PT1725567E - Derivados espirocíclicos de ciclo-hexano com afinidade para o receptor orl-1 - Google Patents

Derivados espirocíclicos de ciclo-hexano com afinidade para o receptor orl-1 Download PDF

Info

Publication number: PT1725567E
Authority: PT; Portugal
Prior art keywords: orl; affinity; receptor; cyclohexane derivatives; spirocyclic cyclohexane
Prior art date: 2003-12-23

Application number

PT04804136T

Other languages

English (en)

Inventor

Friderichs Dr Elmar

Stefan Oberboersch

Bernd Sundermann

Koegel Dr Babette-Yvonne

Derek Saunders

Claudia Hinze

Hans Schick

Birgitta Henkel

Werner Englberger

Sven Frormann

Klaus Linz

Beatrix Merla

Wolfgang Schroeder

Original Assignee

Gruenenthal Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-12-23

Filing date

2004-12-21

Publication date

2008-05-09

2004-12-21 Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh

2008-05-09 Publication of PT1725567E publication Critical patent/PT1725567E/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Addiction (AREA)
Endocrinology (AREA)
Heart & Thoracic Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Hematology (AREA)
Diabetes (AREA)
Orthopedic Medicine & Surgery (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Reproductive Health (AREA)
Child & Adolescent Psychology (AREA)
Dermatology (AREA)
Rheumatology (AREA)
Hospice & Palliative Care (AREA)
Obesity (AREA)
Anesthesiology (AREA)
Gynecology & Obstetrics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

PT04804136T 2003-12-23 2004-12-21 Derivados espirocíclicos de ciclo-hexano com afinidade para o receptor orl-1 PT1725567E (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE10360792A DE10360792A1 (de)	2003-12-23	2003-12-23	Spirocyclische Cyclohexan-Derivate

Publications (1)

Publication Number	Publication Date
PT1725567E true PT1725567E (pt)	2008-05-09

Family

ID=34706497

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT04804136T PT1725567E (pt)	2003-12-23	2004-12-21	Derivados espirocíclicos de ciclo-hexano com afinidade para o receptor orl-1

Country Status (27)

Country	Link
US (1)	US7332519B2 (pt)
EP (1)	EP1725567B1 (pt)
JP (1)	JP4885733B2 (pt)
KR (1)	KR101152693B1 (pt)
CN (1)	CN1922189B (pt)
AR (1)	AR047163A1 (pt)
AT (1)	ATE390430T1 (pt)
AU (1)	AU2004312147B2 (pt)
BR (1)	BRPI0418052A2 (pt)
CA (1)	CA2550868C (pt)
CY (1)	CY1107975T1 (pt)
DE (2)	DE10360792A1 (pt)
DK (1)	DK1725567T3 (pt)
EC (1)	ECSP066667A (pt)
ES (1)	ES2303964T3 (pt)
HR (1)	HRP20080272T3 (pt)
IL (1)	IL176457A (pt)
MX (1)	MXPA06007171A (pt)
NO (1)	NO337127B1 (pt)
NZ (1)	NZ548317A (pt)
PE (1)	PE20050758A1 (pt)
PL (1)	PL1725567T3 (pt)
PT (1)	PT1725567E (pt)
RU (1)	RU2383544C2 (pt)
SI (1)	SI1725567T1 (pt)
WO (1)	WO2005066183A1 (pt)
ZA (1)	ZA200606067B (pt)

Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7776314B2 (en)	2002-06-17	2010-08-17	Grunenthal Gmbh	Abuse-proofed dosage system
DE10252667A1 (de) *	2002-11-11	2004-05-27	Grünenthal GmbH	Spirocyclische Cyclohexan-Derivate
DE10336400A1 (de)	2003-08-06	2005-03-24	Grünenthal GmbH	Gegen Missbrauch gesicherte Darreichungsform
DE102004032051A1 (de)	2004-07-01	2006-01-19	Grünenthal GmbH	Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform
DE10361596A1 (de)	2003-12-24	2005-09-29	Grünenthal GmbH	Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
US8075872B2 (en)	2003-08-06	2011-12-13	Gruenenthal Gmbh	Abuse-proofed dosage form
DE102005005446A1 (de)	2005-02-04	2006-08-10	Grünenthal GmbH	Bruchfeste Darreichungsformen mit retardierter Freisetzung
US20070048228A1 (en)	2003-08-06	2007-03-01	Elisabeth Arkenau-Maric	Abuse-proofed dosage form
DE10360793A1 (de) *	2003-12-23	2005-07-28	Grünenthal GmbH	Spirocyclische Cyclohexan-Derivate
DE102004032049A1 (de)	2004-07-01	2006-01-19	Grünenthal GmbH	Gegen Missbrauch gesicherte, orale Darreichungsform
DE102005005449A1 (de)	2005-02-04	2006-08-10	Grünenthal GmbH	Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
DE102005016460A1 (de) *	2005-04-11	2006-10-19	Grünenthal GmbH	Spriocyclische Cyclohexanderivate zur Behandlung von Substanzabhängigkeit
DE102006019597A1 (de)	2006-04-27	2007-10-31	Grünenthal GmbH	Spirocyclische Cyclohexan-Derivate
DE102006033114A1 (de)	2006-07-18	2008-01-24	Grünenthal GmbH	Spirocyclische Azaindol-Derivate
EP1894938A1 (en) *	2006-08-31	2008-03-05	Evonik Degussa GmbH	New cyclopentadienyl, indenyl or fluorenyl substituted phosphine compounds and their use in catalytic reactions
DE102006046745A1 (de) *	2006-09-29	2008-04-03	Grünenthal GmbH	Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz
DE102007009319A1 (de)	2007-02-22	2008-08-28	Grünenthal GmbH	Spirocyclische Cyclohexan-Derivate
DE102007009235A1 (de) *	2007-02-22	2008-09-18	Grünenthal GmbH	Spirocyclische Cyclohexan-Derivate
DE102007011485A1 (de)	2007-03-07	2008-09-11	Grünenthal GmbH	Darreichungsform mit erschwertem Missbrauch
ES2523580T3 (es)	2008-01-11	2014-11-27	Albany Molecular Research, Inc.	Piridoindoles substituidos con (1-Azinona)
AU2009207796B2 (en)	2008-01-25	2014-03-27	Grunenthal Gmbh	Pharmaceutical dosage form
WO2009118163A1 (de)	2008-03-27	2009-10-01	Grünenthal GmbH	(hetero-)aryl-cyclohexan-derivate
EP2502907B1 (de)	2008-03-27	2018-08-29	Grünenthal GmbH	Substituierte 4-Aminocyclohexan-Derivate
AR071067A1 (es)	2008-03-27	2010-05-26	Gruenenthal Chemie	Ciclohexildiaminas sustituidas
PT2260042E (pt) *	2008-03-27	2011-12-06	Gruenenthal Gmbh	Derivados de ciclo-hexano espirocíclicos substituídos
PL2271613T3 (pl) *	2008-03-27	2014-09-30	Gruenenthal Gmbh	Hydroksymetylocykloheksyloaminy
CA2719736C (en) *	2008-03-27	2016-02-09	Gruenenthal Gmbh	Spiro(5.5)undecane derivatives
KR101690094B1 (ko)	2008-05-09	2016-12-27	그뤼넨탈 게엠베하	분무 응결 단계의 사용하에 중간 분말 제형 및 최종 고체 제형을 제조하는 방법
PL2356123T3 (pl)	2008-11-13	2013-03-29	Hoffmann La Roche	Spiro-5,6-dihudro-4h-2,3,5,10b- tetraazabenzo[e]azuleny
US8629158B2 (en) *	2009-07-01	2014-01-14	Albany Molecular Research, Inc.	Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof
US8618299B2 (en) *	2009-07-01	2013-12-31	Albany Molecular Research, Inc.	Azinone-substituted azapolycycle MCH-1 antagonists, methods of making, and use thereof
US8637501B2 (en) *	2009-07-01	2014-01-28	Albany Molecular Research, Inc.	Azinone-substituted azepino[b]indole and pyrido-pyrrolo-azepine MCH-1 antagonists, methods of making, and use thereof
US9073925B2 (en) *	2009-07-01	2015-07-07	Albany Molecular Research, Inc.	Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof
CA2765971C (en)	2009-07-22	2017-08-22	Gruenenthal Gmbh	Hot-melt extruded controlled release dosage form
ES2428938T3 (es)	2009-07-22	2013-11-12	Grünenthal GmbH	Forma de dosificación resistente a la manipulación y estabilizada frente a la oxidación
UA107943C2 (xx) *	2009-11-16	2015-03-10	Lilly Co Eli	Сполуки спіропіперидину як антагоністи рецептора orl-1
SI2501704T1 (sl) *	2009-11-16	2013-11-29	Eli Lilly Company	Spojine spiropiperidina kot antagonisti oral-1 receptorja
PL3070091T3 (pl)	2010-06-24	2019-09-30	Leo Pharma A/S	Pochodne benzodioksolu jako inhibitory fosfodiesterazy
TWI582092B (zh) *	2010-07-28	2017-05-11	歌林達股份有限公司	順式－四氫－螺旋（環己烷－１,１’－吡啶［３,４－b］吲哚）－４－胺－衍生物
RU2604676C2 (ru)	2010-09-02	2016-12-10	Грюненталь Гмбх	Устойчивая к разрушению лекарственная форма, содержащая неорганическую соль
PL2611425T3 (pl)	2010-09-02	2014-09-30	Gruenenthal Gmbh	Odporna na ingerencję postać dawki zawierająca polimer anionowy
TWI501788B (zh)	2010-09-02	2015-10-01		含陰離子聚合物之抗破碎劑型
WO2012088038A2 (en)	2010-12-21	2012-06-28	Albany Molecular Research, Inc.	Piperazinone-substituted tetrahydro-carboline mch-1 antagonists, methods of making, and uses thereof
US8993765B2 (en)	2010-12-21	2015-03-31	Albany Molecular Research, Inc.	Tetrahydro-azacarboline MCH-1 antagonists, methods of making, and uses thereof
