PT1673354E - Arilindenopiridinas e arilindenopirimidinas e sua utilização como antagonistas do receptor da adenosina a2a - Google Patents
Arilindenopiridinas e arilindenopirimidinas e sua utilização como antagonistas do receptor da adenosina a2a Download PDFInfo
- Publication number
- PT1673354E PT1673354E PT03759708T PT03759708T PT1673354E PT 1673354 E PT1673354 E PT 1673354E PT 03759708 T PT03759708 T PT 03759708T PT 03759708 T PT03759708 T PT 03759708T PT 1673354 E PT1673354 E PT 1673354E
- Authority
- PT
- Portugal
- Prior art keywords
- arylindenopyrimidines
- arylindenopyridines
- adenosine
- receptor antagonists
- pharmaceutical compositions
- Prior art date
Links
- 229940123702 Adenosine A2a receptor antagonist Drugs 0.000 title 1
- 239000002467 adenosine A2a receptor antagonist Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 102000007471 Adenosine A2A receptor Human genes 0.000 abstract 1
- 108010085277 Adenosine A2A receptor Proteins 0.000 abstract 1
- 230000001668 ameliorated effect Effects 0.000 abstract 1
- 230000003042 antagnostic effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychology (AREA)
- Dermatology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2003/031471 WO2005042500A1 (en) | 2003-10-03 | 2003-10-03 | Arylindenopyridines and arylindenopyridines and their use as adenosine a2a receptor antagonist |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1673354E true PT1673354E (pt) | 2009-07-14 |
Family
ID=34548801
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT03759708T PT1673354E (pt) | 2003-10-03 | 2003-10-03 | Arilindenopiridinas e arilindenopirimidinas e sua utilização como antagonistas do receptor da adenosina a2a |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP1673354B1 (pt) |
| JP (1) | JP4725963B2 (pt) |
| CN (1) | CN1878761A (pt) |
| AT (1) | ATE429421T1 (pt) |
| AU (1) | AU2003275430A1 (pt) |
| BR (1) | BR0318521A (pt) |
| CA (1) | CA2540686A1 (pt) |
| CY (1) | CY1109808T1 (pt) |
| DE (1) | DE60327375D1 (pt) |
| DK (1) | DK1673354T3 (pt) |
| EA (1) | EA200600688A1 (pt) |
| EC (1) | ECSP066474A (pt) |
| ES (1) | ES2326075T3 (pt) |
| HR (1) | HRP20060127A2 (pt) |
| IL (1) | IL174678A0 (pt) |
| IS (1) | IS8377A (pt) |
| NO (1) | NO20061981L (pt) |
| PT (1) | PT1673354E (pt) |
| RS (1) | RS20060237A (pt) |
| SI (1) | SI1673354T1 (pt) |
| WO (1) | WO2005042500A1 (pt) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2273599B1 (es) | 2005-10-14 | 2008-06-01 | Universidad De Barcelona | Compuestos para el tratamiento de la fibrilacion auricular. |
| EP2040549B1 (en) | 2006-07-11 | 2013-10-23 | Janssen Pharmaceutica NV | Benzofuro-and benzothienopyryimidine modulators of the histamine h4 receptor |
| US7985745B2 (en) | 2006-10-02 | 2011-07-26 | Abbott Laboratories | Method for pain treatment |
| US8735411B2 (en) | 2006-10-02 | 2014-05-27 | Abbvie Inc. | Macrocyclic benzofused pyrimidine derivatives |
| US7960400B2 (en) | 2007-08-27 | 2011-06-14 | Duquesne University Of The Holy Ghost | Tricyclic compounds having cytostatic and/or cytotoxic activity and methods of use thereof |
| EP2217575A1 (en) | 2007-10-24 | 2010-08-18 | Janssen Pharmaceutica, N.V. | Arylindenopyrimidines and their use as adenosine a2a receptor antagonists |
| PA8801401A1 (es) * | 2007-10-25 | 2009-05-15 | Janssen Pharmaceutica Nv | Arilindenopirimidinas y su uso como adenosina a2a |
| US20100093763A1 (en) * | 2008-10-13 | 2010-04-15 | Barbay J Kent | PHENYL SUBSTITUTED THIENO[2,3-d]PYRIMIDINES AND THEIR USE AS ADENOSINE A2a RECEPTOR ANTAGONISTS |
| US20110105494A1 (en) * | 2009-10-29 | 2011-05-05 | Jackson Paul F | Heteroaryl substituted arylindenopyrimidines and their use as highly selective adenosine a2a receptor antagonists |
| US20110105493A1 (en) * | 2009-10-29 | 2011-05-05 | Jackson Paul F | HETEROCYCLYL SUBSTITUTED ARYLINDENOPYRIMIDINES AND THEIR USE AS HIGHLY SELECTIVE ADENOSINE A2a RECEPTOR ANTAGONISTS |
