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PT1748990E - Processo para a preparação de telmisartan - Google Patents

Processo para a preparação de telmisartan Download PDF

Info

Publication number
PT1748990E
PT1748990E PT05744422T PT05744422T PT1748990E PT 1748990 E PT1748990 E PT 1748990E PT 05744422 T PT05744422 T PT 05744422T PT 05744422 T PT05744422 T PT 05744422T PT 1748990 E PT1748990 E PT 1748990E
Authority
PT
Portugal
Prior art keywords
telmisartan
preparation
Prior art date
Application number
PT05744422T
Other languages
English (en)
Inventor
Rajendra Narayanrao Kankan
Dharmaraj Ramachandra Rao
Pathi L Srinivas
Puppala Ravikumar
Original Assignee
Cipla Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cipla Ltd filed Critical Cipla Ltd
Publication of PT1748990E publication Critical patent/PT1748990E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/20—Two benzimidazolyl-2 radicals linked together directly or via a hydrocarbon or substituted hydrocarbon radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
PT05744422T 2004-05-11 2005-05-10 Processo para a preparação de telmisartan PT1748990E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB0410471A GB2414019A (en) 2004-05-11 2004-05-11 One-step preparation of telmisartan by condensation and hydrolysis

Publications (1)

Publication Number Publication Date
PT1748990E true PT1748990E (pt) 2008-09-10

Family

ID=32526813

Family Applications (1)

Application Number Title Priority Date Filing Date
PT05744422T PT1748990E (pt) 2004-05-11 2005-05-10 Processo para a preparação de telmisartan

Country Status (15)