PL2736495T3 (pl)	2011-07-29	2018-01-31	Gruenenthal Gmbh	Tabletka odporna na ingerencję, zapewniająca natychmiastowe uwalnianie leku
HRP20171458T1 (hr)	2011-07-29	2017-11-17	Grünenthal GmbH	Tableta otporna na mijenjanje koja pruža neposredno oslobađanje lijeka
LT2809320T (lt) *	2012-02-03	2017-05-25	Grünenthal GmbH	(1r,4r)-6`-fluor-(n-metil- arba n,n-dimetil-)-4-fenil-4`,9`-dihidro-3`h-spiro-[cikloheksan-1,1`-pirano[3,4,b]indol]-4-aminas fibromialgijos ir lėtinio nuovargio sindromo gydymui
WO2013127831A1 (en)	2012-02-28	2013-09-06	Grünenthal GmbH	Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer
WO2013127830A1 (en)	2012-02-28	2013-09-06	Grünenthal GmbH	Tamper-resistant pharmaceutical dosage form comprising nonionic surfactant
LT2838512T (lt)	2012-04-18	2018-11-12	GrĆ¼nenthal GmbH	Pažeidimui atspari ir dozės atpalaidavimo nuokrypiui atspari farmacinė vaisto forma
US10064945B2 (en)	2012-05-11	2018-09-04	Gruenenthal Gmbh	Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
WO2013167735A1 (en)	2012-05-11	2013-11-14	Grünenthal GmbH	Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
US8912226B2 (en)	2012-05-18	2014-12-16	Gruenenthal Gmbh	Pharmaceutical composition comprising (1r,4r) -6′-fluoro-N,N-dimethyl-4-phenyl-4′,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano[3,4,b]indol]-4-amine and a NSAR
US9320729B2 (en)	2012-05-18	2016-04-26	Gruenenthal Gmbh	Pharmaceutical composition comprising (1r,4r)-6′-flouro-N,N-dimethyl-4-phenyl-4′,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano-[3,4,b]indol]-4-amine and a propionic acid derivative
US9345689B2 (en) *	2012-05-18	2016-05-24	Gruenenthal Gmbh	Pharmaceutical composition comprising (1r,4r)-6′-fluoro-N, N-dimethyl-4-phenyl-4,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano[3,4,b]indol]-4-amine and an anticonvulsant
US20130310435A1 (en)	2012-05-18	2013-11-21	Gruenenthal Gmbh	Pharmaceutical Composition Comprising (1r,4r)-6'-fluoro-N, N-dimethyl-4-phenyl-4,9' -dihydro-3'H-spiro[cyclohexane-1,1' -pyrano[3,4,b]indol]-4-amine and Paracetamol or Propacetamol
US9320725B2 (en)	2012-05-18	2016-04-26	Gruenenthal Gmbh	Pharmaceutical composition comprising (1r,4r)-6′-fluoro-N,N-dimethyl-4-phenyl-4′9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano[3,4,b]indol]-4-amine and a gabapentinoid
US9855286B2 (en) *	2012-05-18	2018-01-02	Gruenenthal Gmbh	Pharmaceutical composition comprising (1r,4r)-6′-fluoro-N,N-di methyl-4-phenyl-4′,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano-[3,4,b]indol]-4-amine and a salicylic acid component
US9308196B2 (en) *	2012-05-18	2016-04-12	Gruenenthal Gmbh	Pharmaceutical composition comprising (1 r,4r) -6'-fluoro-N ,N-dimethyl-4-phenyl-4',9'-d ihydro-3'H-spiro[cyclohexane-1,1'-pyrano-[3,4,b]indol]-4-amine and an oxicam
US20130310385A1 (en)	2012-05-18	2013-11-21	Gruenenthal Gmbh	Pharmaceutical Composition Comprising (1r,4r)-6'-fluoro-N,N-dimethyl-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine and Antidepressants
EP2970284B1 (en)	2013-03-15	2017-11-01	Grünenthal GmbH	Crystalline cis-(e)-4-(3-fluorophenyl)-2',3',4',9'-tetrahydro-n,n-dimethyl-2'-(1-oxo-3-phenyl-2-propenyl)-spiro[cyclohexane-1,1'[1h]-pyrido[3,4-b]indol]-4-amine
JP6445537B2 (ja)	2013-05-29	2018-12-26	グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング	１個または複数の粒子を含有する改変防止（ｔａｍｐｅｒ−ｒｅｓｉｓｔａｎｔ）剤形
AR096438A1 (es)	2013-05-29	2015-12-30	Gruenenthal Gmbh	Forma de dosificación resistente al uso indebido con perfil de liberación bimodal, proceso
US10624862B2 (en)	2013-07-12	2020-04-21	Grünenthal GmbH	Tamper-resistant dosage form containing ethylene-vinyl acetate polymer
JP6480936B2 (ja)	2013-11-26	2019-03-13	グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング	クライオミリングによる粉末状医薬組成物の調製
EP3082781A1 (en)	2013-12-16	2016-10-26	Grünenthal GmbH	Tamper resistant dosage form with bimodal release profile manufactured by co-extrusion
JP2017518980A (ja)	2014-05-12	2017-07-13	グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング	タペンタドールを含む、改変防止即時放出カプセル製剤
CN106456550A (zh)	2014-05-26	2017-02-22	格吕伦塔尔有限公司	避免乙醇剂量倾泻的多颗粒
ES2686326T3 (es)	2014-07-15	2018-10-17	Grünenthal GmbH	Derivados de azaspiro(4,5)decano sustituidos
TW201607923A (zh)	2014-07-15	2016-03-01	歌林達有限公司	被取代之氮螺環（４．５）癸烷衍生物
WO2016124530A1 (en)	2015-02-03	2016-08-11	Grünenthal GmbH	Tamper-resistant dosage form comprising a polyethylene glycol graft copolymer
KR20170139158A (ko)	2015-04-24	2017-12-18	그뤼넨탈 게엠베하	즉시 방출되고 용매 추출 방지된 변조 방지된 투여 형태
WO2017042325A1 (en)	2015-09-10	2017-03-16	Grünenthal GmbH	Protecting oral overdose with abuse deterrent immediate release formulations
AU2016341527B2 (en)	2015-10-22	2023-04-27	Juno Therapeutics Gmbh	Methods, kits, agents and apparatuses for transduction
CA3029869A1 (en)	2016-07-06	2018-01-11	Grunenthal Gmbh	Reinforced pharmaceutical dosage form
GB202306662D0 (en)	2023-05-05	2023-06-21	Union Therapeutics As	Dosage regimen

