PT3398598T - Derivado de sulfonamida e método de preparação e utilização do mesmo - Google Patents
Derivado de sulfonamida e método de preparação e utilização do mesmoInfo
- Publication number
- PT3398598T PT3398598T PT168812378T PT16881237T PT3398598T PT 3398598 T PT3398598 T PT 3398598T PT 168812378 T PT168812378 T PT 168812378T PT 16881237 T PT16881237 T PT 16881237T PT 3398598 T PT3398598 T PT 3398598T
- Authority
- PT
- Portugal
- Prior art keywords
- preparation
- sulfonamide derivative
- sulfonamide
- derivative
- Prior art date
Links
- HFFXLYHRNRKAPM-UHFFFAOYSA-N 2,4,5-trichloro-n-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide Chemical compound O1C(C)=CC(NS(=O)(=O)C=2C(=CC(Cl)=C(Cl)C=2)Cl)=N1 HFFXLYHRNRKAPM-UHFFFAOYSA-N 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/78—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/96—Sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D411/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201511029249 | 2015-12-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT3398598T true PT3398598T (pt) | 2022-07-12 |
Family
ID=59225913
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT168812378T PT3398598T (pt) | 2015-12-31 | 2016-12-29 | Derivado de sulfonamida e método de preparação e utilização do mesmo |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US11149008B2 (pt) |
| EP (1) | EP3398598B1 (pt) |
| JP (1) | JP6804540B2 (pt) |
| KR (1) | KR102264012B1 (pt) |
| CN (1) | CN106928198B (pt) |
| AU (1) | AU2016382372B2 (pt) |
| CA (1) | CA3010326C (pt) |
| DK (1) | DK3398598T3 (pt) |
| ES (1) | ES2920888T3 (pt) |
| PL (1) | PL3398598T3 (pt) |
| PT (1) | PT3398598T (pt) |
| WO (1) | WO2017114448A1 (pt) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI3191470T1 (sl) | 2015-07-06 | 2019-04-30 | Gilead Sciences, Inc. | Modulatorji COT in postopki njihove uporabe |
| CN109705071B (zh) * | 2017-10-25 | 2020-11-13 | 成都先导药物开发股份有限公司 | Hdac抑制剂及其制备方法和用途 |
| CN108299255B (zh) * | 2018-02-11 | 2020-05-19 | 山东大学 | 组蛋白去乙酰化酶8选择性抑制剂及其制备方法和应用 |
| TWI770527B (zh) | 2019-06-14 | 2022-07-11 | 美商基利科學股份有限公司 | Cot 調節劑及其使用方法 |
| EP4126231A1 (en) | 2020-03-30 | 2023-02-08 | Gilead Sciences, Inc. | Solid forms of (s)-6-(((1-(bicyclo[1.1.1]pentan-1-yl)-1h-1,2,3-triazol-4-yl)2-methyl-1-oxo-1,2- dihydroisoquinolin-5-yl)methyl)))amino)8-chloro-(neopentylamino)quinoline-3-carb onitrile a cot inhibitor compound |
| TWI778562B (zh) | 2020-04-02 | 2022-09-21 | 美商基利科學股份有限公司 | 製備cot抑制劑化合物的方法 |
| CN119173510A (zh) * | 2022-05-20 | 2024-12-20 | 四川汇宇制药股份有限公司 | 一种羟基酰胺类衍生物及其应用 |
| CN116803983A (zh) * | 2022-05-26 | 2023-09-26 | 杭州师范大学 | 一种组蛋白去乙酰化酶和热休克蛋白110KDa双靶点抑制剂及应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2347544T3 (es) * | 2002-03-13 | 2010-11-02 | Janssen Pharmaceutica Nv | Inhibidores de histona-desacetilasas. |
| WO2004013324A1 (ja) * | 2002-08-01 | 2004-02-12 | Mochida Pharmaceutical Co., Ltd. | 結晶性新規トリプターゼおよびその利用 |
| US7345043B2 (en) * | 2004-04-01 | 2008-03-18 | Miikana Therapeutics | Inhibitors of histone deacetylase |
| ITFI20050041A1 (it) * | 2005-03-15 | 2006-09-16 | Menarini Internat Operations Luxembourg Sa | Idrossammati come inibitori dell'istone deacelitasi, loro preparazione e formulazioni farmaceutiche che li contengono |
| AU2008345225A1 (en) * | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| JP2011528013A (ja) * | 2008-07-14 | 2011-11-10 | ノバルティス アーゲー | ヒドロキサム酸系の選択的mmp−12およびmmp−13阻害剤 |
| US9914717B2 (en) * | 2012-12-20 | 2018-03-13 | The Broad Institute, Inc. | Cycloalkenyl hydroxamic acid derivatives and their use as histone deacetylase inhibitors |
| WO2016107541A1 (zh) * | 2014-12-29 | 2016-07-07 | 成都先导药物开发有限公司 | 吡咯酰胺类化合物及其制备方法与用途 |
-
2016
- 2016-12-29 JP JP2018534705A patent/JP6804540B2/ja active Active
- 2016-12-29 ES ES16881237T patent/ES2920888T3/es active Active
- 2016-12-29 KR KR1020187019144A patent/KR102264012B1/ko active Active
- 2016-12-29 CN CN201611243758.3A patent/CN106928198B/zh active Active
- 2016-12-29 DK DK16881237.8T patent/DK3398598T3/da active
- 2016-12-29 EP EP16881237.8A patent/EP3398598B1/en active Active
- 2016-12-29 US US16/067,097 patent/US11149008B2/en active Active
- 2016-12-29 WO PCT/CN2016/112896 patent/WO2017114448A1/zh not_active Ceased
- 2016-12-29 AU AU2016382372A patent/AU2016382372B2/en active Active
- 2016-12-29 PL PL16881237.8T patent/PL3398598T3/pl unknown
- 2016-12-29 CA CA3010326A patent/CA3010326C/en active Active
- 2016-12-29 PT PT168812378T patent/PT3398598T/pt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP3398598A1 (en) | 2018-11-07 |
| DK3398598T3 (da) | 2022-07-11 |
| US20190031612A1 (en) | 2019-01-31 |
| WO2017114448A1 (zh) | 2017-07-06 |
| US11149008B2 (en) | 2021-10-19 |
| CA3010326A1 (en) | 2017-07-06 |
| JP2019501919A (ja) | 2019-01-24 |
| CN106928198B (zh) | 2020-07-28 |
| ES2920888T3 (es) | 2022-08-11 |
| JP6804540B2 (ja) | 2020-12-23 |
| EP3398598B1 (en) | 2022-04-06 |
| KR20180086258A (ko) | 2018-07-30 |
| CA3010326C (en) | 2020-07-14 |
| AU2016382372A1 (en) | 2018-07-19 |
| CN106928198A (zh) | 2017-07-07 |
| EP3398598A4 (en) | 2018-11-07 |
| AU2016382372B2 (en) | 2019-09-19 |
| PL3398598T3 (pl) | 2022-08-22 |
| KR102264012B1 (ko) | 2021-06-10 |
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