PT2877490T - Inteínas clivadas, conjugados e suas utilizações - Google Patents
Inteínas clivadas, conjugados e suas utilizaçõesInfo
- Publication number
- PT2877490T PT2877490T PT13809861T PT13809861T PT2877490T PT 2877490 T PT2877490 T PT 2877490T PT 13809861 T PT13809861 T PT 13809861T PT 13809861 T PT13809861 T PT 13809861T PT 2877490 T PT2877490 T PT 2877490T
- Authority
- PT
- Portugal
- Prior art keywords
- conjugates
- split inteins
- inteins
- split
- Prior art date
Links
- 230000017730 intein-mediated protein splicing Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/90—Fusion polypeptide containing a motif for post-translational modification
- C07K2319/92—Fusion polypeptide containing a motif for post-translational modification containing an intein ("protein splicing")domain
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261665215P | 2012-06-27 | 2012-06-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2877490T true PT2877490T (pt) | 2019-02-12 |
Family
ID=49783989
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT13809861T PT2877490T (pt) | 2012-06-27 | 2013-06-24 | Inteínas clivadas, conjugados e suas utilizações |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US20150344549A1 (pt) |
| EP (3) | EP4219549A1 (pt) |
| JP (2) | JP2015522020A (pt) |
| AU (1) | AU2013280693B2 (pt) |
| CA (1) | CA2877882A1 (pt) |
| DK (2) | DK2877490T3 (pt) |
| ES (2) | ES2709333T3 (pt) |
| PL (1) | PL2877490T3 (pt) |
| PT (1) | PT2877490T (pt) |
| WO (1) | WO2014004336A2 (pt) |
Families Citing this family (90)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2734621B1 (en) | 2011-07-22 | 2019-09-04 | President and Fellows of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| US20150044192A1 (en) | 2013-08-09 | 2015-02-12 | President And Fellows Of Harvard College | Methods for identifying a target site of a cas9 nuclease |
| US9340800B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | Extended DNA-sensing GRNAS |
| US9840699B2 (en) | 2013-12-12 | 2017-12-12 | President And Fellows Of Harvard College | Methods for nucleic acid editing |
| WO2016022363A2 (en) | 2014-07-30 | 2016-02-11 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
| CN104263747B (zh) * | 2014-09-22 | 2017-03-15 | 程永升 | 一种长效蛋白质药物表达复性修饰的双标签载体及方法 |
| CA2964119C (en) * | 2014-11-03 | 2022-10-18 | Merck Patent Gmbh | Soluble intein fusion proteins and methods for purifying biomolecules |
| IL258821B (en) | 2015-10-23 | 2022-07-01 | Harvard College | Nucleobase editors and their uses |
| PL3408292T3 (pl) | 2016-01-29 | 2023-10-02 | The Trustees Of Princeton University | Podzielone inteiny o wyjątkowej aktywności splicingu |
| US11293021B1 (en) | 2016-06-23 | 2022-04-05 | Inscripta, Inc. | Automated cell processing methods, modules, instruments, and systems |
| KR20250103795A (ko) | 2016-08-03 | 2025-07-07 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 아데노신 핵염기 편집제 및 그의 용도 |
| CA3033327A1 (en) | 2016-08-09 | 2018-02-15 | President And Fellows Of Harvard College | Programmable cas9-recombinase fusion proteins and uses thereof |
| WO2018039438A1 (en) | 2016-08-24 | 2018-03-01 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| JP7588390B2 (ja) * | 2016-10-14 | 2024-11-22 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 核酸塩基エディターのａａｖ送達 |
| WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
| WO2018165504A1 (en) | 2017-03-09 | 2018-09-13 | President And Fellows Of Harvard College | Suppression of pain by gene editing |