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3843681A (en) *	1971-06-01	1974-10-22	American Home Prod	1-carboxamido pyrano(thiopyrano)(3,4-6)indole derivatives
FR2663935A1 (fr) *	1990-06-27	1992-01-03	Adir	Nouveaux 1,2,3,4,5,6-hexahydroazepino [4,5-b] indoles et 1,2,3,4-tetrahydrobethacarbolines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
RU2233841C2 (ru) *	1998-06-12	2004-08-10	Сосьете Де Консей Де Решерш Э Д`Аппликасьон Сьентифик Сас	Бета-карболиновые соединения, фармацевтические композиции на их основе и способы связывания, достижения агонистического/антагонистического эффекта
WO2000038720A1 (en) *	1998-12-24	2000-07-06	Meiji Seika Kaisha, Ltd.	Remedies for pain
DE10044649A1 (de) *	2000-09-08	2002-07-04	Gruenenthal Gmbh	Substituierte 4-Phenyl-1-(1-phenyl-cyclohexyl)-1,2,3,6-tetrahydropyridine
DE10123163A1 (de) *	2001-05-09	2003-01-16	Gruenenthal Gmbh	Substituierte Cyclohexan-1,4-diaminderivate
DE10252667A1 (de) *	2002-11-11	2004-05-27	Grünenthal GmbH	Spirocyclische Cyclohexan-Derivate
DE10360793A1 (de) *	2003-12-23	2005-07-28	Grünenthal GmbH	Spirocyclische Cyclohexan-Derivate

