 | Merial | Recombinant vaccine against West Nile Virus |
| DE10143490C2 (de) * | 2001-09-05 | 2003-12-11 | Gsf Forschungszentrum Umwelt | Rekombinantes MVA mit der Fähigkeit zur Expression von HCV Struktur-Antigenen |
| DE10144664B4 (de) * | 2001-09-11 | 2005-06-09 | GSF-Forschungszentrum für Umwelt und Gesundheit GmbH | Vacciniavirus MVA-E3L-Knock-Out-Mutanten und Verwendung hiervon |
| CN1602316A (zh) | 2001-12-04 | 2005-03-30 | 巴法里安诺迪克有限公司 | 黄病毒ns1亚单位疫苗 |
| HU227507B1 (hu) * | 2001-12-20 | 2011-07-28 | Bavarian Nordic As | Eljárás poxvírusok kinyerésére és tisztítására fertõzött sejtekbõl |
| JP4801880B2 (ja) | 2002-04-19 | 2011-10-26 | バヴァリアン・ノルディック・アクティーゼルスカブ | 新生仔予防接種用変異ワクシニアウイルスアンカラ |
| EP1404852B1 (en) * | 2002-05-16 | 2005-12-21 | Bavarian Nordic A/S | Expression of genes in modified vaccinia virus ankara by using the cowpox ati promoter |
| US7501127B2 (en) | 2002-05-16 | 2009-03-10 | Bavarian Nordic A/S | Intergenic regions as novel sites for insertion of HIV DNA sequences in the genome of Modified Vaccinia virus Ankara |
| US7550147B2 (en) | 2002-05-16 | 2009-06-23 | Bavarian Nordic A/S | Intergenic regions as insertion sites in the genome of modified vaccinia virus ankara (MVA) |
| PL215169B1 (pl) | 2002-09-05 | 2013-10-31 | Bavarian Nordic As | Sposób amplifikacji wirusów, kompozycja zawierajaca pokswirusa uzyskanego tym sposobem oraz jego zastosowanie do otrzymywania szczepionki |
| DE10249390A1 (de) * | 2002-10-23 | 2004-05-13 | Ruprecht-Karls-Universität Heidelberg | Rekombinante MVA-Stämme als potentielle Impfstoffe gegen P.falciparum-Malaria |
| EP1567653B1 (en) | 2002-11-25 | 2007-06-20 | Bavarian Nordic A/S | Recombinant poxvirus comprising at least two cowpox ati promoters |
| ATE403005T1 (de) * | 2003-02-18 | 2008-08-15 | Helmholtz Zentrum Muenchen | Rekombinantes mva und verfahren zur erzeugung davon |
| EP2363493B1 (en) * | 2003-02-20 | 2012-11-14 | The Government of the United States of America, as represented by the Secretary, Department of Health and Human Services | Novel insertion sites in pox vectors |
| US7731974B2 (en) * | 2003-03-27 | 2010-06-08 | Ottawa Hospital Research Institute | Mutant vesicular stomatitis viruses and uses thereof |
| ATE417115T1 (de) | 2003-03-27 | 2008-12-15 | Ottawa Health Research Inst | Mutante vesicular stomatitis viren und deren verwendungen |
| WO2004093905A1 (en) * | 2003-04-16 | 2004-11-04 | City Of Hope | Human cytomegalovirus antigens expressed in mva and methods of use |
| GB2402391A (en) * | 2003-06-04 | 2004-12-08 | Oxxon Pharmaccines Ltd | Fowlpox recombinant genome |
| DK1648931T3 (da) | 2003-07-21 | 2011-03-07 | Transgene Sa | Multifunktionelle cytokiner |
| WO2005017208A1 (en) * | 2003-07-31 | 2005-02-24 | George Mason Intellectual Properties, Inc. | Compositions and methods for treating or preventing hiv infection |
| EP1518932A1 (en) | 2003-09-29 | 2005-03-30 | GSF-Forschungszentrum für Umwelt und Gesundheit GmbH | Modified vaccinia virus Ankara (MVA) mutant and use thereof |
| DK1536015T3 (da) * | 2003-11-24 | 2008-02-18 | Bavarian Nordic As | Promotorer til ekspression i modificeret vacciniavirus Ankara |
| EP1710300A4 (en) | 2003-12-05 | 2007-10-24 | Hokkaido Tech Licensing Office | HIGHLY SAFE POX VACCINE VIRUS AND VACCINIA VIRUS VECTOR |
