[go: up one dir, main page]

PT81045B - METHOD FOR THE PREPARATION OF NEW 8-SUBSTITUTED NUCLEOSIDE AND PURINE DERIVATIVES, AND OF CONTAINING PHARMACEUTICAL COMPOSITIONS - Google Patents

METHOD FOR THE PREPARATION OF NEW 8-SUBSTITUTED NUCLEOSIDE AND PURINE DERIVATIVES, AND OF CONTAINING PHARMACEUTICAL COMPOSITIONS

Info

Publication number
PT81045B
PT81045B PT81045A PT8104585A PT81045B PT 81045 B PT81045 B PT 81045B PT 81045 A PT81045 A PT 81045A PT 8104585 A PT8104585 A PT 8104585A PT 81045 B PT81045 B PT 81045B
Authority
PT
Portugal
Prior art keywords
sub
new
purine derivatives
preparation
substituted nucleoside
Prior art date
Application number
PT81045A
Other languages
Portuguese (pt)
Other versions
PT81045A (en
Original Assignee
Pierrel Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierrel Spa filed Critical Pierrel Spa
Publication of PT81045A publication Critical patent/PT81045A/en
Publication of PT81045B publication Critical patent/PT81045B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Luminescent Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)

Abstract

New 8-substituted nucleoside and purine derivatives of the general formula:wherein R represents an amino or an hydroxy group possibly in the corresponding keto tautomeric form, R<sub>1</sub> is hydrogen or an amino group, R<sub>2</sub> is hydrogen or a β-D-ribofuranosyl radical wherein the primary hydroxy group and/or the two secondary hydroxy groups may be derivatized, R<sub>3 </sub>is an optionally substituted aryl or monocyclic heteroaryl radical and, X is-O-or-S-.The new compounds have antihyperlipaemic activity.
PT81045A 1984-09-20 1985-08-28 METHOD FOR THE PREPARATION OF NEW 8-SUBSTITUTED NUCLEOSIDE AND PURINE DERIVATIVES, AND OF CONTAINING PHARMACEUTICAL COMPOSITIONS PT81045B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT22739/84A IT1196261B (en) 1984-09-20 1984-09-20 8-SUBSTITUTED NUCLEOSIDIC AND PURINIC DERIVATIVES

Publications (2)

Publication Number Publication Date
PT81045A PT81045A (en) 1985-09-01
PT81045B true PT81045B (en) 1987-09-18

Family

ID=11199882

Family Applications (1)

Application Number Title Priority Date Filing Date
PT81045A PT81045B (en) 1984-09-20 1985-08-28 METHOD FOR THE PREPARATION OF NEW 8-SUBSTITUTED NUCLEOSIDE AND PURINE DERIVATIVES, AND OF CONTAINING PHARMACEUTICAL COMPOSITIONS

Country Status (14)

