PT2768857T - Métodos para purificar anticorpos - Google Patents
Métodos para purificar anticorposInfo
- Publication number
- PT2768857T PT2768857T PT128426897T PT12842689T PT2768857T PT 2768857 T PT2768857 T PT 2768857T PT 128426897 T PT128426897 T PT 128426897T PT 12842689 T PT12842689 T PT 12842689T PT 2768857 T PT2768857 T PT 2768857T
- Authority
- PT
- Portugal
- Prior art keywords
- methods
- purifying antibodies
- antibodies
- purifying
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/248—IL-6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/249—Interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161548958P | 2011-10-19 | 2011-10-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2768857T true PT2768857T (pt) | 2020-01-27 |
Family
ID=48142817
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT128426897T PT2768857T (pt) | 2011-10-19 | 2012-10-19 | Métodos para purificar anticorpos |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US10047144B2 (pt) |
| EP (1) | EP2768857B1 (pt) |
| JP (2) | JP6435193B2 (pt) |
| AU (2) | AU2012351751B2 (pt) |
| CA (1) | CA2853011C (pt) |
| DK (1) | DK2768857T3 (pt) |
| ES (1) | ES2767135T3 (pt) |
| PT (1) | PT2768857T (pt) |
| WO (1) | WO2013088259A2 (pt) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2767135T3 (es) | 2011-10-19 | 2020-06-16 | Novimmune Sa | Métodos para purificar anticuerpos |
| US10704021B2 (en) | 2012-03-15 | 2020-07-07 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
| EP2925782B1 (en) | 2012-12-03 | 2020-01-22 | NovImmune SA | Anti-cd47 antibodies and methods of use thereof |
| EP3036253B1 (en) * | 2013-08-19 | 2020-09-23 | F. Hoffmann-La Roche AG | Separation of bispecific antibodies and bispecific antibody production side products using hydroxyapatite chromatography |
| WO2015105955A1 (en) | 2014-01-08 | 2015-07-16 | Flodesign Sonics, Inc. | Acoustophoresis device with dual acoustophoretic chamber |
| GB201414823D0 (en) | 2014-08-20 | 2014-10-01 | Argen X Bv | Multispecific antibodies |
| CN114249831A (zh) * | 2015-03-13 | 2022-03-29 | 诺夫免疫股份有限公司 | 纯化双特异性抗体的方法 |
| US11377651B2 (en) | 2016-10-19 | 2022-07-05 | Flodesign Sonics, Inc. | Cell therapy processes utilizing acoustophoresis |
| US11708572B2 (en) | 2015-04-29 | 2023-07-25 | Flodesign Sonics, Inc. | Acoustic cell separation techniques and processes |
| WO2017005649A1 (en) | 2015-07-09 | 2017-01-12 | Genmab A/S | Bispecific and multispecific antibodies and method for isolation of such |
| US11291721B2 (en) | 2016-03-21 | 2022-04-05 | Marengo Therapeutics, Inc. | Multispecific and multifunctional molecules and uses thereof |
| US11214789B2 (en) | 2016-05-03 | 2022-01-04 | Flodesign Sonics, Inc. | Concentration and washing of particles with acoustics |
| IL264631B2 (en) * | 2016-08-16 | 2024-05-01 | Regeneron Pharma | A method for quantifying individual antibodies from a mixture |
| KR101933656B1 (ko) | 2016-08-20 | 2018-12-28 | (주) 아이벤트러스 | 목적하는 이중특이성 항체의 선택적 생산 확인 방법 |
