PT1951747E - Processo e intermediários para a síntese de caspofungina - Google Patents

Processo e intermediários para a síntese de caspofungina Download PDF

Info

Publication number: PT1951747E
Authority: PT; Portugal
Prior art keywords: intermediates; caspofungin; synthesis; processes; preparing
Prior art date: 2005-11-15

Application number

PT06818498T

Other languages

English (en)

Inventor

Johannes Ludescher

Ingolf Macher

Ole Storm

Stephan Bertel

Original Assignee

Sandoz Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-11-15

Filing date

2006-11-13

Publication date

2009-08-12

2006-11-13 Application filed by Sandoz Ag filed Critical Sandoz Ag

2009-08-12 Publication of PT1951747E publication Critical patent/PT1951747E/pt

Links

239000000543 intermediate Substances 0.000 title abstract 4
238000000034 method Methods 0.000 title abstract 3
108010020326 Caspofungin Proteins 0.000 title abstract 2
JYIKNQVWKBUSNH-WVDDFWQHSA-N caspofungin Chemical compound C1([C@H](O)[C@@H](O)[C@H]2C(=O)N[C@H](C(=O)N3CC[C@H](O)[C@H]3C(=O)N[C@H](NCCN)[C@H](O)C[C@@H](C(N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)N2)[C@@H](C)O)=O)NC(=O)CCCCCCCC[C@@H](C)C[C@@H](C)CC)[C@H](O)CCN)=CC=C(O)C=C1 JYIKNQVWKBUSNH-WVDDFWQHSA-N 0.000 title abstract 2
229960003034 caspofungin Drugs 0.000 title abstract 2
230000015572 biosynthetic process Effects 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical group CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
-1 caspofungin Chemical class 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
150000002825 nitriles Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Analytical Chemistry (AREA)
Public Health (AREA)
Communicable Diseases (AREA)
Animal Behavior & Ethology (AREA)
Oncology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

PT06818498T 2005-11-15 2006-11-13 Processo e intermediários para a síntese de caspofungina PT1951747E (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP05024961A EP1785432A1 (en)	2005-11-15	2005-11-15	Process and intermediates for the synthesis of caspofungin.

Publications (1)

Publication Number	Publication Date
PT1951747E true PT1951747E (pt)	2009-08-12

Family

ID=36001076

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT06818498T PT1951747E (pt)	2005-11-15	2006-11-13	Processo e intermediários para a síntese de caspofungina

Country Status (17)

Country	Link
US (1)	US20080319162A1 (pt)
EP (2)	EP1785432A1 (pt)
JP (1)	JP4966314B2 (pt)
KR (1)	KR101342304B1 (pt)
CN (1)	CN101305018B (pt)
AT (1)	ATE435233T1 (pt)
BR (1)	BRPI0618591A2 (pt)
CA (1)	CA2626921C (pt)
DE (1)	DE602006007612D1 (pt)
DK (1)	DK1951747T3 (pt)
ES (1)	ES2327962T3 (pt)
HR (1)	HRP20090474T1 (pt)
IL (1)	IL190333A (pt)
PL (1)	PL1951747T3 (pt)
PT (1)	PT1951747E (pt)
SI (1)	SI1951747T1 (pt)
WO (1)	WO2007057141A1 (pt)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP5373606B2 (ja)	2006-07-26	2013-12-18	サンド・アクチエンゲゼルシヤフト	カスポファンギン製剤
WO2009142761A1 (en) *	2008-05-21	2009-11-26	Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag	Caspofungin bo free of caspofungin co
US8048853B2 (en) *	2008-06-13	2011-11-01	Xellia Pharmaceuticals Aps	Process for preparing pharmaceutical compound and intermediates thereof
CN102076707A (zh) *	2008-06-25	2011-05-25	特瓦药厂私人有限公司	无卡泊芬净杂质a的卡泊芬净
US20100256074A1 (en) *	2008-06-25	2010-10-07	Chaim Eidelman	Processes for preparing high purity aza cyclohexapeptides
TW201024322A (en) *	2008-12-31	2010-07-01	Chunghwa Chemical Synthesis & Biotech Co Ltd	Preparation method for nitrogen containing heterocyclic hexapeptide with high conversion rate
WO2010108637A1 (en)	2009-03-27	2010-09-30	Axellia Pharmaceuticals Aps	Crystalline compound
WO2011014990A1 (zh) *	2009-08-06	2011-02-10	上海天伟生物制药有限公司	一种氮杂环己肽或其药学上可接受的盐及其制备方法和用途
CN103180336B (zh) *	2010-09-28	2016-06-15	中化帝斯曼制药有限公司荷兰公司	用于分离环六肽的方法
CN102367267B (zh)	2010-11-10	2013-09-04	上海天伟生物制药有限公司	一种卡泊芬净的制备方法
CN102367268B (zh)	2010-11-10	2013-11-06	上海天伟生物制药有限公司	一种卡泊芬净类似物及其用途
CN102367269B (zh)	2010-11-10	2013-11-06	上海天伟生物制药有限公司	一种卡泊芬净类似物及其制备方法和用途
KR101331984B1 (ko)	2010-12-09	2013-11-25	종근당바이오 주식회사	카스포펀진 제조방법 및 그의 신규 중간체
CN102219833A (zh) *	2011-04-18	2011-10-19	深圳市健元医药科技有限公司	一种更加安全的棘白菌类抗真菌药的制备方法
CN102746384B (zh) *	2011-04-22	2016-01-20	上海天伟生物制药有限公司	一种高纯度的卡泊芬净或其盐及其制备方法和用途
BR112013026868A2 (pt) *	2011-04-28	2016-09-06	Unitris Biopharma Co Ltd	intermediário para a síntese de caspofungina e método para o seu preparo
CN106478781B (zh) *	2015-09-02	2020-04-07	正大天晴药业集团股份有限公司	卡泊芬净的制备方法
CN105440109B (zh) *	2015-11-26	2019-03-05	成都摩尔生物医药有限公司	一种卡泊芬净的制备方法
CN109721641B (zh) *	2017-10-31	2021-08-03	鲁南制药集团股份有限公司	一种卡泊芬净的合成方法
EP3620462A1 (en)	2018-09-04	2020-03-11	Xellia Pharmaceuticals ApS	Process for the preparation of caspofungin