Country Link
US (1) US4774325A (en)
EP (1) EP0175325B1 (en)
JP (1) JPS61112077A (en)
AT (1) ATE41430T1 (en)
AU (1) AU591462B2 (en)
CA (1) CA1268175A (en)
DE (1) DE3568783D1 (en)
DK (1) DK167318B1 (en)
ES (1) ES8701773A1 (en)
GR (1) GR852261B (en)
IT (1) IT1196261B (en)
NZ (1) NZ213550A (en)
PT (1) PT81045B (en)
ZA (1) ZA857075B (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9111580D0 (en) * 1991-05-30 1991-07-24 Wellcome Found Nucleoside derivative
IT1248528B (en) * 1991-06-21 1995-01-19 Pierrel Spa AROMATIC ETHER AND THIOETHER (HETER) DERIVATIVES HAVING ANTI-HYPERLIPIDEMIC ACTIVITY, PROCEDURE FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
US5233041A (en) * 1991-10-07 1993-08-03 Glaxo Group Limited Synthesis of a 3,4-dihydroxy-1-cyclopentanylpurinone from a 2,3-unsaturated-1-cyclopentanylpurinone
ATE155467T1 (en) * 1993-03-30 1997-08-15 Sanofi Sa ACYCLIC NUCLEOSIDE ANALOGUES AND OLIGONUCLEOTIDE SEQUENCES CONTAINING THEM
US5329008A (en) * 1993-04-07 1994-07-12 Glaxo Inc. Synthesis of a 3,4-dihydroxy-1-cyclopentanylpurinone
US5969135A (en) * 1995-11-02 1999-10-19 Icn Pharmaceuticals, Inc. Oligonucleotide analogs with an amino acid or a modified amino alcohol residue
US20060079493A1 (en) * 2001-03-01 2006-04-13 Lawrence Fritz Methods for treating genetically- defined proliferative disorders with hsp90 inhibitors
CA2464031A1 (en) * 2001-10-30 2003-05-08 Conforma Therapeutics Corporation Purine analogs having hsp90-inhibiting activity
US20070129334A1 (en) * 2001-10-30 2007-06-07 Conforma Therapeutics Corporation Orally Active Purine-Based Inhibitors of Heat Shock Protein 90
US6906190B2 (en) * 2002-01-04 2005-06-14 Ribapharm Inc. Inhibitors for de novo-RNA polymerases and methods of identifying targets for same
JP3929949B2 (en) * 2003-08-08 2007-06-13 独立行政法人科学技術振興機構 Nucleoside releasing functional unit by oxidation and method for producing oligonucleotide containing the same
US7129244B2 (en) * 2003-09-18 2006-10-31 Conforma Therapeutics Corporation Triazolopyrimidines and related analogs as HSP90-inhibitors
AU2006230447A1 (en) 2005-03-30 2006-10-05 Conforma Therapeutics Corporation Alkynyl pyrrolopyrimidines and related analogs as HSP90-inhibitors
WO2007035963A2 (en) * 2005-09-23 2007-03-29 Conforma Therapeutics Corporation Anti-tumor methods using multi drug resistance independent synthetic hsp90 inhibitors

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE111312C (en) * 1897-12-16
US2819260A (en) * 1953-06-04 1958-01-07 Petrolite Corp Process for preparing oxyalkylated derivatives
US3391196A (en) * 1965-08-16 1968-07-02 Wyandotte Chemicals Corp High equivalent weight hydroxy-terminated ethylene oxide-butylene oxide polyether polyols
GB1257546A (en) * 1968-09-10 1971-12-22
JPS5133799B2 (en) * 1973-06-14 1976-09-21
US4048307A (en) * 1974-12-26 1977-09-13 Asahi Kasei Kogyo Kabushiki Kaisha Cyclic adenosine monophosphate 8-substituted derivatives
DE2631046A1 (en) * 1975-07-15 1977-01-20 Snam Progetti ADENIN DERIVATIVES AND PROCESS FOR THEIR PRODUCTION
SU883056A1 (en) * 1980-03-26 1981-11-23 Ленинградский Ордена Ленина И Ордена Трудового Красного Знамени Государственный Университет Им.А.А.Жданова Method of preparing /8-(6-aminohexyl)-adenosin-5'-diphosphate
DE3027279A1 (en) * 1980-07-18 1982-05-06 Byk Gulden Lomberg Chemische Fabrik Gmbh, 7750 Konstanz SUBSTITUTED ADENOSINE-3 ', 5'-PHOSPHORIC ACID CYLINDRIESTER, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
EP0045544B1 (en) * 1980-08-06 1985-03-20 Shell Internationale Researchmaatschappij B.V. Process for the manufacture of polyether polyols and their use for preparing polyurethanes
JPS6094992A (en) * 1983-10-28 1985-05-28 Sankyo Co Ltd Griseolic acid derivative