| CN110662556A (zh) | 2017-03-09 | 2020-01-07 | 哈佛大学的校长及成员们 | 癌症疫苗 |
| JP2020510439A (ja) | 2017-03-10 | 2020-04-09 | プレジデント アンド フェローズ オブ ハーバード カレッジ | シトシンからグアニンへの塩基編集因子 |
| BR112019019655A2 (pt) | 2017-03-23 | 2020-04-22 | Harvard College | editores de nucleobase que compreendem proteínas de ligação a dna programáveis por ácido nucleico |
| WO2018209320A1 (en) | 2017-05-12 | 2018-11-15 | President And Fellows Of Harvard College | Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation |
| WO2018213335A1 (en) * | 2017-05-16 | 2018-11-22 | Scalmibio, Inc. | Activatable antibodies and methods of use thereof |
| US10011849B1 (en) | 2017-06-23 | 2018-07-03 | Inscripta, Inc. | Nucleic acid-guided nucleases |
| US9982279B1 (en) | 2017-06-23 | 2018-05-29 | Inscripta, Inc. | Nucleic acid-guided nucleases |
| CA3066253C (en) | 2017-06-30 | 2023-10-31 | Inscripta, Inc. | Automated cell processing methods, modules, instruments, and systems |
| JP2020534795A (ja) | 2017-07-28 | 2020-12-03 | プレジデント アンド フェローズ オブ ハーバード カレッジ | ファージによって支援される連続的進化（ｐａｃｅ）を用いて塩基編集因子を進化させるための方法および組成物 |
| US11319532B2 (en) | 2017-08-30 | 2022-05-03 | President And Fellows Of Harvard College | High efficiency base editors comprising Gam |
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| JP7642531B2 (ja) | 2018-05-11 | 2025-03-10 | ビーム セラピューティクス インク． | プログラム可能塩基エディターシステムを用いて病原性アミノ酸を置換する方法 |
| WO2019226953A1 (en) | 2018-05-23 | 2019-11-28 | The Broad Institute, Inc. | Base editors and uses thereof |
| KR102894715B1 (ko) | 2018-08-03 | 2025-12-03 | 빔 테라퓨틱스, 인크. | 핵산 표적 서열을 변형시키기 위한 다중-이펙터 핵염기 편집기 및 이를 이용하는 방법 |
| US11142740B2 (en) | 2018-08-14 | 2021-10-12 | Inscripta, Inc. | Detection of nuclease edited sequences in automated modules and instruments |
| IL292273B2 (en) | 2018-08-14 | 2023-10-01 | Inscripta Inc | Devices, modules and methods for improved detection of edited sequences in living cells |
| WO2020051562A2 (en) | 2018-09-07 | 2020-03-12 | Beam Therapeutics Inc. | Compositions and methods for improving base editing |
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| EP3942042A1 (en) | 2019-03-19 | 2022-01-26 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences |
| WO2020198174A1 (en) | 2019-03-25 | 2020-10-01 | Inscripta, Inc. | Simultaneous multiplex genome editing in yeast |
| US11001831B2 (en) * | 2019-03-25 | 2021-05-11 | Inscripta, Inc. | Simultaneous multiplex genome editing in yeast |
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| EP3956349A1 (en) | 2019-04-17 | 2022-02-23 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
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| JP2022536364A (ja) | 2019-06-13 | 2022-08-15 | ザ ジェネラル ホスピタル コーポレイション | 操作されたヒト内在性ウイルス様粒子および細胞への送達のためのその使用方法 |
| WO2021016075A1 (en) | 2019-07-19 | 2021-01-28 | Flagship Pioneering Innovations Vi, Llc | Recombinase compositions and methods of use |
| WO2021025750A1 (en) | 2019-08-08 | 2021-02-11 | The Broad Institute, Inc. | Base editors with diversified targeting scope |
| WO2021040703A1 (en) * | 2019-08-28 | 2021-03-04 | The Trustees Of Princeton University | Atypical split inteins and uses thereof |
| WO2021047559A1 (zh) * | 2019-09-09 | 2021-03-18 | 武汉友芝友生物制药有限公司 | 一种断裂型内含肽、使用其的重组多肽的制备方法 |
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| US20250282815A1 (en) | 2021-05-12 | 2025-09-11 | Cytiva Bioprocess R&D Ab | Improved protein purification |
