PT2411397E - Derivados de isotiazolo-pirimidinadiona como moduladores de trpa1 - Google Patents

Derivados de isotiazolo-pirimidinadiona como moduladores de trpa1

Info

Publication number: PT2411397E
Authority: PT; Portugal
Prior art keywords: isothiazolo; pyrimidinedione derivatives; trpa1 modulators; trpa1; modulators
Prior art date: 2009-03-23

Application number

PT107160491T

Other languages

English (en)

Inventor

Sukeerthi Kumar

Abraham Thomas

Sanjay Margal

Neelima Khairatkar-Joshi

Indranil Mukhopadhyay

Original Assignee

Glenmark Pharmaceuticals Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-03-23

Filing date

2010-03-22

Publication date

2013-06-06

2010-03-22 Application filed by Glenmark Pharmaceuticals Sa filed Critical Glenmark Pharmaceuticals Sa

2013-06-06 Publication of PT2411397E publication Critical patent/PT2411397E/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Dermatology (AREA)
Urology & Nephrology (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Hospice & Palliative Care (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Psychiatry (AREA)
Otolaryngology (AREA)
Vascular Medicine (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

PT107160491T 2009-03-23 2010-03-22 Derivados de isotiazolo-pirimidinadiona como moduladores de trpa1 PT2411397E (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IN665MU2009		2009-03-23
US17135509P	2009-04-21	2009-04-21

Publications (1)

Publication Number	Publication Date
PT2411397E true PT2411397E (pt)	2013-06-06

Family

ID=42236291

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT107160491T PT2411397E (pt)	2009-03-23	2010-03-22	Derivados de isotiazolo-pirimidinadiona como moduladores de trpa1

Country Status (22)

Country	Link
US (1)	US8575178B2 (pt)
EP (1)	EP2411397B1 (pt)
JP (1)	JP2012521405A (pt)
KR (1)	KR20120001746A (pt)
CN (1)	CN102395592A (pt)
AP (1)	AP2011005888A0 (pt)
AU (1)	AU2010227224A1 (pt)
BR (1)	BRPI1009372A2 (pt)
CA (1)	CA2756534A1 (pt)
DK (1)	DK2411397T3 (pt)
EA (1)	EA201190191A1 (pt)
ES (1)	ES2424340T3 (pt)
IL (1)	IL215179A0 (pt)
MX (1)	MX2011009821A (pt)
PE (1)	PE20120764A1 (pt)
PL (1)	PL2411397T3 (pt)
PT (1)	PT2411397E (pt)
SG (2)	SG174403A1 (pt)
SI (1)	SI2411397T1 (pt)
UA (1)	UA107342C2 (pt)
WO (1)	WO2010109328A1 (pt)
ZA (1)	ZA201107646B (pt)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
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EP2411393B1 (en)	2009-03-23	2014-01-22	Glenmark Pharmaceuticals S.A.	Fused pyrimidine-dione derivatives as trpa1 modulators
CA2756535A1 (en)	2009-03-23	2010-09-30	Glenmark Pharmaceuticals, S.A.	Furopyrimidinedione derivatives as trpa1 modulators
EP2655377B1 (en)	2010-12-20	2016-03-30	Glenmark Pharmaceuticals S.A.	2-amino-4-arylthiazole compounds as trpa1 antagonists
EP2520566A1 (en)	2011-05-06	2012-11-07	Orion Corporation	New Pharmaceutical Compounds
CA2836856A1 (en) *	2011-06-13	2012-12-20	Glenmark Pharmaceuticals, S.A.	Treatment of respiratory disorders using trpa1 antagonists
WO2012176105A1 (en)	2011-06-22	2012-12-27	Glenmark Pharmaceuticals Sa	Pharmaceutical composition comprising a trpa1 antagonist and a leukotriene receptor antagonist
BR112013031820A2 (pt)	2011-06-22	2016-12-13	Glenmark Pharmaceutical S A	composições farmacêuticas, incluindo para administração oral e por inalação, usos de quantidade sinergicamente eficaz de antagonista trpa1 e métodos para tratar distúrbios respiratórios e para melhorar a função pulmonar
WO2013014597A1 (en)	2011-07-25	2013-01-31	Glenmark Pharmaceuticals Sa	Pharmaceutical composition comprising a trpa1 antagonist and a steroid
TWI640519B (zh) *	2011-11-29	2018-11-11	泰緯生命科技股份有限公司	Ｈｅｃ１活性調控因子及其調節方法
CA2857109A1 (en)	2011-12-05	2013-06-13	Glenmark Pharmaceuticals S.A.	Pharmaceutical composition comprising a trpa1 antagonist and an anticholinergic agent
MX354014B (es)	2012-06-08	2018-02-08	Glenmark Pharmaceuticals Sa	Amidas de compuestos de 2-amino-4-ariltiazol y sus sales.
AU2013326429B2 (en)	2012-10-01	2017-10-26	Orion Corporation	N-prop-2-ynyl carboxamide derivatives and their use as TRPA1 antagonists
JP2016504988A (ja)	2012-11-14	2016-02-18	エフ．ホフマン−ラロシュアーゲーＦ．Ｈｏｆｆｍａｎｎ−ＬａＲｏｃｈｅＡｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ	イミダゾピリジン誘導体
AU2014282762B2 (en)	2013-06-20	2016-11-10	Ichnos Sciences SA	Nanoparticulate formulation comprising a TRPA1 antagonist
RU2016115093A (ru)	2013-10-15	2017-11-21	Гленмарк Фармасьютикалс С.А.	Фармацевтическая композиция, содержащая антагонист trpa1 и анальгетический агент
WO2015155306A1 (en) *	2014-04-11	2015-10-15	Almirall, S.A.	New trpa1 antagonists
WO2016042501A1 (en)	2014-09-16	2016-03-24	Glenmark Pharmaceuticals S.A.	Trpa1 antagonist for the treatment of pain associated to diabetic neuropathic pain
WO2017060488A1 (en)	2015-10-09	2017-04-13	Almirall, S.A.	New trpa1 antagonists
WO2017064068A1 (en)	2015-10-14	2017-04-20	Almirall, S.A.	New trpa1 antagonists
WO2018233648A1 (zh) *	2017-06-21	2018-12-27	南京明德新药研发股份有限公司	作为TLR8激动剂的异噻唑并[4,3-d]嘧啶-5,7-二胺衍生物
CN112794860B (zh) *	2021-03-24	2021-06-29	上海肇钰医药科技有限公司	噁唑嘧啶酮酰胺类化合物或其可药用盐，制备方法及用途
CN114656480B (zh) *	2022-04-27	2024-01-26	成都施贝康生物医药科技有限公司	噻吩并嘧啶类化合物、异构体或盐及其制备方法和用途

