PT758248E - Formulacoes para o factor ix - Google Patents
Formulacoes para o factor ixInfo
- Publication number
- PT758248E PT758248E PT95915040T PT95915040T PT758248E PT 758248 E PT758248 E PT 758248E PT 95915040 T PT95915040 T PT 95915040T PT 95915040 T PT95915040 T PT 95915040T PT 758248 E PT758248 E PT 758248E
- Authority
- PT
- Portugal
- Prior art keywords
- factor
- formulations
- administration
- methods
- storage
- Prior art date
Links
- 229960004222 factor ix Drugs 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- 102100022641 Coagulation factor IX Human genes 0.000 abstract 2
- 108010076282 Factor IX Proteins 0.000 abstract 2
- 238000009472 formulation Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/233,663 US6372716B1 (en) | 1994-04-26 | 1994-04-26 | Formulations for factor IX |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT758248E true PT758248E (pt) | 2003-11-28 |
Family
ID=22878181
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT95915040T PT758248E (pt) | 1994-04-26 | 1995-04-06 | Formulacoes para o factor ix |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6372716B1 (pt) |
| EP (1) | EP0758248B1 (pt) |
| JP (4) | JPH09512267A (pt) |
| AT (1) | ATE244015T1 (pt) |
| AU (1) | AU695084B2 (pt) |
| CA (1) | CA2182200C (pt) |
| DE (1) | DE69531204T2 (pt) |
| DK (1) | DK0758248T3 (pt) |
| ES (1) | ES2202356T3 (pt) |
| PT (1) | PT758248E (pt) |
| WO (1) | WO1995028954A1 (pt) |
Families Citing this family (90)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6372716B1 (en) * | 1994-04-26 | 2002-04-16 | Genetics Institute, Inc. | Formulations for factor IX |
| US6267958B1 (en) | 1995-07-27 | 2001-07-31 | Genentech, Inc. | Protein formulation |
| US5770700A (en) * | 1996-01-25 | 1998-06-23 | Genetics Institute, Inc. | Liquid factor IX formulations |
| US7786070B2 (en) | 1997-09-10 | 2010-08-31 | Novo Nordisk Healthcare A/G | Subcutaneous administration of coagulation factor VII |
| US7588766B1 (en) | 2000-05-26 | 2009-09-15 | Elan Pharma International Limited | Treatment of amyloidogenic disease |
| US7964192B1 (en) | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
| US20080050367A1 (en) * | 1998-04-07 | 2008-02-28 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
| TWI239847B (en) * | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
| US6787523B1 (en) * | 1997-12-02 | 2004-09-07 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
| US7790856B2 (en) * | 1998-04-07 | 2010-09-07 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize beta amyloid peptide |
| US6761888B1 (en) | 2000-05-26 | 2004-07-13 | Neuralab Limited | Passive immunization treatment of Alzheimer's disease |
| EP1280548B1 (en) | 2000-05-03 | 2013-12-11 | Novo Nordisk Health Care AG | Subcutaneous administration of coagulation factor VII |
| RU2163140C1 (ru) * | 2000-07-05 | 2001-02-20 | Гематологический научный центр РАМН | Концентрат фактора ix системы свертывания крови и способ его получения |
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| US7700751B2 (en) | 2000-12-06 | 2010-04-20 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize β-amyloid peptide |