Also Published As

Publication number Publication date
ES8701773A1 (en) 1987-01-01
US4774325A (en) 1988-09-27
JPS61112077A (en) 1986-05-30
IT8422739A1 (en) 1986-03-20
IT1196261B (en) 1988-11-16
PT81045A (en) 1985-09-01
CA1268175A (en) 1990-04-24
ES547856A0 (en) 1987-01-01
NZ213550A (en) 1989-06-28
DE3568783D1 (en) 1989-04-20
JPH0569109B2 (en) 1993-09-30
GR852261B (en) 1986-01-17
AU4767285A (en) 1986-03-27
DK167318B1 (en) 1993-10-11
DK426185A (en) 1986-03-21
ATE41430T1 (en) 1989-04-15
AU591462B2 (en) 1989-12-07
ZA857075B (en) 1986-06-25
EP0175325A2 (en) 1986-03-26
EP0175325A3 (en) 1987-02-04
EP0175325B1 (en) 1989-03-15
DK426185D0 (en) 1985-09-19
IT8422739A0 (en) 1984-09-20

Similar Documents

Publication Publication Date Title
PT81045B (en) METHOD FOR THE PREPARATION OF NEW 8-SUBSTITUTED NUCLEOSIDE AND PURINE DERIVATIVES, AND OF CONTAINING PHARMACEUTICAL COMPOSITIONS
FI853625A0 (en) TETRAL LINES, DERAS FRAMSTAELLNING OCH ANVAENDNING.
GR3007982T3 (en)
PT83961B (en) PROCESS FOR THE PREPARATION OF PYRAZOLINE DERIVATIVES AND INSECTICIDES AND ACARICIDES THAT CONTAIN THEM
PT702683E (en) O-SUBSTITUTED GUANINA DERIVATIVES PROCESS FOR PREPARING AND USING THEM IN TUMOR CELL TREATMENT
IE821260L (en) Anthracycline derivatives
ES8706148A1 (en) Carbapenem compounds, their preparation and use.
BR9713159A (en) Substantially solid composition, compound, substantially solid salt composition, mixture, and, process for preparing a compound
PL260714A1 (en) Method of obtaining novel optically active substituted 3-aminosidnonoimines
ES556551A0 (en) A PROCEDURE FOR PREPARING A 1,5-BENZOTIAZEPINE DERIVATIVE
PT84680B (en) PROCESS FOR THE PREPARATION OF 1,5-BENZOTIAZEPINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
PT83472B (en) PROCESS FOR THE PREPARATION OF APPROPRIATE ANTI-INFLAMMATORY COMPOSITIONS CONTAINING PYROCYCAMAN
ES8600758A1 (en) 1,3-Dioxolanyl derivatives, method for their preparation, their use and medicine containing these compounds.
BR8300219A (en) HERBICIDIC COMPOSITIONS, CONTAINING THYADIAZOL DERIVATIVES, AND, PROCESS FOR THE PREPARATION OF THESE DERIVATIVES
JPS57146798A (en) Hexosyl nucleoside derivative
PL312966A1 (en) Derivatives of thiocarbamoil
MY116824A (en) Antivaral,highly water soluble,stable,crystalline salts of 2&#39;&#39;,3&#39;&#39;-dideoxyinosine monohydrate,2&#39;&#39;,3&#39;&#39;-dideoxy-2&#39;&#39; ,3&#39;&#39;-didehydrothymidine monohydrate and 2&#39;&#39;,3&#39;&#39;-dideoxy-2&#39;&#39;-fluoroinosine hemihydrate
BG49444A1 (en) Acylureidoamynotiasolylni derivatives and method for their preparation
BR8906505A (en) PROCESS FOR PURIFICATION OF I, I-BIS (CHLOROPHENYL) -2,2,2-TRICLOROETANOL TECNICO
JPS56142296A (en) Adenosine derivative and its preparation
ES8601931A1 (en) Azoles with enol-ether structure, their preparation and use.
IT1222864B (en) New lipophilic salts of S-adenosyl-1-methionine
JPS6422894A (en) Nulceosides
BR9407072A (en) Process for preparing n-cyanodithioiminocarbonates and process for preparing n-cyanodithioiminocarbonates on a large scale
IE872998L (en) 4-hydroxy-4-(substituted alkenyl)- cyclohexanecarboxylic¹acids

Legal Events

Date Code Title Description
MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19960731