PT82935B - Processo de preparacao de derivados n-metilados de lisergol e do 10 alfa-metoxilumilisergol - Google Patents
Processo de preparacao de derivados n-metilados de lisergol e do 10 alfa-metoxilumilisergolInfo
- Publication number
- PT82935B PT82935B PT82935A PT8293586A PT82935B PT 82935 B PT82935 B PT 82935B PT 82935 A PT82935 A PT 82935A PT 8293586 A PT8293586 A PT 8293586A PT 82935 B PT82935 B PT 82935B
- Authority
- PT
- Portugal
- Prior art keywords
- alpha
- methoxylumylisergol
- lisergol
- methylate
- derivatives
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title abstract 2
- BIXJFIJYBLJTMK-UHFFFAOYSA-N Lysergol Natural products C1=CC(C2=CC(CO)CN(C2C2)C)=C3C2=CNC3=C1 BIXJFIJYBLJTMK-UHFFFAOYSA-N 0.000 abstract 1
- BIXJFIJYBLJTMK-MEBBXXQBSA-N lysergol Chemical compound C1=CC(C2=C[C@@H](CO)CN([C@@H]2C2)C)=C3C2=CNC3=C1 BIXJFIJYBLJTMK-MEBBXXQBSA-N 0.000 abstract 1
- 239000012022 methylating agents Substances 0.000 abstract 1
- 239000003880 polar aprotic solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8510621A FR2584719B1 (fr) | 1985-07-11 | 1985-07-11 | Procede de preparation des derives n-methyles du lysergol et du methoxy-10a lumilysergol |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT82935A PT82935A (fr) | 1986-08-01 |
| PT82935B true PT82935B (pt) | 1989-01-30 |
Family
ID=9321196
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT82935A PT82935B (pt) | 1985-07-11 | 1986-07-07 | Processo de preparacao de derivados n-metilados de lisergol e do 10 alfa-metoxilumilisergol |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US4908449A (pt) |
| EP (1) | EP0209456B1 (pt) |
| JP (1) | JPH0667934B2 (pt) |
| KR (1) | KR930010498B1 (pt) |
| AT (1) | ATE60055T1 (pt) |
| CA (1) | CA1246553A (pt) |
| DE (1) | DE3676899D1 (pt) |
| ES (1) | ES2000331A6 (pt) |
| FR (1) | FR2584719B1 (pt) |
| GR (1) | GR861783B (pt) |
| PT (1) | PT82935B (pt) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH674367A5 (pt) * | 1987-06-16 | 1990-05-31 | Arysearch Arylan Ag | |
| US5707949A (en) * | 1996-04-04 | 1998-01-13 | E. I. Du Pont De Nemours And Company | Prevention of dye-bleeding and transfer during laundering |
| FR2786099B1 (fr) | 1998-11-24 | 2000-12-29 | Aventis Laboratoire | Nouvelle application therapeutique de la 1,6-dimethyl-8beta- hydroxymethyl-10alpha-methoxyergoline |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3228943A (en) * | 1962-06-11 | 1966-01-11 | Lumilysergol derivatives | |
| US3183234A (en) * | 1963-11-21 | 1965-05-11 | Lilly Co Eli | Octahydroindoloquinolines |
| FR1440188A (fr) * | 1964-04-28 | 1966-05-27 | Sandoz Sa | Nouveaux dérivés de l'ergolène et leur préparation |
| US3580916A (en) * | 1969-02-20 | 1971-05-25 | Lilly Co Eli | Hydroxyesters of hexa- and octahydroindoloquinolines |
| US3879554A (en) * | 1970-03-20 | 1975-04-22 | Farmaceutici Italia | Use of 1,6-dimethyl-8-{62 -(5-bromonicotinoyloxymethyl)-10 {60 -methoxyergoline in treating cerebral and peripheral metabolic vascular disorders |
| IT1094965B (it) * | 1978-04-05 | 1985-08-10 | Corvi Mora E | Procedimento di preparazione di derivati del lisergolo |
| FR2584720B1 (fr) * | 1985-07-11 | 1987-10-02 | Rhone Poulenc Sante | Procede de preparation de derives n-methyles de l'ergoline |
| US4772709A (en) * | 1985-10-01 | 1988-09-20 | Eli Lilly And Company | Process of making ketoalkanol esters of dihydrolysergic acid |
| US4734501A (en) * | 1985-10-01 | 1988-03-29 | Eli Lilly And Company | N-alkylation of dihydrolysergic acid |
| CH674367A5 (pt) * | 1987-06-16 | 1990-05-31 | Arysearch Arylan Ag |
-
1985
- 1985-07-11 FR FR8510621A patent/FR2584719B1/fr not_active Expired
-
1986
- 1986-07-07 PT PT82935A patent/PT82935B/pt not_active IP Right Cessation
- 1986-07-09 CA CA000513402A patent/CA1246553A/fr not_active Expired
- 1986-07-09 GR GR861783A patent/GR861783B/el unknown
- 1986-07-10 JP JP61160971A patent/JPH0667934B2/ja not_active Expired - Fee Related
- 1986-07-10 DE DE8686401539T patent/DE3676899D1/de not_active Expired - Fee Related
- 1986-07-10 EP EP86401539A patent/EP0209456B1/fr not_active Expired - Lifetime
- 1986-07-10 AT AT86401539T patent/ATE60055T1/de not_active IP Right Cessation
- 1986-07-10 KR KR1019860005572A patent/KR930010498B1/ko not_active Expired - Fee Related
- 1986-07-11 ES ES8600252A patent/ES2000331A6/es not_active Expired
-
1989
- 1989-03-27 US US07/329,387 patent/US4908449A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6236379A (ja) | 1987-02-17 |
| EP0209456B1 (fr) | 1991-01-16 |
| PT82935A (fr) | 1986-08-01 |
| FR2584719B1 (fr) | 1987-10-02 |
| DE3676899D1 (de) | 1991-02-21 |
| KR930010498B1 (ko) | 1993-10-25 |
| US4908449A (en) | 1990-03-13 |
| CA1246553A (fr) | 1988-12-13 |
| FR2584719A1 (fr) | 1987-01-16 |
| JPH0667934B2 (ja) | 1994-08-31 |
| ATE60055T1 (de) | 1991-02-15 |
| KR870001207A (ko) | 1987-03-12 |
| ES2000331A6 (es) | 1988-02-16 |
| EP0209456A1 (fr) | 1987-01-21 |
| GR861783B (en) | 1986-11-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM3A | Annulment or lapse |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 20050103 |