| WO2018038469A1 (ko) * | 2016-08-20 | 2018-03-01 | (주)아이벤트러스 | 목적하는 이중특이성 항체의 선택적 생산 확인 방법 |
| CN118005799A (zh) * | 2016-09-23 | 2024-05-10 | 马伦戈治疗公司 | 包含λ轻链和κ轻链的多特异性抗体分子 |
| AU2017353936A1 (en) | 2016-11-04 | 2019-05-02 | Novimmune Sa | Anti-CD19 antibodies and methods of use thereof |
| WO2018114878A1 (en) | 2016-12-21 | 2018-06-28 | F. Hoffmann-La Roche Ag | Re-use of enzymes in in vitro glycoengineering of antibodies |
| IL267352B2 (en) | 2016-12-21 | 2023-10-01 | Hoffmann La Roche | Method for in vitro glycoengineering of antibodies |
| AU2017384276B9 (en) * | 2016-12-21 | 2020-11-26 | F. Hoffmann-La Roche Ag | In vitro glycoengineering of antibodies |
| US20200291089A1 (en) | 2017-02-16 | 2020-09-17 | Elstar Therapeutics, Inc. | Multifunctional molecules comprising a trimeric ligand and uses thereof |
| US20200190138A1 (en) * | 2017-02-28 | 2020-06-18 | Chugai Seiyaku Kabushiki Kaisha | Protein purification with protein l |
| JP7220161B2 (ja) | 2017-05-26 | 2023-02-09 | ノビミューン エスアー | 抗ＣＤ４７ｘ抗メソテリン抗体およびそれを使用する方法 |
| WO2018222901A1 (en) | 2017-05-31 | 2018-12-06 | Elstar Therapeutics, Inc. | Multispecific molecules that bind to myeloproliferative leukemia (mpl) protein and uses thereof |
| CN111201238B (zh) * | 2017-07-21 | 2023-09-08 | 诺夫免疫股份有限公司 | 产生多特异性抗体混合物及其使用方法 |
| BR112020009889A2 (pt) | 2017-12-14 | 2020-11-03 | Flodesign Sonics, Inc. | acionador e controlador de transdutor acústico |
| WO2019139987A1 (en) | 2018-01-09 | 2019-07-18 | Elstar Therapeutics, Inc. | Calreticulin binding constructs and engineered t cells for the treatment of diseases |
| US20210009711A1 (en) | 2018-03-14 | 2021-01-14 | Elstar Therapeutics, Inc. | Multifunctional molecules and uses thereof |
| US12152073B2 (en) | 2018-03-14 | 2024-11-26 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to calreticulin and uses thereof |
| AU2019235523B2 (en) | 2018-03-14 | 2025-12-18 | Novimmune Sa | Anti-CD3 epsilon antibodies and methods of use thereof |
| US11555071B2 (en) | 2018-06-03 | 2023-01-17 | Lamkap Bio Beta Ltd. | Bispecific antibodies against CEACAM5 and CD47 |
| MA52945A (fr) | 2018-06-22 | 2021-04-28 | Genmab As | Procédé de production d'un mélange contrôlé d'au moins deux anticorps différents |
| CN112955465A (zh) | 2018-07-03 | 2021-06-11 | 马伦戈治疗公司 | 抗tcr抗体分子及其用途 |
| WO2020115283A1 (en) * | 2018-12-07 | 2020-06-11 | Baxalta GmbH | Bispecific antibodies binding factor ixa and factor x |
| TWI874341B (zh) | 2018-12-18 | 2025-03-01 | 美商健生生物科技公司 | 產生異二聚體抗體之方法 |
| JP7734075B2 (ja) | 2018-12-24 | 2025-09-04 | サノフイ | 疑似ｆａｂベースの多重特異性結合タンパク質 |
| EP3911947B1 (en) * | 2019-01-16 | 2025-04-09 | Regeneron Pharmaceuticals, Inc. | Method and system of identifying and quantifying antibody fragmentation |
| SG11202109056TA (en) | 2019-02-21 | 2021-09-29 | Marengo Therapeutics Inc | Multifunctional molecules that bind to calreticulin and uses thereof |
