PT76595B - Procede de preparation de benzoazacycloalkyl-spiro-imidazolidines - Google Patents

Procede de preparation de benzoazacycloalkyl-spiro-imidazolidines

Info

Publication number: PT76595B
Authority: PT; Portugal
Prior art keywords: benzoazacycloalkyl; imidazolidines; spiro; preparation
Prior art date: 1982-04-27

Application number

PT76595A

Other languages

English (en)

Portuguese (pt)

Other versions

PT76595A (fr

Inventor

Charles Malen

Jean-Louis Peglion

Jacques Duhault

Michelle Boulanger

Original Assignee

Adir

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-04-27

Filing date

1983-04-26

Publication date

1986-01-21

1983-04-26 Application filed by Adir filed Critical Adir

1983-05-01 Publication of PT76595A publication Critical patent/PT76595A/fr

1986-01-21 Publication of PT76595B publication Critical patent/PT76595B/fr

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Diabetes (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Ophthalmology & Optometry (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Hematology (AREA)
Obesity (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

PT76595A 1982-04-27 1983-04-26 Procede de preparation de benzoazacycloalkyl-spiro-imidazolidines PT76595B (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR8207203A FR2525603A1 (fr)	1982-04-27	1982-04-27	Benzoazacycloalkyl-spiro-imidazolinines, leur preparation et leur application en therapeutique

Publications (2)

Publication Number	Publication Date
PT76595A PT76595A (fr)	1983-05-01
PT76595B true PT76595B (fr)	1986-01-21

Family

ID=9273425

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT76595A PT76595B (fr)	1982-04-27	1983-04-26	Procede de preparation de benzoazacycloalkyl-spiro-imidazolidines

Country Status (22)

Country	Link
JP (1)	JPS5910584A (fr)
KR (1)	KR840004428A (fr)
AT (1)	ATA125383A (fr)
AU (1)	AU1395383A (fr)
BE (1)	BE896572A (fr)
DD (1)	DD209833A5 (fr)
DE (1)	DE3315106A1 (fr)
DK (1)	DK183583A (fr)
ES (1)	ES8405796A1 (fr)
FR (1)	FR2525603A1 (fr)
GB (1)	GB2133401B (fr)
GR (1)	GR78481B (fr)
IL (1)	IL68497A0 (fr)
IT (1)	IT1167123B (fr)
LU (1)	LU84770A1 (fr)
MA (1)	MA19783A1 (fr)
NL (1)	NL8301476A (fr)
NO (1)	NO831473L (fr)
OA (1)	OA07412A (fr)
PT (1)	PT76595B (fr)
SE (1)	SE8302347L (fr)
ZA (1)	ZA832927B (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4927831A (en) *	1988-10-20	1990-05-22	American Home Products	Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors
AU617541B2 (en) *	1988-10-20	1991-11-28	Wyeth	Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors
US6953787B2 (en)	2002-04-12	2005-10-11	Arena Pharmaceuticals, Inc.	5HT2C receptor modulators
EP2332921B1 (fr)	2003-06-17	2016-03-02	Arena Pharmaceuticals, Inc.	8-Chloro-1 -methyl-2,3,4,5-tetrahydro-1 H-3benzazapine Hydrochloride
CN1805938B (zh)	2003-06-17	2010-06-16	艾尼纳制药公司	用于治疗5ht2c受体相关疾病的苯并氮杂卓衍生物
NZ589756A (en)	2004-12-21	2012-05-25	Arena Pharm Inc	Method for the preparation of crystalline forms of (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride
WO2006071740A2 (fr)	2004-12-23	2006-07-06	Arena Pharmaceuticals, Inc.	Compositions renfermant un modulateur des recepteurs 5ht2c et procedes d'utilisation correspondants
CN101466684B (zh)	2006-04-03	2012-06-20	艾尼纳制药公司	8-氯-1-甲基-2,3,4,5-四氢-1h-3-苯并氮杂卓的制备工艺和其相关中间体
CA2670285A1 (fr)	2006-12-05	2008-06-12	Arena Pharmaceuticals, Inc.	Procedes de preparation de (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine et intermediaires de celle-ci
EP2288585A1 (fr)	2008-03-04	2011-03-02	Arena Pharmaceuticals, Inc.	Procédés de préparation d'intermédiaires se rapportant à l'agoniste 5-ht2c (r)-8-chloro-1-méthyl-2,3,4,5-tétrahydro-1h-3-benzazepine
EP2443080A2 (fr)	2009-06-18	2012-04-25	Arena Pharmaceuticals, Inc.	Procédés pour la préparation d'agonistes du récepteur 5-ht<sb>2c</sb>
US9045431B2 (en)	2010-06-02	2015-06-02	Arena Pharmaceuticals, Inc.	Processes for the preparation of 5-HT2C receptor agonists
WO2012030939A1 (fr)	2010-09-01	2012-03-08	Arena Pharmaceuticals, Inc.	Administration de lorcasérine à des individus présentant une insuffisance rénale
KR20130138770A (ko)	2010-09-01	2013-12-19	아레나 파마슈티칼스, 인크.	광학적으로 활성 산을 갖는 로르카세린의 염
EP2611433A2 (fr)	2010-09-01	2013-07-10	Arena Pharmaceuticals, Inc.	Sels non hygroscopiques d'agonistes de 5-ht2c
EP3485878A1 (fr)	2010-09-01	2019-05-22	Arena Pharmaceuticals, Inc.	Formes posologiques à libération modifiée d'agonistes de 5-ht2c utiles pour la gestion du poids
JP2015534563A (ja)	2012-10-09	2015-12-03	アリーナファーマシューティカルズ，インコーポレイテッド	体重管理の方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4209630A (en) *	1976-10-18	1980-06-24	Pfizer Inc.	Hydantoin derivatives as therapeutic agents
US4235911A (en) *	1979-06-13	1980-11-25	Pfizer Inc.	Hydantoin derivatives

