PT2736920E - Composto inibidor da sinalização da via notch - Google Patents

Composto inibidor da sinalização da via notch Download PDF

Info

Publication number: PT2736920E
Authority: PT; Portugal
Prior art keywords: inhibitor compound; signaling inhibitor; notch pathway; pathway signaling; notch
Prior art date: 2011-07-27

Application number

PT127411924T

Other languages

English (en)

Inventor

Philip Arthur Hipskind

Gregory Alan Stephenson

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2011-07-27

Filing date

2012-07-18

Publication date

2015-09-16

2012-07-18 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2015-09-16 Publication of PT2736920E publication Critical patent/PT2736920E/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Oncology (AREA)
Hematology (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Peptides Or Proteins (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

PT127411924T 2011-07-27 2012-07-18 Composto inibidor da sinalização da via notch PT2736920E (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US201161512016P	2011-07-27	2011-07-27
US201161560486P	2011-11-16	2011-11-16

Publications (1)

Publication Number	Publication Date
PT2736920E true PT2736920E (pt)	2015-09-16

Family

ID=46598983

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT127411924T PT2736920E (pt)	2011-07-27	2012-07-18	Composto inibidor da sinalização da via notch

Country Status (36)

Country	Link
US (1)	US8569286B2 (pt)
EP (1)	EP2736920B1 (pt)
JP (1)	JP6027110B2 (pt)
KR (1)	KR101578309B1 (pt)
CN (1)	CN103732612B (pt)
AP (1)	AP4080A (pt)
AR (1)	AR087107A1 (pt)
AU (1)	AU2012287251B2 (pt)
BR (1)	BR112014001600B1 (pt)
CA (1)	CA2841178C (pt)
CL (1)	CL2014000175A1 (pt)
CO (1)	CO6862159A2 (pt)
CR (1)	CR20140036A (pt)
CY (1)	CY1116645T1 (pt)
DK (1)	DK2736920T3 (pt)
DO (1)	DOP2014000011A (pt)
EA (1)	EA023044B1 (pt)
EC (1)	ECSP14013179A (pt)
ES (1)	ES2544937T3 (pt)
GT (1)	GT201400012A (pt)
HR (1)	HRP20150771T1 (pt)
HU (1)	HUE027534T2 (pt)
IL (1)	IL229988A (pt)
JO (1)	JO3148B1 (pt)
MA (1)	MA35611B1 (pt)
ME (1)	ME02171B (pt)
MX (1)	MX356536B (pt)
MY (1)	MY184303A (pt)
PE (1)	PE20141061A1 (pt)
PH (1)	PH12014500215B1 (pt)
PL (1)	PL2736920T3 (pt)
PT (1)	PT2736920E (pt)
RS (1)	RS54135B1 (pt)
SI (1)	SI2736920T1 (pt)
TW (1)	TWI568730B (pt)
WO (1)	WO2013016081A1 (pt)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2014110506A2 (en) *	2013-01-14	2014-07-17	The Trustees Of Columbia University In The City Of New York	Methods of treating, preventing and diagnosing leukemia and other blood diseases and disorders
CN105764502A (zh)	2013-07-26	2016-07-13	现代化制药公司	改善比生群及其类似物及衍生物的治疗益处的组合方法
TWI704151B (zh)	2014-12-22	2020-09-11	美商美國禮來大藥廠	Ｅｒｋ抑制劑
TWI609687B (zh)	2015-04-14	2018-01-01	美國禮來大藥廠	平滑肌肉瘤之標靶性治療
AR105080A1 (es)	2015-07-07	2017-09-06	Lilly Co Eli	Compuestos inhibidores de la señalización de la vía de notch
TWI781920B (zh)	2016-02-05	2022-11-01	美商戴納立製藥公司	化合物、組合物及方法
EA201892075A1 (ru)	2016-03-15	2019-04-30	Оризон Дженомикс, С.А.	Комбинации ингибиторов lsd1 для применения для лечения солидных опухолей
RU2754452C2 (ru) *	2016-04-12	2021-09-02	Эли Лилли Энд Компани	Комбинированная терапия ингибиторами notch и pi3k/mtor для применения в лечении рака
CA3020875A1 (en) *	2016-04-12	2017-10-19	Eli Lilly And Company	Combination therapy with notch and cdk4/6 inhibitors for the treatment of cancer
ES2904880T3 (es) *	2016-05-20	2022-04-06	Lilly Co Eli	Terapia combinada con inhibidores de Notch y de PD-1 o PD-L1
CN109562114A (zh) *	2016-08-31	2019-04-02	伊莱利利公司	用于治疗实体瘤的给药方案
WO2018071307A1 (en)	2016-10-12	2018-04-19	Eli Lilly And Company	Targeted treatment of mature t-cell lymphoma
PL3552017T3 (pl)	2016-12-09	2022-08-08	Denali Therapeutics Inc.	Związki użyteczne jako inhibitory RIPK1
MX2019009552A (es)	2017-02-17	2019-10-02	Hutchinson Fred Cancer Res	Terapias de combinacion para el tratamiento de canceres relacionados con el antigeno de maduracion de celulas b (bcma) y trastornos autoinmunitarios.
PL3703750T3 (pl)	2017-11-01	2025-04-07	Juno Therapeutics, Inc.	Chimeryczne receptory antygenowe specyficzne dla antygenu dojrzewania komórek b i kodujące polinukleotydy
CA3080395A1 (en) *	2017-11-06	2019-05-09	Juno Therapeutics, Inc.	Combination of a cell therapy and a gamma secretase inhibitor
KR20210005714A (ko) *	2018-05-06	2021-01-14	아얄라 파마큐티컬즈 아이엔씨.	비스플루오로알킬-1,4-벤조디아제피논 화합물을 포함하는 조합 조성물 및 이의 사용 방법
WO2020072601A1 (en)	2018-10-02	2020-04-09	Frequency Therapeutics, Inc.	Pharmaceutical compositions comprising otic therapeutic agents and related methods
CN114340611A (zh)	2019-04-08	2022-04-12	频率医疗公司	用于治疗听力损失的chir99021和丙戊酸的组合
IL314082A (en)	2022-01-12	2024-09-01	Denali Therapeutics Inc	Crystal forms of (S)-5-benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydropyrido[3,2-b][1,4]oxazapin-3-yl)- H4- 1,2,4-triazole-3-carboxamide

