PT2041068T - Pró-fármacos solúveis em água positivamente carregados de ibuprofeno com taxa de penetração de pele muito rápida - Google Patents

Pró-fármacos solúveis em água positivamente carregados de ibuprofeno com taxa de penetração de pele muito rápida

Info

Publication number: PT2041068T
Authority: PT; Portugal
Prior art keywords: ibuprofen; positively charged; skin penetration; penetration rate; charged water
Prior art date: 2006-07-18

Application number

PT67801266T

Other languages

English (en)

Inventor

Yu Chongxi

Xu Lina

Original Assignee

Techfields Biochem Co Ltd

Yu Chongxi

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-07-18

Filing date

2006-07-18

Publication date

2017-02-17

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38956590&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT2041068(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2006-07-18 Application filed by Techfields Biochem Co Ltd, Yu Chongxi filed Critical Techfields Biochem Co Ltd

2017-02-17 Publication of PT2041068T publication Critical patent/PT2041068T/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/35—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/40—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/62—Quaternary ammonium compounds
- C07C211/63—Quaternary ammonium compounds having quaternised nitrogen atoms bound to acyclic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/20—Esters of monothiocarboxylic acids
- C07C327/30—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms, not being part of nitro or nitroso groups

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Ophthalmology & Optometry (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Rheumatology (AREA)
Pulmonology (AREA)
Dermatology (AREA)
Reproductive Health (AREA)
Endocrinology (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicinal Preparation (AREA)

PT67801266T 2006-07-18 2006-07-18 Pró-fármacos solúveis em água positivamente carregados de ibuprofeno com taxa de penetração de pele muito rápida PT2041068T (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP06780126.6A EP2041068B1 (en)	2006-07-18	2006-07-18	Positively charged water-soluble prodrugs of ibuprofen with very fast skin penetration rate
PCT/IB2006/052461 WO2008010025A1 (en)	2006-07-18	2006-07-18	Positively charged water-soluble prodrugs of ibuprofen with very fast skin penetration rate

Publications (1)

Publication Number	Publication Date
PT2041068T true PT2041068T (pt)	2017-02-17

Family

ID=38956590

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT67801266T PT2041068T (pt)	2006-07-18	2006-07-18	Pró-fármacos solúveis em água positivamente carregados de ibuprofeno com taxa de penetração de pele muito rápida

Country Status (11)

Country	Link
EP (2)	EP2041068B1 (pt)
JP (1)	JP5144658B2 (pt)
CN (1)	CN101489985B (pt)
AU (1)	AU2006346288A1 (pt)
CA (1)	CA2657636C (pt)
DK (1)	DK2041068T3 (pt)
ES (1)	ES2616315T3 (pt)
HU (1)	HUE033687T2 (pt)
PL (1)	PL2041068T3 (pt)
PT (1)	PT2041068T (pt)
WO (1)	WO2008010025A1 (pt)

Families Citing this family (24)

