PT2970333T - Inibidores macrocíclicos de lrrk2 quinase - Google Patents
Inibidores macrocíclicos de lrrk2 quinaseInfo
- Publication number
- PT2970333T PT2970333T PT147099626T PT14709962T PT2970333T PT 2970333 T PT2970333 T PT 2970333T PT 147099626 T PT147099626 T PT 147099626T PT 14709962 T PT14709962 T PT 14709962T PT 2970333 T PT2970333 T PT 2970333T
- Authority
- PT
- Portugal
- Prior art keywords
- kinase inhibitors
- lrrk2 kinase
- macrocyclic
- macrocyclic lrrk2
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epidemiology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13305311 | 2013-03-15 | ||
| EP13305314 | 2013-03-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2970333T true PT2970333T (pt) | 2017-08-01 |
Family
ID=50277239
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT147099626T PT2970333T (pt) | 2013-03-15 | 2014-03-14 | Inibidores macrocíclicos de lrrk2 quinase |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20160031905A1 (pt) |
| EP (1) | EP2970333B1 (pt) |
| JP (1) | JP2016510793A (pt) |
| KR (1) | KR20150129016A (pt) |
| CN (1) | CN105143232A (pt) |
| AU (1) | AU2014230485A1 (pt) |
| BR (1) | BR112015019873A2 (pt) |
| CA (1) | CA2904462A1 (pt) |
| DK (1) | DK2970333T3 (pt) |
| EA (1) | EA201591698A1 (pt) |
| ES (1) | ES2635021T3 (pt) |
| MX (1) | MX2015011359A (pt) |
| PL (1) | PL2970333T3 (pt) |
| PT (1) | PT2970333T (pt) |
| SG (1) | SG11201506357RA (pt) |
| TW (1) | TW201444850A (pt) |
| WO (1) | WO2014140235A1 (pt) |
| ZA (1) | ZA201506327B (pt) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2014230111A1 (en) * | 2013-03-15 | 2015-10-29 | Oncodesign S.A | Macrocyclic RIP2 kinase inhibitors |
| WO2016146651A1 (en) | 2015-03-16 | 2016-09-22 | Oncodesign Sa | Macrocyclic activin-like receptor kinase inhibitors |
| JP7092405B2 (ja) * | 2018-04-16 | 2022-06-28 | 深▲チェン▼市塔吉瑞生物医薬有限公司 | キナーゼ活性を阻害するためのジ（ヘテロ）アリール大環状化合物 |
| UY39061A (es) * | 2020-01-31 | 2022-01-31 | Oncodesign Sa | Inhibidores macrocíclicos de rip2-cinasa |
| US11858940B2 (en) * | 2020-03-21 | 2024-01-02 | Arvinas Operations, Inc. | Selective modulators of mutant LRRK2 proteolysis and associated methods of use |
| AR127470A1 (es) * | 2021-10-27 | 2024-01-31 | H Lundbeck As | Inhibidores de lrrk2 |
| WO2023222005A1 (zh) * | 2022-05-18 | 2023-11-23 | 上海翊石医药科技有限公司 | 一种芳杂环类化合物及其中间体、药物组合物和用途 |
| CN117659043A (zh) * | 2022-09-07 | 2024-03-08 | 苏州朗睿生物医药有限公司 | 一种大环咪唑并[1,2-b]哒嗪衍生物及其制备方法和用途 |
| US11958865B1 (en) | 2022-09-15 | 2024-04-16 | H. Lundbeck A/S | Leucine-rich repeat kinase 2 (LRRK2) inhibitors |
| AR132486A1 (es) * | 2023-04-20 | 2025-07-02 | H Lundbeck As | Inhibidores de la cinasa con repeticiones ricas en leucina 2 (lrrk2) |
| WO2024218296A1 (en) * | 2023-04-20 | 2024-10-24 | H. Lundbeck A/S | Combination treatments comprising administration of leucine-rich repeat kinase 2 (lrrk2) inhibitors |