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL158355A0 (en) *	1996-12-23	2004-05-12	Elan Pharm Inc	CYCLOALKYL, LACTAM, LACTONE AND RELATED COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AS beta-AMYLOID PEPTIDE RELEASE INHIBITORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
CA2324474A1 (en)	1998-06-22	1999-12-29	Elan Pharmaceuticals, Inc.	Compounds for inhibiting beta-amyloid peptide release and/or its synthesis
CA2325389A1 (en) *	1998-06-22	1999-12-29	James E. Audia	Compounds for inhibiting beta-amyloid peptide release and/or its synthesis
MXPA05008172A (es)	2003-02-04	2005-10-05	Hoffmann La Roche	Derivados de malonamida como inhibidores gamma-secretasa.
ES2322652T3 (es)	2003-09-09	2009-06-24	F. Hoffmann-La Roche Ag	Derivados de malonamida bloqueantes de la actividad gamma-secretasa.
MXPA06003870A (es)	2003-10-06	2006-07-03	Hoffmann La Roche	Derivados de dibenzo-azepina y benzo-diazepina substituidas utiles como inhibidores de gama-secretasa.
EP2018368B1 (en)	2006-03-27	2012-12-05	F. Hoffmann-La Roche AG	Malonamide derivatives as gamma secretase inhibitors
AU2008209861B2 (en) *	2007-02-02	2012-08-09	F. Hoffmann-La Roche Ag	6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl derivatives
KR20140007979A (ko)	2008-01-11	2014-01-20	에프. 호프만-라 로슈 아게	암 치료를 위한 감마-세크레타제 저해제의 용도
US8637493B2 (en) *	2009-11-12	2014-01-28	University Of Massachusetts	Methods for treating glioblastoma