| WO2020172605A1 (en) | 2019-02-21 | 2020-08-27 | Elstar Therapeutics, Inc. | Antibody molecules that bind to nkp30 and uses thereof |
| GB2599227B (en) | 2019-02-21 | 2024-05-01 | Marengo Therapeutics Inc | Multifunctional molecules that bind to T cells and uses thereof to treat autoimmune disorders |
| JP7710373B2 (ja) | 2019-02-21 | 2025-07-18 | マレンゴ・セラピューティクス，インコーポレーテッド | Ｔ細胞関連のがん細胞に結合する多機能性分子およびその使用 |
| JP2022521751A (ja) | 2019-02-21 | 2022-04-12 | マレンゴ・セラピューティクス，インコーポレーテッド | 抗ｔｃｒ抗体分子およびその使用 |
| KR20220113353A (ko) | 2019-09-18 | 2022-08-12 | 람캅 바이오 알파 에이지 | Ceacam5 및 cd3에 대한 이중특이적 항체 |
| EP3831849A1 (en) | 2019-12-02 | 2021-06-09 | LamKap Bio beta AG | Bispecific antibodies against ceacam5 and cd47 |
| CN111018969A (zh) * | 2019-12-27 | 2020-04-17 | 上海药明生物技术有限公司 | 采用轻链select联合层析色谱纯化双特异性抗体的方法 |
| CA3166629A1 (en) | 2020-01-03 | 2021-07-08 | Marengo Therapeutics, Inc. | Anti-tcr antibody molecules and uses thereof |
| WO2021138407A2 (en) | 2020-01-03 | 2021-07-08 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to cd33 and uses thereof |
| CN115066258A (zh) * | 2020-02-28 | 2022-09-16 | 上海药明生物技术有限公司 | 双特异性抗体的纯化 |
| US20230242671A1 (en) | 2020-03-25 | 2023-08-03 | Eli Lilly And Company | Multispecific binding proteins and methods of developing the same |
| KR20230028242A (ko) | 2020-04-24 | 2023-02-28 | 마렝고 테라퓨틱스, 인크. | T 세포 관련 암 세포에 결합하는 다중기능성 분자 및 그것의 용도 |
| KR20220014531A (ko) * | 2020-07-29 | 2022-02-07 | (주)메디톡스 | 헤테로이량체 Ｆｃ 융합 단백질, 및 관련 조성물, 용도 및 방법 |
| AU2021331076A1 (en) | 2020-08-26 | 2023-04-06 | Marengo Therapeutics, Inc. | Antibody molecules that bind to NKp30 and uses thereof |
| JP2023542080A (ja) | 2020-08-26 | 2023-10-05 | マレンゴ・セラピューティクス，インコーポレーテッド | カルレティキュリンに結合する多機能性分子およびその使用 |
| EP4204458A4 (en) | 2020-08-26 | 2024-10-09 | Marengo Therapeutics, Inc. | METHODS FOR DETECTION OF TRBC1 OR TRBC2 |
| JP2024501809A (ja) | 2020-12-18 | 2024-01-16 | ランカプ バイオ ベータ リミテッド | Ｃｅａｃａｍ５およびｃｄ４７に対する二重特異性抗体 |
| JP2024511137A (ja) | 2021-03-22 | 2024-03-12 | ノビミューン エスアー | Ｃｄ４７およびｐｄ－ｌ１を標的とする二重特異性抗体ならびにその使用方法 |
| IL305828A (en) | 2021-03-22 | 2023-11-01 | Novimmune Sa | Bispecific antibodies targeting CD47 and PD-L1 and methods of using them |
| US20250099579A1 (en) | 2021-04-08 | 2025-03-27 | Marengo Therapeutics, Inc. | Multispecific molecules binding to tcr and uses thereof |
| WO2023174925A1 (en) | 2022-03-14 | 2023-09-21 | Novimmune Sa | Bispecific gpc3xcd28 and gpc3xcd3 antibodies and their combination for targeted killing of gpc3 positive malignant cells |
| CN119137146A (zh) * | 2022-03-17 | 2024-12-13 | 阿斯利康(瑞典)有限公司 | 用于纯化双特异性抗体的方法 |
| CN119562970A (zh) | 2022-03-18 | 2025-03-04 | 进化免疫治疗公司 | 双特异性抗体融合分子及其使用方法 |
| KR20250025384A (ko) | 2022-06-16 | 2025-02-21 | 람카프 바이오 베타 엘티디. | Ceacam5 및 cd47에 대한 이중특이적 항체 및 ceacam5 및 cd3에 대한 이중특이적 항체의 조합 요법 |
| EP4605421A1 (en) | 2022-10-21 | 2025-08-27 | Novimmune S.A. | Pd-l1xcd28 bispecific antibodies for immune checkpoint-dependent t cell activation |
