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PT2787995T - Derivados de espirotienopiran-piperidina como antagonistas do recetor orl-1 para a sua utilização no tratamento da dependência e abuso de álcool - Google Patents

Derivados de espirotienopiran-piperidina como antagonistas do recetor orl-1 para a sua utilização no tratamento da dependência e abuso de álcool

Info

Publication number
PT2787995T
PT2787995T PT127953156T PT12795315T PT2787995T PT 2787995 T PT2787995 T PT 2787995T PT 127953156 T PT127953156 T PT 127953156T PT 12795315 T PT12795315 T PT 12795315T PT 2787995 T PT2787995 T PT 2787995T
Authority
PT
Portugal
Prior art keywords
spirothienopyran
orl
abuse
treatment
receptor antagonists
Prior art date
Application number
PT127953156T
Other languages
English (en)
Inventor
Rorick Kehn Linda
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of PT2787995T publication Critical patent/PT2787995T/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/20Spiro-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/38Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/385Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32Alcohol-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/02Antidotes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/452Piperidinium derivatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Addiction (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
PT127953156T 2011-12-06 2012-11-29 Derivados de espirotienopiran-piperidina como antagonistas do recetor orl-1 para a sua utilização no tratamento da dependência e abuso de álcool PT2787995T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161567242P 2011-12-06 2011-12-06

Publications (1)

Publication Number Publication Date
PT2787995T true PT2787995T (pt) 2016-09-21

Family

ID=47279166

Family Applications (1)

Application Number Title Priority Date Filing Date
PT127953156T PT2787995T (pt) 2011-12-06 2012-11-29 Derivados de espirotienopiran-piperidina como antagonistas do recetor orl-1 para a sua utilização no tratamento da dependência e abuso de álcool

Country Status (27)

Country Link
US (1) US9371335B2 (pt)
EP (1) EP2787995B1 (pt)
JP (1) JP6002778B2 (pt)
KR (1) KR101638265B1 (pt)
CN (1) CN103987387B (pt)
AP (1) AP3880A (pt)
AU (1) AU2012348140B2 (pt)
BR (1) BR112014012849A2 (pt)
CA (1) CA2853500C (pt)
DK (1) DK2787995T3 (pt)
EA (1) EA022874B1 (pt)
ES (1) ES2600911T3 (pt)
HR (1) HRP20161351T1 (pt)
HU (1) HUE029439T2 (pt)
IL (1) IL232654A (pt)
LT (1) LT2787995T (pt)
MX (1) MX352997B (pt)
MY (1) MY172809A (pt)
PL (1) PL2787995T3 (pt)
PT (1) PT2787995T (pt)
RS (1) RS55182B1 (pt)
SG (1) SG11201402745UA (pt)
SI (1) SI2787995T1 (pt)
TW (1) TWI582096B (pt)
UA (1) UA113859C2 (pt)
WO (1) WO2013085781A1 (pt)
ZA (1) ZA201403927B (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO3638B1 (ar) * 2015-09-09 2020-08-27 Lilly Co Eli مركبات مفيدة في تثبيط ror - جاما- t
EP3589637B1 (en) * 2017-03-02 2021-04-14 Eli Lilly and Company Compounds useful for inhibiting ror-gamma-t
PL3589638T3 (pl) 2017-03-02 2021-09-27 Eli Lilly And Company Związki użyteczne do hamowania ror-gamma-t
CN109400618B (zh) * 2018-11-09 2021-08-10 中国药科大学 一种色满衍生物及其制备方法和应用
CN117442618B (zh) * 2023-10-23 2025-11-14 国科大杭州高等研究院 化合物ly2940094在制备治疗中枢神经系统脱髓鞘疾病药物中的应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5140032A (en) * 1990-10-01 1992-08-18 Radecki Thomas E Drug therapy for alcohol abusers
EP1873150A1 (en) * 2006-06-30 2008-01-02 Nikem Research S.R.L. Fluorinated indoleamides useful as ligands of the ORL-1 receptor
MX2009004012A (es) * 2006-10-16 2009-04-27 Mitsubishi Tanabe Pharma Corp Agente para profilaxis o tratamiento de dependencia al alcohol o dependencia a farmacos.
SI2501704T1 (sl) * 2009-11-16 2013-11-29 Eli Lilly Company Spojine spiropiperidina kot antagonisti oral-1 receptorja
UA107943C2 (xx) * 2009-11-16 2015-03-10 Lilly Co Eli Сполуки спіропіперидину як антагоністи рецептора orl-1

Also Published As

Publication number Publication date
JP6002778B2 (ja) 2016-10-05
TWI582096B (zh) 2017-05-11
UA113859C2 (xx) 2017-03-27
AP3880A (en) 2016-10-31
WO2013085781A1 (en) 2013-06-13
PL2787995T3 (pl) 2017-02-28
US20140309251A1 (en) 2014-10-16
CA2853500C (en) 2016-10-04
AP2014007675A0 (en) 2014-06-30
TW201335163A (zh) 2013-09-01
EA201490938A1 (ru) 2014-09-30
JP2015502956A (ja) 2015-01-29
SI2787995T1 (sl) 2016-10-28
BR112014012849A2 (pt) 2017-06-13
AU2012348140A1 (en) 2014-05-22
RS55182B1 (sr) 2017-01-31
KR101638265B1 (ko) 2016-07-08
IL232654A (en) 2017-09-28
HRP20161351T1 (hr) 2016-12-02
ZA201403927B (en) 2016-01-27
CN103987387A (zh) 2014-08-13
MX352997B (es) 2017-12-15
MY172809A (en) 2019-12-12
SG11201402745UA (en) 2014-06-27
HK1196943A1 (zh) 2014-12-24
ES2600911T3 (es) 2017-02-13
IL232654A0 (en) 2014-06-30
HUE029439T2 (en) 2017-02-28
US9371335B2 (en) 2016-06-21
AU2012348140B2 (en) 2015-09-17
LT2787995T (lt) 2016-11-25
NZ624201A (en) 2016-06-24
CN103987387B (zh) 2016-12-28
MX2014006824A (es) 2015-02-12
EP2787995A1 (en) 2014-10-15
EP2787995B1 (en) 2016-08-17
CA2853500A1 (en) 2013-06-13
DK2787995T3 (en) 2016-11-28
EA022874B1 (ru) 2016-03-31
KR20140088894A (ko) 2014-07-11

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