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PT3527670T - Biogénese de mirna em exossomas para diagnóstico e terapia - Google Patents

Biogénese de mirna em exossomas para diagnóstico e terapia

Info

Publication number
PT3527670T
PT3527670T PT191512201T PT19151220T PT3527670T PT 3527670 T PT3527670 T PT 3527670T PT 191512201 T PT191512201 T PT 191512201T PT 19151220 T PT19151220 T PT 19151220T PT 3527670 T PT3527670 T PT 3527670T
Authority
PT
Portugal
Prior art keywords
exosomes
diagnosis
therapy
mirna biogenesis
biogenesis
Prior art date
Application number
PT191512201T
Other languages
English (en)
Original Assignee
Beth Israel Deaconess Medical Ct Inc
The Univ Of Texas System Board Of Regents
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beth Israel Deaconess Medical Ct Inc, The Univ Of Texas System Board Of Regents filed Critical Beth Israel Deaconess Medical Ct Inc
Publication of PT3527670T publication Critical patent/PT3527670T/pt

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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P35/00Antineoplastic agents
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    • C07K14/4703Inhibitors; Suppressors
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57488Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds identifable in body fluids
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C12N2310/00Structure or type of the nucleic acid
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    • C12N2310/14Type of nucleic acid interfering nucleic acids [NA]
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/14Type of nucleic acid interfering nucleic acids [NA]
    • C12N2310/141MicroRNAs, miRNAs
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    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/178Oligonucleotides characterized by their use miRNA, siRNA or ncRNA
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701Details
    • G01N2333/4703Regulators; Modulating activity
    • G01N2333/4704Inhibitors; Supressors
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

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  • Proteomics, Peptides & Aminoacids (AREA)
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PT191512201T 2013-03-15 2014-03-14 Biogénese de mirna em exossomas para diagnóstico e terapia PT3527670T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361791301P 2013-03-15 2013-03-15

Publications (1)

Publication Number Publication Date
PT3527670T true PT3527670T (pt) 2024-01-18

Family

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Family Applications (1)

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PT191512201T PT3527670T (pt) 2013-03-15 2014-03-14 Biogénese de mirna em exossomas para diagnóstico e terapia

Country Status (15)