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US20090238763A1 (en)	2006-07-09	2009-09-24	Chongxi Yu	High penetration compositions and uses thereof
US20090221703A1 (en)	2006-07-09	2009-09-03	Chongxi Yu	High penetration composition and uses thereof
EP2084124B9 (en)	2006-10-02	2015-07-01	Techfields Biochem Co. Ltd	Positively charged water-soluble prodrugs of prostaglandins and related compounds with very high skin penetration rates
AU2006350707A1 (en)	2006-11-08	2008-05-15	Chongxi Yu	Transdermal delivery systems of peptides and related compounds
WO2008072032A1 (en)	2006-12-10	2008-06-19	Chongxi Yu	Transdermal delivery systems of beta-lactam antibiotics
CA2972344C (en)	2007-01-15	2021-10-26	Chongxi Yu	Positively charged water-soluble prodrugs of retinoids and retinoid-like compounds with very high skin penetration rates
CA2675845C (en)	2007-01-31	2019-03-05	Chongxi Yu	Positively charged water-soluble prodrugs of 1h-imidazo[4,5-c]quinolin-4-amines and related compounds with very high skin penetration rates
WO2008110351A2 (en) *	2007-03-15	2008-09-18	Dompe' Pha.R.Ma S.P.A.	Use of (r) and (s)-2-aryl-propionic acid derivatives as antiseptic agents
KR20210103586A (ko)	2007-06-04	2021-08-23	테크필즈 인크	매우 높은 피부 및 막 침투율을 가지는 비스테로이드성 소염제(ｎｓａｉａ) 약물전구체 및 이들의 새로운 의약적 용도
MX380878B (es)	2008-12-04	2025-03-12	Chongxi Yu	Composiciones de alta penetracion y sus aplicaciones.
EP2408443A1 (en) *	2009-03-16	2012-01-25	Genmedica Therapeutics SL	Anti-inflammatory and antioxidant conjugates useful for treating metabolic disorders
KR20180110187A (ko)	2009-05-08	2018-10-08	테크필즈 바이오켐 코., 엘티디.	펩티드 및 펩티드관련 화합물의 고침투성 전구약물 조성물
US9969751B2 (en)	2009-06-10	2018-05-15	Techfields Pharma Co., Ltd.	High penetration prodrug compositions of antimicrobials and antimicrobial-related compounds
CN103607888A (zh) *	2011-04-08	2014-02-26	斯法尔制药私人有限公司	取代的甲基甲酰基试剂以及使用所述试剂改进化合物的物理化学性质和/或药代动力学性质的方法
CA3189252A1 (en)	2012-01-18	2013-11-21	Techfields Pharma Co., Ltd.	High penetration prodrug compositions and pharmaceutical composition thereof for treatment of pulmonary conditions
JP2016516018A (ja)	2013-03-15	2016-06-02	テックフィールズファーマカンパニーリミテッド	パ−キンソン病治療用の新規高透過薬物及びその組成物
US20160168108A1 (en)	2014-12-16	2016-06-16	Adt Pharmaceuticals, Inc.	Method of treating or preventing ras-mediated diseases
US9862698B2 (en)	2014-12-16	2018-01-09	Adt Pharmaceuticals, Inc.	Indenyl compounds, pharmaceutical compositions, and medical uses thereof
JP6153264B2 (ja) *	2015-01-05	2017-06-28	テックフィールズインコーポレイテッド	非常に速い皮膚及び膜浸透速度を有するｎｓａｉａプロドラッグ及びその新規医薬使用
US20200360335A1 (en) *	2017-10-26	2020-11-19	Zhejiang Yuejia Pharmaceuticals Co., Ltd	Stable pharmaceutical composition containing non-steroidal anti-inflammatory drug derivative
JP7169008B2 (ja)	2018-04-26	2022-11-10	エーディーティーファーマシューティカルズ，エルエルシー	抗がんインデン、インダン、アザインデン、アザインダン、医薬組成物および使用
CN109432061B (zh) *	2018-11-09	2020-10-30	北京德默高科医药技术有限公司	含有布洛芬或其结构类似物的多层经皮给药系统
US11389409B2 (en)	2019-08-30	2022-07-19	Remedy Diagnostics LLC	Transdermal device comprising acetaminophen prodrug
CA3199426A1 (en) *	2020-06-05	2021-12-09	Chongxi Yu	Topical administration of 2-(diethylamino)ethyl 2-(4-isobutylphenyl)propionate for treatment of diseases

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ITMI20012025A1 (it) *	2001-09-28	2003-03-28	Dompe Spa	Sali di ammonio quaternari di omega-amminoalchilammidi di acidi r 2-aril-propionici e composizioni farmaceutiche che li contengono
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CA2656858C (en) *	2006-07-09	2016-01-19	Techfields Biochem Co. Ltd	Positively charged water-soluble prodrugs of acetylsalicylic acid
ES2472545T3 (es) *	2006-07-25	2014-07-01	Techfields Biochem Co. Ltd	Profármacos de diclofenaco solubles en agua con carga positiva y con una tasa de penetración en piel muy rápida
CA2660814C (en) *	2006-08-15	2017-07-18	Techfields Biochem Co. Ltd	Positively charged water-soluble prodrugs of aryl- and heteroarylpropionic acids with very fast skin penetration rate

2006
- 2006-07-18 WO PCT/IB2006/052461 patent/WO2008010025A1/en not_active Ceased
- 2006-07-18 DK DK06780126.6T patent/DK2041068T3/en active
- 2006-07-18 PL PL06780126T patent/PL2041068T3/pl unknown
- 2006-07-18 EP EP06780126.6A patent/EP2041068B1/en not_active Not-in-force
- 2006-07-18 ES ES06780126.6T patent/ES2616315T3/es active Active
- 2006-07-18 CA CA2657636A patent/CA2657636C/en active Active
- 2006-07-18 PT PT67801266T patent/PT2041068T/pt unknown
- 2006-07-18 AU AU2006346288A patent/AU2006346288A1/en not_active Abandoned
- 2006-07-18 HU HUE06780126A patent/HUE033687T2/en unknown
- 2006-07-18 CN CN200680055379.XA patent/CN101489985B/zh active Active
- 2006-07-18 JP JP2009520065A patent/JP5144658B2/ja not_active Expired - Fee Related
- 2006-07-18 EP EP17152505.8A patent/EP3210964A1/en not_active Withdrawn