| EP4665392A2 (en) | 2023-02-14 | 2025-12-24 | Evolveimmune Therapeutics, Inc. | Combination of bispecific antibodies and chimeric antigen receptor t cells for treatment |
| WO2025059037A1 (en) | 2023-09-11 | 2025-03-20 | Evolveimmune Therapeutics, Inc. | Bispecific antibody fusion molecules targeting b7-h4 and cd3 and methods of use thereof |
| WO2025064890A1 (en) | 2023-09-20 | 2025-03-27 | Evolveimmune Therapeutics, Inc. | Bispecific antibody fusion molecules targeting cd180 and cd3 and methods of use thereof |
| WO2025064885A1 (en) | 2023-09-20 | 2025-03-27 | Evolveimmune Therapeutics, Inc. | Multispecific antibodies that bind cd3 and cd2 and methods of use thereof |
| US20250171537A1 (en) | 2023-11-28 | 2025-05-29 | Novimmune Sa | Method of treating disease using anti-cd47 x anti-mesothelin antibodies as a sole agent and in combination with anti-pd-1 antibodies |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4745183A (en) * | 1984-02-21 | 1988-05-17 | Bio-Rad Laboratories, Inc. | Use of hydroxylapatite for the analysis and preparation of purified monoclonal antibodies |
| US5859205A (en) * | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US6075181A (en) | 1990-01-12 | 2000-06-13 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US6528624B1 (en) | 1998-04-02 | 2003-03-04 | Genentech, Inc. | Polypeptide variants |
| US6946292B2 (en) | 2000-10-06 | 2005-09-20 | Kyowa Hakko Kogyo Co., Ltd. | Cells producing antibody compositions with increased antibody dependent cytotoxic activity |
| IL157309A0 (en) * | 2003-08-07 | 2004-02-19 | Applied Research Systems | Method for the purification of a non-immunoglobulin protein |
| EP1807205B1 (en) * | 2004-10-21 | 2012-09-26 | GE Healthcare Bio-Sciences AB | A method of antibody purification |
| US7691980B2 (en) | 2007-01-09 | 2010-04-06 | Bio-Rad Laboratories, Inc. | Enhanced capacity and purification of antibodies by mixed mode chromatography in the presence of aqueous-soluble nonionic organic polymers |
| WO2009092014A1 (en) * | 2008-01-18 | 2009-07-23 | Gagnon Peter S | Enhanced purification of antibodies and antibody fragments by apatite chromatography |
| US8188242B2 (en) * | 2008-04-08 | 2012-05-29 | Bio-Rad Laboratories, Inc. | Chromatography purification of antibodies |
| AU2010249470B2 (en) | 2009-05-20 | 2015-06-25 | Novimmune S.A. | Synthetic Polypeptide Libraries And Methods For Generating Naturally Diversified Polypeptide Variants |
| WO2011084255A2 (en) | 2009-12-17 | 2011-07-14 | Novimmune S.A. | Synthetic polypeptide libraries and methods for generating naturally diversified polypeptide variants |
| SG10201710439UA (en) * | 2010-05-25 | 2018-01-30 | Genentech Inc | Methods of purifying polypeptides |
| PL2606064T3 (pl) * | 2010-08-16 | 2015-07-31 | Novimmune Sa | Sposoby wytwarzania wieloswoistych i wielowartościowych przeciwciał |
| EP3165538A1 (en) * | 2010-11-03 | 2017-05-10 | Argen-X Nv | Anti c-met antibodies |
| ES2767135T3 (es) | 2011-10-19 | 2020-06-16 | Novimmune Sa | Métodos para purificar anticuerpos |
