PT2049148T - Formulação líquida estável da hormona do crescimento humana - Google Patents
Formulação líquida estável da hormona do crescimento humanaInfo
- Publication number
- PT2049148T PT2049148T PT67691865T PT06769186T PT2049148T PT 2049148 T PT2049148 T PT 2049148T PT 67691865 T PT67691865 T PT 67691865T PT 06769186 T PT06769186 T PT 06769186T PT 2049148 T PT2049148 T PT 2049148T
- Authority
- PT
- Portugal
- Prior art keywords
- growth hormone
- liquid formulation
- human growth
- stable liquid
- stable
- Prior art date
Links
- 102000002265 Human Growth Hormone Human genes 0.000 title 1
- 108010000521 Human Growth Hormone Proteins 0.000 title 1
- 239000000854 Human Growth Hormone Substances 0.000 title 1
- 239000012669 liquid formulation Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/KR2006/002640 WO2008004717A1 (en) | 2006-07-06 | 2006-07-06 | A stable liquid formulation of human growth hormone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2049148T true PT2049148T (pt) | 2016-12-30 |
Family
ID=38894670
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT67691865T PT2049148T (pt) | 2006-07-06 | 2006-07-06 | Formulação líquida estável da hormona do crescimento humana |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8409586B2 (pt) |
| EP (1) | EP2049148B1 (pt) |
| JP (1) | JP5180202B2 (pt) |
| CN (1) | CN101505789A (pt) |
| BR (1) | BRPI0621841B8 (pt) |
| ES (1) | ES2605022T3 (pt) |
| HK (1) | HK1216992A1 (pt) |
| HU (1) | HUE031329T2 (pt) |
| LT (1) | LT2049148T (pt) |
| PT (1) | PT2049148T (pt) |
| WO (1) | WO2008004717A1 (pt) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011001273A (ja) * | 2009-06-16 | 2011-01-06 | Eci Inc | eMIPを有効成分とする水溶性製剤 |
| CN102665691B (zh) * | 2009-11-17 | 2015-05-27 | 益普生制药股份有限公司 | hGH和rhIGF-1组合的制剂 |
| WO2013096835A1 (en) * | 2011-12-23 | 2013-06-27 | Abbvie Inc. | Stable protein formulations |
| KR101699677B1 (ko) * | 2013-11-12 | 2017-01-24 | 카딜라 핼쓰캐어 리미티드 | 고나도트로핀을 위한 제제 |
| US9908976B2 (en) | 2015-03-18 | 2018-03-06 | Psmg, Llc | Stable polyethylene glycol particle dispersions and methods for forming the stable dispersions |
| CN110151988A (zh) * | 2018-02-11 | 2019-08-23 | 百奥泰生物制药股份有限公司 | 一种靶向治疗TNF-α相关疾病的人抗体制剂 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61296598A (ja) | 1985-06-21 | 1986-12-27 | Mitsubishi Electric Corp | Mosダイナミツクramのダミ−ワ−ド線駆動回路 |
| ES2044941T5 (es) | 1987-08-21 | 1999-02-16 | Mallinckrodt Group Inc | Estabilizador de hormonas promotoras del crecimiento. |
| US5981485A (en) | 1997-07-14 | 1999-11-09 | Genentech, Inc. | Human growth hormone aqueous formulation |
| DE69334134T2 (de) | 1992-07-31 | 2007-12-20 | Genentech, Inc., South San Francisco | Wässrige Formulierung enthaltend Menschliches Wachstumshormon |
| ZA965368B (en) * | 1995-07-14 | 1997-01-14 | Novo Nordisk As | A pharmaceutical formulation |
| KR970006498A (ko) | 1995-07-31 | 1997-02-21 | 유충식 | 활성형 인성장호르몬의 정제 방법 |
| AUPN801296A0 (en) * | 1996-02-12 | 1996-03-07 | Csl Limited | Stabilised growth hormone formulation and method of preparation thereof |
| US20020077461A1 (en) | 1996-04-24 | 2002-06-20 | Soren Bjorn | Pharmaceutical formulation |