1982
- 1982-04-27 FR FR8207203A patent/FR2525603A1/fr active Granted
1983
- 1983-04-08 AT AT0125383A patent/ATA125383A/de not_active IP Right Cessation
- 1983-04-25 DD DD83250187A patent/DD209833A5/de unknown
- 1983-04-25 LU LU84770A patent/LU84770A1/fr unknown
- 1983-04-26 KR KR1019830001753A patent/KR840004428A/ko not_active Withdrawn
- 1983-04-26 IL IL68497A patent/IL68497A0/xx unknown
- 1983-04-26 DK DK183583A patent/DK183583A/da not_active Application Discontinuation
- 1983-04-26 JP JP58073687A patent/JPS5910584A/ja active Pending
- 1983-04-26 AU AU13953/83A patent/AU1395383A/en not_active Abandoned
- 1983-04-26 IT IT48155/83A patent/IT1167123B/it active
- 1983-04-26 BE BE0/210633A patent/BE896572A/fr not_active IP Right Cessation
- 1983-04-26 NO NO831473A patent/NO831473L/no unknown
- 1983-04-26 ZA ZA832927A patent/ZA832927B/xx unknown
- 1983-04-26 GR GR71214A patent/GR78481B/el unknown
- 1983-04-26 PT PT76595A patent/PT76595B/fr unknown
- 1983-04-26 SE SE8302347A patent/SE8302347L/xx not_active Application Discontinuation
- 1983-04-26 NL NL8301476A patent/NL8301476A/nl not_active Application Discontinuation
- 1983-04-27 DE DE19833315106 patent/DE3315106A1/de not_active Withdrawn
- 1983-04-27 GB GB08311508A patent/GB2133401B/en not_active Expired
- 1983-04-27 MA MA20003A patent/MA19783A1/fr unknown
- 1983-04-27 ES ES521895A patent/ES8405796A1/es not_active Expired
- 1983-04-27 OA OA57984A patent/OA07412A/fr unknown

Also Published As

Publication number	Publication date
ES521895A0 (es)	1984-06-16
ATA125383A (de)	1986-05-15
DK183583D0 (da)	1983-04-26
AU1395383A (en)	1983-11-03
FR2525603A1 (fr)	1983-10-28
GB8311508D0 (en)	1983-06-02
GB2133401A (en)	1984-07-25
GB2133401B (en)	1985-10-23
SE8302347L (sv)	1983-10-28
MA19783A1 (fr)	1983-12-31
DE3315106A1 (de)	1983-11-03
IT8348155A0 (it)	1983-04-26
BE896572A (fr)	1983-10-26
IL68497A0 (en)	1983-07-31
LU84770A1 (fr)	1984-11-28
KR840004428A (ko)	1984-10-15
ES8405796A1 (es)	1984-06-16
ZA832927B (en)	1984-06-27
JPS5910584A (ja)	1984-01-20
NO831473L (no)	1983-10-28
GR78481B (fr)	1984-09-27
NL8301476A (nl)	1983-11-16
PT76595A (fr)	1983-05-01
SE8302347D0 (sv)	1983-04-26
DK183583A (da)	1983-10-28
DD209833A5 (de)	1984-05-23
IT1167123B (it)	1987-05-13
FR2525603B1 (fr)	1984-09-14
OA07412A (fr)	1984-11-30

Publication	Publication Date	Title
FR2479187B1 (fr)	1987-10-16	Procede de preparation de n-octadienol
RO86698A (fr)	1985-04-17	Procede pour la preparation des (1-piperidinylalkyle)-pyrhimidinone
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FR2527615B1 (fr)	1986-05-23	Procede de preparation du 26,26,26,27,27,27-hexafluoro-1a,25-dihydroxycholesterol
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FR2550190B1 (fr)	1989-06-09	Procede de preparation de b-phenylserine
PT74559A (fr)	1982-04-01	Procede de preparation de trifluoromethylphenyl-tetrahydropyri-dines substituees
FR2528825B1 (fr)	1986-02-21	Procede de preparation de meta-chlorobenzotrifluorure
FR2529889B1 (fr)	1985-09-06	Procede de preparation des indoles
FR2527603B1 (fr)	1985-07-26	Procede catalytique de preparation de thio-bis-phenols
FR2526021B1 (fr)	1987-06-12	Procede de preparation de 3-hydroxy-benzodiazepinones
FR2537578B1 (fr)	1989-05-19	Procede de preparation de trichloromethyl-carbinols
FR2550790B1 (fr)	1987-09-25	Procede de preparation de la 4-methylionone
FR2493310B1 (fr)	1985-12-13	Procede de preparation de thymosine a1
FR2526790B1 (fr)	1988-02-05	Procede de preparation de la o-phenylenediamine
FR2521556B1 (fr)	1986-04-04	Procede de preparation de 3, 3'-diamino-diphenylsulfones