| US20110105492A1 (en) * | 2009-10-29 | 2011-05-05 | Jackson Paul F | ARYL SUBSTITUTED ARYLINDENOPYRIMIDINES AND THEIR USE AS HIGHLY SELECTIVE ADENOSINE A2a RECEPTOR ANTAGONISTS |
| US20110105541A1 (en) * | 2009-10-29 | 2011-05-05 | Jackson Paul F | ALKYL SUBSTITUTED ARYLINDENOPYRIMIDINES AND THEIR USE AS HIGHLY SELECTIVE ADENOSINE A2a RECEPTOR ANTAGONISTS |
| US20110105540A1 (en) * | 2009-10-29 | 2011-05-05 | Jackson Paul F | 2-AMINO-9-[4-(4-METHOXY-PHENOXY)-PIPERIDIN-1-YL]-4-PHENYL-INDENO[1,2-D]PYRIMIDIN-5-ONE AND ITS USE AS A HIGHLY SELECTIVE ADENOSINE A2a RECEPTOR ANTAGONIST |
| AR103992A1 (es) | 2015-01-16 | 2017-06-21 | Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno | Método para preparar compuestos fenólicos a partir de biomasa |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993008167A1 (fr) * | 1991-10-24 | 1993-04-29 | Nippon Soda Co., Ltd. | Nouveau derive heterocyclique et bactericide agrohorticole le renfermant |
| ES2126773T3 (es) * | 1993-09-15 | 1999-04-01 | Merck Sharp & Dohme | Derivados triciclicos heteroaromaticos condensados como ligandos de subtipos de receptores de dopamina. |
| JP2001139556A (ja) * | 1999-03-18 | 2001-05-22 | Nippon Soda Co Ltd | インデノピリジンおよびインデノピリミジン化合物並びにその製造法 |
| EP1261327B1 (en) * | 2000-02-25 | 2005-04-27 | F.Hoffmann-La Roche Ag | Adenosine receptor modulators |
| JP2004532228A (ja) * | 2001-04-18 | 2004-10-21 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | Ｐｄｅ阻害作用をもつアリールインデノピリジン |
| US6958328B2 (en) * | 2001-04-18 | 2005-10-25 | Ortho-Mcneil Pharmaceutical, Inc | Arylindenopyridines and related therapeutic and prophylactic methods |
-
2003
- 2003-10-03 DK DK03759708T patent/DK1673354T3/da active
- 2003-10-03 SI SI200331625T patent/SI1673354T1/sl unknown
- 2003-10-03 HR HR20060127A patent/HRP20060127A2/xx not_active Application Discontinuation
- 2003-10-03 EA EA200600688A patent/EA200600688A1/ru unknown
- 2003-10-03 WO PCT/US2003/031471 patent/WO2005042500A1/en not_active Ceased
- 2003-10-03 JP JP2005510193A patent/JP4725963B2/ja not_active Expired - Fee Related
- 2003-10-03 BR BRPI0318521-4A patent/BR0318521A/pt not_active IP Right Cessation
- 2003-10-03 ES ES03759708T patent/ES2326075T3/es not_active Expired - Lifetime
- 2003-10-03 DE DE60327375T patent/DE60327375D1/de not_active Expired - Lifetime
- 2003-10-03 AT AT03759708T patent/ATE429421T1/de active
- 2003-10-03 CN CNA2003801107612A patent/CN1878761A/zh active Pending
- 2003-10-03 RS YUP-2006/0237A patent/RS20060237A/sr unknown
- 2003-10-03 EP EP03759708A patent/EP1673354B1/en not_active Expired - Lifetime
- 2003-10-03 PT PT03759708T patent/PT1673354E/pt unknown
- 2003-10-03 CA CA002540686A patent/CA2540686A1/en not_active Abandoned
- 2003-10-03 AU AU2003275430A patent/AU2003275430A1/en not_active Abandoned
-
2006
- 2006-03-27 IS IS8377A patent/IS8377A/is unknown
- 2006-03-30 IL IL174678A patent/IL174678A0/en unknown
- 2006-04-03 EC EC2006006474A patent/ECSP066474A/es unknown
- 2006-05-03 NO NO20061981A patent/NO20061981L/no not_active Application Discontinuation
-
2009
- 2009-07-14 CY CY20091100752T patent/CY1109808T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR0318521A (pt) | 2006-09-12 |
| AU2003275430A1 (en) | 2005-05-19 |
| IS8377A (is) | 2006-03-27 |
| JP2007521243A (ja) | 2007-08-02 |
| EP1673354A1 (en) | 2006-06-28 |
| HK1091200A1 (en) | 2007-01-12 |
| SI1673354T1 (sl) | 2009-10-31 |
| CY1109808T1 (el) | 2014-09-10 |
| ECSP066474A (es) | 2006-10-10 |
| WO2005042500A1 (en) | 2005-05-12 |
| ATE429421T1 (de) | 2009-05-15 |
| EP1673354B1 (en) | 2009-04-22 |
| EA200600688A1 (ru) | 2006-10-27 |
| ES2326075T3 (es) | 2009-09-30 |
| RS20060237A (sr) | 2008-11-28 |
| DK1673354T3 (da) | 2009-07-27 |
| DE60327375D1 (de) | 2009-06-04 |
| CN1878761A (zh) | 2006-12-13 |
| CA2540686A1 (en) | 2005-05-12 |
| NO20061981L (no) | 2006-07-03 |
| IL174678A0 (en) | 2006-08-20 |
| HRP20060127A2 (en) | 2006-07-31 |
| JP4725963B2 (ja) | 2011-07-13 |
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