Country Link
US (2) US20160024503A1 (pt)
EP (2) EP3527670B1 (pt)
JP (2) JP6554458B2 (pt)
KR (1) KR102183406B1 (pt)
CN (2) CN109852695B (pt)
AU (2) AU2014239309B2 (pt)
BR (1) BR112015023275B1 (pt)
CA (2) CA3209023A1 (pt)
ES (1) ES2966571T3 (pt)
HK (1) HK1218143A1 (pt)
IL (2) IL241409B (pt)
MX (2) MX373957B (pt)
PT (1) PT3527670T (pt)
RU (2) RU2644247C2 (pt)
WO (1) WO2014152622A1 (pt)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016150475A1 (en) * 2015-03-22 2016-09-29 Universite De Liege Circulating micrornas for the diagnosis of breast cancer
CN104774966B (zh) * 2015-05-01 2017-07-28 北京博奥医学检验所有限公司 肺腺癌miRNA标记物
EA201890006A1 (ru) 2015-06-10 2018-05-31 Борд Оф Риджентс, Дзе Юниверсити Оф Техас Систем Применение экзосом для лечения болезни
CN107151661A (zh) * 2016-03-02 2017-09-12 上海润腾生物科技有限公司 一种人外泌体蛋白、试剂盒及其应用
CN106202984B (zh) * 2016-08-26 2018-09-04 赵毅 一种基于多层复杂网络对肿瘤miRNA标志物的筛选方法
US20200063208A1 (en) * 2016-10-13 2020-02-27 University Of Louisville Research Foundation, Inc. Exosomal biomarkers for diagnosis and prognosis of cancer and related methods
EP3513346B1 (en) 2016-11-30 2020-04-15 Microsoft Technology Licensing, LLC Dna random access storage system via ligation
US10793897B2 (en) * 2017-02-08 2020-10-06 Microsoft Technology Licensing, Llc Primer and payload design for retrieval of stored polynucleotides
US11377699B2 (en) * 2017-11-30 2022-07-05 Provincial Health Services Authority Methods for evaluating head and neck cancers
CN112513297B (zh) 2018-03-28 2024-10-22 得克萨斯州大学系统董事会 鉴定从外排体分离的dna中的表观遗传改变
IL277605B2 (en) * 2018-03-29 2025-01-01 Technion Res & Dev Foundation PTEN inhibitor-containing vesicles and their uses
TWI805739B (zh) * 2018-04-17 2023-06-21 臺北榮民總醫院 阻斷緊迫導致腫瘤生成之方法
EP3786307A4 (en) 2018-04-25 2022-08-24 Toray Industries, Inc. BLADDER CANCER DETECTION KIT, DEVICE AND METHOD
JP7710849B2 (ja) 2018-10-17 2025-07-22 合同会社H.U.グループ中央研究所 細胞外小胞の回収方法
US11766484B2 (en) 2019-01-03 2023-09-26 International Business Machines Corporation Exosome vessels for delivery of molecular cargo
CA3129248A1 (en) 2019-02-08 2020-08-13 Board Of Regents, The University Of Texas System Telomerase-containing exosomes for treatment of diseases associated with aging and age-related organ dysfunction
WO2020163553A1 (en) * 2019-02-08 2020-08-13 Virginia Commonwealth University Mda-7/il-24 for cancer treatment and methods of monitoring same
EP3904518A4 (en) * 2019-02-26 2023-10-11 Seoul National University R & DB Foundation PHARMACEUTICAL COMPOSITION FOR THE PREVENTION OR TREATMENT OF CANCER, COMPRISING A TUT4/7 EXPRESSION MODULATOR
WO2021003403A1 (en) * 2019-07-02 2021-01-07 Ohio State Innovation Foundation Neurodegenerative disease therapies utilizing the skin-brain axis
US20220275455A1 (en) * 2019-07-08 2022-09-01 Preferred Networks, Inc. Data processing and classification for determining a likelihood score for breast disease
CN110358835A (zh) * 2019-07-26 2019-10-22 泗水县人民医院 生物标志物在胃癌检测、诊断中的应用
KR102212699B1 (ko) * 2019-08-12 2021-02-05 한국원자력의학원 유방암 예방 또는 치료용 조성물
CN110607361A (zh) * 2019-10-08 2019-12-24 南京市儿童医院 miR-431作为靶点在制备促进SP表达的药物中的应用
JP7687963B2 (ja) 2019-12-23 2025-06-03 富士レビオ株式会社 細胞外小胞の回収方法、および採血管
EP3862441A3 (en) * 2020-02-04 2021-10-27 Artemisia S.p.A. Method for the early diagnosis of cancer by means of ddpcr analysis of mirna and protein markers in liquid biopsy
EP3862442A3 (en) * 2020-02-04 2021-10-27 Artemisia S.p.A. Method for the early diagnosis of cancer by means of ddpcr analysis of mirna in liquid biopsy
KR102318328B1 (ko) * 2020-04-13 2021-10-27 고려대학교 산학협력단 Gcc2 단백질을 과발현하는 엑소좀 기반 암 진단 또는 예후 예측용 마커 조성물
US20230227916A1 (en) 2020-04-15 2023-07-20 H.U. Group Research Institute G.K. Method for recovering extracellular vesicle
CN111920961B (zh) * 2020-08-14 2023-09-08 福建医科大学附属协和医院 一种治疗癌症的药物
EP4212632A4 (en) * 2020-09-08 2024-07-17 Urotech. Co., Ltd. METHODS FOR CALCULATION OF THE DIAGNOSTIC PROSTATE CANCER SCORE AND USES THEREOF
KR102497196B1 (ko) 2020-09-08 2023-02-07 (주)유로테크 전립선암 진단 점수 계산 방법 및 그 용도
JP7460203B2 (ja) * 2020-11-11 2024-04-02 国立研究開発法人物質・材料研究機構 細胞で産生された膜小胞に由来する塩基配列を解析する方法、その装置、及び、そのプログラム
CN112662752B (zh) * 2021-01-18 2022-08-23 中国农业大学 一种诊断用生物标志物的应用
CN112760381B (zh) * 2021-02-08 2022-11-01 复旦大学附属中山医院 一种检测肺腺癌预后的miRNA试剂盒
KR102310302B1 (ko) * 2021-02-08 2021-10-06 을지대학교 산학협력단 엑소좀 기반 방광암 진단을 위한 정보 제공 방법
CN117802235B (zh) * 2022-09-30 2025-08-19 上海思路迪生物医学科技有限公司 血液胞外囊泡miRNA在卵巢癌诊断中的应用
CN116121377A (zh) * 2022-11-01 2023-05-16 山西医科大学 一种食管鳞癌外泌体富含的miRNA作为诊断食管鳞癌的标志物中的应用
CN117778574B (zh) * 2023-12-25 2024-09-03 山东中医药大学 Mir937基因组拷贝数扩增在卵巢癌诊断和/或治疗中的应用
CN118421798B (zh) * 2024-05-22 2025-02-07 南通市海门区人民医院 用于检测结直肠癌相关血清生物标志物、sers传感器及制备方法
EP4667011A1 (en) * 2024-06-17 2025-12-24 Bios-Therapy, Physiological Systems for Health S.p.A. Epigenau/11: a natural matrix with therapeutic activity

