PT1847539E - Derivados de quinazolina - Google Patents

Derivados de quinazolina Download PDF

Info

Publication number: PT1847539E
Authority: PT; Portugal
Prior art keywords: quinazoline derivatives; quinazoline; derivatives
Prior art date: 2002-12-24

Application number

PT07009390T

Other languages

English (en)

Inventor

Nicola Murdoch Heron

Andrew Austen Mortlock

Frederic Henri Jung

Georges Rene Pasquet

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-12-24

Filing date

2003-12-22

Publication date

2009-10-06

2003-12-22 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2009-10-06 Publication of PT1847539E publication Critical patent/PT1847539E/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Hematology (AREA)
Oncology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

PT07009390T 2002-12-24 2003-12-22 Derivados de quinazolina PT1847539E (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP02293238		2002-12-24
EP03291315		2003-06-02

Publications (1)

Publication Number	Publication Date
PT1847539E true PT1847539E (pt)	2009-10-06

Family

ID=32683824

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
PT07009390T PT1847539E (pt)	2002-12-24	2003-12-22	Derivados de quinazolina
PT03782672T PT1578755E (pt)	2002-12-24	2003-12-22	Derivados de fosfonooxiquinazolina e sua utilização farmacêutica

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
PT03782672T PT1578755E (pt)	2002-12-24	2003-12-22	Derivados de fosfonooxiquinazolina e sua utilização farmacêutica

Country Status (29)