| TWI255272B (en) * | 2000-12-06 | 2006-05-21 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
| AU2002351756A1 (en) | 2001-12-21 | 2003-07-15 | Novo Nordisk Health Care Ag | Liquid composition of factor vii polypeptides |
| MY139983A (en) * | 2002-03-12 | 2009-11-30 | Janssen Alzheimer Immunotherap | Humanized antibodies that recognize beta amyloid peptide |
| AU2003240438A1 (en) | 2002-06-21 | 2004-01-06 | Novo Nordisk A/S | Stabilised solid compositions of factor vii polypeptides |
| MXPA05008156A (es) * | 2003-02-01 | 2005-09-30 | Neuralab Ltd | Inmunizacion activa para generar anticuerpos para beta-a soluble. |
| US7897734B2 (en) | 2003-03-26 | 2011-03-01 | Novo Nordisk Healthcare Ag | Method for the production of proteins |
| BRPI0409936A (pt) | 2003-05-23 | 2006-04-25 | Novo Nordisk Healthcare Ag | uso de um material, recipiente pelo menos parcialmente cheio, e, kit médico |
| TWI306458B (en) * | 2003-05-30 | 2009-02-21 | Elan Pharma Int Ltd | Humanized antibodies that recognize beta amyloid peptide |
| ATE547114T1 (de) | 2003-06-25 | 2012-03-15 | Novo Nordisk Healthcare Ag | Flüssige zusammensetzungen von factor vii polypeptiden |
| CA2534028A1 (en) | 2003-08-14 | 2005-02-24 | Novo Nordisk Health Care Ag | Liquid, aqueous pharmaceutical composition of factor vii polypeptides |
| KR20130026498A (ko) | 2003-12-19 | 2013-03-13 | 노보 노르디스크 헬스 케어 악티엔게젤샤프트 | 인자 vii 폴리펩티드의 안정화된 조성물 |
| AU2005260763B2 (en) * | 2004-06-30 | 2011-12-22 | Nektar Therapeutics | Polymer-factor IX moiety conjugates |
| US20060051347A1 (en) | 2004-09-09 | 2006-03-09 | Winter Charles M | Process for concentration of antibodies and therapeutic products thereof |
| ES2434732T3 (es) * | 2004-12-15 | 2013-12-17 | Janssen Alzheimer Immunotherapy | Anticuerpos para beta-amiloide humanizados para su uso en mejorar la cognición |
| PE20061401A1 (es) * | 2004-12-15 | 2006-12-23 | Neuralab Ltd | ANTICUERPOS Aß PARA MEJORAR LA COGNICION |
| ES2396555T3 (es) * | 2004-12-15 | 2013-02-22 | Janssen Alzheimer Immunotherapy | Anticuerpos que reconocen péptido beta amiloide |
| JP2008528638A (ja) * | 2005-01-28 | 2008-07-31 | ワイス | ポリペプチドの安定化液体処方 |
| GT200600031A (es) * | 2005-01-28 | 2006-08-29 | Formulacion anticuerpo anti a beta | |
| RU2518295C2 (ru) | 2005-06-21 | 2014-06-10 | Ксома Текнолоджи Лтд. | IL-1бета-СВЯЗЫВАЮЩИЕ АНТИТЕЛА И ИХ ФРАГМЕНТЫ |
| KR20110128957A (ko) | 2005-11-01 | 2011-11-30 | 와이어쓰 엘엘씨 | 약물 재구성 또는 희석을 위한 염화나트륨 용액 |
| RU2008118166A (ru) * | 2005-11-22 | 2009-12-27 | Вайет (Us) | Составы, содержащие гибридные белки, включающие иммуноглобулин |
| US8784810B2 (en) * | 2006-04-18 | 2014-07-22 | Janssen Alzheimer Immunotherapy | Treatment of amyloidogenic diseases |
| US7695718B2 (en) | 2006-12-20 | 2010-04-13 | Xoma Technology Ltd. | Methods for the treatment of IL-1β related diseases |
| US20080292625A1 (en) * | 2007-04-18 | 2008-11-27 | Sally Schroeter | Prevention and treatment of cerebral amyloid angiopathy |