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DE2248231A1 (de) *	1972-10-02	1974-04-11	Basf Ag	3-aminoisothiazolo eckige klammer auf 3,4-d eckige klammer zu pyrimidine
SE9701398D0 (sv)	1997-04-15	1997-04-15	Astra Pharma Prod	Novel compounds
ES2193839B1 (es)	2001-06-22	2005-02-16	Almirall Prodesfarma, S.A.	Nuevos derivados de 6-fenildihidropirrolpirimidindiona.
WO2004014916A1 (en)	2002-08-13	2004-02-19	Warner-Lambert Company Llc	Pyrimidine fused bicyclic metalloproteinase inhibitors
WO2004055054A1 (en)	2002-12-18	2004-07-01	Novartis Ag	Anktm1, a cold-activated trp-like channel expressed in nociceptive neurons
SE0300119D0 (sv) *	2003-01-17	2003-01-17	Astrazeneca Ab	Novel compounds
EP1713815A4 (en) *	2004-02-11	2009-03-11	Smithkline Beecham Corp	PTH AGONISTS
WO2005089206A2 (en)	2004-03-13	2005-09-29	Irm Llc	Modulators of ion channel trpa1
WO2006083005A1 (ja)	2005-02-03	2006-08-10	Takeda Pharmaceutical Company Limited	縮合ピリミジン誘導体およびその用途
ES2436225T3 (es)	2005-12-22	2013-12-27	Hydra Biosciences, Inc.	Inhibidores TRPA1 para tratamiento del dolor
TW200800997A (en)	2006-03-22	2008-01-01	Astrazeneca Ab	Chemical compounds
CL2008000252A1 (es)	2007-01-29	2008-03-14	Xenon Pharmaceuticals Inc	Compuestos derivados de quinazolinona o pirimidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar enfermedades mediadas por los canales de calcio, tales como dolor, depresion, enfermedades cardiovasculares, respir
EP3663295A1 (en) *	2007-06-22	2020-06-10	Eli Lilly And Co.	2,6-dioxo,-2,3-dihydro-1h-purine compounds useful for treating disorders related to the activity of the trpa1 channel
WO2009158719A2 (en)	2008-06-27	2009-12-30	Hydra Biosciences, Inc.	Methods and compositions for treating disorders