Country	Link
US (4)	US7528121B2 (pt)
EP (2)	EP1847539B1 (pt)
JP (3)	JP4422102B2 (pt)
KR (1)	KR101010299B1 (pt)
AR (2)	AR042668A1 (pt)
AT (2)	ATE370958T1 (pt)
AU (1)	AU2003290313B2 (pt)
BR (1)	BRPI0317717B8 (pt)
CA (1)	CA2511613C (pt)
CL (1)	CL2003002731A1 (pt)
CY (2)	CY1107775T1 (pt)
DE (2)	DE60315892T2 (pt)
DK (2)	DK1578755T3 (pt)
ES (2)	ES2329623T3 (pt)
IL (2)	IL169112A (pt)
IS (2)	IS2504B (pt)
MX (1)	MXPA05006918A (pt)
MY (2)	MY147761A (pt)
NO (2)	NO335193B1 (pt)
NZ (1)	NZ540698A (pt)
PL (2)	PL223998B1 (pt)
PT (2)	PT1847539E (pt)
RU (3)	RU2357971C2 (pt)
SA (1)	SA04240504B1 (pt)
SI (2)	SI1578755T1 (pt)
TW (2)	TWI393710B (pt)
UA (1)	UA83814C2 (pt)
UY (1)	UY28149A1 (pt)
WO (1)	WO2004058781A1 (pt)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
UA82058C2 (uk) *	2001-12-24	2008-03-11	Астразенека Аб	Заміщені похідні хіназоліну як інгібітори ауроракінази, спосіб їх одержання, фармацевтична композиція на їх основі
CA2508921A1 (en) *	2002-12-24	2004-07-15	Astrazeneca Ab	Quinazoline compounds
US7528121B2 (en)	2002-12-24	2009-05-05	Astrazeneca Ab	Phosphonooxy quinazoline derivatives and their pharmaceutical use
CA2522079A1 (en) *	2003-04-16	2004-11-04	Astrazeneca Ab	Quinazoline derivatives for treatment of cancer
AU2004247626B8 (en) *	2003-05-15	2011-05-19	Arqule, Inc.	Imidazothiazoles and imidazoxazole derivatives as inhibitors of p38
US20060135541A1 (en) *	2003-06-02	2006-06-22	Astrazeneca Ab	(3-((Quinazolin-4-yl) amino)-1h-pyrazol-1-yl)acetamide derivatives and related compounds as aurora kinase inhibitors for the treatment of proliferative diseases such as cancer
JP2007514759A (ja)	2003-12-19	2007-06-07	タケダサンディエゴインコーポレイテッド	キナーゼ阻害剤
JP2008510734A (ja)	2004-08-18	2008-04-10	タケダサンディエゴインコーポレイテッド	キナーゼ阻害剤
EP1802608A1 (en) *	2004-10-12	2007-07-04	AstraZeneca AB	Quinazoline derivatives for use against cancer
WO2006040520A1 (en) *	2004-10-12	2006-04-20	Astrazeneca Ab	Quinazoline derivatives
DE602005023333D1 (de)	2004-10-15	2010-10-14	Takeda Pharmaceutical	Kinaseinhibitoren
WO2006044869A1 (en) *	2004-10-19	2006-04-27	Arqule, Inc.	Synthesis of imidazooxazole and imidazothiazole inhibitors of p38 map kinase
US8119655B2 (en)	2005-10-07	2012-02-21	Takeda Pharmaceutical Company Limited	Kinase inhibitors
UY30183A1 (es)	2006-03-02	2007-10-31	Astrazeneca Ab	Derivados de quinolina
WO2007123892A2 (en) *	2006-04-17	2007-11-01	Arqule Inc.	Raf inhibitors and their uses
GB0609621D0 (en) *	2006-05-16	2006-06-21	Astrazeneca Ab	Novel co-crystal
GB0609619D0 (en) *	2006-05-16	2006-06-21	Astrazeneca Ab	Combination
GB0609617D0 (en) *	2006-05-16	2006-06-21	Astrazeneca Ab	Process & intermediate
BRPI0719883A2 (pt)	2006-10-09	2015-05-05	Takeda Pharmaceutical	Inibidores de quinase
US20110136766A1 (en) *	2008-03-04	2011-06-09	Vitae Pharmaceuticals, Inc.	Aurora kinase inhibitors
WO2009114703A2 (en) *	2008-03-12	2009-09-17	Fox Chase Cancer Center	Combination therapy for the treatment of cancer
ES2616255T3 (es)	2008-04-30	2017-06-12	National Health Research Institutes	Compuestos de pirimidina bicíclicos condensados como inhibidores de las aurora cinasas
JP2011526912A (ja) *	2008-07-03	2011-10-20	メルクパテントゲゼルシャフトミットベシュレンクテルハフツング	プロテインキナーゼ阻害剤としてのナフチリジノン
EP2361254A1 (en) *	2008-12-05	2011-08-31	ArQule, Inc.	Raf inhibitors and their uses