| US8003097B2 (en) * | 2007-04-18 | 2011-08-23 | Janssen Alzheimer Immunotherapy | Treatment of cerebral amyloid angiopathy |
| EP2150537A4 (en) * | 2007-06-01 | 2010-09-22 | Acologix Inc | STABLE PEPTIDE FORMULATION AT HIGH TEMPERATURE |
| SI2182983T1 (sl) | 2007-07-27 | 2014-09-30 | Janssen Alzheimer Immunotherapy | Zdravljenje amiloidogenih bolezni s humaniziranimi protitelesi proti abeta |
| JO3076B1 (ar) * | 2007-10-17 | 2017-03-15 | Janssen Alzheimer Immunotherap | نظم العلاج المناعي المعتمد على حالة apoe |
| PL2391650T3 (pl) | 2007-12-20 | 2015-03-31 | Xoma Us Llc | Sposoby leczenia dny |
| BRPI0821591A2 (pt) * | 2007-12-21 | 2016-05-03 | Inspiration Biopharmaceuticals Inc | composição liofilizada e métodos de preparação de composição seca estável do fator ix e de liofilização de formulação farmacêutica |
| US9067981B1 (en) | 2008-10-30 | 2015-06-30 | Janssen Sciences Ireland Uc | Hybrid amyloid-beta antibodies |
| EP2465542B1 (en) * | 2008-12-16 | 2015-01-21 | Genzyme Corporation | Oligosaccharide-protein conjugates |
| WO2012092539A2 (en) | 2010-12-31 | 2012-07-05 | Takeda Pharmaceutical Company Limited | Antibodies to dll4 and uses thereof |
| EP2663580B1 (en) | 2011-01-10 | 2016-12-07 | CT Atlantic Ltd. | Combination therapy including tumor associated antigen binding antibodies |
| WO2012163769A1 (en) | 2011-06-03 | 2012-12-06 | Ct Atlantic Ltd. | Magea3 binding antibodies |
| WO2012163771A1 (en) | 2011-06-03 | 2012-12-06 | Ct Atlantic Ltd. | Magea3 binding antibodies |
| WO2013096516A1 (en) | 2011-12-19 | 2013-06-27 | Xoma Technology Ltd. | Methods for treating acne |
| JP6684490B2 (ja) | 2012-01-09 | 2020-04-22 | ザ・スクリップス・リサーチ・インスティテュート | 超長相補性決定領域及びその使用 |
| CA2862979A1 (en) | 2012-01-09 | 2013-07-18 | The Scripps Research Institute | Humanized antibodies with ultralong cdr3s |
| EP3542861A1 (en) * | 2012-09-25 | 2019-09-25 | Bioverativ Therapeutics Inc. | Methods of using fix polypeptides |
| WO2014075033A2 (en) | 2012-11-09 | 2014-05-15 | Puget Sound Blood Center | Protein stabilizing factors |
| WO2014138725A1 (en) | 2013-03-08 | 2014-09-12 | Curators Of The University Of Missouri | Methods and compositions for the treatment and/or prevention of type 1 diabetes |
| UY35463A (es) | 2013-03-15 | 2014-10-31 | Biogen Idec Inc | Formulaciones de polipéptido fc-factor ix. |
| CA2917814C (en) | 2013-07-11 | 2022-12-13 | The California Institute For Biomedical Research | Coiled coil immunoglobulin fusion proteins and compositions thereof |
| CN105814074B (zh) | 2013-07-18 | 2020-04-21 | 图鲁斯生物科学有限责任公司 | 具有超长互补决定区的人源化抗体 |
| WO2015017146A2 (en) | 2013-07-18 | 2015-02-05 | Fabrus, Inc. | Antibodies with ultralong complementarity determining regions |
| ES2927607T3 (es) | 2013-09-13 | 2022-11-08 | Scripps Research Inst | Agentes terapéuticos modificados y composiciones de los mismos |
| BR112016007487A2 (pt) | 2013-10-09 | 2017-08-01 | Nestec Sa | composições compreendendo citrulina e leucina e seu uso no tratamento de diabetes e de síndrome meta-bólica |
| CN105829349B (zh) | 2013-10-15 | 2023-02-03 | 斯克利普斯研究所 | 肽嵌合抗原受体t细胞开关和其用途 |