2003
- 2003-12-23 DE DE10360792A patent/DE10360792A1/de not_active Withdrawn
2004
- 2004-12-21 RU RU2006126787/04A patent/RU2383544C2/ru not_active IP Right Cessation
- 2004-12-21 MX MXPA06007171A patent/MXPA06007171A/es active IP Right Grant
- 2004-12-21 HR HR20080272T patent/HRP20080272T3/xx unknown
- 2004-12-21 BR BRPI0418052A patent/BRPI0418052A2/pt not_active Application Discontinuation
- 2004-12-21 DK DK04804136T patent/DK1725567T3/da active
- 2004-12-21 CA CA2550868A patent/CA2550868C/en not_active Expired - Fee Related
- 2004-12-21 JP JP2006546040A patent/JP4885733B2/ja not_active Expired - Fee Related
- 2004-12-21 PL PL04804136T patent/PL1725567T3/pl unknown
- 2004-12-21 DE DE502004006697T patent/DE502004006697D1/de not_active Expired - Lifetime
- 2004-12-21 EP EP04804136A patent/EP1725567B1/de not_active Expired - Lifetime
- 2004-12-21 ES ES04804136T patent/ES2303964T3/es not_active Expired - Lifetime
- 2004-12-21 PT PT04804136T patent/PT1725567E/pt unknown
- 2004-12-21 NZ NZ548317A patent/NZ548317A/en not_active IP Right Cessation
- 2004-12-21 SI SI200430663T patent/SI1725567T1/sl unknown
- 2004-12-21 AT AT04804136T patent/ATE390430T1/de active
- 2004-12-21 WO PCT/EP2004/014539 patent/WO2005066183A1/de not_active Ceased
- 2004-12-21 KR KR1020067014815A patent/KR101152693B1/ko not_active Expired - Fee Related
- 2004-12-21 AU AU2004312147A patent/AU2004312147B2/en not_active Ceased
- 2004-12-21 CN CN2004800420360A patent/CN1922189B/zh not_active Expired - Fee Related
- 2004-12-22 AR ARP040104857A patent/AR047163A1/es not_active Application Discontinuation
- 2004-12-23 US US11/019,372 patent/US7332519B2/en not_active Expired - Fee Related
2005
- 2005-01-03 PE PE2005000023A patent/PE20050758A1/es not_active Application Discontinuation
2006
- 2006-06-21 EC EC2006006667A patent/ECSP066667A/es unknown
- 2006-06-21 IL IL176457A patent/IL176457A/en not_active IP Right Cessation
- 2006-07-21 ZA ZA200606067A patent/ZA200606067B/en unknown
- 2006-07-24 NO NO20063422A patent/NO337127B1/no not_active IP Right Cessation
2008
- 2008-05-29 CY CY20081100557T patent/CY1107975T1/el unknown