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030064949A1 (en) 1998-02-17 2003-04-03 Loretta Nielsen Combined tumor suppressor gene therapy and chemotherapy in the treatment of neoplasms
FR2766205B1 (fr) 1997-07-16 2002-08-30 Inst Nat Sante Rech Med Nouveau procede de sensibilisation de cellules presentatrices d'antigene et nouveaux moyens pour la mise en oeuvre du procede
KR100519384B1 (ko) 2002-08-13 2005-10-06 (주)누백스 유전자 이입을 이용한 엑소좀의 제조방법 및 상기 엑소좀의 용도
CN1281279C (zh) * 2004-09-16 2006-10-25 浙江大学 针对表皮生长因子基因的小干扰核糖核酸分子及其用途
EP2613149B1 (en) * 2007-07-25 2014-09-17 University Of Louisville Research Foundation, Inc. Exosome-associated microRNA as a diagnostic marker
EP3112464A1 (en) * 2007-09-14 2017-01-04 The Ohio State University Research Foundation Mirna expression in human peripheral blood microvesicles and uses thereof
EP2197497B1 (en) * 2007-09-27 2016-06-01 ImmunoVaccine Technologies Inc. Use of liposomes in a carrier comprising a continuous hydrophobic phase for delivery of polynucleotides in vivo
ES2936256T3 (es) 2008-02-01 2023-03-15 Massachusetts Gen Hospital Uso de microvesículas en el diagnóstico, y pronóstico de enfermedades y afecciones médicas
CN104031984A (zh) * 2008-02-28 2014-09-10 俄亥俄州立大学研究基金会 用于前列腺相关病症的诊断、预后和治疗的基于微rna的方法和组合物
WO2009126563A1 (en) 2008-04-11 2009-10-15 The University Of North Carolina At Chapel Hill Methods and compositions for the regulation of microrna processing
WO2009147519A1 (en) 2008-06-06 2009-12-10 Centre National De La Recherche Scientifique - Cnrs- Use of endo-lysosomal system and secreted vesicles (exosome-like) in treatments and diagnostics based on small rna and experimental study of small rna
WO2013022995A2 (en) * 2011-08-08 2013-02-14 Caris Life Sciences Luxembourg Holdings, S.A.R.L. Biomarker compositions and methods
BRPI0921043A2 (pt) * 2008-11-12 2018-08-07 Caris Life Sciences Luxembourg Holdings métodos e sistemas para usar exossomas para determinar fenótipos
KR20130043104A (ko) * 2010-04-06 2013-04-29 카리스 라이프 사이언스 룩셈부르크 홀딩스 질병용 순환 생물학적 지표들
EP2561072A4 (en) * 2010-04-20 2016-04-06 Univ Florida NANOZYME, METHOD FOR THE PRODUCTION OF NANOCYMENTS AND METHOD FOR THE USE OF NANOCYMENTS
ES2629502T3 (es) 2011-03-11 2017-08-10 Children's Medical Center Corporation Métodos y composiciones relacionados con exosomas de células madre mesenquimales
CA2871089A1 (en) 2011-04-20 2012-10-26 Smith Holdings, Llc Methods and compositions for modulating gene expression using components that self assemble in cells and produce rnai activity
US9777042B2 (en) 2011-12-15 2017-10-03 Morehouse School Of Medicine Method of purifying HIV/SIV Nef from exosomal fusion proteins
JP2017501694A (ja) 2013-12-04 2017-01-19 ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム 診断および療法のためのエキソソーム中のゲノムdna、rnaおよびタンパク質の分析
MX2019002339A (es) * 2016-09-02 2019-05-16 Dicerna Pharmaceuticals Inc Analogos de 4'-fosfato y oligonucleotidos que los comprenden.

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BR112015023275B1 (pt) 2022-06-21
IL241409B (en) 2020-04-30
WO2014152622A1 (en) 2014-09-25
EP3527670B1 (en) 2023-10-18
JP2018138057A (ja) 2018-09-06
CA2905081C (en) 2023-10-03
RU2015144212A (ru) 2017-04-21
RU2644247C2 (ru) 2018-02-08
US20160024503A1 (en) 2016-01-28
AU2014239309A1 (en) 2015-10-08
US11926824B2 (en) 2024-03-12
JP6807351B2 (ja) 2021-01-06
IL273829A (en) 2020-05-31
CN109852695A (zh) 2019-06-07
KR102183406B1 (ko) 2020-12-11
HK1218143A1 (zh) 2017-02-03
MX2015013141A (es) 2016-06-21
MX2020005165A (es) 2020-08-20
AU2020203590A1 (en) 2020-06-18
ES2966571T3 (es) 2024-04-23
RU2018101152A3 (pt) 2019-02-21
BR112015023275A8 (pt) 2018-01-23
US20200255831A1 (en) 2020-08-13
CN109852695B (zh) 2023-11-21
BR112015023275A2 (pt) 2017-07-18
AU2020203590B2 (en) 2023-06-22
IL273829B (en) 2021-12-01
CN105264092A (zh) 2016-01-20
IL241409A0 (en) 2015-11-30
JP2016520803A (ja) 2016-07-14
EP3527670A1 (en) 2019-08-21
CN105264092B (zh) 2019-02-22
KR20160006673A (ko) 2016-01-19
MX373957B (es) 2020-07-13
CA3209023A1 (en) 2014-09-25
EP2971162B1 (en) 2019-05-08
RU2018101152A (ru) 2019-02-21
JP6554458B2 (ja) 2019-07-31
CA2905081A1 (en) 2014-09-25
EP2971162A4 (en) 2016-11-16
AU2014239309B2 (en) 2020-03-05
EP2971162A1 (en) 2016-01-20

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