EP2373326B1 (en)	2008-12-11	2016-03-09	Axcentua Pharmaceutucals AB	Crystalline forms of genistein
US7863325B2 (en)	2008-12-11	2011-01-04	Axcentua Pharmaceuticals Ab	Crystalline genistein sodium salt dihydrate
BRPI0923579A2 (pt)	2008-12-22	2020-01-14	Millennium Pharm Inc	combinação de inibidores de aurora quinase e anticorpos anti-cd20
ES2609578T3 (es)	2011-03-04	2017-04-21	Glaxosmithkline Intellectual Property Development Limited	Amino-quinolinas como inhibidores de quinasa
TWI547494B (zh)	2011-08-18	2016-09-01	葛蘭素史克智慧財產發展有限公司	作為激酶抑制劑之胺基喹唑啉類
TWI592417B (zh)	2012-09-13	2017-07-21	葛蘭素史克智慧財產發展有限公司	胺基喹唑啉激酶抑制劑之前藥
TW201425307A (zh)	2012-09-13	2014-07-01	Glaxosmithkline Llc	作為激酶抑制劑之胺基－喹啉類
EP2956138B1 (en)	2013-02-15	2022-06-22	Kala Pharmaceuticals, Inc.	Therapeutic compounds and uses thereof
ES2831625T3 (es)	2013-02-20	2021-06-09	Kala Pharmaceuticals Inc	Compuestos terapéuticos y sus usos
US9688688B2 (en)	2013-02-20	2017-06-27	Kala Pharmaceuticals, Inc.	Crystalline forms of 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one and uses thereof
BR112015019624A2 (pt) *	2013-02-21	2017-07-18	Glaxosmithkline Ip Dev Ltd	quinazolinas como inibidores de quinase
HUE034490T2 (en) *	2013-09-16	2018-02-28	Astrazeneca Ab	Therapeutic polymer nanoparticles and methods for their preparation and use
CN108530458A (zh)	2013-11-01	2018-09-14	卡拉制药公司	治疗化合物的结晶形式及其用途
US9890173B2 (en)	2013-11-01	2018-02-13	Kala Pharmaceuticals, Inc.	Crystalline forms of therapeutic compounds and uses thereof
WO2015085289A1 (en)	2013-12-06	2015-06-11	Millennium Pharmaceuticals, Inc.	Combination of aurora kinase inhibitors and anti-cd30 antibodies
JP2018524292A (ja)	2015-07-21	2018-08-30	ミレニアムファーマシューティカルズ，インコーポレイテッドＭｉｌｌｅｎｎｉｕｍＰｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ．	オーロラキナーゼインヒビターと化学療法剤の投与
EP3509423A4 (en)	2016-09-08	2020-05-13	Kala Pharmaceuticals, Inc.	CRYSTALLINE FORMS OF THERAPEUTIC COMPOUNDS AND USES THEREOF
US10253036B2 (en)	2016-09-08	2019-04-09	Kala Pharmaceuticals, Inc.	Crystalline forms of therapeutic compounds and uses thereof
EP3509421A4 (en)	2016-09-08	2020-05-20	Kala Pharmaceuticals, Inc.	CRYSTALLINE FORMS OF THERAPEUTIC COMPOUNDS AND USES THEREOF
HUE066413T2 (hu)	2017-09-08	2024-08-28	Univ Leland Stanford Junior	ENPP1 inhibitorok és alkalmazásuk rák kezelésére
WO2019195658A1 (en)	2018-04-05	2019-10-10	Dana-Farber Cancer Institute, Inc.	Sting levels as a biomarker for cancer immunotherapy
WO2020049208A1 (es)	2018-09-09	2020-03-12	Fundacio Privada Institut De Recerca De La Sida - Caixa	Aurora cinasa como diana para tratar, prevenir o curar una infección por vih o sida
WO2021041532A1 (en)	2019-08-26	2021-03-04	Dana-Farber Cancer Institute, Inc.	Use of heparin to promote type 1 interferon signaling
US20210161897A1 (en)	2019-11-12	2021-06-03	Astrazeneca Ab	Epidermal growth factor receptor tyrosine kinase inhibitors for the treatment of cancer
CN112939948B (zh) *	2019-12-11	2022-05-17	苏州美诺医药科技有限公司	新型含喹唑啉类化合物及其中间体与应用
WO2021260582A1 (en)	2020-06-24	2021-12-30	Astrazeneca Uk Limited	Combination of antibody-drug conjugate and aurora b inhibitor
WO2022192139A1 (en)	2021-03-10	2022-09-15	Astrazeneca Ab	Aurora kinase b inhibitors for use for treating cancer

