PT752813E - Inibidores de proteases de parasitas metazoarios - Google Patents

Inibidores de proteases de parasitas metazoarios

Info

Publication number: PT752813E
Authority: PT; Portugal
Prior art keywords: parasite; metazoan; pct; protease; metaboal
Prior art date: 1992-09-11

Application number

PT93921592T

Other languages

English (en)

Inventor

Zhe Li

Fred Ehrenkranz Cohen

James Hobson Mckerrow

Christine Sun Young Ring

Philip Jon Rosenthal

George Lommel Kenyon

Original Assignee

Univ California

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-09-11

Filing date

1993-09-13

Publication date

2003-04-30

1993-09-13 Application filed by Univ California filed Critical Univ California

2003-04-30 Publication of PT752813E publication Critical patent/PT752813E/pt

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
- A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
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- A61K31/4164—1,3-Diazoles
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
- A—HUMAN NECESSITIES
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Tropical Medicine & Parasitology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Furan Compounds (AREA)
Pyrane Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Indole Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Quinoline Compounds (AREA)

PT93921592T 1992-09-11 1993-09-13 Inibidores de proteases de parasitas metazoarios PT752813E (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US94392592A	1992-09-11	1992-09-11

Publications (1)

Publication Number	Publication Date
PT752813E true PT752813E (pt)	2003-04-30

Family

ID=25480499

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT93921592T PT752813E (pt)	1992-09-11	1993-09-13	Inibidores de proteases de parasitas metazoarios

Country Status (11)

Country	Link
US (1)	US5610192A (pt)
EP (1)	EP0752813B1 (pt)
JP (1)	JPH08502048A (pt)
AT (1)	ATE229331T1 (pt)
AU (1)	AU4923093A (pt)
DE (1)	DE69332567T2 (pt)
DK (1)	DK0752813T3 (pt)
ES (1)	ES2183817T3 (pt)
OA (1)	OA10132A (pt)
PT (1)	PT752813E (pt)
WO (1)	WO1994006280A1 (pt)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5795768A (en) *	1991-02-12	1998-08-18	Heska Corporation	Filariid nematode cysteine protease proteins, nucleic acid molecules and uses thereof
US6419923B1 (en)	1991-02-12	2002-07-16	Heska Corporation	Filariid nematode cysteine protease proteins, and uses thereof
US5739170A (en) *	1992-09-11	1998-04-14	The Regents Of The University Of California	Inhibitors of metazoan parasite proteases
CA2189741A1 (en) *	1994-05-26	1995-12-07	Cynthia Ann Tripp	Novel parasite protease genes and proteins
US5863716A (en) *	1994-09-19	1999-01-26	The Leland Stanford Junior University Board Of Trustees	Treatment of plasmodium
US5936120A (en) *	1997-12-10	1999-08-10	University Of New Mexico	Deoxygossylic compounds
JP2001526265A (ja) *	1997-12-22	2001-12-18	ファルマシア・アンド・アップジョン・カンパニー	抗ウイルス剤としての４−ヒドロキシキノリン−３−カルボキサミドおよびヒドラジド
SE9903894D0 (sv) *	1999-10-28	1999-10-28	New Pharma Research Ab	Novel compounds
EP1130009A1 (en) *	2000-03-01	2001-09-05	Therascope AG	Generation and screening of a dynamic combinatorial library
AU2003251828A1 (en) *	2002-07-12	2004-02-02	Janssen Pharmaceutica N.V.	Naphthol, quinoline and isoquinoline-derivatives as modulators of vanilloid vr1 receptor
EP1680426B1 (en) *	2003-06-10	2007-09-19	F. Hoffmann-La Roche Ag	1.3.4-triaza-phenalene and 1,3,4,6-tetraazaphenalene derivatives
US20080039528A1 (en) *	2004-03-17	2008-02-14	Kansas State University Research Foundation	Zinc finger ejectors and methods of use thereof
WO2007104695A1 (en) *	2006-03-15	2007-09-20	Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.	Quinolin-4-ylhydrazine derivatives as antimalarial agent
EP2698365B8 (en) *	2011-04-15	2018-02-14	National University Corporation Tottori University	Synthesis and analysis of novel compound capable of inducing differentiation of human mesenchymal stem cell into hepatocyte
EP2782643A1 (en) *	2011-11-23	2014-10-01	The Provost, Fellows, Foundation Scholars, & the other members of Board, of the College of the Holy & Undiv. Trinity of Queen Elizabeth near Dublin	Androgen receptor ligands
EP2633855A1 (en)	2012-03-01	2013-09-04	Veterinärmedizinische Universität Wien	Protease inhibitors for treating Trichomonas gallinae infections
WO2013142669A1 (en) *	2012-03-21	2013-09-26	Case Western Reserve University	Method of modulating ribonucleotide reductase
WO2015188130A1 (en) *	2014-06-05	2015-12-10	The University Of Kansas	Marmelin analogs and methods of use in cancer treatment
RU2719593C2 (ru)	2014-09-02	2020-04-21	Неокьюли Пти Лтд	Способы лечения протозойных инфекций
CN105777578B (zh) *	2016-04-01	2017-12-29	西北师范大学	一种酰腙类氰根离子传感器分子及其合成及在含水体系中检测氰根离子的应用
CN107759489A (zh) *	2017-11-08	2018-03-06	海南医学院	一种苯甲酰肼衍生物p及其合成和应用
CN117946055A (zh) *	2024-01-25	2024-04-30	贵州医科大学	一种色烯芳基酰肼类衍生物及其制备方法和应用