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| JPWO2023027169A1 (pt) * | 2021-08-27 | 2023-03-02 | ||
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| US20240417719A1 (en) | 2021-10-25 | 2024-12-19 | The Broad Institute, Inc. | Methods and compositions for editing a genome with prime editing and a recombinase |
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| WO2024077267A1 (en) | 2022-10-07 | 2024-04-11 | The Broad Institute, Inc. | Prime editing methods and compositions for treating triplet repeat disorders |
| WO2024097763A1 (en) * | 2022-11-01 | 2024-05-10 | Memorial Sloan-Kettering Cancer Center | Intein-based sorting system and modular chimeric polypeptides |
| EP4619515A1 (en) | 2022-11-17 | 2025-09-24 | The Broad Institute, Inc. | Prime editor delivery by aav |
| WO2024163862A2 (en) | 2023-02-03 | 2024-08-08 | The Broad Institute, Inc. | Gene editing methods, systems, and compositions for treating spinal muscular atrophy |
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2013
- 2013-06-24 JP JP2015520347A patent/JP2015522020A/ja active Pending
- 2013-06-24 EP EP22186326.9A patent/EP4219549A1/en active Pending
- 2013-06-24 ES ES13809861T patent/ES2709333T3/es active Active
- 2013-06-24 DK DK13809861.1T patent/DK2877490T3/en active
- 2013-06-24 PL PL13809861T patent/PL2877490T3/pl unknown
- 2013-06-24 US US14/411,702 patent/US20150344549A1/en not_active Abandoned
- 2013-06-24 DK DK18192415.0T patent/DK3431497T3/da active
- 2013-06-24 ES ES18192415T patent/ES2930185T3/es active Active
- 2013-06-24 EP EP18192415.0A patent/EP3431497B1/en active Active
- 2013-06-24 WO PCT/US2013/047235 patent/WO2014004336A2/en not_active Ceased
- 2013-06-24 AU AU2013280693A patent/AU2013280693B2/en active Active
- 2013-06-24 PT PT13809861T patent/PT2877490T/pt unknown
- 2013-06-24 CA CA2877882A patent/CA2877882A1/en active Pending
- 2013-06-24 EP EP13809861.1A patent/EP2877490B1/en active Active
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2017
- 2017-11-09 JP JP2017216730A patent/JP6591511B2/ja active Active
- 2017-11-10 US US15/809,440 patent/US10526401B2/en active Active
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2019
- 2019-11-21 US US16/690,213 patent/US11161899B2/en active Active
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2021
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Also Published As
| Publication number | Publication date |
|---|---|
| US20180057577A1 (en) | 2018-03-01 |
| EP3431497A1 (en) | 2019-01-23 |
| US10526401B2 (en) | 2020-01-07 |
| JP2015522020A (ja) | 2015-08-03 |
| US20150344549A1 (en) | 2015-12-03 |
| EP2877490B1 (en) | 2018-09-05 |
| AU2013280693A1 (en) | 2015-02-12 |
| WO2014004336A3 (en) | 2014-03-27 |
| WO2014004336A2 (en) | 2014-01-03 |
| PL2877490T3 (pl) | 2019-03-29 |
| US11161899B2 (en) | 2021-11-02 |
| US12054541B2 (en) | 2024-08-06 |
| AU2013280693B2 (en) | 2018-01-04 |
| EP4219549A1 (en) | 2023-08-02 |
| ES2930185T3 (es) | 2022-12-07 |
| ES2709333T3 (es) | 2019-04-16 |
| DK2877490T3 (en) | 2018-12-17 |
| CA2877882A1 (en) | 2014-01-03 |
| EP2877490A4 (en) | 2016-07-06 |
| EP2877490A2 (en) | 2015-06-03 |
| DK3431497T3 (da) | 2022-10-10 |
| US20220098293A1 (en) | 2022-03-31 |
| US20200087388A1 (en) | 2020-03-19 |
| EP3431497B1 (en) | 2022-07-27 |
| JP6591511B2 (ja) | 2019-10-16 |
| JP2018111685A (ja) | 2018-07-19 |
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