Also Published As

Publication number	Publication date
ES2616315T3 (es)	2017-06-12
PL2041068T3 (pl)	2017-05-31
JP5144658B2 (ja)	2013-02-13
HK1135958A1 (en)	2010-06-18
WO2008010025A1 (en)	2008-01-24
CN101489985A (zh)	2009-07-22
EP2041068A1 (en)	2009-04-01
DK2041068T3 (en)	2017-02-27
CA2657636A1 (en)	2008-01-24
EP3210964A1 (en)	2017-08-30
HUE033687T2 (en)	2017-12-28
AU2006346288A1 (en)	2008-01-24
JP2009543857A (ja)	2009-12-10
CN101489985B (zh)	2014-01-08
EP2041068B1 (en)	2017-01-25
EP2041068A4 (en)	2010-09-29
CA2657636C (en)	2021-11-09

Publication	Publication Date	Title
EP2041068A4 (en)	2010-09-29	POSITIVE-LOADED, WATER-SOLUBLE PRODRUGS OF IBUPROFEN WITH A VERY FAST SKIN PENETRATION RATE
EP2046727A4 (en)	2010-09-01	POSITIVELY LOADED, WATER-SOLUBLE PRODRUGS FROM DICLOFENAC WITH VERY FAST SKIN PENETRATION SPEED
EP2061749A4 (en)	2010-12-29	POSITIVELY CHARGED WATER-SOLUBLE PRODRUGS OF ACETAMINOPHEN AND COMPOUNDS ASSOCIATED WITH VERY HIGH SKIN PENETRATION SPEED
PT2125697T (pt)	2016-10-18	Pró-fármacos solúveis em água positivamente carregados de retinóides e compostos tipo retinóide com taxas de penetração na pele muito altas
IL209383A0 (en)	2011-01-31	Carbonate prodrugs and methods of using the same
EP2459062A4 (en)	2017-04-05	Non-invasive deep muscle electromyography
PL2250299T3 (pl)	2015-03-31	Ciało powleczone materiałem twardym
PL3031948T3 (pl)	2017-07-31	Korpus powlekany twardym materiałem
IL214274A0 (en)	2011-09-27	Controlled release formulation with continuous efficacy
EP2255730A4 (en)	2014-12-10	ULTRASOUND
PT3660073T (pt)	2023-08-31	Poli-(lactídeo-co-glicolídeo) de libertação imediata reduzida
EP2449102A4 (en)	2013-01-02	ARGINASE FORMULATIONS AND METHODS
PL2623495T3 (pl)	2019-11-29	Dodatnio naładowane rozpuszczalne w wodzie proleki kwasów n-aryloantranilowych o bardzo dużej szybkości przenikania przez skórę
EP2084124A4 (en)	2011-11-09	WATER-SOLUBLE PRODRUGS OF PROSTAGLANDINS AND POSITIVE CHARGED ANALOGOUS COMPOUNDS AT VERY HIGH SKIN PENETRATION RATES
PT2049482E (pt)	2016-02-24	Profármacos solúveis em água carregados positivamente de ácidos aril- e heteroarilacéticos com velocidade de penetração na pele muito rápida
EP2084165A4 (en)	2011-01-05	PRO-DRUGS OF WATER-SOLUBLE OXICAMS POSITIVE AND RELATED COMPOUNDS WITH VERY HIGH SKIN PENETRATION SPEED
GB201118517D0 (en)	2011-12-07	Article formed using nanostructured ferritic alloy
GB2457675B (en)	2012-02-22	Target member
EP2322608A4 (en)	2012-03-21	TRANSFECTION AGENT
EP2077991A4 (en)	2011-11-16	POSITIVELY LOADED, WATER-SOLUBLE PRODRUGS OF LOTS AND RELATED COMPOUNDS WITH VERY HIGH SKIN PENETRATION RATES
ZA201208210B (en)	2014-04-30	A combination composition comprising ibuprofen and paracetamal
PL2440526T3 (pl)	2015-04-30	3-halogeno-6-(arylo)-4-iminotetrahydropikoliniany i ich zastosowanie jako herbicydów
IL216441A0 (en)	2012-02-29	Ectoparasiticidal methods and formulations
IL213560A0 (en)	2011-07-31	Enema formulations
AU2010903481A0 (en)	2010-08-19	Antigravity Whole Body Exercisers