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5202309A (en)	1989-06-30	1993-04-13	Merck & Co., Inc.	Antibiotic cyclopeptide fermentation product
US5194377A (en)	1989-06-30	1993-03-16	Merck & Co., Inc.	Antibiotic agent
US6030944A (en)	1991-10-01	2000-02-29	Merck & Co., Inc.	Cyclohexapeptidyl bisamine compounds
AU5354094A (en) *	1992-10-16	1994-05-09	Merck & Co., Inc.	An improved process for cyclohexapeptidyl bisamine compounds
US5378804A (en) *	1993-03-16	1995-01-03	Merck & Co., Inc.	Aza cyclohexapeptide compounds
CA2195975C (en) *	1994-08-23	2001-05-15	James M. Balkovec	An improved process for preparing side chain derivatives of cyclohexapeptidyl lipopeptides
US5552521A (en)	1995-02-10	1996-09-03	Merck & Co., Inc.	Process for preparing certain aza cyclohexapeptides
HRP970318B1 (en)	1996-06-14	2002-06-30	Merck & Co Inc	A process for preparing certain aza cyclohexapeptides
US5936062A (en)	1997-06-12	1999-08-10	Merck & Co., Inc.	Process for preparing certain aza cyclohexapeptides
US5972996A (en) *	1997-08-22	1999-10-26	Merck & Co., Inc.	4-cyano-4-deformylsordarin derivatives
US5965612A (en) *	1997-08-22	1999-10-12	Merck & Co., Inc.	4-cyano-4-deformylsordaricin derivatives
EP1351701A2 (en) *	2001-01-09	2003-10-15	Merck & Co., Inc.	Active metabolite of antifungal compound
AR035808A1 (es)	2001-04-12	2004-07-14	Merck & Co Inc	Proceso de deshidratacion capaz de minimizar la epimerizacion de un grupo hidroxilo por ciertas equinocandinas

2005
- 2005-11-15 EP EP05024961A patent/EP1785432A1/en not_active Withdrawn
2006
- 2006-11-13 SI SI200630411T patent/SI1951747T1/sl unknown
- 2006-11-13 HR HR20090474T patent/HRP20090474T1/xx unknown
- 2006-11-13 CA CA2626921A patent/CA2626921C/en not_active Expired - Fee Related
- 2006-11-13 BR BRPI0618591-6A patent/BRPI0618591A2/pt not_active IP Right Cessation
- 2006-11-13 PT PT06818498T patent/PT1951747E/pt unknown
- 2006-11-13 PL PL06818498T patent/PL1951747T3/pl unknown
- 2006-11-13 WO PCT/EP2006/010867 patent/WO2007057141A1/en not_active Ceased
- 2006-11-13 DK DK06818498T patent/DK1951747T3/da active
- 2006-11-13 EP EP06818498A patent/EP1951747B1/en active Active
- 2006-11-13 US US12/093,657 patent/US20080319162A1/en not_active Abandoned
- 2006-11-13 CN CN2006800422331A patent/CN101305018B/zh not_active Expired - Fee Related
- 2006-11-13 ES ES06818498T patent/ES2327962T3/es active Active
- 2006-11-13 DE DE602006007612T patent/DE602006007612D1/de active Active
- 2006-11-13 JP JP2008540498A patent/JP4966314B2/ja not_active Expired - Fee Related
- 2006-11-13 AT AT06818498T patent/ATE435233T1/de active
2008
- 2008-03-20 IL IL190333A patent/IL190333A/en not_active IP Right Cessation
- 2008-05-14 KR KR1020087011523A patent/KR101342304B1/ko not_active Expired - Fee Related

Also Published As

Publication number	Publication date
WO2007057141A1 (en)	2007-05-24
BRPI0618591A2 (pt)	2011-09-06
DE602006007612D1 (de)	2009-08-13
IL190333A (en)	2010-12-30
HRP20090474T1 (hr)	2009-10-31
KR20080069998A (ko)	2008-07-29
US20080319162A1 (en)	2008-12-25
ATE435233T1 (de)	2009-07-15
CN101305018B (zh)	2013-03-27
PL1951747T3 (pl)	2009-12-31
JP4966314B2 (ja)	2012-07-04
KR101342304B1 (ko)	2013-12-16
CN101305018A (zh)	2008-11-12
CA2626921A1 (en)	2007-05-24
EP1951747A1 (en)	2008-08-06
EP1951747B1 (en)	2009-07-01
ES2327962T3 (es)	2009-11-05
CA2626921C (en)	2013-09-17
SI1951747T1 (sl)	2009-12-31
DK1951747T3 (da)	2009-10-12
JP2009515917A (ja)	2009-04-16
EP1785432A1 (en)	2007-05-16

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