Country Link
US (1) US8691999B2 (pt)
EP (1) EP1748990B1 (pt)
JP (1) JP5160219B2 (pt)
KR (1) KR101183034B1 (pt)
AR (1) AR048954A1 (pt)
AT (1) ATE399157T1 (pt)
AU (1) AU2005240836B2 (pt)
CA (1) CA2566431C (pt)
DE (1) DE602005007734D1 (pt)
ES (1) ES2308494T3 (pt)
GB (1) GB2414019A (pt)
NZ (1) NZ551255A (pt)
PT (1) PT1748990E (pt)
WO (1) WO2005108375A1 (pt)
ZA (1) ZA200609290B (pt)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006044754A2 (en) 2004-10-18 2006-04-27 Dr. Reddy's Laboratories Ltd. Process for preparing telmisartan
WO2006136916A2 (en) * 2005-06-20 2006-12-28 Glenmark Pharmaceuticals Limited Substantially pure micronized particles of telmisartan and pharmaceutical compositions containing same
CN101172968B (zh) * 2006-11-01 2010-05-12 浙江天宇药业有限公司 2-正丙基-4甲基-6-(甲基苯并咪唑-2-基)苯并咪唑盐及其制备方法
CZ302272B6 (cs) 2007-07-09 2011-01-19 Zentiva, A. S. Zpusob výroby 4´-[[4-methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazol-1-yl]methyl]biphenyl-2-karboxylové kyseliny (telmisartanu)
WO2009123483A1 (en) 2008-03-31 2009-10-08 Zaklady Farmaceutyczne Polpharma Sa Process for preparation of telmisartan
EP2123648A1 (en) 2008-05-20 2009-11-25 Chemo Ibérica, S.A. A process for the preparation of Telmisartan.
WO2010018441A2 (en) * 2008-08-11 2010-02-18 Cadila Pharmaceuticals Ltd. An improved process for the preparation of substantially pure telmisartan
KR100893652B1 (ko) 2008-11-10 2009-04-17 주식회사종근당 신규한 텔미사르탄 아연염 및 그의 제조방법
WO2010146187A2 (en) * 2009-06-19 2010-12-23 Krka, Tovarna Zdravil, D.D., Novo Mesto Process for the preparation of telmisartan
JP5711888B2 (ja) * 2010-01-26 2015-05-07 株式会社Ｄｎｐファインケミカル宇都宮 テルミサルタンアルキルエステルの製造法
KR20110094751A (ko) * 2010-02-17 2011-08-24 동화약품주식회사 텔미사탄의 개선된 제조방법
EP2632438A1 (en) 2010-10-27 2013-09-04 KRKA, tovarna zdravil, d.d., Novo mesto Multilayer pharmaceutical composition comprising telmisartan and amlodipine
CN102219746B (zh) * 2011-04-07 2014-02-26 威海迪素制药有限公司 替米沙坦杂质b的制备方法
CN102212034B (zh) * 2011-04-14 2014-02-26 威海迪素制药有限公司 替米沙坦杂质b的制备方法
CN102267949A (zh) * 2011-06-14 2011-12-07 张长利 替米沙坦制备新工艺
KR101607661B1 (ko) * 2013-12-24 2016-03-31 주식회사 파마코스텍 텔미사르탄의 신규 제조 방법
JP6284861B2 (ja) * 2014-09-03 2018-02-28 株式会社トクヤマ テルミサルタンの製造方法
CN106008356B (zh) * 2016-06-07 2023-02-28 浙江华海药业股份有限公司 一种替米沙坦的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5614519A (en) 1991-02-06 1997-03-25 Karl Thomae Gmbh (1-(2,3 or 4-N-morpholinoalkyl)-imidazol-4-yl)-benizimidazol-1-yl-methyl]-biphenyls useful as angiotensin-II antagonists
SI9210098B (sl) * 1991-02-06 2000-06-30 Dr. Karl Thomae Benzimidazoli, zdravila, ki te spojine vsebujejo, in postopek za njihovo pripravo
DE4408497A1 (de) * 1994-03-14 1995-09-21 Thomae Gmbh Dr K Benzimidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
US6416487B1 (en) 1997-07-30 2002-07-09 Renal Tech International Llc Method of removing beta-2 microglobulin from blood
WO2000027397A1 (en) * 1998-11-06 2000-05-18 Glaxo Group Limited Antihypertensive medicaments containing lacidipine and telmisartan
DE19901921C2 (de) * 1999-01-19 2001-01-04 Boehringer Ingelheim Pharma Polymorphe von Telmisartan, Verfahren zu deren Herstellung und deren Verwendung zur Herstellung eines Arzneimittels
US6358986B1 (en) 1999-01-19 2002-03-19 Boehringer Ingelheim Pharma Kg Polymorphs of telmisartan
CN1182122C (zh) * 2001-07-30 2004-12-29 中国科学院上海药物研究所 替米沙坦的合成新路线
CN1204124C (zh) 2001-10-15 2005-06-01 中国科学院上海药物研究所 替米沙坦的一种制备路线
DE10201725A1 (de) * 2002-01-18 2003-08-14 Boehringer Ingelheim Pharma Verfahren zur Herstellung und Reinigung von 1,7'-Dimethyl-2'-propyl-2,5'-bi-1H-benzimidazol
DE10314702A1 (de) * 2003-03-31 2004-10-21 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung von Telmisartan

Also Published As

Publication number Publication date
GB2414019A (en) 2005-11-16
JP2007537222A (ja) 2007-12-20
DE602005007734D1 (de) 2008-08-07
ATE399157T1 (de) 2008-07-15
WO2005108375A1 (en) 2005-11-17
US20080015359A1 (en) 2008-01-17
CA2566431A1 (en) 2005-11-17
ZA200609290B (en) 2008-05-28
EP1748990B1 (en) 2008-06-25
AR048954A1 (es) 2006-06-14
JP5160219B2 (ja) 2013-03-13
EP1748990A1 (en) 2007-02-07
AU2005240836A1 (en) 2005-11-17
US8691999B2 (en) 2014-04-08
KR101183034B1 (ko) 2012-09-17
GB0410471D0 (en) 2004-06-16
CA2566431C (en) 2013-04-09
KR20070012546A (ko) 2007-01-25
NZ551255A (en) 2010-03-26
ES2308494T3 (es) 2008-12-01
AU2005240836B2 (en) 2010-09-23

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