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PT2914593T - Estabilização de solvatos de tiotrópio - Google Patents

Estabilização de solvatos de tiotrópio

Info

Publication number
PT2914593T
PT2914593T PT127868016T PT12786801T PT2914593T PT 2914593 T PT2914593 T PT 2914593T PT 127868016 T PT127868016 T PT 127868016T PT 12786801 T PT12786801 T PT 12786801T PT 2914593 T PT2914593 T PT 2914593T
Authority
PT
Portugal
Prior art keywords
tiotropium
solvates
stabilization
tiotropium solvates
Prior art date
Application number
PT127868016T
Other languages
English (en)
Inventor
Hajicek Josef
Cerna Igor
Dammer Ondrej
Kebbati Mokhtar
Billot Pascal
Hosek Patrik
Original Assignee
Zentiva Ks
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zentiva Ks filed Critical Zentiva Ks
Publication of PT2914593T publication Critical patent/PT2914593T/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D451/00Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06Oxygen atoms
    • C07D451/10Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Cleaning And De-Greasing Of Metallic Materials By Chemical Methods (AREA)
  • Medicinal Preparation (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Steroid Compounds (AREA)
PT127868016T 2012-11-05 2012-11-05 Estabilização de solvatos de tiotrópio PT2914593T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CZ2012/000112 WO2014067499A1 (en) 2012-11-05 2012-11-05 Stabilization of tiotropium solvates

Publications (1)

Publication Number Publication Date
PT2914593T true PT2914593T (pt) 2017-04-03

Family

ID=47178436

Family Applications (1)

Application Number Title Priority Date Filing Date
PT127868016T PT2914593T (pt) 2012-11-05 2012-11-05 Estabilização de solvatos de tiotrópio

Country Status (24)

Country Link
EP (1) EP2914593B1 (pt)
JP (1) JP6158939B2 (pt)
KR (1) KR20150079671A (pt)
CN (1) CN104797579A (pt)
BR (1) BR112015009654A2 (pt)
CY (1) CY1118828T1 (pt)
DK (1) DK2914593T3 (pt)
EA (1) EA025960B1 (pt)
ES (1) ES2620758T3 (pt)
HK (1) HK1207625A1 (pt)
HR (1) HRP20170523T1 (pt)
HU (1) HUE032455T2 (pt)
IL (1) IL238503A0 (pt)
LT (1) LT2914593T (pt)
ME (1) ME02679B (pt)
MX (1) MX2015005319A (pt)
PL (1) PL2914593T3 (pt)
PT (1) PT2914593T (pt)
RS (1) RS55919B1 (pt)
SI (1) SI2914593T1 (pt)
SM (1) SMT201700226T1 (pt)
UA (1) UA115888C2 (pt)
WO (1) WO2014067499A1 (pt)
ZA (1) ZA201503043B (pt)

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3931041C2 (de) 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
AP1572A (en) 2000-10-12 2006-02-13 Boehringer Ingelheim Pharma Crystalline monohydrate, method for producing the same and use thereof in the production of a medicament.
PL208137B1 (pl) 2001-06-22 2011-03-31 Boehringer Ingelheim Pharma Bezwodny krystaliczny bromek tiotropium, sposób jego wytwarzania i zastosowanie krystalicznego monohydratu bromku tiotropium do wytwarzania krystalicznego bezwodnego bromku tiotropium
JP4553902B2 (ja) 2003-11-03 2010-09-29 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 抗コリン作用を有する新規結晶性無水物
SI1881980T1 (sl) 2005-05-02 2012-12-31 Boehringer Ingelheim International Gmbh Nove kristalinične oblike tiotropijevega bromida
RU2007144531A (ru) * 2005-05-02 2009-06-10 БЕРИНГЕР ИНГЕЛЬХАЙМ ИНТЕРНАЦИОНАЛЬ ГмбХ (DE) Новые кристаллические формы тиотропийбромида
BRPI0608427A2 (pt) 2005-12-19 2009-12-29 Sicor Inc novas formas de brometo de tiotrópio e processos para seu preparo
CN101331128B (zh) * 2005-12-19 2013-05-29 西科尔公司 噻托溴铵的形式及其制备方法
EP2403851B1 (en) * 2009-03-06 2015-06-17 Mahmut Bilgic New crystalline forms of tiotropium bromide
WO2011015883A1 (en) 2009-08-07 2011-02-10 Generics [Uk] Limited Dichloromethane solvate of tiotropium bromide and its use

Also Published As

Publication number Publication date
EP2914593A1 (en) 2015-09-09
SMT201700226T1 (it) 2017-07-18
MX2015005319A (es) 2015-07-14
HRP20170523T1 (hr) 2017-06-02
LT2914593T (lt) 2017-04-10
EA025960B1 (ru) 2017-02-28
EA201590872A1 (ru) 2015-10-30
JP6158939B2 (ja) 2017-07-05
JP2016502518A (ja) 2016-01-28
PL2914593T3 (pl) 2017-07-31
BR112015009654A2 (pt) 2017-07-04
ME02679B (me) 2017-06-20
KR20150079671A (ko) 2015-07-08
EP2914593B1 (en) 2017-01-11
WO2014067499A1 (en) 2014-05-08
CN104797579A (zh) 2015-07-22
RS55919B1 (sr) 2017-09-29
SI2914593T1 (sl) 2017-05-31
DK2914593T3 (en) 2017-04-18
UA115888C2 (uk) 2018-01-10
CY1118828T1 (el) 2018-01-10
HUE032455T2 (en) 2017-09-28
HK1207625A1 (en) 2016-02-05
ZA201503043B (en) 2016-01-27
ES2620758T3 (es) 2017-06-29
IL238503A0 (en) 2015-06-30

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