2012
- 2012-07-10 AR ARP120102486A patent/AR087107A1/es not_active Application Discontinuation
- 2012-07-10 JO JOP/2012/0190A patent/JO3148B1/ar active
- 2012-07-13 TW TW101125459A patent/TWI568730B/zh active
- 2012-07-18 EA EA201490161A patent/EA023044B1/ru not_active IP Right Cessation
- 2012-07-18 CA CA2841178A patent/CA2841178C/en active Active
- 2012-07-18 BR BR112014001600-3A patent/BR112014001600B1/pt active IP Right Grant
- 2012-07-18 AU AU2012287251A patent/AU2012287251B2/en active Active
- 2012-07-18 PE PE2014000129A patent/PE20141061A1/es active IP Right Grant
- 2012-07-18 KR KR1020147001731A patent/KR101578309B1/ko active Active
- 2012-07-18 MY MYPI2014700183A patent/MY184303A/en unknown
- 2012-07-18 HU HUE12741192A patent/HUE027534T2/en unknown
- 2012-07-18 WO PCT/US2012/047100 patent/WO2013016081A1/en not_active Ceased
- 2012-07-18 CN CN201280037471.9A patent/CN103732612B/zh active Active
- 2012-07-18 PH PH1/2014/500215A patent/PH12014500215B1/en unknown
- 2012-07-18 ES ES12741192.4T patent/ES2544937T3/es active Active
- 2012-07-18 ME MEP-2015-105A patent/ME02171B/me unknown
- 2012-07-18 HR HRP20150771TT patent/HRP20150771T1/hr unknown
- 2012-07-18 AP AP2014007362A patent/AP4080A/en active
- 2012-07-18 MX MX2014001084A patent/MX356536B/es active IP Right Grant
- 2012-07-18 US US13/551,681 patent/US8569286B2/en active Active
- 2012-07-18 SI SI201230246T patent/SI2736920T1/sl unknown
- 2012-07-18 PL PL12741192T patent/PL2736920T3/pl unknown
- 2012-07-18 EP EP12741192.4A patent/EP2736920B1/en active Active
- 2012-07-18 JP JP2014522877A patent/JP6027110B2/ja active Active
- 2012-07-18 RS RS20150496A patent/RS54135B1/sr unknown
- 2012-07-18 DK DK12741192.4T patent/DK2736920T3/en active
- 2012-07-18 PT PT127411924T patent/PT2736920E/pt unknown
2013
- 2013-12-17 IL IL229988A patent/IL229988A/en active IP Right Grant
2014
- 2014-01-22 MA MA36712A patent/MA35611B1/fr unknown
- 2014-01-22 DO DO2014000011A patent/DOP2014000011A/es unknown
- 2014-01-23 CL CL2014000175A patent/CL2014000175A1/es unknown
- 2014-01-24 GT GT201400012A patent/GT201400012A/es unknown
- 2014-01-24 CO CO14014585A patent/CO6862159A2/es active IP Right Grant
- 2014-01-24 CR CR20140036A patent/CR20140036A/es unknown
- 2014-01-27 EC ECSP14013179 patent/ECSP14013179A/es unknown
2015
- 2015-08-25 CY CY20151100742T patent/CY1116645T1/el unknown

Also Published As

Publication number	Publication date
AR087107A1 (es)	2014-02-12
PH12014500215A1 (en)	2014-03-17
CO6862159A2 (es)	2014-02-10
EP2736920A1 (en)	2014-06-04
EP2736920B1 (en)	2015-07-01
RS54135B1 (sr)	2015-12-31
NZ618891A (en)	2015-12-24
HRP20150771T1 (hr)	2015-08-28
SI2736920T1 (sl)	2015-08-31
DOP2014000011A (es)	2014-07-31
ES2544937T3 (es)	2015-09-07
JP2014527042A (ja)	2014-10-09
US20130029972A1 (en)	2013-01-31
ME02171B (me)	2015-10-20
AP2014007362A0 (en)	2014-01-31
HK1194086A1 (en)	2014-10-10
KR101578309B1 (ko)	2015-12-16
MX2014001084A (es)	2014-02-27
AU2012287251B2 (en)	2015-05-14
TW201315732A (zh)	2013-04-16
BR112014001600A2 (pt)	2017-02-21
WO2013016081A1 (en)	2013-01-31
EA023044B1 (ru)	2016-04-29
JP6027110B2 (ja)	2016-11-16
CL2014000175A1 (es)	2014-08-22
CN103732612A (zh)	2014-04-16
JO3148B1 (ar)	2017-09-20
AU2012287251A1 (en)	2014-01-30
CN103732612B (zh)	2015-09-23
BR112014001600B1 (pt)	2022-09-13
EA201490161A1 (ru)	2014-04-30
TWI568730B (zh)	2017-02-01
CY1116645T1 (el)	2017-03-15
ECSP14013179A (es)	2014-03-31
KR20140026624A (ko)	2014-03-05
PH12014500215B1 (en)	2018-09-07
CA2841178C (en)	2016-12-20
DK2736920T3 (en)	2015-07-20
MY184303A (en)	2021-03-31
CA2841178A1 (en)	2013-01-31
AP4080A (en)	2017-03-29
US8569286B2 (en)	2013-10-29
PE20141061A1 (es)	2014-09-06
CR20140036A (es)	2014-03-21
MA35611B1 (fr)	2014-11-01
GT201400012A (es)	2014-07-16
HUE027534T2 (en)	2016-11-28
MX356536B (es)	2018-06-01
PL2736920T3 (pl)	2015-11-30
IL229988A (en)	2017-07-31

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