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL89029A (en)	1988-01-29	1993-01-31	Lilly Co Eli	Fungicidal quinoline and cinnoline derivatives, compositions containing them, and fungicidal methods of using them
US5480883A (en)	1991-05-10	1996-01-02	Rhone-Poulenc Rorer Pharmaceuticals Inc.	Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
US5710158A (en)	1991-05-10	1998-01-20	Rhone-Poulenc Rorer Pharmaceuticals Inc.	Aryl and heteroaryl quinazoline compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
US5721237A (en)	1991-05-10	1998-02-24	Rhone-Poulenc Rorer Pharmaceuticals Inc.	Protein tyrosine kinase aryl and heteroaryl quinazoline compounds having selective inhibition of HER-2 autophosphorylation properties
EP0584222B1 (en)	1991-05-10	1997-10-08	Rhone-Poulenc Rorer International (Holdings) Inc.	Bis mono-and bicyclic aryl and heteroaryl compounds which inhibit egf and/or pdgf receptor tyrosine kinase
AU2737295A (en)	1994-06-09	1996-01-04	Glaxo Group Limited	Phenethanolamine derivatives and their use as atypical beta-adrenoceptor agonists
GB9510757D0 (en)	1994-09-19	1995-07-19	Wellcome Found	Therapeuticaly active compounds
TW321649B (pt)	1994-11-12	1997-12-01	Zeneca Ltd
GB9514265D0 (en)	1995-07-13	1995-09-13	Wellcome Found	Hetrocyclic compounds
GB9624482D0 (en)	1995-12-18	1997-01-15	Zeneca Phaema S A	Chemical compounds
CA2239692C (en)	1995-12-18	2008-12-16	Sugen, Inc.	Diagnosis and treatment of aur-1 and/or aur-2 related disorders
US6716575B2 (en)	1995-12-18	2004-04-06	Sugen, Inc.	Diagnosis and treatment of AUR1 and/or AUR2 related disorders
KR19990082463A (ko)	1996-02-13	1999-11-25	돈 리사 로얄	혈관 내피 성장 인자 억제제로서의 퀴나졸린유도체
AU719327B2 (en)	1996-03-05	2000-05-04	Astrazeneca Ab	4-anilinoquinazoline derivatives
GB9718972D0 (en)	1996-09-25	1997-11-12	Zeneca Ltd	Chemical compounds
GB9714249D0 (en)	1997-07-08	1997-09-10	Angiogene Pharm Ltd	Vascular damaging agents
ZA986732B (en)	1997-07-29	1999-02-02	Warner Lambert Co	Irreversible inhibitiors of tyrosine kinases
BR9914326A (pt) *	1998-10-08	2001-06-26	Astrazeneca Ab	Uso de um composto, composto, processo para a preparação do mesmo, composição farmacêutica, e, método para produzir um efeito antiangiogênico e/ou de redução da permeabilidade vascular em animais de sangue quente em necessidade de um tal tratamento
GB9900334D0 (en)	1999-01-07	1999-02-24	Angiogene Pharm Ltd	Tricylic vascular damaging agents
GB9900752D0 (en)	1999-01-15	1999-03-03	Angiogene Pharm Ltd	Benzimidazole vascular damaging agents
GB9922171D0 (en)	1999-09-21	1999-11-17	Zeneca Ltd	Chemical compounds
CZ20021009A3 (cs)	1999-09-21	2002-06-12	Astrazeneca Ab	Deriváty chinazolinu, způsob jejich přípravy a jejich pouľití jako léčiv
EP1289952A1 (en)	2000-05-31	2003-03-12	AstraZeneca AB	Indole derivatives with vascular damaging activity
WO2002000649A1 (en) *	2000-06-28	2002-01-03	Astrazeneca Ab	Substituted quinazoline derivatives and their use as inhibitors
WO2002008213A1 (en)	2000-07-07	2002-01-31	Angiogene Pharmaceuticals Limited	Colchinol derivatives as angiogenesis inhibitors
MXPA02012905A (es)	2000-07-07	2004-07-30	Angiogene Pharm Ltd	Derivados de colquinol como agentes de dano vascular..
CA2426440C (en) *	2000-08-18	2011-03-15	Millennium Pharmaceuticals, Inc.	Quinazoline derivatives as kinase inhibitors
US6610677B2 (en)	2000-09-15	2003-08-26	Vertex Pharmaceuticals Incorporated	Pyrazole compounds useful as protein kinase inhibitors
EP1408980A4 (en) *	2001-06-21	2004-10-20	Ariad Pharma Inc	NEW QUINAZOLINES AND THEIR USE
GB0124299D0 (en) *	2001-10-10	2001-11-28	Astrazeneca Ab	Crystal structure of enzyme and uses thereof
UA82058C2 (uk) *	2001-12-24	2008-03-11	Астразенека Аб	Заміщені похідні хіназоліну як інгібітори ауроракінази, спосіб їх одержання, фармацевтична композиція на їх основі
CA2508921A1 (en) *	2002-12-24	2004-07-15	Astrazeneca Ab	Quinazoline compounds
US7528121B2 (en) *	2002-12-24	2009-05-05	Astrazeneca Ab	Phosphonooxy quinazoline derivatives and their pharmaceutical use
CA2522079A1 (en) *	2003-04-16	2004-11-04	Astrazeneca Ab	Quinazoline derivatives for treatment of cancer