1993
- 1993-09-13 US US08/387,760 patent/US5610192A/en not_active Expired - Fee Related
- 1993-09-13 DE DE69332567T patent/DE69332567T2/de not_active Expired - Fee Related
- 1993-09-13 EP EP93921592A patent/EP0752813B1/en not_active Expired - Lifetime
- 1993-09-13 AU AU49230/93A patent/AU4923093A/en not_active Abandoned
- 1993-09-13 ES ES93921592T patent/ES2183817T3/es not_active Expired - Lifetime
- 1993-09-13 JP JP6508279A patent/JPH08502048A/ja active Pending
- 1993-09-13 WO PCT/US1993/008708 patent/WO1994006280A1/en not_active Ceased
- 1993-09-13 PT PT93921592T patent/PT752813E/pt unknown
- 1993-09-13 AT AT93921592T patent/ATE229331T1/de not_active IP Right Cessation
- 1993-09-13 DK DK93921592T patent/DK0752813T3/da active
1995
- 1995-03-07 OA OA60620A patent/OA10132A/en unknown

Also Published As

Publication number	Publication date
ES2183817T3 (es)	2003-04-01
ATE229331T1 (de)	2002-12-15
JPH08502048A (ja)	1996-03-05
EP0752813B1 (en)	2002-12-11
WO1994006280A1 (en)	1994-03-31
DK0752813T3 (da)	2003-01-06
DE69332567T2 (de)	2003-04-17
EP0752813A4 (en)	1997-08-20
DE69332567D1 (de)	2003-01-23
OA10132A (en)	1996-12-18
US5610192A (en)	1997-03-11
AU4923093A (en)	1994-04-12
EP0752813A1 (en)	1997-01-15

Publication	Publication Date	Title
PT752813E (pt)	2003-04-30	Inibidores de proteases de parasitas metazoarios
AU7321598A (en)	1998-09-22	Use of cholinesterase inhibitors to treat disorders of attention
AU2483000A (en)	2000-07-24	Treatment of asthma with mek inhibitors
GR3033667T3 (en)	2000-10-31	Use of non-steroidal cyclooxygenase inhibitors to treat elevated intraocular pressure
EE9400341A (et)	1996-04-15	Kolesterooli biosünteesi inhibiitori ja kolesterooli absorptsiooni ß-laktaaminhibiitori kombinatsioon
AR037060A1 (es)	2004-10-20	Compuesto anti-virus de herpes que no son nucleosidos, procedimiento para prepararlos, composicion farmaceutica que los contiene, metodo para inhibir replicacion de un virus de herpes, metodo para tratar una infeccion por herpes en un mamifero, inhibidor de helicasa-primasa de herpes, metodo para id
DE69309094D1 (de)	1997-04-24	Hemmung der TNF - Bildung
ES2131185T3 (es)	1999-07-16	Arilalcanil-n-hidroxiureas y heteroalquilalcanil-n-hidroxiureas sustituidas que pueden inhibir la biosintesis de leucotrienos.
ATE409486T1 (de)	2008-10-15	Behandlung hyperproliferativer erkrankungen
DE69616375D1 (de)	2001-11-29	Nicht-allosterische GABA A Agonisten zur Behandlung von Schlafstörungen
MX9306295A (es)	1994-04-29	Composiciones farmaceuticas para tratar sintomas de resfriado.
ATE147981T1 (de)	1997-02-15	Verabreichung von lamotrigin zur behandlung von neuro-aids
ES2146249T3 (es)	2000-08-01	Composicion farmaceutica para tratar la impotencia que contiene un inhibidor alfa-1 y un inhibidor alfa-2.
ATE350032T1 (de)	2007-01-15	Verwendung der protein-kinase-c-epsilon- inhibitoren zur behandlung von schmerzen
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