-
2012
- 2012-10-19 ES ES12842689T patent/ES2767135T3/es active Active
- 2012-10-19 US US13/655,955 patent/US10047144B2/en active Active
- 2012-10-19 EP EP12842689.7A patent/EP2768857B1/en active Active
- 2012-10-19 CA CA2853011A patent/CA2853011C/en active Active
- 2012-10-19 WO PCT/IB2012/003028 patent/WO2013088259A2/en not_active Ceased
- 2012-10-19 JP JP2014536354A patent/JP6435193B2/ja active Active
- 2012-10-19 PT PT128426897T patent/PT2768857T/pt unknown
- 2012-10-19 AU AU2012351751A patent/AU2012351751B2/en active Active
- 2012-10-19 DK DK12842689.7T patent/DK2768857T3/da active
-
2017
- 2017-08-30 AU AU2017221794A patent/AU2017221794B2/en not_active Ceased
-
2018
- 2018-07-11 US US16/032,873 patent/US20190040117A1/en not_active Abandoned
- 2018-09-03 JP JP2018164683A patent/JP2018184487A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2012351751B2 (en) | 2017-09-07 |
| JP6435193B2 (ja) | 2018-12-05 |
| US10047144B2 (en) | 2018-08-14 |
| AU2017221794A1 (en) | 2017-09-21 |
| AU2012351751A1 (en) | 2014-06-05 |
| US20130317200A1 (en) | 2013-11-28 |
| EP2768857A2 (en) | 2014-08-27 |
| US20190040117A1 (en) | 2019-02-07 |
| WO2013088259A3 (en) | 2013-11-14 |
| EP2768857B1 (en) | 2020-01-01 |
| DK2768857T3 (da) | 2020-02-03 |
| AU2017221794B2 (en) | 2019-04-18 |
| CA2853011A1 (en) | 2013-06-20 |
| ES2767135T3 (es) | 2020-06-16 |
| JP2014530848A (ja) | 2014-11-20 |
| JP2018184487A (ja) | 2018-11-22 |
| WO2013088259A2 (en) | 2013-06-20 |
| CA2853011C (en) | 2022-09-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PT2768857T (pt) | Métodos para purificar anticorpos | |
| IL232558B (en) | A method for antibody purification | |
| ZA201403108B (en) | Purification of anti-c-met antibodies | |
| ZA201305971B (en) | Method for the purification of biphephos | |
| PT2791176T (pt) | Um método de purificação de anticorpos | |
| GB201103955D0 (en) | Antibodies | |
| GB201112056D0 (en) | Antibodies | |
| IL229254A0 (en) | Therapeutic antibodies | |
| IL228438A0 (en) | New methods for protein purification | |
| IL227581A0 (en) | A method for constructing certain coefficients | |
| IL232055B (en) | Anti-1htra antibodies and methods of use | |
| ZA201305972B (en) | Method for the preparation of biphephos | |
| SG11201501921SA (en) | A method of purifying proteins | |
| IL228913A0 (en) | A method for cleaning Mitzfungin | |
| HUE043121T2 (hu) | Eljárás antitest tisztítására | |
| IL235483A0 (en) | Crystallization methods for purification of monoclonal antibodies | |
| EP2743258A4 (en) | PROCESS FOR PURIFYING LEVO-OXIRACETAM | |
| GB201121564D0 (en) | Use of antibody | |
| GB201105407D0 (en) | Purification method | |
| EP2714713A4 (en) | PURIFICATION OF ANTIBODIES | |
| EP2714074A4 (en) | ANTIBODIES AGAINST EMR1 | |
| GB2495076B (en) | Separation of gases | |
| GB201119607D0 (en) | Method of manufacture | |
| GB201100937D0 (en) | Epitope purification methods | |
| ZA201308992B (en) | Therapeutic antibodies |