| KR100210840B1 (ko) | 1996-12-24 | 1999-07-15 | 구본준 | 기계 화학적 연마 방법 및 그 장치 |
| KR19990001217A (ko) | 1997-06-13 | 1999-01-15 | 윤종용 | 스탠바이 모드에서의 시스템 구동방법 및 장치 |
| JP3723857B2 (ja) | 1998-02-04 | 2005-12-07 | 日本ケミカルリサーチ株式会社 | ヒト成長ホルモン含有水性医薬組成物 |
| KR100316347B1 (ko) | 1998-09-15 | 2002-08-27 | 한미약품(주) | 대장균엔테로톡신ⅱ신호펩티드의변형체와인체성장호르몬의융합단백질을발현하는재조합미생물및그를이용한인체성장호르몬의제조방법 |
| KR100573704B1 (ko) | 1998-12-02 | 2006-07-21 | 동아제약주식회사 | 인성장 호르몬의 안정화된 액상제제_ |
| ATE464062T1 (de) | 1999-10-04 | 2010-04-15 | Novartis Vaccines & Diagnostic | Stabilisierte flüssige pharmazeutische zusammensetzung enthaltend tfpi |
| CN1284603C (zh) | 1999-10-08 | 2006-11-15 | 内科塔治疗亚拉巴马公司 | 杂双官能聚乙二醇衍生物和它们的制备方法 |
| MXPA03000073A (es) | 2000-06-26 | 2003-09-25 | Monsanto Technology Llc | Formulaciones que contienen agente tensioactivo no acuoso para la liberacion prolongada de somatrotopina. |
| AR040529A1 (es) * | 2002-07-09 | 2005-04-13 | Grandis Biotech Gmbh | Formulaciones de hgh en alta concentracion que contienen 1,2-propilenglicol |
| CA2516314C (en) * | 2003-03-18 | 2012-01-03 | Ares Trading Sa | Liquid growth hormone formulation and process of preparation thereof |
| KR100537260B1 (ko) | 2003-09-03 | 2005-12-19 | 한미약품 주식회사 | 인간 성장 호르몬의 안정화된 액상 제제용 조성물 |
| JP2007537981A (ja) | 2003-09-19 | 2007-12-27 | ノボ ノルディスク アクティーゼルスカブ | 新規の血漿タンパク質親和性タグ |
| CA2540172A1 (en) * | 2003-09-25 | 2005-03-31 | Cangene Corporation | Liquid human growth hormone formulation containing polyethylene glycol |
| DE10355189B4 (de) | 2003-11-26 | 2015-04-30 | Johnson & Johnson Medical Gmbh | Verfahren zum Herstellen eines chirurgischen Implantats sowie chirurgisches Implantat |
| CA2551510C (en) | 2003-12-23 | 2013-07-30 | Pharmacia Corporation | Stable growth hormone liquid formulation |
-
2006
- 2006-07-06 BR BRPI0621841A patent/BRPI0621841B8/pt active IP Right Grant
- 2006-07-06 US US12/307,661 patent/US8409586B2/en active Active
- 2006-07-06 CN CNA2006800556995A patent/CN101505789A/zh active Pending
- 2006-07-06 JP JP2009517937A patent/JP5180202B2/ja active Active
- 2006-07-06 EP EP06769186.5A patent/EP2049148B1/en active Active
- 2006-07-06 ES ES06769186.5T patent/ES2605022T3/es active Active
- 2006-07-06 LT LTEP06769186.5T patent/LT2049148T/lt unknown
- 2006-07-06 WO PCT/KR2006/002640 patent/WO2008004717A1/en not_active Ceased
- 2006-07-06 HU HUE06769186A patent/HUE031329T2/hu unknown
- 2006-07-06 PT PT67691865T patent/PT2049148T/pt unknown
-
2016
- 2016-04-29 HK HK16104967.3A patent/HK1216992A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2009542629A (ja) | 2009-12-03 |
| WO2008004717A1 (en) | 2008-01-10 |
| LT2049148T (lt) | 2016-11-25 |
| EP2049148B1 (en) | 2016-09-28 |
| BRPI0621841A2 (pt) | 2011-12-20 |
| CN101505789A (zh) | 2009-08-12 |
| ES2605022T3 (es) | 2017-03-10 |
| EP2049148A1 (en) | 2009-04-22 |
| BRPI0621841B1 (pt) | 2020-12-29 |
| US20090298768A1 (en) | 2009-12-03 |
| HUE031329T2 (hu) | 2017-07-28 |
| EP2049148A4 (en) | 2013-12-11 |
| US8409586B2 (en) | 2013-04-02 |
| BRPI0621841B8 (pt) | 2021-05-25 |
| JP5180202B2 (ja) | 2013-04-10 |
| WO2008004717A9 (en) | 2013-08-29 |
| HK1216992A1 (zh) | 2016-12-16 |
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