| EP1683870A1 (en) * | 2005-01-24 | 2006-07-26 | GSF-Forschungszentrum für Umwelt und Gesundheit GmbH | Vaccines based on the use of MVA |
| WO2006113927A2 (en) * | 2005-04-20 | 2006-10-26 | University Of Washington | Immunogenic vaccinia peptides and methods of using same |
| EP2023954B1 (en) * | 2006-05-19 | 2013-07-17 | Sanofi Pasteur, Inc. | Immunological composition |
| EP2029756B1 (en) * | 2006-06-20 | 2016-11-09 | Transgene S.A. | Process for producing poxviruses and poxvirus compositions |
| WO2008076157A2 (en) * | 2006-09-08 | 2008-06-26 | Duke University | Modified vaccinia ankara virus vaccine |
| US8481023B2 (en) | 2006-09-15 | 2013-07-09 | Ottawa Hospital Research Institute | Oncolytic rhabdovirus |
| DK2073837T3 (da) | 2006-10-06 | 2014-09-29 | Bavarian Nordic Inc | Rekombinant modificeret vaccinia-ankara-virus, der koder for et her-2-antigen, i kombination med en taxan til anvendelse til behandling af cancer |
| US20080241139A1 (en) * | 2006-10-31 | 2008-10-02 | Regents Of The University Of Colorado | Adjuvant combinations comprising a microbial tlr agonist, a cd40 or 4-1bb agonist, and optionally an antigen and the use thereof for inducing a synergistic enhancement in cellular immunity |
| EP2117558A4 (en) * | 2007-01-26 | 2013-04-03 | Univ Colorado | METHOD FOR MODULATING THE IMMUNO FUNCTION |
| EP2152736B1 (en) | 2007-05-03 | 2017-07-05 | Lysomab GmbH | Complement factor h-derived short consensus repeat-antibody constructs |
| CA2676149C (en) * | 2007-05-14 | 2016-06-21 | Bavarian Nordic A/S | Purification of vaccinia virus- and recombinant vaccinia virus-based vaccines |
| US8003363B2 (en) * | 2007-05-14 | 2011-08-23 | Bavarian Nordic A/S | Purification of vaccinia virus- and recombinant vaccinia virus-based vaccines |
| US8003364B2 (en) | 2007-05-14 | 2011-08-23 | Bavarian Nordic A/S | Purification of vaccinia viruses using hydrophobic interaction chromatography |
| US20100285050A1 (en) * | 2007-10-05 | 2010-11-11 | Isis Innovation Limited | Compositions and Methods |
| BRPI0800485B8 (pt) * | 2008-01-17 | 2021-05-25 | Univ Minas Gerais | vetores virais recombinantes, composição vacinal para leishmaniose e método de vacinação para leishmaniose |
| JP2011511640A (ja) | 2008-02-12 | 2011-04-14 | サノフィ パストゥール リミテッド | ポックス・ウイルスの精製方法 |
| WO2009152969A1 (en) * | 2008-06-20 | 2009-12-23 | Bavarian Nordic A/S | Recombinant modified vaccinia virus measles vaccine |
| US8691502B2 (en) | 2008-10-31 | 2014-04-08 | Tremrx, Inc. | T-cell vaccination with viral vectors via mechanical epidermal disruption |
| WO2010127115A1 (en) | 2009-04-30 | 2010-11-04 | Centre Hospitalier Universitaire Vaudois Lausanne (Chuv) | Modified immunization vectors |
| RU2555346C2 (ru) * | 2009-08-07 | 2015-07-10 | Трансген Са | Композиция для лечения инфекции вирусом гепатита в |
| JP5798124B2 (ja) * | 2009-11-20 | 2015-10-21 | タケダ ワクチン, インコーポレイテッドTakeda Vaccines, Inc. | ワクチン構築物におけるポックスウイルスエレメントに関する免疫原性組成物 |
| US9005632B2 (en) | 2009-11-20 | 2015-04-14 | Takeda Vaccines, Inc. | Compositions, methods and uses for poxvirus elements in vaccine constructs against influenza virus subtypes or strains |
| AU2011230619C1 (en) | 2010-03-25 | 2016-06-23 | Oregon Health & Science University | CMV glycoproteins and recombinant vectors |
