PT3162378T - Sistema de vacinação nasal para vacina contra a gripe - Google Patents
Sistema de vacinação nasal para vacina contra a gripeInfo
- Publication number
- PT3162378T PT3162378T PT158115048T PT15811504T PT3162378T PT 3162378 T PT3162378 T PT 3162378T PT 158115048 T PT158115048 T PT 158115048T PT 15811504 T PT15811504 T PT 15811504T PT 3162378 T PT3162378 T PT 3162378T
- Authority
- PT
- Portugal
- Prior art keywords
- influenza vaccine
- vaccination system
- nasal vaccination
- vaccine nasal
- influenza
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/001—Particle size control
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/006—Sprayers or atomisers specially adapted for therapeutic purposes operated by applying mechanical pressure to the liquid to be sprayed or atomised
- A61M11/007—Syringe-type or piston-type sprayers or atomisers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/06—Sprayers or atomisers specially adapted for therapeutic purposes of the injector type
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B1/00—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means
- B05B1/34—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl
- B05B1/3405—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl to produce swirl
- B05B1/341—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl to produce swirl before discharging the liquid or other fluent material, e.g. in a swirl chamber upstream the spray outlet
- B05B1/3421—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl to produce swirl before discharging the liquid or other fluent material, e.g. in a swirl chamber upstream the spray outlet with channels emerging substantially tangentially in the swirl chamber
- B05B1/3431—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl to produce swirl before discharging the liquid or other fluent material, e.g. in a swirl chamber upstream the spray outlet with channels emerging substantially tangentially in the swirl chamber the channels being formed at the interface of cooperating elements, e.g. by means of grooves
- B05B1/3436—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl to produce swirl before discharging the liquid or other fluent material, e.g. in a swirl chamber upstream the spray outlet with channels emerging substantially tangentially in the swirl chamber the channels being formed at the interface of cooperating elements, e.g. by means of grooves the interface being a plane perpendicular to the outlet axis
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
- B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
- B05B11/02—Membranes or pistons acting on the contents inside the container, e.g. follower pistons
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/543—Mucosal route intranasal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2206/00—Characteristics of a physical parameter; associated device therefor
- A61M2206/10—Flow characteristics
- A61M2206/16—Rotating swirling helical flow, e.g. by tangential inflows
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/06—Head
- A61M2210/0618—Nose
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Anesthesiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Dispersion Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pulmonology (AREA)
- Organic Chemistry (AREA)
- Mechanical Engineering (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2014130365 | 2014-06-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT3162378T true PT3162378T (pt) | 2024-03-05 |
Family
ID=54938207
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT158115048T PT3162378T (pt) | 2014-06-25 | 2015-06-24 | Sistema de vacinação nasal para vacina contra a gripe |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US11103453B2 (pt) |
| EP (1) | EP3162378B1 (pt) |
| JP (1) | JP6456379B2 (pt) |
| KR (1) | KR102491446B1 (pt) |
| CN (1) | CN106573045B (pt) |
| AU (1) | AU2015281148B2 (pt) |
| CA (1) | CA2951982C (pt) |
| DK (1) | DK3162378T3 (pt) |
| ES (1) | ES2973258T3 (pt) |
| FI (1) | FI3162378T3 (pt) |
| HU (1) | HUE065638T2 (pt) |
| IL (1) | IL249500A0 (pt) |
| LT (1) | LT3162378T (pt) |
| MA (1) | MA40181A (pt) |
| MX (1) | MX2017000154A (pt) |
| MY (1) | MY192073A (pt) |
| NZ (1) | NZ727360A (pt) |
| PH (1) | PH12016502529A1 (pt) |
| PL (1) | PL3162378T3 (pt) |
| PT (1) | PT3162378T (pt) |
| RU (1) | RU2696483C2 (pt) |
| SG (2) | SG10201811438XA (pt) |
| SI (1) | SI3162378T1 (pt) |
| TW (1) | TWI721949B (pt) |
| WO (1) | WO2015199129A1 (pt) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3099430A1 (en) * | 2018-06-05 | 2019-12-12 | Toko Yakuhin Kogyo Co., Ltd. | Hepatitis b vaccine transnasal administration system |