2003
- 2003-12-22 US US10/539,220 patent/US7528121B2/en active Active
- 2003-12-22 SI SI200330965T patent/SI1578755T1/sl unknown
- 2003-12-22 DK DK03782672T patent/DK1578755T3/da active
- 2003-12-22 SI SI200331673T patent/SI1847539T1/sl unknown
- 2003-12-22 RU RU2005123485/04A patent/RU2357971C2/ru active
- 2003-12-22 NZ NZ540698A patent/NZ540698A/en not_active IP Right Cessation
- 2003-12-22 MX MXPA05006918A patent/MXPA05006918A/es active IP Right Grant
- 2003-12-22 AU AU2003290313A patent/AU2003290313B2/en not_active Expired
- 2003-12-22 DE DE60315892T patent/DE60315892T2/de not_active Expired - Lifetime
- 2003-12-22 EP EP07009390A patent/EP1847539B1/en not_active Expired - Lifetime
- 2003-12-22 ES ES07009390T patent/ES2329623T3/es not_active Expired - Lifetime
- 2003-12-22 DK DK07009390T patent/DK1847539T3/da active
- 2003-12-22 MY MYPI20071321A patent/MY147761A/en unknown
- 2003-12-22 JP JP2005509716A patent/JP4422102B2/ja not_active Expired - Lifetime
- 2003-12-22 UA UAA200507294A patent/UA83814C2/ru unknown
- 2003-12-22 DE DE60328735T patent/DE60328735D1/de not_active Expired - Lifetime
- 2003-12-22 CL CL200302731A patent/CL2003002731A1/es unknown
- 2003-12-22 AT AT03782672T patent/ATE370958T1/de active
- 2003-12-22 CA CA2511613A patent/CA2511613C/en not_active Expired - Lifetime
- 2003-12-22 PL PL412704A patent/PL223998B1/pl unknown
- 2003-12-22 PT PT07009390T patent/PT1847539E/pt unknown
- 2003-12-22 MY MYPI20034944A patent/MY136174A/en unknown
- 2003-12-22 PL PL377680A patent/PL221490B1/pl unknown
- 2003-12-22 ES ES03782672T patent/ES2290529T3/es not_active Expired - Lifetime
- 2003-12-22 BR BRPI0317717A patent/BRPI0317717B8/pt not_active IP Right Cessation
- 2003-12-22 KR KR1020057012015A patent/KR101010299B1/ko not_active Expired - Lifetime
- 2003-12-22 AT AT07009390T patent/ATE438644T1/de active
- 2003-12-22 WO PCT/GB2003/005613 patent/WO2004058781A1/en not_active Ceased
- 2003-12-22 PT PT03782672T patent/PT1578755E/pt unknown
- 2003-12-22 RU RU2007121850/04A patent/RU2350611C1/ru active
- 2003-12-22 EP EP03782672A patent/EP1578755B1/en not_active Expired - Lifetime
- 2003-12-23 TW TW099134275A patent/TWI393710B/zh not_active IP Right Cessation
- 2003-12-23 UY UY28149A patent/UY28149A1/es not_active Application Discontinuation
- 2003-12-23 AR ARP030104824A patent/AR042668A1/es active IP Right Grant
- 2003-12-23 TW TW092136601A patent/TWI336327B/zh not_active IP Right Cessation
2004
- 2004-02-18 SA SA04240504A patent/SA04240504B1/ar unknown
2005
- 2005-06-09 IL IL169112A patent/IL169112A/en active IP Right Grant
- 2005-06-13 NO NO20052855A patent/NO335193B1/no not_active IP Right Cessation
- 2005-07-20 IS IS7948A patent/IS2504B/is unknown
2007
- 2007-05-16 AR ARP070102117A patent/AR057753A2/es not_active Application Discontinuation
- 2007-06-13 RU RU2007121850/04K patent/RU2007121850A/ru unknown
- 2007-06-28 JP JP2007169891A patent/JP4906608B2/ja not_active Expired - Lifetime