| GB201006405D0 (en) | 2010-04-16 | 2010-06-02 | Isis Innovation | Poxvirus expression system |
| US20110262965A1 (en) * | 2010-04-23 | 2011-10-27 | Life Technologies Corporation | Cell culture medium comprising small peptides |
| WO2012101509A2 (en) | 2011-01-28 | 2012-08-02 | Sanofi Pasteur Sa | Immunological compositions against hiv |
| WO2012151272A2 (en) | 2011-05-02 | 2012-11-08 | Tremrx, Inc. | T-cell vaccination with viral vectors via mechanical epidermal disruption |
| HRP20180607T1 (hr) | 2011-06-10 | 2019-04-05 | Oregon Health & Science University | Glikoproteini i rekombinantni vektori cmv |
| KR102022952B1 (ko) * | 2011-08-05 | 2019-09-20 | 신라젠(주) | 백시니아 바이러스의 생산을 위한 방법 및 조성물 |
| CA2789539A1 (en) | 2011-09-12 | 2013-03-12 | International Aids Vaccine Initiative | Immunoselection of recombinant vesicular stomatitis virus expressing hiv-1 proteins by broadly neutralizing antibodies |
| ES2683820T3 (es) * | 2011-09-26 | 2018-09-28 | Theravectys | Uso de proteínas GAG no de subtipo B para encapsidación lentiviral |
| US9402894B2 (en) | 2011-10-27 | 2016-08-02 | International Aids Vaccine Initiative | Viral particles derived from an enveloped virus |
| WO2013083254A1 (en) | 2011-12-09 | 2013-06-13 | Bavarian Nordic A/S | Poxvirus vector for the expression of bacterial antigens linked to tetanus toxin fragment c |
| EP2620446A1 (en) | 2012-01-27 | 2013-07-31 | Laboratorios Del Dr. Esteve, S.A. | Immunogens for HIV vaccination |
| EP2679596B1 (en) | 2012-06-27 | 2017-04-12 | International Aids Vaccine Initiative | HIV-1 env glycoprotein variant |
| EA029492B1 (ru) | 2012-07-10 | 2018-04-30 | Трансген Са | Вакцина на основе микобактериальных антигенов |
| WO2014009433A1 (en) | 2012-07-10 | 2014-01-16 | Transgene Sa | Mycobacterium resuscitation promoting factor for use as adjuvant |
| WO2014043535A1 (en) | 2012-09-14 | 2014-03-20 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Compositions for the treatment of cancer |
| WO2014066443A1 (en) | 2012-10-23 | 2014-05-01 | Emory University | Gm-csf and il-4 conjugates, compositions, and methods related thereto |
| US20140286981A1 (en) * | 2013-03-14 | 2014-09-25 | Wisconsin Alumni Research Foundation | Broadly reactive mosaic peptide for influenza vaccine |
| DE102013004595A1 (de) | 2013-03-15 | 2014-09-18 | Emergent Product Development Germany Gmbh | RSV-Impfstoffe |
| EP2848937A1 (en) | 2013-09-05 | 2015-03-18 | International Aids Vaccine Initiative | Methods of identifying novel HIV-1 immunogens |
| EP2873423B1 (en) | 2013-10-07 | 2017-05-31 | International Aids Vaccine Initiative | Soluble hiv-1 envelope glycoprotein trimers |
| WO2015104380A1 (en) | 2014-01-09 | 2015-07-16 | Transgene Sa | Fusion of heterooligomeric mycobacterial antigens |
| GB201412494D0 (en) | 2014-07-14 | 2014-08-27 | Ospedale San Raffaele And Fond Telethon | Vector production |
| EP3868398A1 (en) | 2014-09-26 | 2021-08-25 | Beth Israel Deaconess Medical Center, Inc. | Methods and compositions for inducing protective immunity against human immunodeficiency virus infection |
| EP3244919A4 (en) | 2015-01-12 | 2018-06-27 | Geovax, Inc. | Compositions and methods for generating an immune response to a hemorrhagic fever virus |