| JP7288270B2 (ja) * | 2018-09-26 | 2023-06-07 | デンカ株式会社 | 不活化全粒子インフルエンザワクチン及びその調製法 |
| CN113058149B (zh) * | 2021-04-27 | 2024-11-29 | 任进 | 内外两用喷注器 |
| GB202202890D0 (en) * | 2022-03-02 | 2022-04-13 | Consort Medical Ltd | Improvements relating to nasal pieces |
| US11759586B1 (en) * | 2022-04-13 | 2023-09-19 | Ferrer Medical Innovations, LLC | Nasal spray bottle with improved nozzle and system of application |
| CN219022752U (zh) * | 2022-07-28 | 2023-05-16 | 纳索菲德(上海)制药技术有限公司 | 向鼻内喷射药液的喷雾头及其装置 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3669359A (en) | 1970-09-18 | 1972-06-13 | Precision Valve Corp | Aerosol mechanical break-up nozzle insert |
| JPH0291553A (ja) | 1988-09-29 | 1990-03-30 | Toshiba Corp | 産業用ct装置 |
| JPH0529703Y2 (pt) | 1988-12-28 | 1993-07-29 | ||
| US5158761A (en) * | 1989-04-05 | 1992-10-27 | Toko Yakuhin Kogyo Kabushiki Kaisha | Spray gel base and spray gel preparation using thereof |
| JPH0678245B2 (ja) | 1989-07-04 | 1994-10-05 | 東興薬品工業株式会社 | 鼻腔内噴霧投与用インフルエンザワクチンゲル製剤 |
| US5215739A (en) * | 1989-04-05 | 1993-06-01 | Toko Yakuhin Kogyo Kabushiki Kaisha | Spray gel base and spray gel preparation using thereof |
| JP2922935B2 (ja) | 1989-08-11 | 1999-07-26 | 東興薬品工業株式会社 | 粘稠液用鼻孔内噴霧容器の使捨てアダプタ |
| JPH03114248A (ja) | 1990-08-30 | 1991-05-15 | Ibiden Co Ltd | 半導体搭載用プリント配線基板の製造方法 |
| IT1249600B (it) | 1991-02-21 | 1995-03-09 | Elettro Plastica Spa | Erogatore nasale di sostanze farmaceutiche nebulizzate |
| US5601077A (en) | 1991-08-07 | 1997-02-11 | Becton, Dickinson And Company | Nasal syringe sprayer with removable dose limiting structure |
| KR0151476B1 (ko) * | 1995-04-29 | 1998-10-15 | 배순훈 | 헤드드럼 조립체 및 그 조립방법 |
| FR2773784B1 (fr) * | 1998-01-16 | 2000-03-24 | Valois Sa | Tete de pulverisation pour un distributeur de produit fluide |
| EP1092447B1 (en) | 1999-10-14 | 2004-01-07 | Becton Dickinson and Company | Nasal delivery device including spray nozzle |
| CN100528257C (zh) | 2002-05-09 | 2009-08-19 | 葛兰素集团有限公司 | 流体分配设备 |
| WO2007123207A1 (ja) * | 2006-04-21 | 2007-11-01 | Toko Yakuhin Kogyo Kabushiki Kaisha | 流体用容器およびこれを用いたエアレス式流体投与システム |
| BRPI0710654B1 (pt) | 2006-04-21 | 2021-11-03 | Toko Yakuhin Kogyo Kabushiki Kaisha | Preparação de adesivo para pele/mucosa do tipo gel, pulverizável, e sistema de administração usando a preparação |
| JP5427185B2 (ja) | 2007-11-29 | 2014-02-26 | グラクソ グループ リミテッド | 分配デバイス |
| US9603919B2 (en) | 2009-03-31 | 2017-03-28 | Japan As Represented By The Director-General Of National Institute Of Infectious Diseases | Method for prophylaxis of influenza using vaccine for intranasal administration |
| FR2951442B1 (fr) | 2009-10-20 | 2012-01-20 | Valois Sas | Tete de distribution pour dispositif de distribution de produit fluide. |
| KR101706837B1 (ko) | 2012-03-30 | 2017-02-14 | 가부시키가이샤 요시노 고교쇼 | 주사기형 정량 디스펜서 |
| JP5917367B2 (ja) | 2012-10-31 | 2016-05-11 | 株式会社吉野工業所 | 蓄圧式シリンジ型空気混合液噴出器 |
| DK2939692T3 (da) | 2012-12-28 | 2019-07-08 | Japan As Represented By Director General Of Nat Institute Of Infectious Diseases | Nasal influenzavaccinesammensætning |
-
2015
- 2015-06-24 FI FIEP15811504.8T patent/FI3162378T3/fi active
- 2015-06-24 CN CN201580033878.8A patent/CN106573045B/zh active Active
- 2015-06-24 EP EP15811504.8A patent/EP3162378B1/en active Active
- 2015-06-24 MX MX2017000154A patent/MX2017000154A/es unknown
- 2015-06-24 PT PT158115048T patent/PT3162378T/pt unknown
- 2015-06-24 AU AU2015281148A patent/AU2015281148B2/en active Active
- 2015-06-24 MY MYPI2016704626A patent/MY192073A/en unknown
- 2015-06-24 DK DK15811504.8T patent/DK3162378T3/da active
- 2015-06-24 HU HUE15811504A patent/HUE065638T2/hu unknown
- 2015-06-24 CA CA2951982A patent/CA2951982C/en active Active
- 2015-06-24 LT LTEPPCT/JP2015/068198T patent/LT3162378T/lt unknown
- 2015-06-24 SG SG10201811438XA patent/SG10201811438XA/en unknown
- 2015-06-24 SG SG11201610567TA patent/SG11201610567TA/en unknown
- 2015-06-24 MA MA040181A patent/MA40181A/fr unknown
- 2015-06-24 NZ NZ727360A patent/NZ727360A/en unknown
- 2015-06-24 US US15/322,001 patent/US11103453B2/en active Active
- 2015-06-24 ES ES15811504T patent/ES2973258T3/es active Active
- 2015-06-24 SI SI201531995T patent/SI3162378T1/sl unknown
- 2015-06-24 TW TW104120290A patent/TWI721949B/zh active
- 2015-06-24 RU RU2017101987A patent/RU2696483C2/ru active
- 2015-06-24 PL PL15811504.8T patent/PL3162378T3/pl unknown
- 2015-06-24 KR KR1020177001509A patent/KR102491446B1/ko active Active
- 2015-06-24 JP JP2016529629A patent/JP6456379B2/ja active Active
- 2015-06-24 WO PCT/JP2015/068198 patent/WO2015199129A1/ja not_active Ceased
-
2016
- 2016-12-12 IL IL249500A patent/IL249500A0/en unknown
- 2016-12-16 PH PH12016502529A patent/PH12016502529A1/en unknown
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