- 2007-08-09 IL IL185176A patent/IL185176A/en active IP Right Grant
- 2007-10-24 CY CY20071101369T patent/CY1107775T1/el unknown
2008
- 2008-02-13 IS IS8714A patent/IS2884B/is unknown
- 2008-10-15 JP JP2008265949A patent/JP4503090B2/ja not_active Expired - Lifetime
2009
- 2009-04-28 US US12/431,165 patent/US8268841B2/en not_active Expired - Lifetime
- 2009-10-13 CY CY20091101054T patent/CY1109479T1/el unknown
2012
- 2012-08-21 US US13/590,662 patent/US9018191B2/en not_active Expired - Lifetime
2013
- 2013-11-01 NO NO20131444A patent/NO335446B1/no not_active IP Right Cessation
2015
- 2015-03-18 US US14/661,657 patent/US9567358B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
NO335193B1 (no)	2014-10-20
US20140162984A1 (en)	2014-06-12
TWI336327B (en)	2011-01-21
TWI393710B (zh)	2013-04-21
AU2003290313A1 (en)	2004-07-22
AU2003290313B2 (en)	2007-05-10
SI1847539T1 (sl)	2010-01-29
US9567358B2 (en)	2017-02-14
US20100069412A1 (en)	2010-03-18
PL223998B1 (pl)	2016-11-30
BR0317717A (pt)	2005-11-22
US20150307534A1 (en)	2015-10-29
JP2007326862A (ja)	2007-12-20
HK1111417A1 (en)	2008-08-08
KR20050088333A (ko)	2005-09-05
EP1847539B1 (en)	2009-08-05
PT1578755E (pt)	2007-10-19
IL169112A0 (en)	2009-02-11
IS8714A (is)	2008-02-13
JP4503090B2 (ja)	2010-07-14
CY1107775T1 (el)	2013-06-19
DK1847539T3 (da)	2009-11-09
DK1578755T3 (da)	2007-11-12
PL377680A1 (pl)	2006-02-06
SA04240504B1 (ar)	2008-04-01
NZ540698A (en)	2008-05-30
NO20052855D0 (no)	2005-06-13
ES2329623T3 (es)	2009-11-27
DE60328735D1 (de)	2009-09-17
SA04240504A (ar)	2005-12-03
IL185176A0 (en)	2007-12-03
IS7948A (is)	2005-07-20
US8268841B2 (en)	2012-09-18
NO20052855L (no)	2005-08-03
NO335446B1 (no)	2014-12-15
RU2005123485A (ru)	2006-03-10
EP1578755B1 (en)	2007-08-22
US20060116357A1 (en)	2006-06-01
EP1578755A1 (en)	2005-09-28
ES2290529T3 (es)	2008-02-16
CY1109479T1 (el)	2014-08-13
HK1080481A1 (en)	2006-04-28
DE60315892D1 (de)	2007-10-04
UA83814C2 (ru)	2008-08-26
BRPI0317717B1 (pt)	2017-12-19
TW201102369A (en)	2011-01-16
AR042668A1 (es)	2005-06-29
AR057753A2 (es)	2007-12-19
CL2003002731A1 (es)	2005-01-07
WO2004058781A1 (en)	2004-07-15
JP4422102B2 (ja)	2010-02-24
IL169112A (en)	2010-12-30
UY28149A1 (es)	2004-07-30
MXPA05006918A (es)	2005-08-18
ATE370958T1 (de)	2007-09-15
BRPI0317717B8 (pt)	2021-05-25
PL221490B1 (pl)	2016-04-29
KR101010299B1 (ko)	2011-01-25
SI1578755T1 (sl)	2007-12-31
DE60315892T2 (de)	2008-08-14
US7528121B2 (en)	2009-05-05
IL185176A (en)	2011-10-31
IS2504B (is)	2009-04-15
RU2350611C1 (ru)	2009-03-27
JP2006512418A (ja)	2006-04-13
US9018191B2 (en)	2015-04-28
JP4906608B2 (ja)	2012-03-28
JP2009046514A (ja)	2009-03-05
EP1847539A1 (en)	2007-10-24
MY147761A (en)	2013-01-31
CA2511613A1 (en)	2004-07-15
CA2511613C (en)	2012-10-02
MY136174A (en)	2008-08-29
TW200510342A (en)	2005-03-16
RU2357971C2 (ru)	2009-06-10
RU2007121850A (ru)	2008-12-20
IS2884B (is)	2014-06-15
NO20131444L (no)	2005-08-03
PL412704A1 (pl)	2015-10-12
ATE438644T1 (de)	2009-08-15