| WO2016128542A1 (en) | 2015-02-13 | 2016-08-18 | Transgene Sa | Immunotherapeutic vaccine and antibody combination therapy |
| WO2016131945A1 (en) | 2015-02-20 | 2016-08-25 | Transgene Sa | Combination product with autophagy modulator |
| EP3069730A3 (en) | 2015-03-20 | 2017-03-15 | International Aids Vaccine Initiative | Soluble hiv-1 envelope glycoprotein trimers |
| EP3072901A1 (en) | 2015-03-23 | 2016-09-28 | International Aids Vaccine Initiative | Soluble hiv-1 envelope glycoprotein trimers |
| MA44059B1 (fr) | 2015-12-15 | 2019-11-29 | Janssen Vaccines & Prevention Bv | Antigènes du virus de l'immunodéficience humaine, vecteurs, compositions, et leurs procédés d'utilisation |
| AU2017206102C1 (en) * | 2016-01-08 | 2022-02-10 | Geovax Inc. | Compositions and methods for generating an immune response to a tumor associated antigen |
| BR112018015696A2 (pt) | 2016-02-03 | 2018-12-26 | Geovax Inc | composições e métodos para gerar uma resposta imune para um flavivírus |
| BR112018016948A2 (pt) * | 2016-02-25 | 2019-01-08 | Memorial Sloan Kettering Cancer Center | mva recombinante ou mva¿e3l que expressa flt3l humano e uso do mesmo como agente imunoterapêutico contra tumores sólidos |
| EP3452081A1 (en) | 2016-05-04 | 2019-03-13 | Transgene SA | Combination therapy with cpg tlr9 ligand |
| CA3027454A1 (en) | 2016-06-16 | 2017-12-21 | Janssen Vaccines & Prevention B.V. | Hiv vaccine formulation |
| CA3035759A1 (en) | 2016-09-02 | 2018-03-08 | Janssen Vaccines & Prevention B.V. | Methods for inducing an immune response against human immunodeficiency virus infection in subjects undergoing antiretroviral treatment |
| LT3512543T (lt) | 2016-09-15 | 2020-11-10 | Janssen Vaccines & Prevention B.V. | Trimerą stabilizuojančios živ apvalkalo baltymo mutacijos |
| WO2018069316A2 (en) | 2016-10-10 | 2018-04-19 | Transgene Sa | Immunotherapeutic product and mdsc modulator combination therapy |
| BR112019026126A2 (pt) | 2017-06-15 | 2020-06-30 | Janssen Vaccines & Prevention B.V. | vetores de poxvírus que codificam antígenos do hiv e métodos de uso dos mesmos |
| CA3067405A1 (en) | 2017-06-21 | 2018-12-27 | Transgene Sa | Personalized vaccine comprising a recombinant poxvirus expressing a fusioin of nepopeptides |
| KR20200031655A (ko) | 2017-07-19 | 2020-03-24 | 얀센 백신스 앤드 프리벤션 비.브이. | 삼량체를 안정화하는 hiv 엔벨로프 단백질 돌연변이 |
| US20190022212A1 (en) | 2017-07-21 | 2019-01-24 | Beth Israel Deaconess Medical Center, Inc. | Methods for safe induction of cross-clade immunity against human immunodeficiency virus infection in human |
| US20190083620A1 (en) | 2017-09-18 | 2019-03-21 | Janssen Vaccines & Prevention B.V. | Methods for inducing an immune response against human immunodeficiency virus infection in subjects undergoing antiretroviral treatment |
| US11311612B2 (en) | 2017-09-19 | 2022-04-26 | Geovax, Inc. | Compositions and methods for generating an immune response to treat or prevent malaria |
| CA3081436A1 (en) | 2017-10-31 | 2019-05-09 | Western Oncolytics Ltd. | Platform oncolytic vector for systemic delivery |
| WO2020051766A1 (zh) | 2018-09-11 | 2020-03-19 | 上海市公共卫生临床中心 | 一种广谱抗流感疫苗免疫原及其应用 |
| TW202110476A (zh) | 2019-05-22 | 2021-03-16 | 荷蘭商傑森疫苗防護公司 | 於接受抗反轉錄病毒治療之個體中誘發抗人類免疫缺乏病毒感染之免疫反應的方法 |