| AR132487A1 (es) * | 2023-04-20 | 2025-07-02 | H Lundbeck As | Inhibidores de la cinasa con repeticiones ricas en leucina 2 (lrrk2) |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201008134D0 (en) * | 2010-05-14 | 2010-06-30 | Medical Res Council Technology | Compounds |
| GB201015949D0 (en) * | 2010-09-22 | 2010-11-03 | Medical Res Council Technology | Compounds |
| EP2699572B1 (en) * | 2011-04-21 | 2016-08-10 | Origenis GmbH | Heterocyclic compounds as kinase inhibitors |
| WO2013001310A1 (en) * | 2011-06-30 | 2013-01-03 | Centro Nacional De Investigaciones Oncológicas (Cnio) | Macrocyclic compounds and their use as cdk8 inhibitors |
| UA113186C2 (xx) * | 2011-09-30 | 2016-12-26 | Макроциклічні інгібітори lrrk2 кінази | |
| EA025881B1 (ru) * | 2011-09-30 | 2017-02-28 | Онкодизайн С.А. | Макроциклические ингибиторы flt3-киназы |
-
2014
- 2014-03-14 CN CN201480014168.6A patent/CN105143232A/zh active Pending
- 2014-03-14 PT PT147099626T patent/PT2970333T/pt unknown
- 2014-03-14 BR BR112015019873A patent/BR112015019873A2/pt not_active IP Right Cessation
- 2014-03-14 WO PCT/EP2014/055049 patent/WO2014140235A1/en not_active Ceased
- 2014-03-14 JP JP2015562173A patent/JP2016510793A/ja not_active Abandoned
- 2014-03-14 EA EA201591698A patent/EA201591698A1/ru unknown
- 2014-03-14 AU AU2014230485A patent/AU2014230485A1/en not_active Abandoned
- 2014-03-14 US US14/777,495 patent/US20160031905A1/en not_active Abandoned
- 2014-03-14 KR KR1020157029380A patent/KR20150129016A/ko not_active Withdrawn
- 2014-03-14 CA CA2904462A patent/CA2904462A1/en not_active Abandoned
- 2014-03-14 ES ES14709962.6T patent/ES2635021T3/es active Active
- 2014-03-14 MX MX2015011359A patent/MX2015011359A/es unknown
- 2014-03-14 PL PL14709962T patent/PL2970333T3/pl unknown
- 2014-03-14 SG SG11201506357RA patent/SG11201506357RA/en unknown
- 2014-03-14 DK DK14709962.6T patent/DK2970333T3/en active
- 2014-03-14 EP EP14709962.6A patent/EP2970333B1/en not_active Not-in-force
- 2014-03-14 TW TW103109451A patent/TW201444850A/zh unknown
-
2015
- 2015-08-28 ZA ZA2015/06327A patent/ZA201506327B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HK1219481A1 (en) | 2017-04-07 |
| MX2015011359A (es) | 2015-12-16 |
| JP2016510793A (ja) | 2016-04-11 |
| US20160031905A1 (en) | 2016-02-04 |
| CN105143232A (zh) | 2015-12-09 |
| ES2635021T3 (es) | 2017-10-02 |
| AU2014230485A1 (en) | 2015-09-24 |
| ZA201506327B (en) | 2017-02-22 |
| DK2970333T3 (en) | 2017-08-21 |
| KR20150129016A (ko) | 2015-11-18 |
| WO2014140235A1 (en) | 2014-09-18 |
| EA201591698A1 (ru) | 2016-02-29 |
| TW201444850A (zh) | 2014-12-01 |
| PL2970333T3 (pl) | 2017-12-29 |
| EP2970333A1 (en) | 2016-01-20 |
| CA2904462A1 (en) | 2014-09-18 |
| EP2970333B1 (en) | 2017-05-03 |
| SG11201506357RA (en) | 2015-09-29 |
| BR112015019873A2 (pt) | 2017-07-18 |
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