Publication	Publication Date	Title
GB0215823D0 (en)	2002-08-14	Quinazoline derivatives
PT1847539E (pt)	2009-10-06	Derivados de quinazolina
GB0322409D0 (en)	2003-10-29	Quinazoline derivatives
IL174534A0 (en)	2006-08-01	Quinazoline derivatives
GB0321648D0 (en)	2003-10-15	Quinazoline derivatives
IL174284A0 (en)	2006-08-01	Quinazoline derivatives
IL174257A0 (en)	2006-08-01	Quinazoline derivatives
AP1850A (en)	2008-05-26	Spiroindolineplperidine derivatives
EG24050A (en)	2008-04-13	Heterocylocarboxamide derivatives
SI1474420T1 (sl)	2012-06-29	Spojine kinazolina
EP1522540A4 (en)	2011-08-10	AZAARENE DERIVATIVES
IL174390A0 (en)	2011-08-01	Quinazoline derivatives
GB0326459D0 (en)	2003-12-17	Quinazoline derivatives
GB0330002D0 (en)	2004-01-28	Quinazoline derivatives
PL377474A1 (pl)	2006-02-06	Pochodne 3H-chinazolin-4-onu
GB2410025B (en)	2007-03-28	Quinazolin-4-one derivatives
AU2003222659A8 (en)	2003-11-03	23-o-substituted 5-o-mycaminosyltylonide derivatives
PL374817A1 (en)	2005-10-31	Quinazoline derivatives
GB0321621D0 (en)	2003-10-15	Quinazoline derivatives
EP1531854A4 (en)	2006-06-28	O-DERIVATED NOCATHIACIN DERIVATIVES
GB0321620D0 (en)	2003-10-15	Quinazoline derivatives
GB0213488D0 (en)	2002-07-24	2-Naphthamide derivatives
AU2003243397A8 (en)	2003-12-19	Homo-camptothecin derivatives
GB0215825D0 (en)	2002-08-14	Quinazoline derivatives
AU2003290279A1 (en)	2004-07-14	Quinazoline derivatives