| WO2021076998A1 (en) * | 2019-10-16 | 2021-04-22 | KaliVir Immunotherapeutics LLC | Producer viruses for generation of retroviruses in situ |
| CN116322757A (zh) | 2019-11-14 | 2023-06-23 | 埃利克斯疗法公司 | 用于疫苗的剂量方案 |
| EP3842065A1 (en) | 2019-12-23 | 2021-06-30 | Transgene | Process for designing a recombinant poxvirus for a therapeutic vaccine |
| EP3928789A1 (en) | 2020-06-24 | 2021-12-29 | Consejo Superior de Investigaciones Científicas (CSIC) | Mva-based vaccine against covid-19 expressing sars-cov-2 antigens |
| WO2021260065A1 (en) | 2020-06-24 | 2021-12-30 | Consejo Superior De Investigaciones Científicas (Csic) | Mva-based vaccine against covid-19 expressing sars-cov-2 antigens |
| CA3197371A1 (en) | 2020-11-19 | 2022-05-27 | Kalivir Immunotherapeutics, Inc. | Oncolytic immunotherapy by tumor micro-environment remodeling |
| PE20250454A1 (es) | 2021-04-30 | 2025-02-19 | Kalivir Immunotherapeutics Inc | Virus oncoliticos para la expresion modificada del mhc |
| EP4108257A1 (en) | 2021-06-23 | 2022-12-28 | Consejo Superior De Investigaciones Científicas | Mva-based vaccine against covid-19 expressing a prefusion-stabilized sars-cov-2 s protein |
| EP4358999A1 (en) | 2021-06-23 | 2024-05-01 | Consejo Superior De Investigaciones Científicas | Mva-based vaccine expressing a prefusion-stabilized sars-cov-2 s protein |
| WO2023077147A2 (en) | 2021-11-01 | 2023-05-04 | Pellis Therapeutics, Inc. | T-cell vaccines for patients with reduced humoral immunity |
| WO2023213763A1 (en) | 2022-05-02 | 2023-11-09 | Transgene | Poxvirus encoding a binding agent comprising an anti- pd-l1 sdab |
| WO2023213764A1 (en) | 2022-05-02 | 2023-11-09 | Transgene | Fusion polypeptide comprising an anti-pd-l1 sdab and a member of the tnfsf |
| WO2023220283A1 (en) | 2022-05-12 | 2023-11-16 | Pellis Therapeutics, Inc. | Poxvirus adjuvant for t-cell vaccination |
| EP4316514A1 (en) | 2022-08-03 | 2024-02-07 | Consejo Superior de Investigaciones Científicas (CSIC) | Mva-based vectors and their use as vaccine against sars-cov-2 |
| IL322666A (en) | 2023-03-17 | 2025-10-01 | Helmholtz Zentrum M?Nchen Deutsches Forschungszentrum F?R Gesundheit Und Umwelt Gmbh | A preparation containing HBV antigen for the treatment of hepatitis B |
| WO2025172435A1 (en) | 2024-02-13 | 2025-08-21 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Hbv antigen formulation for treating hepatitis b |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE787901A (fr) | 1971-09-11 | 1972-12-18 | Freistaat Bayern Represente Pa | Vaccin antivariolique |
| AU570940B2 (en) | 1982-11-30 | 1988-03-31 | United States of America, as represented by the Secretary, U.S. Department of Commerce, The | Process for producing poxvirus recombinants for expression offoreign genes |
| US5679511A (en) * | 1986-10-06 | 1997-10-21 | Donald Guthrie Foundation For Medical Research, Inc. | CDNA clones for a regulatory protein in the melanin-production pathway |
| CA1341245C (en) * | 1988-01-12 | 2001-06-05 | F. Hoffmann-La Roche Ag | Recombinant vaccinia virus mva |
| US5221610A (en) * | 1988-05-26 | 1993-06-22 | Institut Pasteur | Diagnostic method and composition for early detection of HIV infection |
| CN1042564A (zh) * | 1988-11-11 | 1990-05-30 | 中国科学院上海生物化学研究所 | 乙肝疫苗的制备方法及其制品 |