2010
- 2010-03-22 PL PL10716049T patent/PL2411397T3/pl unknown
- 2010-03-22 EA EA201190191A patent/EA201190191A1/ru unknown
- 2010-03-22 JP JP2012501411A patent/JP2012521405A/ja not_active Withdrawn
- 2010-03-22 PT PT107160491T patent/PT2411397E/pt unknown
- 2010-03-22 ES ES10716049T patent/ES2424340T3/es active Active
- 2010-03-22 CA CA2756534A patent/CA2756534A1/en not_active Abandoned
- 2010-03-22 DK DK10716049.1T patent/DK2411397T3/da active
- 2010-03-22 US US13/257,241 patent/US8575178B2/en not_active Expired - Fee Related
- 2010-03-22 BR BRPI1009372A patent/BRPI1009372A2/pt not_active IP Right Cessation
- 2010-03-22 PE PE2011001703A patent/PE20120764A1/es not_active Application Discontinuation
- 2010-03-22 AP AP2011005888A patent/AP2011005888A0/xx unknown
- 2010-03-22 KR KR1020117023383A patent/KR20120001746A/ko not_active Withdrawn
- 2010-03-22 EP EP10716049.1A patent/EP2411397B1/en not_active Not-in-force
- 2010-03-22 SG SG2011066495A patent/SG174403A1/en unknown
- 2010-03-22 MX MX2011009821A patent/MX2011009821A/es unknown
- 2010-03-22 WO PCT/IB2010/000834 patent/WO2010109328A1/en not_active Ceased
- 2010-03-22 CN CN2010800168801A patent/CN102395592A/zh active Pending
- 2010-03-22 SI SI201030232T patent/SI2411397T1/sl unknown
- 2010-03-22 AU AU2010227224A patent/AU2010227224A1/en not_active Abandoned
- 2010-03-22 SG SG2012069464A patent/SG184766A1/en unknown
- 2010-03-23 UA UAA201111149A patent/UA107342C2/ru unknown
2011
- 2011-09-15 IL IL215179A patent/IL215179A0/en unknown
- 2011-10-19 ZA ZA2011/07646A patent/ZA201107646B/en unknown

Also Published As

Publication number	Publication date
ES2424340T3 (es)	2013-10-01
US20120010223A1 (en)	2012-01-12
AU2010227224A1 (en)	2011-09-29
ZA201107646B (en)	2012-06-25
EP2411397B1 (en)	2013-05-29
EP2411397A1 (en)	2012-02-01
IL215179A0 (en)	2011-12-29
SG174403A1 (en)	2011-10-28
KR20120001746A (ko)	2012-01-04
SI2411397T1 (sl)	2013-07-31
PE20120764A1 (es)	2012-06-27
US8575178B2 (en)	2013-11-05
SG184766A1 (en)	2012-10-30
CN102395592A (zh)	2012-03-28
AP2011005888A0 (en)	2011-10-31
JP2012521405A (ja)	2012-09-13
CA2756534A1 (en)	2010-09-30
WO2010109328A1 (en)	2010-09-30
HK1166081A1 (en)	2012-10-19
PL2411397T3 (pl)	2013-10-31
BRPI1009372A2 (pt)	2016-05-31
AU2010227224A2 (en)	2011-10-27
DK2411397T3 (da)	2013-08-05
EA201190191A1 (ru)	2012-11-30
MX2011009821A (es)	2012-01-25
UA107342C2 (en)	2014-12-25

Publication	Publication Date	Title
AP2948A (en)	2014-07-31	Thienopyrmidinedione derivatives as TRPA1 modulators
ZA201107646B (en)	2012-06-25	Isothiazolo-prrimidinedione derivatives as trpa1 modulators
AP3280A (en)	2015-05-31	Fused pyrimidine-dione derivatives as TRPA1 modulators
IL219087A0 (en)	2012-06-28	Benzimidazole-imidazole derivatives
IL217956A0 (en)	2012-03-29	N1-sulfonyl-5-fluoropyrimidinone derivatives
IL217953A0 (en)	2012-03-29	5-fluoropyrimidinone derivatives
IL215169A0 (en)	2011-12-29	Isoxazole -pyridine derivatives as gaba modulators
IL216007A0 (en)	2012-01-31	Isoxazole-pyridine derivatives
IL215109A0 (en)	2011-12-29	Isoxazole-pyridazine derivatives
IL214941A0 (en)	2011-11-30	Isoxazole-pyrazole derivatives
IL217952A0 (en)	2012-03-29	N1-acyl-5-fluoropyrimidinone derivatives
IL213927A0 (en)	2011-07-31	Deoxyactagardine derivatives
IL216761A0 (en)	2012-02-29	Pyrazinooxazepine derivatives
GB0921967D0 (en)	2010-02-03	Novel Aryloxyanilide Derivatives
IL213262A0 (en)	2011-07-31	Tetrahydronaphthalen-2-ol derivatives
GB0912499D0 (en)	2009-08-26	Indopyl-pyridone derivatives
AP2011005883A0 (en)	2011-10-31	Furopyrimidinedione derivatives as TRPA1 modulators.