| CA2926698C (en) | 2013-10-15 | 2021-06-22 | The California Institute For Biomedical Research | Chimeric antigen receptor t cell switches and uses thereof |
| EP3082797A4 (en) | 2013-12-18 | 2017-12-13 | The California Institute for Biomedical Research | Modified therapeutic agents, stapled peptide lipid conjugates, and compositions thereof |
| SG10201913735SA (en) | 2014-03-24 | 2020-03-30 | Bioverativ Therapeutics Inc | Lyophilized factor ix formulations |
| WO2016154621A1 (en) | 2015-03-26 | 2016-09-29 | The California Institute For Biomedical Research | SWITCHABLE NON-scFv CHIMERIC RECEPTORS, SWITCHES, AND USES THEREOF |
| EP3283113A4 (en) | 2015-04-15 | 2018-12-05 | The California Institute for Biomedical Research | Optimized pne-based chimeric receptor t cell switches and uses thereof |
| CA2987877A1 (en) | 2015-06-01 | 2016-12-08 | Medigene Immunotherapies Gmbh | T-cell receptor specific antibodies |
| NZ737400A (en) | 2015-06-01 | 2019-09-27 | Medigene Immunotherapies Gmbh | T cell receptor library |
| US11292838B2 (en) | 2015-06-01 | 2022-04-05 | Medigene Immunotherapies Gmbh | Method for generating antibodies against T cell receptor |
| WO2016205488A1 (en) | 2015-06-17 | 2016-12-22 | The California Institute For Biomedical Research | Modified therapeutic agents and compositions thereof |
| MX2017015817A (es) | 2015-07-06 | 2018-04-10 | Ucb Biopharma Sprl | Anticuerpos de union a tau. |
| JP6951825B2 (ja) | 2015-09-04 | 2021-10-20 | ザ スクリプス リサーチ インスティテュート | インスリン免疫グロブリン融合タンパク質 |
| US11161891B2 (en) | 2015-12-09 | 2021-11-02 | The Scripps Research Institute | Relaxin immunoglobulin fusion proteins and methods of use |
| AU2016374874B2 (en) | 2015-12-23 | 2020-12-03 | Helmholtz Zentrum Munchen Deutsches Forschungszentrum Fur Gesundheit Und Umwelt (Gmbh) | Dendritic cell composition |
| US11174306B2 (en) | 2016-10-19 | 2021-11-16 | The Scripps Research Institute | Chimeric antigen receptor effector cell switches with humanized targeting moieties and/or optimized chimeric antigen receptor interacting domains and uses thereof |
| US20200199207A1 (en) | 2017-06-23 | 2020-06-25 | Mabylon Ag | Anti-allergen antibodies |
| WO2019241430A2 (en) | 2018-06-12 | 2019-12-19 | Angiex, Inc. | Antibody-oligonucleotide conjugates |
| US12098212B2 (en) | 2019-08-12 | 2024-09-24 | Purinomia Biotech, Inc. | Methods and compositions for promoting and potentiating T-cell mediated immune responses through ADCC targeting of CD39 expressing cells |
| CN115551594A (zh) | 2019-10-24 | 2022-12-30 | 米诺陶治疗公司 | 经细胞因子修饰的嵌合抗体及其使用方法 |
| US20250197525A1 (en) | 2021-04-28 | 2025-06-19 | Minotaur Therapeutics, Inc. | Humanized chimeric bovine antibodies and methods of use |
| IL309067A (en) | 2021-06-09 | 2024-02-01 | Scripps Research Inst | Long-acting dual gip/glp-1 peptide conjugates and methods of use |
| TW202332471A (zh) | 2021-12-01 | 2023-08-16 | 比利時商Ucb生物製藥公司 | 調配物 |
| JP2025509284A (ja) * | 2022-03-08 | 2025-04-11 | コネクスト カンパニー リミテッド | コラゲナーゼ、カルシウム、ヒスチジン及びグリシンを含む組成物及びコラゲナーゼの安定化方法 |