| JPH03271233A (ja) | 1990-03-19 | 1991-12-03 | Inst Pasteur | ウイルスエンベロープ糖タンパク質及びその糖タンパク質の中和エピトープに対応するペプチドの間の相乗作用による、ウイルス性感染に対する防御の誘発 |
| CA2122263A1 (en) * | 1991-10-28 | 1993-05-13 | Marc Girard | Induction of protection against viral infection by synergy between virus envelope glycoprotein and peptides corresponding to neutralization epitopes of the glycoprotein |
| DE69331813T4 (de) * | 1992-12-22 | 2003-07-10 | Ludwig Institute For Cancer Research, New York | Verfahren zur Detektion und Behandlung von Individuen mit abnormal hla-a2/tyrosinase-peptidantigenen exprimierenden Zellen |
| US5620886A (en) * | 1993-03-18 | 1997-04-15 | Ludwig Institute For Cancer Research | Isolated nucleic acid sequence coding for a tumor rejection antigen precursor processed to at least one tumor rejection antigen presented by HLA-A2 |
| WO1995011255A1 (en) * | 1993-10-19 | 1995-04-27 | Ajinomoto Co., Inc. | Peptide capable of inducing immune response against hiv and aids preventive or remedy containing the peptide |
| US5676950A (en) * | 1994-10-28 | 1997-10-14 | University Of Florida | Enterically administered recombinant poxvirus vaccines |
| UA68327C2 (en) * | 1995-07-04 | 2004-08-16 | Gsf Forschungszentrum Fur Unwe | A recombinant mva virus, an isolated eukaryotic cell, infected with recombinant mva virus, a method for production in vitro of polypeptides with use of said cell, a method for production in vitro of virus parts (variants), vaccine containing the recombinant mva virus, a method for immunization of animals |
-
1996
- 1996-03-07 UA UA97126424A patent/UA68327C2/uk unknown
- 1996-07-03 DK DK96925654T patent/DK0836648T3/da active
- 1996-07-03 HU HU0402350A patent/HU229261B1/hu unknown
- 1996-07-03 EP EP03001378A patent/EP1312678B1/en not_active Expired - Lifetime
- 1996-07-03 JP JP50482497A patent/JP4312260B2/ja not_active Expired - Lifetime
- 1996-07-03 CN CNA2005101248556A patent/CN1782071A/zh active Pending
- 1996-07-03 ES ES96925654T patent/ES2199294T3/es not_active Expired - Lifetime
- 1996-07-03 HU HU9802217A patent/HU224061B1/hu active IP Right Grant
- 1996-07-03 DE DE69628011T patent/DE69628011T2/de not_active Expired - Lifetime
- 1996-07-03 EP EP03001379A patent/EP1312679B8/en not_active Expired - Lifetime
- 1996-07-03 SI SI9630719T patent/SI1312679T1/sl unknown
- 1996-07-03 UA UA20031212890A patent/UA75410C2/uk unknown
- 1996-07-03 ES ES03001379T patent/ES2249648T3/es not_active Expired - Lifetime
- 1996-07-03 EE EEP200300332A patent/EE04753B1/xx unknown
- 1996-07-03 DE DE69635172T patent/DE69635172T2/de not_active Expired - Lifetime
- 1996-07-03 DK DK03001379T patent/DK1312679T3/da active
- 1996-07-03 CZ CZ19974241A patent/CZ292460B6/cs not_active IP Right Cessation
- 1996-07-03 IL IL12212096A patent/IL122120A/xx not_active IP Right Cessation
- 1996-07-03 NZ NZ313597A patent/NZ313597A/xx not_active IP Right Cessation
- 1996-07-03 RU RU98101904/13A patent/RU2198217C2/ru active
- 1996-07-03 AT AT96925654T patent/ATE239796T1/de active
- 1996-07-03 AU AU66110/96A patent/AU721735B2/en not_active Expired
- 1996-07-03 CN CN2004100367144A patent/CN1554764B/zh not_active Expired - Lifetime
- 1996-07-03 AT AT03001378T patent/ATE304057T1/de active