Also Published As

Publication number	Publication date
AU2004312147B2 (en)	2010-06-10
ES2303964T3 (es)	2008-09-01
DE502004006697D1 (de)	2008-05-08
MXPA06007171A (es)	2006-08-23
NZ548317A (en)	2010-01-29
RU2383544C2 (ru)	2010-03-10
PE20050758A1 (es)	2005-10-18
CN1922189A (zh)	2007-02-28
ATE390430T1 (de)	2008-04-15
RU2006126787A (ru)	2008-01-27
US7332519B2 (en)	2008-02-19
EP1725567B1 (de)	2008-03-26
WO2005066183A1 (de)	2005-07-21
ECSP066667A (es)	2006-10-25
SI1725567T1 (sl)	2008-06-30
CY1107975T1 (el)	2013-09-04
NO20063422L (no)	2006-09-25
IL176457A (en)	2013-11-28
CA2550868C (en)	2012-03-06
NO337127B1 (no)	2016-01-25
EP1725567A1 (de)	2006-11-29
IL176457A0 (en)	2006-10-05
HRP20080272T3 (en)	2008-09-30
JP2007515446A (ja)	2007-06-14
US20050192333A1 (en)	2005-09-01
ZA200606067B (en)	2007-10-31
CA2550868A1 (en)	2005-07-21
DE10360792A1 (de)	2005-07-28
DK1725567T3 (da)	2008-06-16
JP4885733B2 (ja)	2012-02-29
HK1095831A1 (zh)	2007-05-18
CN1922189B (zh)	2010-06-16
AR047163A1 (es)	2006-01-11
AU2004312147A1 (en)	2005-07-21
KR20070014117A (ko)	2007-01-31
PL1725567T3 (pl)	2008-09-30
BRPI0418052A2 (pt)	2017-04-18
KR101152693B1 (ko)	2012-06-15

Publication	Publication Date	Title
PT1725567E (pt)	2008-05-09	Derivados espirocíclicos de ciclo-hexano com afinidade para o receptor orl-1
SI1697379T1 (sl)	2009-08-31	Spirociklični cikloheksanski derivati
PL390420A1 (pl)	2010-04-26	Spirocykliczne pochodne cykloheksanu, sposoby ich wytwarzania, ich zastosowania oraz środek leczniczy zawierający te związki
GB2418405B (en)	2010-03-10	Rotorcraft
AU2003286870A8 (en)	2005-01-04	Targeting polypeptides to the central nervous system
ZA200906736B (en)	2010-10-27	New 3-([1,2,4] Triazolo [4,3-A]Pyridin-7-YL) Benzamide derivatives
IL186354A0 (en)	2008-01-20	INTERMEDIATE COMPOUNDS FOR THE PREPARATION OF TRANS -5-CHLORO-2-METHYL-2,3,3a,12b-TETRAHYDRO-1H -DIBENZ[2,3:6,7] OXEPINO [4,5-c] PYRROLE
ZA200700684B (en)	2008-10-29	Tricyclic indeno-pyrrole derivatives as serotonin receptor modulators
IL199015A0 (en)	2010-02-17	Quinuclidinol derivatives as muscarinic receptor antagonists
IL189453A0 (en)	2008-08-07	Carboxamide derivatives as muscarinic receptor antagonists
ZA200609234B (en)	2008-08-27	Substituted azeplne derivatives as serotonin receptor modulators
EP1890696A4 (en)	2010-05-05	Suitable as new ORL-1 receptor modulators are 3-pyrolytic indolyl derivatives
AU2003205964A1 (en)	2004-08-30	Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
IL178622A0 (en)	2007-02-11	Piperazinylpiperidine derivatives as chemokine receptor antagonists
AU2003214520A1 (en)	2004-11-01	Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
AU2002347552A1 (en)	2004-07-14	1-substituted-3-pyrrolidine derivatives as muscarinic receptor antagonists
ZA200903496B (en)	2010-03-31	Spiro-piperidine derivatives as via receptor antagonists
AU2003223010A1 (en)	2004-11-01	Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
PT1761514E (pt)	2008-10-28	Novos derivados de tetra-hidrofurano tetracíclicos
ZA200608369B (en)	2009-04-29	Piperazinylpiperidine derivatives as chemokine receptor antagonists
ZA200508200B (en)	2006-07-26	Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
HK1107979A (en)	2008-04-25	Muscarinic receptor antagonists
IL165695A0 (en)	2006-01-15	Novel tricyclic spiropiperidines or spiropyrrolidines
GB0314675D0 (en)	2003-07-30	Improvements to helicopters
HK1106509A (en)	2008-03-14	Pyrrolidine derivatives as muscarinic receptor antagonists