| KR20250006965A (ko) | 2022-04-29 | 2025-01-13 | 퓨리노미아 바이오테크, 아이엔씨. | 호산구에 의해 유발되는 질환 및 장애의 치료를 위한 방법 및 조성물 |
| EP4635980A1 (en) | 2024-04-19 | 2025-10-22 | Medigene Immunotherapies GmbH | Uni-tags specific antibody |
| WO2025238135A2 (en) | 2024-05-17 | 2025-11-20 | UCB Biopharma SRL | Antibody with binding specificity for il-11 |
| WO2025238133A1 (en) | 2024-05-17 | 2025-11-20 | UCB Biopharma SRL | Multispecific antibody with binding specificity for il-11 and il-17 |
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|---|---|---|---|---|
| JPS5480406A (en) * | 1977-12-09 | 1979-06-27 | Tanabe Seiyaku Co Ltd | Preparation of urokinase for injection |
| DE3045153A1 (de) * | 1980-11-29 | 1982-07-08 | Behringwerke Ag, 3550 Marburg | Verfahren zur herstellung von blutgerinnungsfaktoren und danach hergestellte praeparation der faktoren ix und x |
| US4495278A (en) | 1981-04-27 | 1985-01-22 | Baxter Travenol Laboratories, Inc. | Process for making novel blood clotting enzyme compositions |
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| AT376881B (de) * | 1983-05-02 | 1985-01-10 | Immuno Ag | Verfahren zur inaktivierung von vermehrungsfaehigen krankheitserregern |
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| US6372716B1 (en) * | 1994-04-26 | 2002-04-16 | Genetics Institute, Inc. | Formulations for factor IX |
-
1994
- 1994-04-26 US US08/233,663 patent/US6372716B1/en not_active Expired - Lifetime
-
1995
- 1995-04-06 CA CA002182200A patent/CA2182200C/en not_active Expired - Lifetime
- 1995-04-06 PT PT95915040T patent/PT758248E/pt unknown
- 1995-04-06 WO PCT/US1995/004263 patent/WO1995028954A1/en not_active Ceased
- 1995-04-06 DE DE69531204T patent/DE69531204T2/de not_active Expired - Lifetime
- 1995-04-06 DK DK95915040T patent/DK0758248T3/da active
- 1995-04-06 JP JP7527660A patent/JPH09512267A/ja not_active Withdrawn
- 1995-04-06 EP EP95915040A patent/EP0758248B1/en not_active Expired - Lifetime
- 1995-04-06 AU AU22075/95A patent/AU695084B2/en not_active Expired
- 1995-04-06 ES ES95915040T patent/ES2202356T3/es not_active Expired - Lifetime
- 1995-04-06 AT AT95915040T patent/ATE244015T1/de active
-
2006
- 2006-05-22 JP JP2006141780A patent/JP4789698B2/ja not_active Expired - Lifetime
-
2007
- 2007-06-13 JP JP2007156252A patent/JP2007224052A/ja not_active Withdrawn
-
2009
- 2009-11-25 JP JP2009267797A patent/JP2010077148A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| CA2182200A1 (en) | 1995-11-02 |
| WO1995028954A1 (en) | 1995-11-02 |
| DK0758248T3 (da) | 2003-10-27 |
| JP2007224052A (ja) | 2007-09-06 |
| US6372716B1 (en) | 2002-04-16 |
| JP2010077148A (ja) | 2010-04-08 |
| AU695084B2 (en) | 1998-08-06 |
| CA2182200C (en) | 1999-02-02 |
| DE69531204T2 (de) | 2004-04-22 |
| ES2202356T3 (es) | 2004-04-01 |
| JPH09512267A (ja) | 1997-12-09 |
| EP0758248A1 (en) | 1997-02-19 |
| EP0758248B1 (en) | 2003-07-02 |
| JP2006219500A (ja) | 2006-08-24 |
| ATE244015T1 (de) | 2003-07-15 |
| AU2207595A (en) | 1995-11-16 |
| DE69531204D1 (de) | 2003-08-07 |
| JP4789698B2 (ja) | 2011-10-12 |
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