- 1996-07-03 EP EP96925654A patent/EP0836648B1/en not_active Expired - Lifetime
- 1996-07-03 PT PT96925654T patent/PT836648E/pt unknown
- 1996-07-03 EE EE9700344A patent/EE04199B1/xx unknown
- 1996-07-03 CA CA2608864A patent/CA2608864C/en not_active Expired - Lifetime
- 1996-07-03 SI SI9630623T patent/SI0836648T1/xx unknown
- 1996-07-03 DE DE69635173T patent/DE69635173T2/de not_active Expired - Lifetime
- 1996-07-03 MX MX9800025A patent/MX9800025A/es unknown
- 1996-07-03 KR KR1019970709939A patent/KR19990028617A/ko not_active Ceased
- 1996-07-03 UA UA20031212892A patent/UA75411C2/uk unknown
- 1996-07-03 ES ES03001378T patent/ES2249647T3/es not_active Expired - Lifetime
- 1996-07-03 CA CA002225278A patent/CA2225278C/en not_active Expired - Lifetime
- 1996-07-03 DK DK03001378T patent/DK1312678T3/da active
- 1996-07-03 CA CA2596274A patent/CA2596274C/en not_active Expired - Lifetime
- 1996-07-03 SI SI9630718T patent/SI1312678T1/sl unknown
- 1996-07-03 PL PL96324347A patent/PL186857B1/pl unknown
- 1996-07-03 CN CNB961952547A patent/CN1154742C/zh not_active Expired - Lifetime
- 1996-07-03 BR BRPI9609303-0B8A patent/BR9609303B8/pt active IP Right Grant
- 1996-07-03 WO PCT/EP1996/002926 patent/WO1997002355A1/en not_active Ceased
- 1996-07-03 EE EEP200300331A patent/EE05138B1/xx unknown
- 1996-07-03 AT AT03001379T patent/ATE304058T1/de active
- 1996-12-31 TW TW085116379A patent/TW575664B/zh not_active IP Right Cessation
- 1996-12-31 TW TW092116681A patent/TWI245075B/zh not_active IP Right Cessation
-
1998
- 1998-01-02 NO NO19980026A patent/NO322476B1/no not_active IP Right Cessation
- 1998-01-02 US US09/002,443 patent/US6440422B1/en not_active Expired - Lifetime
-
2002
- 2002-05-15 US US10/147,284 patent/US7198934B2/en not_active Expired - Fee Related
-
2004
- 2004-09-28 IL IL164318A patent/IL164318A/en not_active IP Right Cessation
-
2006
- 2006-09-19 US US11/523,004 patent/US20070071769A1/en not_active Abandoned
- 2006-09-19 US US11/522,889 patent/US8153138B2/en not_active Expired - Fee Related
- 2006-09-19 US US11/523,030 patent/US20070071770A1/en not_active Abandoned
-
2007
- 2007-03-12 JP JP2007062630A patent/JP4764366B2/ja not_active Expired - Lifetime
- 2007-03-12 JP JP2007062631A patent/JP4764367B2/ja not_active Expired - Lifetime
-
2009
- 2009-12-01 IL IL202448A patent/IL202448A0/en unknown
-
2010
- 2010-06-14 US US12/814,602 patent/US8197825B2/en not_active Expired - Fee Related
-
2011
- 2011-05-17 IL IL212933A patent/IL212933A0/en unknown
-
2012
- 2012-05-02 IL IL219528A patent/IL219528A0/en unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PT836648E (pt) | Virus mva recombinante e sua utilizacao | |
| DE69332831T2 (de) | Rekombinanter schweinepocken-virus | |
| FI973309A0 (fi) | Menetelmä yhdistelmä-DNA-adenovirusgenomin valmistamiseksi | |
| NZ333975A (en) | Recombinant swinepox virus | |
| FR2702152B1 (fr) | Virus recombinants et leur utilisation en thérapie génique. | |
| HUP9802587A2 (hu) | Glükózzal indukálható rekombináns virális vektor, ezt tartalmazó gyógyszerkészítmény és ezzel transzformált sejtek | |
| MY134484A (en) | Recombinant mva virus, and the use thereof | |
| MY119381A (en) | Recombinant mva virus, and the use thereof | |
| MY157873A (en) | Recombinant mva virus, and the use thereof |